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Wyszukujesz frazę ""Membrane Transport Proteins"" wg kryterium: Temat


Tytuł :
Identification and functional analysis of novel SLC25A19 variants causing thiamine metabolism dysfunction syndrome 4.
Autorzy :
Chen Y; Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.; Henan Key Laboratory of Pediatric Inherited and Metabolic Diseases, Henan Children's Hospital, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China.
Fang B; Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Hu X; Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.; Henan Key Laboratory of Pediatric Inherited and Metabolic Diseases, Henan Children's Hospital, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China.
Guo R; Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.; Henan Key Laboratory of Pediatric Inherited and Metabolic Diseases, Henan Children's Hospital, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China.
Guo J; Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.; Henan Key Laboratory of Pediatric Inherited and Metabolic Diseases, Henan Children's Hospital, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China.
Fang K; Pediatric Intensive Care Unit, Luoyang Maternal and Child Health Hospital, Luoyang, China.
Ni J; Pediatric Intensive Care Unit, Luoyang Maternal and Child Health Hospital, Luoyang, China.
Li W; Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.; Henan Key Laboratory of Pediatric Inherited and Metabolic Diseases, Henan Children's Hospital, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China.
Qian S; Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. .
Hao C; Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. .; Henan Key Laboratory of Pediatric Inherited and Metabolic Diseases, Henan Children's Hospital, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China. .
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Źródło :
Orphanet journal of rare diseases [Orphanet J Rare Dis] 2021 Sep 29; Vol. 16 (1), pp. 403. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Diseases*
Mitochondrial Membrane Transport Proteins*/genetics
Thiamine Deficiency/*genetics
Humans ; Membrane Transport Proteins/genetics ; Mutation/genetics ; Phenotype ; Thiamine
Czasopismo naukowe
Tytuł :
SLC6A3 ( DAT1 ) as a Novel Candidate Biomarker Gene for Suicidal Behavior.
Autorzy :
Rafikova E; Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia.
Shadrina M; Institute of Molecular Genetics of National Research Centre, Kurchatov Institute, 123182 Moscow, Russia.
Slominsky P; Institute of Molecular Genetics of National Research Centre, Kurchatov Institute, 123182 Moscow, Russia.
Guekht A; Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, 115419 Moscow, Russia.
Ryskov A; Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia.
Shibalev D; Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia.
Vasilyev V; Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia.
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Źródło :
Genes [Genes (Basel)] 2021 Jun 04; Vol. 12 (6). Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Depression/*genetics
Dopamine Plasma Membrane Transport Proteins/*genetics
Suicide, Attempted/*statistics & numerical data
Adult ; Catechol O-Methyltransferase/genetics ; Female ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Serotonin Plasma Membrane Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Focus on Human Monoamine Transporter Selectivity. New Human DAT and NET Models, Experimental Validation, and SERT Affinity Exploration.
Autorzy :
Ortore G; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Orlandini E; Research Center 'E. Piaggio', University of Pisa, Pisa 56122, Italy.; Department of Earth Sciences, University of Pisa, Via Santa Maria 53-55, 56100 Pisa, Italy.
Betti L; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Giannaccini G; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Mazzoni MR; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Camodeca C; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Nencetti S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2020 Oct 21; Vol. 11 (20), pp. 3214-3232. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Norepinephrine Plasma Membrane Transport Proteins*/metabolism
Serotonin Plasma Membrane Transport Proteins*/metabolism
Serotonin Uptake Inhibitors*
Animals ; Binding Sites ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Humans ; Models, Theoretical ; Rabbits
Czasopismo naukowe
Tytuł :
The TIM22 complex mediates the import of sideroflexins and is required for efficient mitochondrial one-carbon metabolism.
Autorzy :
Jackson TD; Department of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Hock DH; Department of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Fujihara KM; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3010, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.
Palmer CS; Department of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Frazier AE; Murdoch Children's Research Institute and.; Department of Paediatrics, University of Melbourne, Melbourne, Victoria 3052, Australia.
Low YC; Murdoch Children's Research Institute and.; Department of Paediatrics, University of Melbourne, Melbourne, Victoria 3052, Australia.
Kang Y; Department of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Ang CS; Bio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, Victoria 3010, Australia.
Clemons NJ; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3010, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.
Thorburn DR; Murdoch Children's Research Institute and.; Victorian Clinical Genetics Services Royal Children's Hospital, Melbourne, Victoria 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Victoria 3052, Australia.
Stroud DA; Department of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Stojanovski D; Department of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
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Źródło :
Molecular biology of the cell [Mol Biol Cell] 2021 Mar 15; Vol. 32 (6), pp. 475-491. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Membrane Transport Proteins/*metabolism
Mitochondria/*metabolism
Mitochondrial Proteins/*metabolism
Phosphotransferases (Alcohol Group Acceptor)/*metabolism
Carbon/metabolism ; Carrier Proteins/metabolism ; Cell Culture Techniques ; Humans ; MCF-7 Cells ; Membrane Proteins/metabolism ; Membrane Transport Proteins/physiology ; Mitochondria/physiology ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Membranes/metabolism ; Mitochondrial Membranes/physiology ; Mitochondrial Proteins/physiology ; Mutation ; Phenotype ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Primary Cell Culture ; Proteomics/methods
Czasopismo naukowe
Tytuł :
Investigation of the Optical Isomers of Methcathinone, and Two Achiral Analogs, at Monoamine Transporters and in Intracranial Self-Stimulation Studies in Rats.
Autorzy :
Davies RA
Baird TR
Nguyen VT
Ruiz B
Sakloth F
Eltit JM
Negus SS
Glennon RA
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2020 Jun 17; Vol. 11 (12), pp. 1762-1769. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dopamine Plasma Membrane Transport Proteins*
Propiophenones*
Animals ; Norepinephrine Plasma Membrane Transport Proteins ; Rats ; Self Stimulation ; Serotonin Plasma Membrane Transport Proteins
Czasopismo naukowe
Tytuł :
Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae.
Autorzy :
Bharatham N; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.; The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bengaluru, Karnataka, India.
Bhowmik P; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.; The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bengaluru, Karnataka, India.
Aoki M; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Okada U; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Sharma S; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.; The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bengaluru, Karnataka, India.
Yamashita E; Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
Shanbhag AP; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.
Rajagopal S; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.
Thomas T; St. John's Research Institute, Bengaluru, Karnataka, India.
Sarma M; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.
Narjari R; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.
Nagaraj S; St. John's Medical Hospital, Bengaluru, Karnataka, India.
Ramachandran V; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.; The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bengaluru, Karnataka, India.
Katagihallimath N; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.; The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bengaluru, Karnataka, India.
Datta S; Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd, Bengaluru, Karnataka, India.
Murakami S; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 13; Vol. 12 (1), pp. 5400. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*genetics
Drug Resistance, Multiple, Bacterial/*genetics
Klebsiella pneumoniae/*genetics
Membrane Transport Proteins/*genetics
Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Binding Sites/genetics ; Crystallography, X-Ray ; Klebsiella pneumoniae/metabolism ; Membrane Transport Proteins/chemistry ; Membrane Transport Proteins/metabolism ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Protein Multimerization ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Auxin transport mechanism of membrane transporter encoded by AEC gene of Bacillus licheniformis isolated from metagenome of Tapta Kund Hotspring of Uttrakhand, India.
Autorzy :
Rai N; Department of Biotechnology, School of Life Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India.
Kumar V; Department of Biotechnology, School of Life Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India.
Sharma M; Department of Biotechnology, School of Life Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India. Electronic address: .
Akhter Y; Department of Biotechnology, School of Life Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 277-286. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Bacillus licheniformis/*isolation & purification
Hot Springs/*microbiology
Indoleacetic Acids/*metabolism
Membrane Transport Proteins/*chemistry
Membrane Transport Proteins/*genetics
Amino Acid Sequence ; Bacillus licheniformis/genetics ; Bacillus licheniformis/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biological Transport ; India ; Membrane Transport Proteins/metabolism ; Metagenomics ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Domains ; Protein Structure, Tertiary
Czasopismo naukowe
Tytuł :
Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90.
Autorzy :
Brandherm L; Institute for Biochemistry and Pathobiochemistry, Ruhr-University Bochum, 44801 Bochum, Germany.
Kobaš AM; Institute for Biochemistry and Pathobiochemistry, Ruhr-University Bochum, 44801 Bochum, Germany.
Klöhn M; Department of Molecular & Medical Virology, Ruhr-University Bochum, 44801 Bochum, Germany.
Brüggemann Y; Department of Molecular & Medical Virology, Ruhr-University Bochum, 44801 Bochum, Germany.
Pfaender S; Department of Molecular & Medical Virology, Ruhr-University Bochum, 44801 Bochum, Germany.
Rassow J; Institute for Biochemistry and Pathobiochemistry, Ruhr-University Bochum, 44801 Bochum, Germany.
Kreimendahl S; Institute for Biochemistry and Pathobiochemistry, Ruhr-University Bochum, 44801 Bochum, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 26; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*transmission
Coronavirus Nucleocapsid Proteins/*metabolism
HSP90 Heat-Shock Proteins/*metabolism
Mitochondrial Membrane Transport Proteins/*metabolism
SARS-CoV-2/*pathogenicity
Animals ; Binding Sites/genetics ; COVID-19/immunology ; COVID-19/virology ; Chlorocebus aethiops ; Coronavirus Nucleocapsid Proteins/genetics ; Coronavirus Nucleocapsid Proteins/immunology ; Coronavirus Nucleocapsid Proteins/isolation & purification ; Humans ; Interferon Type I/immunology ; Interferon Type I/metabolism ; Mitochondrial Membrane Transport Proteins/genetics ; Mitochondrial Membrane Transport Proteins/isolation & purification ; Mutation ; Phosphoproteins/genetics ; Phosphoproteins/immunology ; Phosphoproteins/isolation & purification ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Binding/genetics ; Protein Binding/immunology ; Protein Domains/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Vero Cells
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia.
Autorzy :
Rodrigues-Amorim D; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
Iglesias-Martínez-Almeida M; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.; Translational Neuroscience Group, Universidade de Vigo, 36310 Vigo, Spain.
Rivera-Baltanás T; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
Fernández-Palleiro P; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.; Translational Neuroscience Group, Universidade de Vigo, 36310 Vigo, Spain.
Freiría-Martínez L; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.; Translational Neuroscience Group, Universidade de Vigo, 36310 Vigo, Spain.
Rodríguez-Jamardo C; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.; Translational Neuroscience Group, Universidade de Vigo, 36310 Vigo, Spain.
Comís-Tuche M; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
Vallejo-Curto MDC; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
Álvarez-Ariza M; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
López-García M; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
de Las Heras E; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
García-Caballero A; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
Olivares JM; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.; Department of Psychiatry, Hospital Álvaro Cunqueiro, 36213 Vigo, Spain.
Spuch C; Translational Neuroscience Research Group, Galicia Sur Health Research Institute, CIBERSAM, Hospital Álvaro Cunqueiro, Bloque Técnico, Planta 2, Sala de Investigación, Estrada Clara Campoamor, 341, 36212 Vigo, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 07; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Neurotrophin 3/*chemistry
Norepinephrine Plasma Membrane Transport Proteins/*chemistry
Receptor, trkC/*chemistry
Schizophrenia/*etiology
Adult ; Biomarkers/metabolism ; Female ; Humans ; Male ; Middle Aged ; Neurotrophin 3/genetics ; Neurotrophin 3/metabolism ; Norepinephrine Plasma Membrane Transport Proteins/genetics ; Norepinephrine Plasma Membrane Transport Proteins/metabolism ; Protein Structure, Secondary ; Receptor, trkC/genetics ; Receptor, trkC/metabolism ; Schizophrenia/genetics ; Schizophrenia/metabolism
Czasopismo naukowe
Tytuł :
Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases.
Autorzy :
Kim J; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Cater RJ; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Choy BC; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Mancia F; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Aug 06; Vol. 433 (16), pp. 167005. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Resistance, Microbial*/genetics
Anti-Infective Agents/*chemistry
Anti-Infective Agents/*pharmacology
Membrane Transport Proteins/*chemistry
Membrane Transport Proteins/*metabolism
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Anti-Infective Agents/therapeutic use ; Drug Resistance, Multiple ; Humans ; Membrane Transport Proteins/genetics ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Open, engage, bind, translocate: The multi-level dynamics of bacterial protein translocation.
Autorzy :
Chen W; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Komives EA; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA. Electronic address: .
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Źródło :
Structure (London, England : 1993) [Structure] 2021 Aug 05; Vol. 29 (8), pp. 781-782.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Membrane Transport Proteins*/genetics
Membrane Transport Proteins*/metabolism
Adenosine Triphosphatases/metabolism ; Protein Transport ; SEC Translocation Channels/genetics ; SecA Proteins
Czasopismo naukowe
Tytuł :
Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants' temperament at 3 months.
Autorzy :
Provenzi L; IRCCS Mondino Foundation, Pavia, Italy. .
Mambretti F; Scientific Institute IRCCS E. Medea, Bosisio Parini, Italy.
Villa M; Scientific Institute IRCCS E. Medea, Bosisio Parini, Italy.
Grumi S; IRCCS Mondino Foundation, Pavia, Italy.
Citterio A; Scientific Institute IRCCS E. Medea, Bosisio Parini, Italy.
Bertazzoli E; ASST Lodi, Lodi, Italy.
Biasucci G; Guglielmo da Saliceto Hospital, Piacenza, Italy.
Decembrino L; ASST Pavia, Pavia, Italy.
Falcone R; ASST Pavia, Pavia, Italy.
Gardella B; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; University of Pavia, Pavia, Italy.
Longo MR; ASST Lodi, Lodi, Italy.
Nacinovich R; Università Bicocca, Milano, Italy.; San Gerardo Hospital, ASST Monza, Monza, Italy.
Pisoni C; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Prefumo F; ASST Spedali Civili, Brescia, Italy.; University of Brescia, Brescia, Italy.
Orcesi S; IRCCS Mondino Foundation, Pavia, Italy.; University of Pavia, Pavia, Italy.
Scelsa B; ASST Sacco Fatebenefratelli, Milan, Italy.
Giorda R; Scientific Institute IRCCS E. Medea, Bosisio Parini, Italy.
Borgatti R; IRCCS Mondino Foundation, Pavia, Italy.; University of Pavia, Pavia, Italy.
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Źródło :
Scientific reports [Sci Rep] 2021 Aug 02; Vol. 11 (1), pp. 15658. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/epidemiology
COVID-19*/genetics
COVID-19*/metabolism
DNA Methylation*
Pandemics*
Prenatal Exposure Delayed Effects*/epidemiology
Prenatal Exposure Delayed Effects*/genetics
Prenatal Exposure Delayed Effects*/metabolism
Serotonin Plasma Membrane Transport Proteins*/genetics
Serotonin Plasma Membrane Transport Proteins*/metabolism
Stress, Physiological*
SARS-CoV-2/*metabolism
Adult ; Female ; Humans ; Infant, Newborn ; Longitudinal Studies ; Male ; Pregnancy
Czasopismo naukowe
Tytuł :
[ F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging.
Autorzy :
Hoffmann C; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.; Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Faculty of Medicine, and University Hospital Cologne, 50937 Cologne, Germany.
Evcüman S; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Neumaier F; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.; Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Faculty of Medicine, and University Hospital Cologne, 50937 Cologne, Germany.
Zlatopolskiy BD; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.; Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Faculty of Medicine, and University Hospital Cologne, 50937 Cologne, Germany.
Humpert S; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Bier D; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Holschbach M; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Schulze A; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Endepols H; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.; Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Faculty of Medicine, and University Hospital Cologne, 50937 Cologne, Germany.; Nuclear Medicine Department, University of Cologne, Faculty of Medicine, and University Hospital Cologne, 50937 Cologne, Germany.
Neumaier B; Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.; Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Faculty of Medicine, and University Hospital Cologne, 50937 Cologne, Germany.; Max Planck Institute of Metabolism Research, 50931 Cologne, Germany.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Sep 15; Vol. 12 (18), pp. 3335-3346. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glycine Plasma Membrane Transport Proteins*/metabolism
Prodrugs*
Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Humans ; Positron-Emission Tomography ; Rats ; Receptors, N-Methyl-D-Aspartate/metabolism ; Sarcosine
Czasopismo naukowe
Tytuł :
OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.
Autorzy :
Ames J; Department of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Yadavalli T; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Suryawanshi R; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Hopkins J; Department of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Agelidis A; Department of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Patil C; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Fredericks B; Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Tseng H; Duke Eye Center and Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Valyi-Nagy T; Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Shukla D; Department of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA. .; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 13; Vol. 12 (1), pp. 5401. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*genetics
Central Nervous System/*metabolism
Herpes Simplex/*genetics
Membrane Transport Proteins/*genetics
Animals ; Autophagy/genetics ; Cell Cycle Proteins/metabolism ; Cells, Cultured ; Central Nervous System/virology ; Chlorocebus aethiops ; HeLa Cells ; Herpes Simplex/metabolism ; Herpes Simplex/virology ; Herpesvirus 1, Human/physiology ; Humans ; Membrane Transport Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Necroptosis/genetics ; Neurons/metabolism ; Neurons/virology ; Neuroprotective Agents/metabolism ; RNA Interference ; Vero Cells ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
Evaluation of 5-HTTLPR (insertion/deletion) and BDNF (rs6265) genetic variations in the Slovakian individuals suffering from affective disorders.
Autorzy :
Bednarova A; 2nd Department of Psychiatry, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia.
Cizmarikova M
Habalova V
Jarcuskova D
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Źródło :
General physiology and biophysics [Gen Physiol Biophys] 2021 Sep; Vol. 40 (5), pp. 365-376.
Typ publikacji :
Journal Article
MeSH Terms :
Brain-Derived Neurotrophic Factor*/genetics
Brain-Derived Neurotrophic Factor*/metabolism
Serotonin Plasma Membrane Transport Proteins*/genetics
Genetic Variation ; Humans ; Male ; Mood Disorders/genetics
Czasopismo naukowe
Tytuł :
Effect of the deletion of lprG and p55 genes in the K10 strain of Mycobacterium avium subspecies paratuberculosis.
Autorzy :
Viale MN; Instituto de Agrobiotecnología y Biología Molecular (IABIMO), INTA-CONICET, Hurlingham, Buenos Aires 1686, Argentina.
Colombatti Olivieri MA; Instituto de Agrobiotecnología y Biología Molecular (IABIMO), INTA-CONICET, Hurlingham, Buenos Aires 1686, Argentina.
Alonso N; Instituto de Agrobiotecnología y Biología Molecular (IABIMO), INTA-CONICET, Hurlingham, Buenos Aires 1686, Argentina.
Moyano RD; Instituto de Agrobiotecnología y Biología Molecular (IABIMO), INTA-CONICET, Hurlingham, Buenos Aires 1686, Argentina.
Imperiale B; Instituto de Medicina Experimental (IMEX-CONICET), Academia Nacional de Medicina, Buenos Aires, Argentina.
Morcillo N; Laboratorio de Referencia en el Control de la Tuberculosis, Hospital Dr. Antonio A. Cetrángolo, Vicente López, Buenos Aires 8185, Argentina.
Santangelo MP; Instituto de Agrobiotecnología y Biología Molecular (IABIMO), INTA-CONICET, Hurlingham, Buenos Aires 1686, Argentina. Electronic address: .
Davis W; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Romano MI; Instituto de Agrobiotecnología y Biología Molecular (IABIMO), INTA-CONICET, Hurlingham, Buenos Aires 1686, Argentina.
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Źródło :
Research in veterinary science [Res Vet Sci] 2021 Sep; Vol. 138, pp. 1-10. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Deletion*
Bacterial Proteins/*genetics
Membrane Transport Proteins/*genetics
Mycobacterium avium subsp. paratuberculosis/*genetics
Mycobacterium avium subsp. paratuberculosis/*pathogenicity
Virulence Factors/*genetics
Animals ; Bacterial Proteins/metabolism ; Cattle ; Female ; Macrophages/microbiology ; Membrane Transport Proteins/metabolism ; Mice ; Mice, Inbred BALB C ; Operon ; Virulence/genetics ; Virulence Factors/metabolism
Czasopismo naukowe
Tytuł :
Structural snapshot of the mitochondrial protein import gate.
Autorzy :
Araiso Y; Department of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Japan.
Imai K; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan.
Endo T; Faculty of Life Sciences, Kyoto Sangyo University, Japan.; Institute for Protein Dynamics, Kyoto Sangyo University, Japan.
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Źródło :
The FEBS journal [FEBS J] 2021 Sep; Vol. 288 (18), pp. 5300-5310. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Conformation*
Carrier Proteins/*ultrastructure
Mitochondrial Membrane Transport Proteins/*ultrastructure
Saccharomyces cerevisiae Proteins/*ultrastructure
Carrier Proteins/genetics ; Mitochondria/genetics ; Mitochondria/ultrastructure ; Mitochondrial Membrane Transport Proteins/genetics ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/ultrastructure ; Multiprotein Complexes/genetics ; Multiprotein Complexes/ultrastructure ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand/genetics ; Protein Transport/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/ultrastructure ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
MICU1 opens the gates to cold-induced death.
Autorzy :
Dietsche F; Institute of Molecular Medicine, University Medical Center Mainz, Germany.
Zhang L; Institute of Molecular Medicine, University Medical Center Mainz, Germany.
Elrod JW; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University. 3500 N. Broad St., Philadelphia, PA 19140, United States. Electronic address: .
Methner A; Institute of Molecular Medicine, University Medical Center Mainz, Germany. Electronic address: .
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Źródło :
Cell calcium [Cell Calcium] 2021 Sep; Vol. 98, pp. 102451. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Cation Transport Proteins*
Mitochondrial Membrane Transport Proteins*/metabolism
Calcium/metabolism ; Calcium-Binding Proteins ; Mitochondria/metabolism
Czasopismo naukowe
Tytuł :
A comprehensive assessment of genetic variation in serotonin transporter gene (5-HTTLPR+rs25531) and the response to dapoxetine in Chinese patients with premature ejaculation.
Autorzy :
Huang Y; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Gao J; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Gao P; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Peng D; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Dai Y; Department of Andrology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China.
Jiang H; Department of Andrology, Peking University Third Hospital, Beijing, China.; Department of Human Sperm Bank, Peking University Third Hospital, Beijing, China.
Zhang X; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
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Źródło :
Andrologia [Andrologia] 2021 Sep; Vol. 53 (8), pp. e14141. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Premature Ejaculation*/drug therapy
Premature Ejaculation*/genetics
Serotonin Plasma Membrane Transport Proteins*/genetics
Benzylamines ; China ; Ejaculation ; Humans ; Male ; Naphthalenes ; Polymorphism, Genetic ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Autorzy :
Plenge P; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yang D; Vollum Institute, Oregon Health & Science University, Portland, OR, USA.
Salomon K; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Laursen L; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kalenderoglou IE; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Newman AH; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Gouaux E; Vollum Institute, Oregon Health & Science University, Portland, OR, USA.; Howard Hughes Medical Institute, Oregon Health & Science University, Portland, OR, USA.
Coleman JA; Vollum Institute, Oregon Health & Science University, Portland, OR, USA. .; Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA, USA. .
Loland CJ; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 20; Vol. 12 (1), pp. 5063. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antidepressive Agents/*pharmacology
Serotonin Plasma Membrane Transport Proteins/*metabolism
Serotonin Uptake Inhibitors/*pharmacology
Vilazodone Hydrochloride/*pharmacology
Allosteric Regulation/drug effects ; Animals ; Binding Sites ; COS Cells ; Chlorocebus aethiops ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Mutant Proteins/metabolism ; Mutation/genetics ; Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/ultrastructure
Czasopismo naukowe

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