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    Tytuł:
    Tetramethyl-phenanthroline copper complexes in the development of drugs to treat cancer: synthesis, characterization and cytotoxicity studies of a series of copper(II)-L-dipeptide-3,4,7,8-tetramethyl-phenanthroline complexes.
    Autorzy:
    Alvarez N; Facultad de Química, Universidad de la República, Av. General Flores 2124, Montevideo, Uruguay.
    Leite CM; Departamento de Química, Universidade Federal de São Carlos, CP 676, São Carlos, SP, 13565-905, Brazil.
    Napoleone A; Facultad de Química, Universidad de la República, Av. General Flores 2124, Montevideo, Uruguay.
    Mendes LFS; Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, 14040-901, Brazil.
    Fernández CY; Facultad de Química, Universidad de la República, Av. General Flores 2124, Montevideo, Uruguay.
    Ribeiro RR; Departamento de Química, Centro Politécnico, Universidade Federal do Paraná, Curitiba, PR, Brazil.
    Ellena J; Instituto de Física de São Carlos, Universidade de São Paulo, Av. do Trabalhador São-carlense 400, São Carlos, SP, 13566-590, Brazil.
    Batista AA; Departamento de Química, Universidade Federal de São Carlos, CP 676, São Carlos, SP, 13565-905, Brazil.
    Costa-Filho AJ; Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, 14040-901, Brazil.
    Facchin G; Facultad de Química, Universidad de la República, Av. General Flores 2124, Montevideo, Uruguay. .
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    Źródło:
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2022 Aug; Vol. 27 (4-5), pp. 431-441. Date of Electronic Publication: 2022 May 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents*/pharmacology
    Coordination Complexes*/chemistry
    Triple Negative Breast Neoplasms*
    Cisplatin/pharmacology ; Copper/chemistry ; Copper/pharmacology ; DNA/chemistry ; Dipeptides/chemistry ; Humans ; MCF-7 Cells ; Phenanthrolines/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate.
    Autorzy:
    Freire MCLC; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.
    Basso LGM; Physical Sciences Laboratory, State University of Northern Rio de Janeiro Darcy Ribeiro (UENF), Campos dos Goytacazes, RJ, Brazil.
    Mendes LFS; Departament of Physics, Ribeirao Preto School of Philosophy, Science and Literature, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
    Mesquita NCMR; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.
    Mottin M; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil.
    Fernandes RS; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.
    Policastro LR; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.
    Godoy AS; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.
    Santos IA; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil.
    Ruiz UEA; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil.
    Caruso IP; Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Sao Paulo State University (Unesp), Campus Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil.; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Sousa BKP; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil.
    Jardim ACG; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil.; Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Sao Paulo State University (Unesp), Campus Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil.
    Almeida FCL; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; National Center of Nuclear Magnetic Resonance (CNRMN), Center of Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Gil LHVG; Instituto Aggeu Magalhaes (IAM-FIOCRUZ), Recife, PE, Brazil.
    Andrade CH; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil.
    Oliva G; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil. .
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    Źródło:
    Scientific reports [Sci Rep] 2022 Jun 22; Vol. 12 (1), pp. 10601. Date of Electronic Publication: 2022 Jun 22.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Chikungunya Fever*
    Chikungunya virus*/genetics
    Antiviral Agents/therapeutic use ; Humans ; Ligands ; RNA/metabolism ; RNA-Dependent RNA Polymerase ; Virus Replication
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Conformational flexibility of GRASPs and their constituent PDZ subdomains reveals structural basis of their promiscuous interactome.
    Autorzy:
    Mendes LFS; Molecular Biophysics Laboratory, Ribeirão Preto School of Philosophy, Sciences and Literature, Physics Department, University of São Paulo, Ribeirão Preto, Brazil.; Department of Biochemistry, University of Oxford, UK.
    Batista MRB; Molecular Biophysics Laboratory, Ribeirão Preto School of Philosophy, Sciences and Literature, Physics Department, University of São Paulo, Ribeirão Preto, Brazil.
    Judge PJ; Department of Biochemistry, University of Oxford, UK.
    Watts A; Department of Biochemistry, University of Oxford, UK.
    Redfield C; Department of Biochemistry, University of Oxford, UK.
    Costa-Filho AJ; Molecular Biophysics Laboratory, Ribeirão Preto School of Philosophy, Sciences and Literature, Physics Department, University of São Paulo, Ribeirão Preto, Brazil.
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    Źródło:
    The FEBS journal [FEBS J] 2020 Aug; Vol. 287 (15), pp. 3255-3272. Date of Electronic Publication: 2020 Jan 20.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    PDZ Domains*
    Protein Conformation*
    Golgi Matrix Proteins/*chemistry
    Golgi Matrix Proteins/*metabolism
    Amino Acid Sequence ; Crystallography, X-Ray ; Humans ; Molecular Dynamics Simulation ; Protein Binding ; Sequence Homology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The GRASP domain in golgi reassembly and stacking proteins: differences and similarities between lower and higher Eukaryotes.
    Autorzy:
    Mendes LFS; Departamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
    Fontana NA; Departamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
    Oliveira CG; Departamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
    Freire MCLC; Centro de Pesquisas Aggeu Magalhães - Fundação Oswaldo Cruz (FIOCRUZ- PE), Recife, Brazil.
    Lopes JLS; Departamento de Física Aplicada, Instituto de Física, Universidade de São Paulo, São Paulo, Brazil.
    Melo FA; Departamento de Física, Centro Multiusuário de Inovação Biomolecular, IBILCE, Universidade Estadual Paulista Júlio Mesquita, São Paulo, Brazil.
    Costa-Filho AJ; Departamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
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    Źródło:
    The FEBS journal [FEBS J] 2019 Sep; Vol. 286 (17), pp. 3340-3358. Date of Electronic Publication: 2019 May 22.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Structural Homology, Protein*
    Fungal Proteins/*chemistry
    Golgi Matrix Proteins/*chemistry
    Cryptococcus neoformans ; Evolution, Molecular ; Fungal Proteins/genetics ; Golgi Matrix Proteins/genetics ; Golgi Matrix Proteins/metabolism ; Saccharomyces cerevisiae
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The yeast GRASP Grh1 displays a high polypeptide backbone mobility along with an amyloidogenic behavior.
    Autorzy:
    Fontana NA; Departamento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
    Fonseca-Maldonado R; Departamento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.; Instituto Federal de Ciência e Tecnologia de São Paulo, Jacareí, SP, Brazil.
    Mendes LFS; Departamento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
    Meleiro LP; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
    Costa-Filho AJ; Departamento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. .
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    Źródło:
    Scientific reports [Sci Rep] 2018 Oct 24; Vol. 8 (1), pp. 15690. Date of Electronic Publication: 2018 Oct 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Amyloidogenic Proteins/*chemistry
    Intrinsically Disordered Proteins/*chemistry
    Peptides/*chemistry
    Saccharomyces cerevisiae Proteins/*chemistry
    Vesicular Transport Proteins/*chemistry
    Amino Acid Sequence ; Amyloid/chemistry ; Benzothiazoles/chemistry ; Circular Dichroism ; Congo Red/chemistry ; Golgi Apparatus/metabolism ; Golgi Matrix Proteins/chemistry ; Optical Imaging ; Protein Conformation, beta-Strand ; Protein Denaturation ; Saccharomyces cerevisiae/metabolism ; Solvents/chemistry ; Spectrometry, Fluorescence ; Temperature ; trans-Golgi Network/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Lignocellulose binding of a Cel5A-RtCBM11 chimera with enhanced β-glucanase activity monitored by electron paramagnetic resonance.
    Autorzy:
    Fonseca-Maldonado R; Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, São Paulo Brazil.; Departamento de Gestão, Instituto Federal de Educação, Ciência e Tecnologia de São Paulo/IFSP Campus Jacareí, Jacareí, São Paulo Brazil.
    Meleiro LP; Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, São Paulo Brazil.
    Mendes LFS; Departamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo Brazil.
    Alves LF; Departamento de Bioquímica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo Brazil.
    Carli S; Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, São Paulo Brazil.
    Morero LD; Departamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo Brazil.
    Basso LGM; Departamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo Brazil.
    Costa-Filho AJ; Departamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo Brazil.
    Ward RJ; Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, São Paulo Brazil.
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    Źródło:
    Biotechnology for biofuels [Biotechnol Biofuels] 2017 Nov 14; Vol. 10, pp. 269. Date of Electronic Publication: 2017 Nov 14 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-6 z 6

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