Autor: "Mells, George" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Cholangiocyte organoids can repair bile ducts after transplantation in the human liver.
Autorzy:: Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK. .; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Muraro D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
Tysoe OC; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
Sawiak S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK.
Beach TE; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
Godfrey EM; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Brevini T; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
Wesley BT; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
Garcia-Bernardo J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.
Mahbubani K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
Canu G; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
Gieseck R 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Berntsen NL; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Mulcahy VL; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Academic Department of Medical Genetics, University of Cambridge, Cambridge, Cambridgeshire, UK.
Crick K; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Fear C; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Robinson S; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Swift L; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Gambardella L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
Bargehr J; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
Ortmann D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
Brown SE; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
Osnato A; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, Cambridgeshire, UK.
Corbett G; Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Gelson WTH; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Mells GF; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.; Academic Department of Medical Genetics, University of Cambridge, Cambridge, Cambridgeshire, UK.
Humphreys P; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
Davies SE; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Amin I; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Gibbs P; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Sinha S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, Cambridgeshire, UK.
Butler AJ; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
See TC; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Melum E; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Watson CJE; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.; National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre and the NIHR Blood and Transplant Research Unit (BTRU), Cambridge, Cambridgeshire, UK.; University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT), Cambridge, Cambridgeshire, UK.
Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Vallier L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK. .; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 839-846.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell- and Tissue-Based Therapy*
Bile Duct Diseases/*therapy
Bile Ducts/*cytology
Bile Ducts, Intrahepatic/*physiology
Epithelial Cells/*cytology
Organoids/*transplantation
Animals ; Bile ; Bile Ducts/physiology ; Bile Ducts, Intrahepatic/cytology ; Common Bile Duct/cytology ; Epithelial Cells/physiology ; Gallbladder/cytology ; Gene Expression Regulation ; Humans ; Liver/physiology ; Liver Transplantation ; Mesenchymal Stem Cell Transplantation ; Mice ; Organoids/physiology ; RNA-Seq ; Tissue and Organ Procurement ; Transcriptome

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Skocz do pozycji: 2.

Tytuł:: Letter: histology is relevant for risk stratification in primary biliary cholangitis.
Autorzy:: Carbone M; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK.; Division of Gastroenterology, University of Milan-Bicocca, Milan, Italy.
D'Amato D; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK.; Division of Gastroenterology, University of Milan-Bicocca, Milan, Italy.
Hirschfield GM; Toronto Centre for Liver Disease, University of Toronto, Toronto, ON, Canada.
Jones DEJ; Institute of Cellular Medicine, Newcastle University, Newcastle, UK.
Mells GF; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK.; Division of Hepatology, Addenbrooke's Hospital, Cambridge, UK.; Pokaż więcej
Źródło:: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2020 Jan; Vol. 51 (1), pp. 192-193.
Typ publikacji:: Letter; Comment
MeSH Terms:: Liver Cirrhosis, Biliary*
Cholagogues and Choleretics ; Humans ; Risk Assessment ; Ursodeoxycholic Acid

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Tytuł:: Editorial: rapid assessment of health-related quality of life in primary biliary cholangitis-no excuse not to ask. Authors' reply.
Autorzy:: Alrubaiy L; St Mark's hospital, London, UK.; Swansea University Medical School, Swansea, UK.
Mells G; Department of Medical Genetics, University of Cambridge, Cambridge, UK.
Flack S; Department of Medical Genetics, University of Cambridge, Cambridge, UK.
Bosomworth H; Institute of Cellular Medicine, Newcastle University, Newcastle, UK.
Hutchings H; Swansea University Medical School, Swansea, UK.
Williams J; Swansea University Medical School, Swansea, UK.
Jones D; Institute of Cellular Medicine, Newcastle University, Newcastle, UK.; Pokaż więcej
Źródło:: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2020 Jan; Vol. 51 (1), pp. 183.
Typ publikacji:: Editorial; Comment
MeSH Terms:: Cholangitis*
Cholangitis, Sclerosing*
Liver Cirrhosis, Biliary*
Humans ; Quality of Life

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Tytuł:: PBC-10: a short quality of life measure for clinical screening in primary biliary cholangitis.
Autorzy:: Alrubaiy L; St Mark's Hospital, London, UK.; Swansea University Medical School, Swansea, UK.
Mells G; Department of Medical Genetics, University of Cambridge, Cambridge, UK.
Flack S; Department of Medical Genetics, University of Cambridge, Cambridge, UK.
Bosomworth H; Institute of Cellular Medicine, Newcastle University, Newcastle, UK.
Hutchings H; Swansea University Medical School, Swansea, UK.
Williams J; Swansea University Medical School, Swansea, UK.
Jones D; Institute of Cellular Medicine, Newcastle University, Newcastle, UK.; Pokaż więcej
Corporate Authors:: UK-PBC Research Consortium
Źródło:: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2019 Dec; Vol. 50 (11-12), pp. 1223-1231. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji:: Journal Article
MeSH Terms:: Liver Cirrhosis, Biliary*
Quality of Life*
Surveys and Questionnaires*
Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Psychometrics ; Reproducibility of Results

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Skocz do pozycji: 5.

Tytuł:: Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.
Autorzy:: Darlay R; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Ayers KL; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Mells GF; Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom.
Hall LS; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.; Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Liu JZ; Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Almarri MA; Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.; Department of Forensic Science and Criminology, Dubai Police HQ, Dubai, United Arab Emirates.
Alexander GJ; Department of Hepatology, Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, United Kingdom.
Jones DE; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.
Sandford RN; Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom.
Anderson CA; Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Cordell HJ; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2018 Dec 03; Vol. 14 (12), pp. e1007833. Date of Electronic Publication: 2018 Dec 03 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Major Histocompatibility Complex*
HLA Antigens/*genetics
Liver Cirrhosis, Biliary/*genetics
Liver Cirrhosis, Biliary/*immunology
Amino Acid Sequence ; Amino Acid Substitution ; Genes, MHC Class II ; Genetic Association Studies ; Genetic Predisposition to Disease ; HLA Antigens/chemistry ; HLA-C Antigens/genetics ; HLA-DP beta-Chains/chemistry ; HLA-DP beta-Chains/genetics ; HLA-DQ alpha-Chains/genetics ; HLA-DQ beta-Chains/genetics ; HLA-DRB1 Chains/genetics ; Humans ; Models, Genetic ; Models, Molecular ; Polymorphism, Single Nucleotide ; Protein Conformation ; Regression Analysis ; Static Electricity