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Tytuł :
Modeling Challenge Data to Quantify Endogenous Lactate Production.
Autorzy :
Stefanovski D; Department of Clinical Studies - New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States.
Wilkins PA; Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana-Champaign, IL, United States.
Boston RC; Department of Clinical Studies- New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States.
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Źródło :
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Jun 28; Vol. 12, pp. 656054. Date of Electronic Publication: 2021 Jun 28 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Clearance Rate*
Models, Statistical*
Lactic Acid/*administration & dosage
Lactic Acid/*metabolism
Animals ; Humans ; Infusion Pumps ; Kinetics
Czasopismo naukowe
Tytuł :
The fructose-dependent acceleration of ethanol metabolism.
Autorzy :
Villalobos-García D; Department of Cell Biology and Development, Institute of Cellular Physiology, Universidad Nacional Autónoma de México (UNAM), Apdo. Postal 70-243, Coyoacán, 04510 Mexico City, Mexico.
Ayhllon-Osorio CA; Department of Cell Biology and Development, Institute of Cellular Physiology, Universidad Nacional Autónoma de México (UNAM), Apdo. Postal 70-243, Coyoacán, 04510 Mexico City, Mexico.
Hernández-Muñoz R; Department of Cell Biology and Development, Institute of Cellular Physiology, Universidad Nacional Autónoma de México (UNAM), Apdo. Postal 70-243, Coyoacán, 04510 Mexico City, Mexico. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jun; Vol. 188, pp. 114498. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ethanol/*metabolism
Fructose/*administration & dosage
Hepatocytes/*drug effects
Hepatocytes/*metabolism
Metabolic Clearance Rate/*drug effects
Alcohol Dehydrogenase/antagonists & inhibitors ; Alcohol Dehydrogenase/metabolism ; Animals ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Injections, Intraperitoneal ; Male ; Metabolic Clearance Rate/physiology ; Rats
Czasopismo naukowe
Tytuł :
There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions.
Autorzy :
Benet LZ; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, California, 94143-0912, USA. .
Sodhi JK; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, California, 94143-0912, USA.
Makrygiorgos G; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California, 94720-1462, USA.
Mesbah A; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California, 94720-1462, USA. .
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Źródło :
The AAPS journal [AAPS J] 2021 May 10; Vol. 23 (3), pp. 67. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Dosage Calculations*
Metabolic Clearance Rate*
Models, Biological*
Carrier Proteins/*metabolism
Pharmacology, Clinical/*standards
Chemical Engineering ; Chemistry, Pharmaceutical/methods ; Chemistry, Pharmaceutical/standards ; Dose-Response Relationship, Drug ; Humans ; Pharmacology, Clinical/methods
Czasopismo naukowe
Tytuł :
Choroid Plexus and Drug Removal Mechanisms.
Autorzy :
Sun A; Department of Pharmaceutics, University of Washington, Health Science Building Room H-272J, Box 357610, Seattle, Washington, 98195-7610, USA.
Wang J; Department of Pharmaceutics, University of Washington, Health Science Building Room H-272J, Box 357610, Seattle, Washington, 98195-7610, USA. .
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Źródło :
The AAPS journal [AAPS J] 2021 May 03; Vol. 23 (3), pp. 61. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Metabolic Clearance Rate*
Blood-Brain Barrier/*metabolism
Choroid Plexus/*metabolism
Glymphatic System/*metabolism
Animals ; Humans
Czasopismo naukowe
Tytuł :
A Drug-Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver.
Autorzy :
Vassiliou D; Centre for Inherited Metabolic Diseases (CMMS), Porphyria Centre Sweden, Karolinska University Hospital, Stockholm, Sweden.; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Sardh E; Centre for Inherited Metabolic Diseases (CMMS), Porphyria Centre Sweden, Karolinska University Hospital, Stockholm, Sweden.; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Harper P; Centre for Inherited Metabolic Diseases (CMMS), Porphyria Centre Sweden, Karolinska University Hospital, Stockholm, Sweden.; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Simon AR; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
Clausen VA; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
Najafian N; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
Robbie GJ; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
Agarwal S; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
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Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Nov; Vol. 110 (5), pp. 1250-1260. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylgalactosamine/*analogs & derivatives
Cytochrome P-450 Enzyme System/*metabolism
Drug Interactions/*physiology
Enzyme Activation/*physiology
Liver/*metabolism
Pyrrolidines/*metabolism
RNA, Small Interfering/*metabolism
5-Aminolevulinate Synthetase/metabolism ; Acetylgalactosamine/administration & dosage ; Acetylgalactosamine/metabolism ; Adult ; Caffeine/administration & dosage ; Caffeine/metabolism ; Cross-Over Studies ; Enzyme Activation/drug effects ; Female ; Humans ; Liver/drug effects ; Male ; Metabolic Clearance Rate/drug effects ; Metabolic Clearance Rate/physiology ; Midazolam/administration & dosage ; Midazolam/metabolism ; Middle Aged ; Omeprazole/administration & dosage ; Omeprazole/metabolism ; Porphyrias, Hepatic/drug therapy ; Porphyrias, Hepatic/metabolism ; Pyrrolidines/administration & dosage
Czasopismo naukowe
Tytuł :
Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants.
Autorzy :
Taniguchi-Takizawa T; Discovery Technology Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.
Kato H; Drug Metabolism and Pharmacokinetics Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.
Shimizu M; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan.
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Źródło :
Current drug metabolism [Curr Drug Metab] 2021; Vol. 22 (3), pp. 208-214.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Clearance Rate*
Oxygenases/*metabolism
Chemistry, Pharmaceutical ; Computer Simulation ; Cytochrome P-450 CYP3A/metabolism ; Drug Discovery ; Humans ; Indoles/chemistry ; Indoles/pharmacokinetics ; Isoquinolines/chemistry ; Isoquinolines/pharmacokinetics ; Models, Chemical ; Oxidation-Reduction ; Piperazines/chemistry ; Piperazines/pharmacokinetics ; Pyridines/chemistry ; Pyridines/pharmacokinetics ; Thiadiazoles/chemistry ; Thiadiazoles/pharmacokinetics
Czasopismo naukowe
Tytuł :
Murburn Precepts for Cytochrome P450 Mediated Drug/Xenobiotic Metabolism and Homeostasis.
Autorzy :
Parashar A; Satyamjayatu: The Science & Ethics Foundation, Snehatheeram, Kulappully, Shoranur-2 (PO), Kerala-679122, India.
Manoj KM; Satyamjayatu: The Science & Ethics Foundation, Snehatheeram, Kulappully, Shoranur-2 (PO), Kerala-679122, India.
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Źródło :
Current drug metabolism [Curr Drug Metab] 2021; Vol. 22 (4), pp. 315-326.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Clearance Rate*
Cytochrome P-450 Enzyme System/*metabolism
Reactive Oxygen Species/*metabolism
Xenobiotics/*metabolism
Biocatalysis ; Computer Simulation ; Drug Interactions ; Humans ; Microsomes, Liver/enzymology ; Thermodynamics
Czasopismo naukowe
Tytuł :
Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment.
Autorzy :
Albash R; Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt.
Yousry C; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Al-Mahallawi AM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Department of Pharmaceutics, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
Alaa-Eldin AA; Department of Pharmaceutics, Faculty of Pharmacy, Fayoum University, Elfayoum, Egypt.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 1-9.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents/*administration & dosage
Ceramides/*chemistry
Drug Carriers/*chemistry
Imidazoles/*administration & dosage
Polyethylene Glycols/*chemistry
Administration, Cutaneous ; Animals ; Antifungal Agents/pharmacokinetics ; Area Under Curve ; Chemistry, Pharmaceutical ; Dermatologic Agents/administration & dosage ; Dermatologic Agents/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Stability ; Imidazoles/pharmacokinetics ; Male ; Metabolic Clearance Rate ; Microscopy, Electron, Transmission ; Particle Size ; Rats, Wistar ; Skin Absorption/drug effects ; Surface Properties ; Surface-Active Agents
Czasopismo naukowe
Tytuł :
Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer.
Autorzy :
Kuehl PJ; Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Yingling CM; Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Dubose D; Lonza-Bend Research Institute, Bend, OR, USA.
Burke M; Lonza-Bend Research Institute, Bend, OR, USA.
Revelli DA; Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Chen W; Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Dye WW; Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Belinsky SA; Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Tessema M; Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 767-775.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms/*drug therapy
Topoisomerase I Inhibitors/*pharmacology
Topotecan/*pharmacology
Administration, Inhalation ; Animals ; Antineoplastic Combined Chemotherapy Protocols ; Cell Line, Tumor ; Chemistry, Pharmaceutical ; Genes, erbB-1/genetics ; Half-Life ; Humans ; Metabolic Clearance Rate ; Proto-Oncogene Proteins p21(ras)/genetics ; Rats ; Rats, Sprague-Dawley ; Topoisomerase I Inhibitors/administration & dosage ; Topoisomerase I Inhibitors/pharmacokinetics ; Topotecan/administration & dosage ; Topotecan/pharmacokinetics ; Tumor Burden ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Development and optimization of sitagliptin and dapagliflozin loaded oral self-nanoemulsifying formulation against type 2 diabetes mellitus.
Autorzy :
Kazi M; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alqahtani A; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ahmad A; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Noman OM; Medicinal Aromatic, and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Aldughaim MS; Research Center, King Fahad Medical City, Riyadh, Saudi Arabia.
Alqahtani AS; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alanazi FK; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 100-114.
Typ publikacji :
Journal Article
MeSH Terms :
Benzhydryl Compounds/*administration & dosage
Diabetes Mellitus, Experimental/*drug therapy
Emulsions/*chemistry
Glucosides/*administration & dosage
Nanoparticles/*chemistry
Sitagliptin Phosphate/*administration & dosage
Animals ; Area Under Curve ; Benzhydryl Compounds/pharmacokinetics ; Chemistry, Pharmaceutical ; Diabetes Mellitus, Type 2/drug therapy ; Drug Combinations ; Drug Liberation ; Glucosides/pharmacokinetics ; Hypoglycemic Agents ; Male ; Metabolic Clearance Rate ; Mice ; Microscopy, Electron, Transmission ; Particle Size ; Plant Oils/chemistry ; Rats ; Rats, Wistar ; Sitagliptin Phosphate/pharmacokinetics ; Solubility ; Surface Properties
Czasopismo naukowe
Tytuł :
Ruxolitinib exposure in patients with acute and chronic graft versus host disease in routine clinical practice-a prospective single-center trial.
Autorzy :
Isberner N; Department of Internal Medicine II, University Hospital Würzburg, Oberdürrbacher Strasse 6, 97080, Würzburg, Germany. .
Kraus S; Department of Internal Medicine II, University Hospital Würzburg, Oberdürrbacher Strasse 6, 97080, Würzburg, Germany.
Grigoleit GU; Department of Internal Medicine II, University Hospital Würzburg, Oberdürrbacher Strasse 6, 97080, Würzburg, Germany.; Department of Hematology, Oncology and Immunology, Helios Hospital Duisburg, Duisburg, Germany.
Aghai F; Department of Internal Medicine II, University Hospital Würzburg, Oberdürrbacher Strasse 6, 97080, Würzburg, Germany.
Kurlbaum M; Department of Internal Medicine I and Core Unit Clinical Mass Spectrometry, Division of Endocrinology and Diabetology, University Hospital Würzburg, Würzburg, Germany.
Zimmermann S; Institute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany.
Klinker H; Department of Internal Medicine II, University Hospital Würzburg, Oberdürrbacher Strasse 6, 97080, Würzburg, Germany.
Scherf-Clavel O; Institute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany.
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Źródło :
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2021 Dec; Vol. 88 (6), pp. 973-983. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Interactions*
Cytochrome P-450 CYP2C9 Inhibitors/*pharmacology
Cytochrome P-450 CYP3A Inhibitors/*pharmacokinetics
Graft vs Host Disease/*drug therapy
Nitriles/*pharmacokinetics
Practice Patterns, Physicians'/*statistics & numerical data
Primary Myelofibrosis/*drug therapy
Pyrazoles/*pharmacokinetics
Pyrimidines/*pharmacokinetics
Acute Disease ; Adult ; Aged ; Chronic Disease ; Cytochrome P-450 CYP2C9/chemistry ; Cytochrome P-450 CYP3A/chemistry ; Female ; Follow-Up Studies ; Graft vs Host Disease/metabolism ; Graft vs Host Disease/pathology ; Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; Nitriles/administration & dosage ; Nitriles/blood ; Primary Myelofibrosis/metabolism ; Primary Myelofibrosis/pathology ; Prognosis ; Prospective Studies ; Pyrazoles/administration & dosage ; Pyrazoles/blood ; Pyrimidines/administration & dosage ; Pyrimidines/blood ; Tissue Distribution ; Young Adult
Czasopismo naukowe
Tytuł :
β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation.
Autorzy :
Malik NS; Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan.
Ahmad M; Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.
Alqahtani MS; Department of Pharmaceutics, Nanobiotechnology Unit, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mahmood A; College of Pharmacy, Al Ain University, Abu Dhabi, UAE.
Barkat K; Faculty of Pharmacy, University of Lahore, Lahore, Pakistan.
Khan MT; Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan.
Tulain UR; Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan.
Rashid A; Department of Pharmacy, The Women University, Multan, Pakistan.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 1093-1108.
Typ publikacji :
Journal Article
MeSH Terms :
Acyclovir/*pharmacokinetics
Antiviral Agents/*pharmacokinetics
Chitosan/*chemistry
Hydrogels/*chemistry
beta-Cyclodextrins/*chemistry
Acrylamides/chemistry ; Acyclovir/administration & dosage ; Acyclovir/adverse effects ; Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Area Under Curve ; Chemistry, Pharmaceutical ; Delayed-Action Preparations ; Dose-Response Relationship, Drug ; Drug Delivery Systems ; Drug Liberation ; Female ; Hydrogen-Ion Concentration ; Metabolic Clearance Rate ; Methacrylates/chemistry ; Rabbits ; Rats ; Rats, Wistar ; Surface Properties
Czasopismo naukowe
Tytuł :
Population pharmacokinetics of oxycodone: Premature neonates to adults.
Autorzy :
Morse JD; Department of Pharmacology & Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.
Sundermann M; Department of Pharmacology & Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.
Hannam JA; Department of Pharmacology & Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.
Kokki H; School of Medicine, University of Eastern Finland, Kuopio, Finland.
Kokki M; Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland.
Anderson BJ; Department of Anaesthesiology, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand.
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Źródło :
Paediatric anaesthesia [Paediatr Anaesth] 2021 Dec; Vol. 31 (12), pp. 1332-1339. Date of Electronic Publication: 2021 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
Oxycodone*/therapeutic use
Pain, Postoperative*/drug therapy
Administration, Intravenous ; Adult ; Child ; Humans ; Infant ; Infant, Newborn ; Metabolic Clearance Rate ; Models, Biological ; Nonlinear Dynamics
Czasopismo naukowe
Tytuł :
The Impact of Chronic Kidney Disease in Patients With Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiation.
Autorzy :
Dudani S; The Ottawa Hospital Cancer Centre/University of Ottawa, Ottawa, Ontario, Canada.
Marginean H; The Ottawa Hospital Cancer Centre/University of Ottawa, Ottawa, Ontario, Canada.
Gotfrit J; The Ottawa Hospital Cancer Centre/University of Ottawa, Ottawa, Ontario, Canada.
Tang PA; Alberta Health Services/University of Calgary, Calgary, Alberta, Canada.
Monzon JG; Alberta Health Services/University of Calgary, Calgary, Alberta, Canada.
Dennis K; The Ottawa Hospital Cancer Centre/University of Ottawa, Ottawa, Ontario, Canada.
Kennecke HF; British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Powell ED; Dr. H Bliss Murphy Cancer Centre, St. John's, Newfoundland, Canada.
Babak S; Alberta Health Services/University of Calgary, Calgary, Alberta, Canada.
Cheung WY; British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Vickers MM; The Ottawa Hospital Cancer Centre/University of Ottawa, Ottawa, Ontario, Canada.
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Źródło :
Diseases of the colon and rectum [Dis Colon Rectum] 2021 Dec 01; Vol. 64 (12), pp. 1471-1478.
Typ publikacji :
Journal Article; Multicenter Study; Webcast
MeSH Terms :
Neoadjuvant Therapy/*methods
Rectal Neoplasms/*drug therapy
Rectal Neoplasms/*radiotherapy
Renal Insufficiency, Chronic/*complications
Adult ; Aged ; Aged, 80 and over ; Canada/epidemiology ; Chemoradiotherapy/methods ; Disease-Free Survival ; Female ; Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; Neoplasm Staging/methods ; Outcome Assessment, Health Care ; Rectal Neoplasms/pathology ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/physiopathology ; Retrospective Studies ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
A proposed "steric-like effect" for the slowdown of enrofloxacin antibiotic metabolism by ciprofloxacin, and its mechanism.
Autorzy :
Xu X; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
Lu Q; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
Yang Y; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
Martínez MA; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain.
Lopez-Torres B; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain.
Martínez-Larrañaga MR; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain.
Wang X; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Hubei, 430070, China. Electronic address: .
Anadón A; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain. Electronic address: .
Ares I; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain.
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Źródło :
Chemosphere [Chemosphere] 2021 Dec; Vol. 284, pp. 131347. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Ciprofloxacin*
Fluoroquinolones*
Animals ; Anti-Bacterial Agents ; Enrofloxacin ; Metabolic Clearance Rate ; Swine
Czasopismo naukowe
Tytuł :
Functional evaluation of vandetanib metabolism by CYP3A4 variants and potential drug interactions in vitro.
Autorzy :
Han M; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Zhang X; The Seventh People's Hospital of Wenzhou, Wenzhou, Zhejiang, PR China.
Ye Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Wang J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Qian J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Hu G; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China. Electronic address: .
Cai J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Dec 01; Vol. 350, pp. 109700. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 CYP3A/*genetics
Cytochrome P-450 CYP3A/*metabolism
Piperidines/*metabolism
Protein Kinase Inhibitors/*metabolism
Quinazolines/*metabolism
Alleles ; Biotransformation ; Cytochrome P-450 CYP3A Inhibitors/administration & dosage ; Drug Interactions ; Genetic Association Studies ; Genetic Variation ; Humans ; In Vitro Techniques ; Ketoconazole/administration & dosage ; Kinetics ; Metabolic Clearance Rate ; Piperidines/administration & dosage ; Piperidines/pharmacokinetics ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/pharmacokinetics ; Quinazolines/administration & dosage ; Quinazolines/pharmacokinetics ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination.
Autorzy :
Eide TT; Renal Research Group, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Hufthammer KO; Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway.
Brun A; Laboratory for Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.
Brackman D; Department of Pediatrics, Haukeland University Hospital, 5021, Bergen, Norway.
Svarstad E; Renal Research Group, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Tøndel C; Renal Research Group, Department of Clinical Medicine, University of Bergen, Bergen, Norway. .; Department of Pediatrics, Haukeland University Hospital, 5021, Bergen, Norway. .
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Źródło :
Scientific reports [Sci Rep] 2021 Dec 01; Vol. 11 (1), pp. 23224. Date of Electronic Publication: 2021 Dec 01.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glomerular Filtration Rate*
Blood Specimen Collection/*methods
Iohexol/*administration & dosage
Administration, Intravenous ; Adolescent ; Child ; Humans ; Iohexol/pharmacokinetics ; Metabolic Clearance Rate ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis
Czasopismo naukowe
Tytuł :
Cytochrome P450 Enzymes and Drug Metabolism in Humans.
Autorzy :
Zhao M; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
Ma J; Institutes for Shanghai Pudong Decoding Life, Shanghai 200135, China.
Li M; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
Zhang Y; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
Jiang B; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
Zhao X; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
Huai C; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
Shen L; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
Zhang N; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
He L; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
Qin S; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 26; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Inactivation, Metabolic*
Cytochrome P-450 Enzyme System/*metabolism
Pharmaceutical Preparations/*metabolism
Xenobiotics/*metabolism
Animals ; Cytochrome P-450 Enzyme System/genetics ; Humans ; Metabolic Clearance Rate ; Polymorphism, Genetic
Czasopismo naukowe
Tytuł :
Determination of the segmental hepatic clearance rate of Tc-mebrofenin and its application in the functional assessment of future liver remnant after liver resection.
Autorzy :
Uña-Gorospe JA; Servicio de Medicina Nuclear, Hospital Universitario Nuestra Señora de Candelaria, Carretera del Rosario 145, 38010, Santa Cruz de Tenerife, Canarias, Spain. Electronic address: .
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Źródło :
Revista espanola de medicina nuclear e imagen molecular [Rev Esp Med Nucl Imagen Mol (Engl Ed)] 2021 Nov-Dec; Vol. 40 (6), pp. 385-396. Date of Electronic Publication: 2021 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
Aniline Compounds/*pharmacokinetics
Glycine/*pharmacokinetics
Hepatectomy/*adverse effects
Liver/*metabolism
Liver Failure/*diagnostic imaging
Organotechnetium Compounds/*pharmacokinetics
Postoperative Complications/*diagnostic imaging
Radiopharmaceuticals/*pharmacokinetics
Aniline Compounds/blood ; Glycine/blood ; Humans ; Liver/anatomy & histology ; Liver/diagnostic imaging ; Metabolic Clearance Rate ; Organ Size ; Time Factors ; Tomography, Emission-Computed, Single-Photon/methods ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Population pharmacokinetics and genetics of oral meltdose tacrolimus (Envarsus) in stable adult liver transplant recipients.
Autorzy :
Martial LC; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.
Biewenga M; Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, Netherlands.
Ruijter BN; Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, Netherlands.
Keizer R; InsightRX, San Francisco, CA, USA.
Swen JJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.
van Hoek B; Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, Netherlands.
Moes DJAR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.
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Źródło :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Nov; Vol. 87 (11), pp. 4262-4272. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver Transplantation*
Tacrolimus*
Adult ; Cytochrome P-450 CYP3A/genetics ; Genotype ; Humans ; Immunosuppressive Agents ; Metabolic Clearance Rate ; Models, Biological ; Tissue Donors ; Transplant Recipients
Czasopismo naukowe

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