Temat: "Metabolic Clearance Rate" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: In vitro-in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization.
Autorzy :: Morita K; Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.; Translational Research Division, Chugai Pharmaceutical, Co., Ltd, Kanagawa, Japan.
Kato M; Research Division, Chugai Pharmaceutical, Co., Ltd, Shizuoka, Japan.
Kudo T; Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.
Ito K; Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.; Pokaż więcej
Źródło :: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Sep; Vol. 50 (9), pp. 1064-1075. Date of Electronic Publication: 2020 Mar 12.
Typ publikacji :: Journal Article
MeSH Terms :: Metabolic Clearance Rate*
Microsomes, Liver/*physiology
Cytochrome P-450 CYP3A ; Hepatocytes ; Humans ; Kinetics ; Liver ; Midazolam/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver.
Autorzy :: Sawada T; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd, Tsukuba, Japan.
Yamaura Y; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd, Tsukuba, Japan.
Higuchi S; Corporate Planning Department, Ono Pharmaceutical Co., Ltd, Osaka, Japan.
Imawaka H; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd, Tsukuba, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.; Pokaż więcej
Źródło :: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 May; Vol. 50 (5), pp. 526-535. Date of Electronic Publication: 2019 Sep 13.
Typ publikacji :: Journal Article
MeSH Terms :: Metabolic Clearance Rate*
Models, Biological*
Animals ; Chimera ; Hepatocytes ; Humans ; Kinetics ; Liver ; Mice ; Microsomes, Liver ; Pharmacokinetics ; Protein Binding ; Species Specificity
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Persistent Rivaroxaban Effect Due to Impaired Renal Clearance and Medication Effects.
Autorzy :: Milito C; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.
McRae H; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.
Victor A; Department of Hematology and Oncology, University of Rochester Medical Center, Rochester, New York.
Refaai MA; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.
Schmidt AE; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.; Pokaż więcej
Źródło :: Laboratory medicine [Lab Med] 2020 Mar 10; Vol. 51 (2), pp. 211-216.
Typ publikacji :: Case Reports; Journal Article
MeSH Terms :: Metabolic Clearance Rate*
Atrial Flutter/*complications
Atrial Flutter/*drug therapy
Factor Xa Inhibitors/*pharmacokinetics
Hemorrhage/*chemically induced
Renal Insufficiency/*complications
Rivaroxaban/*pharmacokinetics
Aged ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/adverse effects ; Humans ; Male ; Prothrombin Time ; Rivaroxaban/administration & dosage ; Rivaroxaban/adverse effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Prediction of Clearance in Children from Adults Following Drug-Drug Interaction Studies: Application of Age-Dependent Exponent Model.
Autorzy :: Mahmood I; Office of Tissue and Advanced Therapies (OTAT), Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002, USA. .; Mahmood Clinical Pharmacology Consultancy, LLC, 1709, Piccard Dr, Rockville, MD, 20850, USA. .; Pokaż więcej
Źródło :: Drugs in R&D [Drugs R D] 2020 Mar; Vol. 20 (1), pp. 47-54.
Typ publikacji :: Journal Article
MeSH Terms :: Metabolic Clearance Rate*
Models, Biological*
Pharmaceutical Preparations/*metabolism
Adolescent ; Adult ; Child ; Child, Preschool ; Drug Interactions ; Humans ; Infant ; Infant, Newborn
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 5 5.

Tytuł :: Extrapolation of Drug Clearance in Children ≤ 2 Years of Age from Empirical Models Using Data from Children (> 2 Years) and Adults.
Autorzy :: Mahmood I; Office of Tissue and Advanced Therapies (OTAT), Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002, USA. .; Mahmood Clinical Pharmacology, Consultancy, LLC, 1709, Piccard Dr, Rockville, MD, 20850, USA. .; Pokaż więcej
Źródło :: Drugs in R&D [Drugs R D] 2020 Mar; Vol. 20 (1), pp. 1-10.
Typ publikacji :: Journal Article
MeSH Terms :: Metabolic Clearance Rate*
Models, Biological*
Adult ; Alfentanil/administration & dosage ; Alfentanil/metabolism ; Amikacin/administration & dosage ; Amikacin/metabolism ; Busulfan/administration & dosage ; Busulfan/metabolism ; Ceftizoxime/administration & dosage ; Ceftizoxime/analogs & derivatives ; Ceftizoxime/metabolism ; Child, Preschool ; Humans ; Infant ; Injections, Intravenous ; Meperidine/administration & dosage ; Meperidine/metabolism ; Oxycodone/administration & dosage ; Oxycodone/metabolism ; Propofol/administration & dosage ; Propofol/metabolism ; Sufentanil/administration & dosage ; Sufentanil/metabolism ; Theophylline/administration & dosage ; Theophylline/metabolism ; Tobramycin/administration & dosage ; Tobramycin/metabolism
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 6 6.

Tytuł :: Identification and quantitation of enzyme and transporter contributions to hepatic clearance for the assessment of potential drug-drug interactions.
Autorzy :: Kimoto E; ADME Sciences, Medicine Design, Worldwide Research and Development, Pfizer Inc., Groton, CT, USA. Electronic address: .
Obach RS; ADME Sciences, Medicine Design, Worldwide Research and Development, Pfizer Inc., Groton, CT, USA.
Varma MVS; ADME Sciences, Medicine Design, Worldwide Research and Development, Pfizer Inc., Groton, CT, USA.; Pokaż więcej
Źródło :: Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2020 Feb; Vol. 35 (1), pp. 18-29. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Metabolic Clearance Rate*
Enzymes/*metabolism
Liver/*metabolism
Membrane Transport Proteins/*metabolism
Pharmaceutical Preparations/*metabolism
Drug Interactions ; Humans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion transporting polypeptide (OATP) 1B transporters.
Autorzy :: Nozaki Y; Drug Metabolism and Pharmacokinetics Tsukuba, Eisai Co.,Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki, 300-2635, Japan. Electronic address: .
Izumi S; Drug Metabolism and Pharmacokinetics Tsukuba, Eisai Co.,Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki, 300-2635, Japan.; Pokaż więcej
Źródło :: Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2020 Feb; Vol. 35 (1), pp. 56-70. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Metabolic Clearance Rate*
Hepatocytes/*metabolism
Liver-Specific Organic Anion Transporter 1/*metabolism
Pharmaceutical Preparations/*metabolism
Drug Interactions ; Humans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Drug dosing in neonates.
Autorzy :: Correia, M.; Pokaż więcej
Źródło :: Southern African Journal of Anaesthesia & Analgesia. 2020 Supplement3, pS21-S29. 9p.
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 9 9.

Tytuł :: Obstructive sleep apnoea and polymorphisms: implications for anaesthesia care.
Autorzy :: Coté, C. J.; Pokaż więcej
Źródło :: Southern African Journal of Anaesthesia & Analgesia. 2020 Supplement2, pS14-S18. 5p.
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 10 10.

Tytuł :: Development of a three-compartment toxicokinetic model for T-2 toxin in shrimp by blindfold particle swarm optimization algorithm.
Autorzy :: Ye L; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Zhanjiang 524088, China. Electronic address: .
Liu J; Faculty of Electrics and Information Engineering, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address: .
Wang Y; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Zhanjiang 524088, China. Electronic address: .
Sun L; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Zhanjiang 524088, China.
Fang Z; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Zhanjiang 524088, China.
Deng Q; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Zhanjiang 524088, China.
Qiu M; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, Zhanjiang 524088, China.
Zhao J; School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: .; Pokaż więcej
Źródło :: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Jan 15; Vol. 208, pp. 111698. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :: Journal Article
MeSH Terms :: Algorithms*
Penaeidae/*metabolism
T-2 Toxin/*pharmacokinetics
Adsorption ; Animals ; Hemolymph/drug effects ; Hemolymph/metabolism ; Metabolic Clearance Rate ; Penaeidae/drug effects ; Seafood ; T-2 Toxin/toxicity ; Tissue Distribution ; Toxicokinetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Impacts of microplastic fibres on the marine mussel, Mytilus galloprovinciallis.
Autorzy :: Alnajar N; School of Biological and Marine Sciences and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK.
Jha AN; School of Biological and Marine Sciences and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK.
Turner A; School of Geography, Earth and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK. Electronic address: .; Pokaż więcej
Źródło :: Chemosphere [Chemosphere] 2021 Jan; Vol. 262, pp. 128290. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :: Journal Article
MeSH Terms :: DNA Damage*
Microplastics/*toxicity
Mytilus/*drug effects
Water Pollutants, Chemical/*toxicity
Animals ; Comet Assay ; Copper/toxicity ; Gills/drug effects ; Gills/metabolism ; Hemolymph/drug effects ; Hemolymph/metabolism ; Metabolic Clearance Rate ; Models, Theoretical ; Mytilus/genetics ; Mytilus/metabolism ; Seawater/chemistry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes.
Autorzy :: Wang W; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Teresa M; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Cai J; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Zhang C; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Wong S; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Yan Z; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Khojasteh SC; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Zhang D; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.; Pokaż więcej
Źródło :: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jan; Vol. 51 (1), pp. 15-23. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :: Journal Article
MeSH Terms :: Hepatocytes/*metabolism
Metabolic Clearance Rate/*physiology
Pharmaceutical Preparations/*metabolism
Animals ; Metabolome ; Rats ; Rats, Sprague-Dawley
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: Pharmacogenetics and drug metabolism: historical perspective and appraisal.
Autorzy :: Smith RL; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Mitchell SC; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Pokaż więcej
Źródło :: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Jan; Vol. 50 (1), pp. 3-8. Date of Electronic Publication: 2019 Sep 25.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Metabolic Clearance Rate*
Pharmacogenetics*
Inactivation, Metabolic ; Xenobiotics/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: Potential Therapeutic Roles for Direct Factor Xa Inhibitors in Coronavirus Infections.
Autorzy :: Al-Horani RA; Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA, 70125-1089, USA. .; Pokaż więcej
Źródło :: American journal of cardiovascular drugs : drugs, devices, and other interventions [Am J Cardiovasc Drugs] 2020 Dec; Vol. 20 (6), pp. 525-533.
Typ publikacji :: Journal Article; Review
MeSH Terms :: COVID-19/*drug therapy
COVID-19/*physiopathology
Factor Xa Inhibitors/*pharmacology
Factor Xa Inhibitors/*therapeutic use
Blood Coagulation/drug effects ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/physiopathology ; Cytokines/biosynthesis ; Drug Interactions ; Factor Xa/metabolism ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/pharmacokinetics ; Half-Life ; Humans ; Inflammation Mediators/metabolism ; Metabolic Clearance Rate ; Multiple Organ Failure/physiopathology ; Multiple Organ Failure/prevention & control ; Pandemics ; Protein Binding/physiology ; SARS-CoV-2 ; Severity of Illness Index
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: Physiologically-Based Pharmacokinetic Modeling to Predict the Clinical Efficacy of the Coadministration of Lopinavir and Ritonavir against SARS-CoV-2.
Autorzy :: Thakur A; Innovations in Food and Chemical Safety, Agency for Science, Technology, and Research, Singapore City, Singapore.; Skin Research Institute of Singapore, Agency for Science, Technology, and Research, Singapore City, Singapore.
Tan SPF; Innovations in Food and Chemical Safety, Agency for Science, Technology, and Research, Singapore City, Singapore.; Skin Research Institute of Singapore, Agency for Science, Technology, and Research, Singapore City, Singapore.
Chan JCY; Innovations in Food and Chemical Safety, Agency for Science, Technology, and Research, Singapore City, Singapore.; Skin Research Institute of Singapore, Agency for Science, Technology, and Research, Singapore City, Singapore.; Singapore Institute of Food and Biotechnology Innovation, Agency for Science, Technology, and Research, Singapore City, Singapore.; Pokaż więcej
Źródło :: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2020 Dec; Vol. 108 (6), pp. 1176-1184. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Antiviral Agents/*pharmacokinetics
COVID-19/*drug therapy
Lopinavir/*pharmacokinetics
Ritonavir/*pharmacokinetics
Area Under Curve ; Asian Continental Ancestry Group ; Dose-Response Relationship, Drug ; European Continental Ancestry Group ; HIV Infections/drug therapy ; Half-Life ; Humans ; Lopinavir/pharmacology ; Lung/metabolism ; Metabolic Clearance Rate ; Models, Biological ; Ritonavir/pharmacology ; SARS-CoV-2
SCR Protocol :: COVID-19 drug treatment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Resveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability.
Autorzy :: Wu M; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, Heilongjiang, China.; Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang, China.
Zhong C; State Key laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Deng Y; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, Heilongjiang, China.; Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang, China.
Zhang Q; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, Heilongjiang, China.; Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang, China.
Zhang X; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, Heilongjiang, China.; Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang, China.
Zhao X; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, Heilongjiang, China.; Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang, China.; Pokaż więcej
Źródło :: Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 81-90.
Typ publikacji :: Journal Article
MeSH Terms :: Drug Carriers/*chemistry
Glycyrrhizic Acid/*chemistry
Nanoparticles/*chemistry
Resveratrol/*pharmacokinetics
Serum Albumin, Human/*chemistry
Animals ; Female ; Male ; Metabolic Clearance Rate ; Rats ; Resveratrol/administration & dosage ; Resveratrol/adverse effects ; Solubility ; Tissue Distribution
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 17 17.

Tytuł :: Nonadditivity in human microsomal drug metabolism revealed in a study with coumarin 152, a polyspecific cytochrome P450 substrate.
Autorzy :: Dangi B; Department of Chemistry, Washington State University, Pullman, WA, USA.
Davydova NY; Department of Chemistry, Washington State University, Pullman, WA, USA.
Vavilov NE; Institute of Biomedical Chemistry, Moscow, Russia.
Zgoda VG; Institute of Biomedical Chemistry, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, Russia.
Davydov DR; Department of Chemistry, Washington State University, Pullman, WA, USA.; Pokaż więcej
Źródło :: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Dec; Vol. 50 (12), pp. 1393-1405. Date of Electronic Publication: 2020 Jul 26.
Typ publikacji :: Journal Article
MeSH Terms :: Coumarins/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
Metabolic Clearance Rate/*physiology
Cytochrome P-450 CYP1A2/metabolism ; Cytochrome P-450 CYP2C19/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Humans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism.
Autorzy :: Sanoh S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Naritomi Y; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan.
Kitamura S; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan.
Shinagawa A; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Kakuni M; Study Service Dept, PhoenixBio, Co., Ltd, Tsukuba, Japan.
Tateno C; R&D Dept, PhoenixBio, Co., Ltd, Higashi-Hiroshima, Japan.; Research Center for Hepatology and Gastroenterology, Hiroshima University, Higashi-Hiroshima, Japan.
Ohta S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.; Wakayama Medical University, Wakayama, Japan.; Pokaż więcej
Źródło :: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Nov; Vol. 50 (11), pp. 1370-1379. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :: Journal Article
MeSH Terms :: Liver/*metabolism
Organic Anion Transporters/*metabolism
Pharmaceutical Preparations/*metabolism
Animals ; Humans ; Inactivation, Metabolic ; Metabolic Clearance Rate ; Mice ; Pharmacokinetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Delayed Norfentanyl Clearance During Pregnancy.
Autorzy :: Wanar A; Departments of Obstetrics and Gynecology and Psychiatry, Boston University School of Medicine, and the Department of Obstetrics and Gynecology, Boston Medical Center, Boston, Massachusetts.
Saia K
Field TA; Pokaż więcej
Źródło :: Obstetrics and gynecology [Obstet Gynecol] 2020 Nov; Vol. 136 (5), pp. 905-907.
Typ publikacji :: Case Reports; Journal Article
MeSH Terms :: Analgesics, Opioid/*pharmacokinetics
Fentanyl/*analogs & derivatives
Fentanyl/*pharmacokinetics
Opioid-Related Disorders/*urine
Pregnancy Complications/*urine
Adult ; Female ; Fentanyl/urine ; Humans ; Metabolic Clearance Rate ; Pregnancy
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: Clearance Confusion: An Exploratory Analysis of Inpatient Dosing Discordances Between Renal Estimating Equations.
Autorzy :: McConachie SM; Wayne State University, Detroit, MI, USA.; Beaumont Hospital, Dearborn, MI, USA.
Shammout L; Beaumont Hospital, Dearborn, MI, USA.
Martirosov DM; Beaumont Hospital, Dearborn, MI, USA.; Pokaż więcej
Źródło :: The Annals of pharmacotherapy [Ann Pharmacother] 2020 Nov; Vol. 54 (11), pp. 1102-1108. Date of Electronic Publication: 2020 May 15.
Typ publikacji :: Journal Article
MeSH Terms :: Renal Elimination*
Anti-Bacterial Agents/*administration & dosage
Diet/*methods
Histamine H2 Antagonists/*administration & dosage
Kidney/*metabolism
Renal Insufficiency, Chronic/*metabolism
Adult ; Aged ; Anti-Bacterial Agents/pharmacokinetics ; Body Weight ; Cross-Sectional Studies ; Dose-Response Relationship, Drug ; Female ; Histamine H2 Antagonists/pharmacokinetics ; Humans ; Inpatients ; Kidney/drug effects ; Kidney Function Tests ; Male ; Metabolic Clearance Rate ; Middle Aged
: Czasopismo naukowe

Szczegóły

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