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Tytuł:
Vaccination Decreases the Infectious Viral Load of Delta Variant SARS-CoV-2 in Asymptomatic Patients.
Autorzy:
Plante JA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Machado RRG; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-900, CEP, Brazil.
Mitchell BM; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Shinde DP; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Walker J; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Scharton D; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
McConnell A; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Saada N; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Liu J; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518071, China.
Khan B; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Molecular Pathology, Dow University of Health Sciences, Karachi 74200, Pakistan.
Campos RK; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
Johnson BA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Levine CB; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
Ren P; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
McLellan SLF; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
Plante KS; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Weaver SC; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
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Źródło:
Viruses [Viruses] 2022 Sep 18; Vol. 14 (9). Date of Electronic Publication: 2022 Sep 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*/prevention & control
Vaccines*
Asymptomatic Infections ; Humans ; Immunoglobulin A ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Vaccination ; Viral Load
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
Autorzy:
Johnson BA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Zhou Y; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Lokugamage KG; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Vu MN; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Bopp N; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Crocquet-Valdes PA; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Kalveram B; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Schindewolf C; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Liu Y; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Scharton D; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.
Plante JA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.
Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Aguilar P; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America.
Weaver SC; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.
Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Drug Discovery, University of Texas Medical Branch, Galveston, Texas, United States of America.
Walker DH; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America.
Routh AL; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.
Plante KS; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.
Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Jun 21; Vol. 18 (6), pp. e1010627. Date of Electronic Publication: 2022 Jun 21 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
COVID-19*/genetics
SARS-CoV-2*/genetics
Glycogen Synthase Kinase 3 ; Humans ; Mutation ; Nucleocapsid ; Spike Glycoprotein, Coronavirus/genetics
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A new tool to probe SARS-CoV-2 variants.
Autorzy:
Johnson BA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Dec 24; Vol. 374 (6575), pp. 1557-1558. Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms:
COVID-19*
SARS-CoV-2*
Humans
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.
Autorzy:
Muruato A; Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Vu MN; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Johnson BA; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Davis-Gardner ME; Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Vanderheiden A; Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Lokugamage K; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Schindewolf C; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Crocquet-Valdes PA; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Langsjoen RM; Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Plante JA; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.
Plante KS; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.
Weaver SC; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.
Debbink K; Department of Natural Science, Bowie State University, Bowie, Maryland, United States of America.
Routh AL; Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.
Walker D; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Suthar MS; Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Shi PY; Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.
Xie X; Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Menachery VD; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2021 Nov 04; Vol. 19 (11), pp. e3001284. Date of Electronic Publication: 2021 Nov 04 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19/*prevention & control
COVID-19 Vaccines/*immunology
SARS-CoV-2/*immunology
Animals ; COVID-19/pathology ; COVID-19 Vaccines/therapeutic use ; Cell Line ; Disease Models, Animal ; Female ; Humans ; Lung/pathology ; Mice ; Mice, Inbred BALB C ; Reverse Genetics ; Serial Passage ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Binding and entering: COVID finds a new home.
Autorzy:
Vu MN; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Aug 30; Vol. 17 (8), pp. e1009857. Date of Electronic Publication: 2021 Aug 30 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*virology
SARS-CoV-2/*physiology
Spike Glycoprotein, Coronavirus/*metabolism
COVID-19/metabolism ; Humans ; SARS-CoV-2/pathogenicity ; Virus Internalization
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hypergraph models of biological networks to identify genes critical to pathogenic viral response.
Autorzy:
Feng S; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Heath E; Department of Mathematics, University of Illinois, Urbana-Champaign, IL, USA.
Jefferson B; Computing and Analytics Division, Pacific Northwest National Laboratory, Seattle, WA, USA.
Joslyn C; Computing and Analytics Division, Pacific Northwest National Laboratory, Seattle, WA, USA.; Systems Science Program, Portland State University, Portland, OR, USA.
Kvinge H; Computing and Analytics Division, Pacific Northwest National Laboratory, Seattle, WA, USA.
Mitchell HD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Praggastis B; Computing and Analytics Division, Pacific Northwest National Laboratory, Seattle, WA, USA.
Eisfeld AJ; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, 53711, Madison, WI, USA.
Sims AC; Signature Science and Technology Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Thackray LB; Department of Medicine, Washington University School of Medicine, 63110, Saint Louis, MO, USA.
Fan S; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, 53711, Madison, WI, USA.
Walters KB; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, 53711, Madison, WI, USA.
Halfmann PJ; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, 53711, Madison, WI, USA.
Westhoff-Smith D; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, 53711, Madison, WI, USA.
Tan Q; Department of Medicine, Washington University School of Medicine, 63110, Saint Louis, MO, USA.
Menachery VD; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cockrell AS; KNOWBIO LLC., Durham, NC, 27703, USA.
Kocher JF; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Stratton KG; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Heller NC; Computing and Analytics Division, Pacific Northwest National Laboratory, Seattle, WA, USA.
Bramer LM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Diamond MS; Department of Medicine, Washington University School of Medicine, 63110, Saint Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Waters KM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.; Department of Comparative Medicine, University of Washington, Seattle, WA, USA.
Kawaoka Y; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, 53711, Madison, WI, USA.; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.; ERATO Infection-Induced Host Responses Project, Saitama, 332-0012, Japan.; Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
McDermott JE; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.
Purvine E; Computing and Analytics Division, Pacific Northwest National Laboratory, Seattle, WA, USA. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2021 May 29; Vol. 22 (1), pp. 287. Date of Electronic Publication: 2021 May 29.
Typ publikacji:
Journal Article
MeSH Terms:
Algorithms*
Models, Biological*
Genomics ; Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.
Autorzy:
Trimarco JD; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.
Heaton BE; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.
Chaparian RR; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.
Burke KN; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.
Binder RA; Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America.
Gray GC; Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America.
Smith CM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.
Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.
Heaton NS; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 May 27; Vol. 17 (5), pp. e1009599. Date of Electronic Publication: 2021 May 27 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Coronavirus 229E, Human/*drug effects
Host Microbial Interactions/*physiology
Membrane Proteins/*metabolism
Animals ; Antiviral Agents/pharmacology ; COVID-19/metabolism ; Cell Line ; Chlorocebus aethiops ; Coronavirus 229E, Human/physiology ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/virology ; Host Microbial Interactions/genetics ; Humans ; Membrane Proteins/physiology ; SARS-CoV-2/drug effects ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Vero Cells ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.
Autorzy:
Graham JB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, Unites States of America.
Swarts JL; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, Unites States of America.
Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
Menachery VD; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.; Department of Microbiology and Immunology, University of Texas Medical Center, Galveston, Texas, Unites States of America.
Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
Jeng S; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.
Miller DR; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
Mooney MA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, Unites States of America.
McWeeney SK; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, Oregon, Unites States of America.; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, Unites States of America.
Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
Pardo-Manuel de Villena F; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
Heise MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Unites States of America.
Lund JM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, Unites States of America.; Department of Global Health, University of Washington, Seattle, Wasington, Unites States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Jan 29; Vol. 17 (1), pp. e1009287. Date of Electronic Publication: 2021 Jan 29 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
COVID-19/*immunology
COVID-19/*virology
SARS-CoV-2/*physiology
T-Lymphocytes/*immunology
Animals ; COVID-19/genetics ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Phenotype ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium.
Autorzy:
Fiege JK; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.
Thiede JM; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America.
Nanda HA; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota, United States of America.
Matchett WE; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.
Moore PJ; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.
Montanari NR; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.
Thielen BK; Department of Pediatrics, Division of Infectious Diseases, University of Minnesota, United States of America.
Daniel J; University of Minnesota Genomics Center, Minneapolis, Minnesota, United States of America.
Stanley E; University of Minnesota Genomics Center, Minneapolis, Minnesota, United States of America.
Hunter RC; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.
Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Shen SS; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota, United States of America.
Bold TD; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America.
Langlois RA; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Jan 28; Vol. 17 (1), pp. e1009292. Date of Electronic Publication: 2021 Jan 28 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Viral Tropism*/drug effects
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Antiviral Agents/*pharmacology
COVID-19/*immunology
COVID-19/*virology
SARS-CoV-2/*physiology
Adenosine Monophosphate/pharmacology ; Alanine/pharmacology ; COVID-19/genetics ; Epithelium/immunology ; Epithelium/virology ; Humans ; Interferons/genetics ; Interferons/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Lung/immunology ; Lung/virology ; SARS-CoV-2/drug effects ; Virus Replication/drug effects ; COVID-19 Drug Treatment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The search for a COVID-19 animal model.
Autorzy:
Lakdawala SS; Department of Microbiology and Molecular Genetics, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. .
Menachery VD; Department of Microbiology and Immunology, Institute for Human Infection and Immunity, World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch at Galveston, Galveston, TX, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2020 May 29; Vol. 368 (6494), pp. 942-943.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms:
Severe acute respiratory syndrome-related coronavirus*
Severe Acute Respiratory Syndrome*
Animals ; Animals, Domestic ; Betacoronavirus ; COVID-19 ; Cats ; Coronavirus Infections ; Dogs ; Ferrets ; Models, Animal ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Return of the Coronavirus: 2019-nCoV.
Autorzy:
Gralinski LE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA.
Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
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Źródło:
Viruses [Viruses] 2020 Jan 24; Vol. 12 (2). Date of Electronic Publication: 2020 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Betacoronavirus*/genetics
Betacoronavirus*/isolation & purification
Coronavirus Infections*/epidemiology
Coronavirus Infections*/transmission
Coronavirus Infections*/virology
Disease Outbreaks*
Pneumonia, Viral*/epidemiology
Pneumonia, Viral*/transmission
Pneumonia, Viral*/virology
Animals ; COVID-19 ; China ; Communicable Diseases, Emerging ; Disease Reservoirs ; Disease Susceptibility ; Genome, Viral ; Humans ; Nucleocapsid Proteins/chemistry ; Severe acute respiratory syndrome-related coronavirus/chemistry ; Severe acute respiratory syndrome-related coronavirus/genetics ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/virology ; Social Media ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Zoonoses
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Shortening of Zika virus CD-loop reduces neurovirulence while preserving antigenicity.
Autorzy:
Dinnon Iii KH; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Gallichotte EN; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Fritch EJ; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Menachery VD; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Baric RS; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2019 Mar 07; Vol. 13 (3), pp. e0007212. Date of Electronic Publication: 2019 Mar 07 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Central Nervous System/*virology
Viral Envelope Proteins/*immunology
Viral Vaccines/*immunology
Zika Virus/*immunology
Zika Virus/*pathogenicity
Zika Virus Infection/*prevention & control
Animals ; Antibodies, Viral/immunology ; Humans ; Mice ; Mice, Knockout ; Mutation ; Viral Envelope Proteins/chemistry ; Viral Envelope Proteins/genetics ; Virulence ; Virus Replication/genetics ; Zika Virus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism.
Autorzy:
Schindewolf C; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555 TX, USA. .
Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555 TX, USA. .
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Źródło:
Viruses [Viruses] 2019 Jan 17; Vol. 11 (1). Date of Electronic Publication: 2019 Jan 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Coronavirus Infections/*prevention & control
Middle East Respiratory Syndrome Coronavirus/*immunology
Viral Vaccines/*immunology
Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Coronavirus Infections/immunology ; Disease Models, Animal ; Humans ; Mice ; Middle East Respiratory Syndrome Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Vaccination ; Vaccines, Attenuated/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats ( Rousettus aegyptiacus ).
Autorzy:
van Doremalen N; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. .
Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .
Menachery VD; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .
Letko M; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. .
Bushmaker T; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. .
Fischer RJ; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. .
Figueroa DM; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. .
Hanley PW; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. .
Saturday G; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. .
Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .
Munster VJ; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. .
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Źródło:
Viruses [Viruses] 2018 Dec 19; Vol. 10 (12). Date of Electronic Publication: 2018 Dec 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:
Virus Replication*
Chiroptera/*virology
Coronavirus/*physiology
Coronavirus Infections/*virology
Animals ; Antibodies, Viral/blood ; Coronavirus/genetics ; Coronavirus Infections/immunology ; Disease Models, Animal ; Male ; Oropharynx/virology ; RNA, Viral/genetics ; Severe acute respiratory syndrome-related coronavirus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CC002/Unc females are mouse models of exercise-induced paradoxical fat response.
Autorzy:
McMullan RC; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Genetics and Molecular Biology Curriculum, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Ferris MT; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Bell TA; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Menachery VD; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Baric RS; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Hua K; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Pomp D; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Smith-Ryan AE; Department of Exercise and Sport Science, College of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
de Villena FP; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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Źródło:
Physiological reports [Physiol Rep] 2018 Jun; Vol. 6 (12), pp. e13716.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
Adipose Tissue/*physiology
Physical Conditioning, Animal/*physiology
Animals ; Biometry/methods ; Body Composition/physiology ; Body Weight/physiology ; Female ; Male ; Mice, Inbred Strains ; Physical Exertion/physiology ; Sex Characteristics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice.
Autorzy:
Gralinski LE; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
Menachery VD; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
Morgan AP; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Totura AL; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599.
Beall A; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Kocher J; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
Plante J; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
Harrison-Shostak DC; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Schäfer A; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599.
Pardo-Manuel de Villena F; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599.
Ferris MT; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Baric RS; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 .; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599.
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2017 Jun 07; Vol. 7 (6), pp. 1653-1663. Date of Electronic Publication: 2017 Jun 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Alleles*
Genetic Predisposition to Disease*
Genetic Variation*
Host-Pathogen Interactions/*genetics
Severe acute respiratory syndrome-related coronavirus/*physiology
Severe Acute Respiratory Syndrome/*genetics
Severe Acute Respiratory Syndrome/*virology
Animals ; Cell Line ; Chromosome Mapping ; Disease Models, Animal ; Female ; Genotype ; Male ; Mice ; Mice, Knockout ; Phenotype ; Quantitative Trait Loci ; Severe Acute Respiratory Syndrome/diagnosis ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.
Autorzy:
Gralinski LE; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Ferris MT; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Aylor DL; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Whitmore AC; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Green R; Department of Microbiology, University of Washington, Seattle, Washington, United States of America.
Frieman MB; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Deming D; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Menachery VD; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Miller DR; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Buus RJ; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Bell TA; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Churchill GA; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Threadgill DW; Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America.
Katze MG; Department of Microbiology, University of Washington, Seattle, Washington, United States of America.
McMillan L; Department of Computer Science, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Valdar W; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Heise MT; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Pardo-Manuel de Villena F; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
Baric RS; Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2015 Oct 09; Vol. 11 (10), pp. e1005504. Date of Electronic Publication: 2015 Oct 09 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Host-Pathogen Interactions*
Inflammation/*genetics
Severe acute respiratory syndrome-related coronavirus/*genetics
Severe Acute Respiratory Syndrome/*genetics
Animals ; Disease Models, Animal ; Disease Susceptibility ; Humans ; Inflammation/pathology ; Inflammation/virology ; Mice ; Phenotype ; Severe acute respiratory syndrome-related coronavirus/pathogenicity ; Severe Acute Respiratory Syndrome/pathology ; Severe Acute Respiratory Syndrome/virology ; Virus Replication/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
New Metrics for Evaluating Viral Respiratory Pathogenesis.
Autorzy:
Menachery VD; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Jun 26; Vol. 10 (6), pp. e0131451. Date of Electronic Publication: 2015 Jun 26 (Print Publication: 2015).
Typ publikacji:
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Influenza A Virus, H1N1 Subtype*
Plethysmography, Whole Body*
Severe acute respiratory syndrome-related coronavirus*
Orthomyxoviridae Infections/*physiopathology
Severe Acute Respiratory Syndrome/*physiopathology
Animals ; Chlorocebus aethiops ; Disease Models, Animal ; Dogs ; Lung/pathology ; Lung/virology ; Madin Darby Canine Kidney Cells ; Mice ; Mice, Inbred C57BL ; Predictive Value of Tests ; Vero Cells ; Viral Load ; Virus Replication/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
Autorzy:
Selinger C; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. .
Tisoncik-Go J; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. .
Menachery VD; Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA. .
Agnihothram S; Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA. .
Law GL; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. .
Chang J; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. .
Kelly SM; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. .
Sova P; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. .
Baric RS; Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA. .
Katze MG; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. .
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Źródło:
BMC genomics [BMC Genomics] 2014 Dec 22; Vol. 15, pp. 1161. Date of Electronic Publication: 2014 Dec 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Expression Profiling*
Genomics*
Immunity, Innate*/drug effects
Cytokines/*pharmacology
Host-Pathogen Interactions/*immunology
Middle East Respiratory Syndrome Coronavirus/*genetics
Middle East Respiratory Syndrome Coronavirus/*physiology
Cell Line ; Humans ; Inflammation/virology ; Middle East Respiratory Syndrome Coronavirus/isolation & purification ; STAT3 Transcription Factor/metabolism ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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