Temat: "Mendelian Randomization Analysis" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Mendelian genetics of male infertility.
Autorzy:: Hwang K; Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
Yatsenko AN
Jorgez CJ
Mukherjee S
Nalam RL
Matzuk MM
Lamb DJ; Pokaż więcej
Źródło:: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2010 Dec; Vol. 1214, pp. E1-E17.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:: Infertility, Male/*genetics
Infertility, Male/*therapy
Mendelian Randomization Analysis/*methods
Animals ; Humans ; Infertility, Male/pathology ; Male ; Mendelian Randomization Analysis/trends ; Reproductive Techniques, Assisted/trends ; Spermatogenesis/physiology

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Skocz do pozycji: 2.

Tytuł:: Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study.
Autorzy:: Lewis SJ; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. />Araya R
Smith GD
Freathy R
Gunnell D
Palmer T
Munafò M; Pokaż więcej
Źródło:: PloS one [PLoS One] 2011; Vol. 6 (7), pp. e21689. Date of Electronic Publication: 2011 Jul 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Affect*
Mendelian Randomization Analysis*
Depression/*complications
Depression/*genetics
Smoking/*genetics
Female ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide/genetics ; Pregnancy ; Risk Factors

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Skocz do pozycji: 3.

Tytuł:: Type II secretory phospholipase A2 and prognosis in patients with stable coronary heart disease: mendelian randomization study.
Autorzy:: Breitling LP; Division C070 Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. />Koenig W
Fischer M
Mallat Z
Hengstenberg C
Rothenbacher D
Brenner H; Pokaż więcej
Źródło:: PloS one [PLoS One] 2011; Vol. 6 (7), pp. e22318. Date of Electronic Publication: 2011 Jul 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mendelian Randomization Analysis*
Coronary Disease/*diagnosis
Coronary Disease/*enzymology
Group II Phospholipases A2/*genetics
Adult ; Aged ; Biomarkers/blood ; Biomarkers/metabolism ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/enzymology ; Cardiovascular Diseases/genetics ; Cohort Studies ; Coronary Disease/epidemiology ; Coronary Disease/genetics ; Female ; Follow-Up Studies ; Group II Phospholipases A2/blood ; Group II Phospholipases A2/metabolism ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prognosis

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Skocz do pozycji: 4.

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Skocz do pozycji: 5.

Tytuł:: A comparison of three methods of Mendelian randomization when the genetic instrument, the risk factor and the outcome are all binary.
Autorzy:: Vuistiner P; University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland. />Bochud M
Rousson V; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (5), pp. e35951. Date of Electronic Publication: 2012 May 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mendelian Randomization Analysis*
Models, Genetic*

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Skocz do pozycji: 6.

Tytuł:: Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D.
Autorzy:: Berry DJ; Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, United Kingdom.
Vimaleswaran KS
Whittaker JC
Hingorani AD
Hyppönen E; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (5), pp. e37465. Date of Electronic Publication: 2012 May 21.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Markers*
Mendelian Randomization Analysis/*methods
Vitamin D/*analogs & derivatives
Adult ; Alleles ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Vitamin D/genetics ; White People/genetics

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Skocz do pozycji: 7.

Tytuł:: Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis.
Autorzy:: Theodoratou E; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom. />Palmer T
Zgaga L
Farrington SM
McKeigue P
Din FV
Tenesa A
Davey-Smith G
Dunlop MG
Campbell H; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (6), pp. e37662. Date of Electronic Publication: 2012 Jun 06.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Colorectal Neoplasms/*blood
Colorectal Neoplasms/*etiology
Vitamin D Deficiency/*complications
Vitamin D Deficiency/*epidemiology
25-Hydroxyvitamin D 2/blood ; 25-Hydroxyvitamin D 2/genetics ; Adult ; Aged ; Case-Control Studies ; Chromatography, Liquid ; Female ; Genotype ; Humans ; Likelihood Functions ; Male ; Mendelian Randomization Analysis ; Middle Aged ; Odds Ratio ; Polymorphism, Single Nucleotide/genetics ; Risk Factors ; Scotland/epidemiology ; Tandem Mass Spectrometry

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Skocz do pozycji: 8.

Tytuł:: Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children.
Autorzy:: Bonilla C; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. />Lawlor DA
Taylor AE
Gunnell DJ
Ben-Shlomo Y
Ness AR
Timpson NJ
St Pourcain B
Ring SM
Emmett PM
Smith AD
Refsum H
Pennell CE
Brion MJ
Smith GD
Lewis SJ; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (12), pp. e51084. Date of Electronic Publication: 2012 Dec 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Intelligence Tests*
Mendelian Randomization Analysis*
Parents*
Vitamin B 12/*blood
Adult ; Child ; Confounding Factors, Epidemiologic ; Dietary Supplements ; Female ; Fetal Blood/metabolism ; Genetic Association Studies ; Haplotypes ; Humans ; Longitudinal Studies ; Male ; Polymorphism, Single Nucleotide/genetics ; Pregnancy ; United Kingdom

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Skocz do pozycji: 9.

Tytuł:: The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach.
Autorzy:: Nordestgaard BG; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark.
Palmer TM
Benn M
Zacho J
Tybjaerg-Hansen A
Davey Smith G
Timpson NJ; Pokaż więcej
Źródło:: PLoS medicine [PLoS Med] 2012; Vol. 9 (5), pp. e1001212. Date of Electronic Publication: 2012 May 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Body Mass Index*
Myocardial Ischemia/*etiology
Obesity/*complications
Adiposity ; Adult ; Aged ; Alleles ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Female ; Genotype ; Humans ; Incidence ; Male ; Membrane Proteins/genetics ; Mendelian Randomization Analysis/methods ; Middle Aged ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/genetics ; Obesity/genetics ; Odds Ratio ; Proteins/genetics ; Receptor, Melanocortin, Type 4/genetics ; Risk Factors

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Skocz do pozycji: 10.

Tytuł:: Body mass index and depressive symptoms: instrumental-variables regression with genetic risk score.
Autorzy:: Jokela M; Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Elovainio M; National Institute for Health and Welfare, Helsinki, Finland.
Keltikangas-Järvinen L; Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Batty GD; Department of Epidemiology and Public Health, University College London, London, UK.; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Hintsanen M; Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.; Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland.
Seppälä I; Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland.; Medical School, University of Tampere, Tampere, Finland.
Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Viikari JS; Department of Medicine, Turku University Hospital.
Raitakari OT; Department of Clinical Physiology, Turku University Hospital and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Lehtimäki T; Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland.; Medical School, University of Tampere, Tampere, Finland.
Kivimäki M; Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.; Department of Epidemiology and Public Health, University College London, London, UK.; Pokaż więcej
Źródło:: Genes, brain, and behavior [Genes Brain Behav] 2012 Nov; Vol. 11 (8), pp. 942-8. Date of Electronic Publication: 2012 Oct 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Body Mass Index*
Depressive Disorder/*genetics
Genetic Predisposition to Disease/*genetics
Obesity/*genetics
Adolescent ; Adult ; Body Weight/genetics ; Cohort Studies ; Female ; Finland ; Genetic Markers/genetics ; Humans ; Male ; Mendelian Randomization Analysis ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Prospective Studies

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Skocz do pozycji: 11.

Tytuł:: Mendelian randomization suggests non-causal associations of testosterone with cardiometabolic risk factors and mortality.
Autorzy:: Haring R; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Strasse, Greifswald, Germany. />Teumer A
Völker U
Dörr M
Nauck M
Biffar R
Völzke H
Baumeister SE
Wallaschofski H; Pokaż więcej
Źródło:: Andrology [Andrology] 2013 Jan; Vol. 1 (1), pp. 17-23. Date of Electronic Publication: 2012 Aug 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mendelian Randomization Analysis*
Cardiovascular Diseases/*blood
Cardiovascular Diseases/*mortality
Testosterone/*blood
Adult ; Aged ; Biomarkers/blood ; Blood Glucose/analysis ; Blood Pressure ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/physiopathology ; Chromosomes, Human, X ; Confounding Factors, Epidemiologic ; Cross-Sectional Studies ; Down-Regulation ; Genetic Predisposition to Disease ; Germany ; Humans ; Least-Squares Analysis ; Linear Models ; Lipids/blood ; Longitudinal Studies ; Male ; Middle Aged ; Phenotype ; Polymorphism, Genetic ; Prognosis ; Prospective Studies ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Sex Hormone-Binding Globulin/genetics ; Time Factors ; Waist Circumference ; Young Adult

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Skocz do pozycji: 12.

Tytuł:: Vitamin D status, filaggrin genotype, and cardiovascular risk factors: a Mendelian randomization approach.
Autorzy:: Skaaby T; Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark. />Husemoen LL
Martinussen T
Thyssen JP
Melgaard M
Thuesen BH
Pisinger C
Jørgensen T
Johansen JD
Menné T
Carlsen B
Szecsi PB
Stender S
Fenger RV
Fenger M
Linneberg A; Pokaż więcej
Źródło:: PloS one [PLoS One] 2013; Vol. 8 (2), pp. e57647. Date of Electronic Publication: 2013 Feb 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Mendelian Randomization Analysis*
Cardiovascular Diseases/*blood
Cardiovascular Diseases/*genetics
Intermediate Filament Proteins/*genetics
Vitamin D/*blood
Adolescent ; Adult ; Aged ; Female ; Filaggrin Proteins ; Genotype ; Humans ; Linear Models ; Male ; Middle Aged ; Risk Factors ; Young Adult

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Skocz do pozycji: 13.

Tytuł:: Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.
Autorzy:: Vimaleswaran KS; Centre for Paediatric Epidemiology and Biostatistics and MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom.
Berry DJ
Lu C
Tikkanen E
Pilz S
Hiraki LT
Cooper JD
Dastani Z
Li R
Houston DK
Wood AR
Michaëlsson K
Vandenput L
Zgaga L
Yerges-Armstrong LM
McCarthy MI
Dupuis J
Kaakinen M
Kleber ME
Jameson K
Arden N
Raitakari O
Viikari J
Lohman KK
Ferrucci L
Melhus H
Ingelsson E
Byberg L
Lind L
Lorentzon M
Salomaa V
Campbell H
Dunlop M
Mitchell BD
Herzig KH
Pouta A
Hartikainen AL
Streeten EA
Theodoratou E
Jula A
Wareham NJ
Ohlsson C
Frayling TM
Kritchevsky SB
Spector TD
Richards JB
Lehtimäki T
Ouwehand WH
Kraft P
Cooper C
März W
Power C
Loos RJ
Wang TJ
Järvelin MR
Whittaker JC
Hingorani AD
Hyppönen E; Pokaż więcej
Corporate Authors:: Genetic Investigation of Anthropometric Traits-GIANT Consortium
Źródło:: PLoS medicine [PLoS Med] 2013; Vol. 10 (2), pp. e1001383. Date of Electronic Publication: 2013 Feb 05.
Typ publikacji:: Journal Article; Meta-Analysis; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:: Mendelian Randomization Analysis*
Polymorphism, Single Nucleotide*
Obesity/*genetics
Vitamin D Deficiency/*genetics
Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Body Mass Index ; Europe ; Evidence-Based Medicine ; Female ; Genetic Predisposition to Disease ; Humans ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; North America ; Obesity/diagnosis ; Obesity/ethnology ; Obesity/therapy ; Phenotype ; Risk Assessment ; Risk Factors ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/ethnology ; Vitamin D Deficiency/prevention & control ; White People/genetics

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Skocz do pozycji: 14.

Tytuł:: The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.
Autorzy:: Fall T; Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Hägg S
Mägi R
Ploner A
Fischer K
Horikoshi M
Sarin AP
Thorleifsson G
Ladenvall C
Kals M
Kuningas M
Draisma HH
Ried JS
van Zuydam NR
Huikari V
Mangino M
Sonestedt E
Benyamin B
Nelson CP
Rivera NV
Kristiansson K
Shen HY
Havulinna AS
Dehghan A
Donnelly LA
Kaakinen M
Nuotio ML
Robertson N
de Bruijn RF
Ikram MA
Amin N
Balmforth AJ
Braund PS
Doney AS
Döring A
Elliott P
Esko T
Franco OH
Gretarsdottir S
Hartikainen AL
Heikkilä K
Herzig KH
Holm H
Hottenga JJ
Hyppönen E
Illig T
Isaacs A
Isomaa B
Karssen LC
Kettunen J
Koenig W
Kuulasmaa K
Laatikainen T
Laitinen J
Lindgren C
Lyssenko V
Läärä E
Rayner NW
Männistö S
Pouta A
Rathmann W
Rivadeneira F
Ruokonen A
Savolainen MJ
Sijbrands EJ
Small KS
Smit JH
Steinthorsdottir V
Syvänen AC
Taanila A
Tobin MD
Uitterlinden AG
Willems SM
Willemsen G
Witteman J
Perola M
Evans A
Ferrières J
Virtamo J
Kee F
Tregouet DA
Arveiler D
Amouyel P
Ferrario MM
Brambilla P
Hall AS
Heath AC
Madden PA
Martin NG
Montgomery GW
Whitfield JB
Jula A
Knekt P
Oostra B
van Duijn CM
Penninx BW
Smith GD
Kaprio J
Samani NJ
Gieger C
Peters A
Wichmann HE
Boomsma DI
de Geus EJ
Tuomi T
Power C
Hammond CJ
Spector TD
Lind L
Orho-Melander M
Palmer CN
Morris AD
Groop L
Järvelin MR
Salomaa V
Vartiainen E
Hofman A
Ripatti S
Metspalu A
Thorsteinsdottir U
Stefansson K
Pedersen NL
McCarthy MI
Ingelsson E
Prokopenko I; Pokaż więcej
Corporate Authors:: European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium
Źródło:: PLoS medicine [PLoS Med] 2013; Vol. 10 (6), pp. e1001474. Date of Electronic Publication: 2013 Jun 25.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:: Mendelian Randomization Analysis*
Quantitative Trait, Heritable*
Adiposity/*genetics
Cardiovascular Diseases/*genetics
Cardiovascular Diseases/*metabolism
Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Body Mass Index ; Case-Control Studies ; Confounding Factors, Epidemiologic ; Genetic Association Studies ; Humans ; Meta-Analysis as Topic ; Polymorphism, Single Nucleotide/genetics ; Proteins/genetics

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Skocz do pozycji: 15.

Tytuł:: Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population.
Autorzy:: Mente A; Population Health Research Institute, Hamilton, Canada.
Meyre D
Lanktree MB
Heydarpour M
Davis AD
Miller R
Gerstein H
Hegele RA
Yusuf S
Anand SS; Pokaż więcej
Corporate Authors:: SHARE Investigators
SHARE-AP Investigators
Źródło:: PloS one [PLoS One] 2013 Jun 24; Vol. 8 (6), pp. e66808. Date of Electronic Publication: 2013 Jun 24 (Print Publication: 2013).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mendelian Randomization Analysis*
Adiponectin/*genetics
Ethnicity/*genetics
Metabolism/*genetics
Adiponectin/blood ; Adult ; Aged ; Female ; Genetic Association Studies ; Genotype ; Homeostasis/genetics ; Humans ; Insulin Resistance/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait, Heritable ; Regression Analysis

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Skocz do pozycji: 16.

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Skocz do pozycji: 17.

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Skocz do pozycji: 18.

Tytuł:: Using Mendelian randomisation to infer causality in depression and anxiety research.
Autorzy:: Gage SH; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, United Kingdom.
Smith GD
Zammit S
Hickman M
Munafò MR; Pokaż więcej
Źródło:: Depression and anxiety [Depress Anxiety] 2013 Dec; Vol. 30 (12), pp. 1185-93. Date of Electronic Publication: 2013 Jul 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Mendelian Randomization Analysis*
Anxiety Disorders/*genetics
Depressive Disorder/*genetics
Smoking/*genetics
Substance-Related Disorders/*genetics
Anxiety Disorders/epidemiology ; Causality ; Depressive Disorder/epidemiology ; Humans ; Linkage Disequilibrium ; Polymorphism, Single Nucleotide ; Research Design ; Smoking/epidemiology ; Substance-Related Disorders/epidemiology

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Skocz do pozycji: 19.

Tytuł:: The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach.
Autorzy:: Binder AM; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. .
Michels KB; Pokaż więcej
Źródło:: BMC bioinformatics [BMC Bioinformatics] 2013 Dec 04; Vol. 14, pp. 353. Date of Electronic Publication: 2013 Dec 04.
Typ publikacji:: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Erythrocytes/*physiology
Fetal Blood/*metabolism
Folic Acid/*physiology
Mendelian Randomization Analysis/*methods
Adult ; Child ; CpG Islands/genetics ; DNA Methylation ; Epigenomics ; Erythrocytes/metabolism ; Female ; Folic Acid/blood ; Genotype ; Humans ; Infant ; Oligonucleotide Array Sequence Analysis ; Random Allocation

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Skocz do pozycji: 20.

Tytuł:: Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach.
Autorzy:: Huang T
Ren J
Huang J
Li D; Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, China. .; Pokaż więcej
Źródło:: BMC genomics [BMC Genomics] 2013 Dec 10; Vol. 14, pp. 867. Date of Electronic Publication: 2013 Dec 10.
Typ publikacji:: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms:: Diabetes Mellitus, Type 2/*genetics
Homocysteine/*blood
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Alleles ; Diabetes Mellitus, Type 2/blood ; Genetic Predisposition to Disease ; Genotype ; Humans ; Mendelian Randomization Analysis ; Risk Factors

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