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    Wyświetlanie 1-12 z 12
    Tytuł:
    Galacto-Oligosaccharides Increase the Abundance of Beneficial Probiotic Bacteria and Improve Gut Architecture and Goblet Cell Expression in Poorly Performing Piglets, but Not Performance.
    Autorzy:
    Lee A; Division of Microbiology, Brewing and Biotechnology, School of Biosciences, Sutton Bonington Campus, University of Nottingham, Loughborough, Leicestershire LE12 5RD, UK.
    Mansbridge SC; Agriculture and Environment Department, Harper Adams University, Shropshire TF10 8NB, UK.
    Liang L; Division of Microbiology, Brewing and Biotechnology, School of Biosciences, Sutton Bonington Campus, University of Nottingham, Loughborough, Leicestershire LE12 5RD, UK.
    Connerton IF; Division of Microbiology, Brewing and Biotechnology, School of Biosciences, Sutton Bonington Campus, University of Nottingham, Loughborough, Leicestershire LE12 5RD, UK.
    Mellits KH; Division of Microbiology, Brewing and Biotechnology, School of Biosciences, Sutton Bonington Campus, University of Nottingham, Loughborough, Leicestershire LE12 5RD, UK.
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    Źródło:
    Animals : an open access journal from MDPI [Animals (Basel)] 2023 Jan 08; Vol. 13 (2). Date of Electronic Publication: 2023 Jan 08.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin.
    Autorzy:
    Al-Beltagi S; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
    Goulding LV; The Pirbright Institute, Woking, UK.
    Chang DKE; Department of Chemical and Biological Engineering, University of Sheffield, Sheffield, UK.
    Mellits KH; School of Biosciences, University of Nottingham, Nottingham, UK.
    Hayes CJ; School of Chemistry, University of Nottingham, University Park, Nottingham, UK.
    Gershkovich P; School of Pharmacy, University of Nottingham, University Park, Nottingham, UK.
    Coleman CM; School of Life Sciences, University of Nottingham, University Park, Nottingham, UK.
    Chang KC; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
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    Źródło:
    Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 2946-2956.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Coinfection*
    SARS-CoV-2*/drug effects
    Thapsigargin*/pharmacology
    Thapsigargin*/therapeutic use
    COVID-19 Drug Treatment*
    Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Humans ; Pandemics
    SCR Organism:
    SARS-CoV-2 variants
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus.
    Autorzy:
    Al-Beltagi S; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Nottingham LE12 5RD, UK.
    Preda CA; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Nottingham LE12 5RD, UK.
    Goulding LV; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.
    James J; Animal and Plant Health Agency (APHA), Weybridge, Woodham Lane, Addlestone KT15 3NB, UK.
    Pu J; Key Laboratory of Animal Epidemiology, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, 2 Yuanmingyuan West Road, Beijing 100193, China.
    Skinner P; Animal and Plant Health Agency (APHA), Weybridge, Woodham Lane, Addlestone KT15 3NB, UK.
    Jiang Z; Key Laboratory of Animal Epidemiology, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, 2 Yuanmingyuan West Road, Beijing 100193, China.
    Wang BL; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Nottingham LE12 5RD, UK.
    Yang J; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Nottingham LE12 5RD, UK.
    Banyard AC; Animal and Plant Health Agency (APHA), Weybridge, Woodham Lane, Addlestone KT15 3NB, UK.
    Mellits KH; School of Biosciences, University of Nottingham, Sutton Bonington, Nottingham LE12 5RD, UK.
    Gershkovich P; School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
    Hayes CJ; School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
    Nguyen-Van-Tam J; School of Medicine, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
    Brown IH; Animal and Plant Health Agency (APHA), Weybridge, Woodham Lane, Addlestone KT15 3NB, UK.
    Liu J; Key Laboratory of Animal Epidemiology, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, 2 Yuanmingyuan West Road, Beijing 100193, China.
    Chang KC; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Nottingham LE12 5RD, UK.
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    Źródło:
    Viruses [Viruses] 2021 Feb 03; Vol. 13 (2). Date of Electronic Publication: 2021 Feb 03.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antiviral Agents/*pharmacology
    Betacoronavirus/*drug effects
    Coronavirus OC43, Human/*drug effects
    Influenza A Virus, H1N1 Subtype/*drug effects
    Respiratory Syncytial Virus, Human/*drug effects
    SARS-CoV-2/*drug effects
    Thapsigargin/*pharmacology
    Animals ; Antiviral Agents/therapeutic use ; Betacoronavirus/physiology ; Cell Line ; Cell Line, Tumor ; Cells, Cultured ; Coronavirus OC43, Human/physiology ; Endoplasmic Reticulum Stress ; Humans ; Influenza A Virus, H1N1 Subtype/physiology ; Mice ; Microbial Sensitivity Tests ; Orthomyxoviridae Infections/drug therapy ; Orthomyxoviridae Infections/virology ; Respiratory Syncytial Virus, Human/physiology ; Ribavirin/pharmacology ; SARS-CoV-2/physiology ; Thapsigargin/therapeutic use ; Virus Replication/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation.
    Autorzy:
    Chang P; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
    Kuchipudi SV; Veterinary and Biochemical Sciences, Pennsylvania State University, Wiley Lane, PA 16802, USA.
    Mellits KH; School of Biosciences, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
    Sebastian S; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
    James J; Avian Infectious Diseases, The Pirbright Institute, Compton Laboratory, RG20 7NN, UK.
    Liu J; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
    Shelton H; Avian Infectious Diseases, The Pirbright Institute, Compton Laboratory, RG20 7NN, UK.
    Chang KC; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
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    Źródło:
    Scientific reports [Sci Rep] 2015 Dec 08; Vol. 5, pp. 17999. Date of Electronic Publication: 2015 Dec 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Apoptosis*
    Virus Replication*
    Influenza A virus/*physiology
    Macrophages, Alveolar/*metabolism
    Macrophages, Alveolar/*virology
    Orthomyxoviridae Infections/*metabolism
    Orthomyxoviridae Infections/*virology
    Animals ; Humans ; Influenza A virus/classification ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/pathology ; Mutation ; Orthomyxoviridae Infections/immunology ; Polymorphism, Genetic ; Swine
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Induction of a chemoattractant transcriptional response by a Campylobacter jejuni boiled cell extract in colonocytes.
    Autorzy:
    Mellits KH; Division of Food Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK. ken.mellits@nottingham.ac.uk
    Connerton IF
    Loughlin MF
    Clarke P
    Smith J
    Dillon E
    Connerton PL
    Mulholland F
    Hawkey CJ
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    Źródło:
    BMC microbiology [BMC Microbiol] 2009 Feb 04; Vol. 9, pp. 28. Date of Electronic Publication: 2009 Feb 04.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Profiling*
    Campylobacter jejuni/*chemistry
    Campylobacter jejuni/*immunology
    Chemotactic Factors/*immunology
    Colon/*immunology
    Epithelial Cells/*immunology
    Cell Line ; Chemokines/biosynthesis ; Chemotactic Factors/isolation & purification ; Colon/cytology ; Down-Regulation ; Humans ; Oligonucleotide Array Sequence Analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/immunology ; Up-Regulation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells.
    Autorzy:
    Offermann MK; Division of Hematology/Oncology, Emory University, Atlanta, USA.
    Zimring J
    Mellits KH
    Hagan MK
    Shaw R
    Medford RM
    Mathews MB
    Goodbourn S
    Jagus R
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    Źródło:
    European journal of biochemistry [Eur J Biochem] 1995 Aug 15; Vol. 232 (1), pp. 28-36.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Endothelium, Vascular/*metabolism
    Protein Serine-Threonine Kinases/*metabolism
    RNA, Double-Stranded/*metabolism
    Vascular Cell Adhesion Molecule-1/*biosynthesis
    Cell Adhesion ; Cells, Cultured ; Gene Expression Regulation ; Humans ; RNA, Double-Stranded/chemistry ; eIF-2 Kinase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-12 z 12

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