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Wyszukujesz frazę ""Metabolic Detoxication, Phase I"" wg kryterium: Temat


Tytuł :
Eurotium cristatum Fermented Loose Dark Tea Ameliorates Cigarette Smoke-Induced Lung Injury by MAPK Pathway and Enhances Hepatic Metabolic Detoxification by PXR / AhR Pathway in Mice.
Autorzy :
Huang XX; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Xu S; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Yu LJ; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Zhou YF; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Zhou Y; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Liu ZH; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.; Hunan Provincial Key Laboratory for Germplasm Innovation and Utilization of Crop, Hunan Agricultural University, Changsha 410128, China.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Mar 10; Vol. 2021, pp. 6635080. Date of Electronic Publication: 2021 Mar 10 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Detoxication, Phase I*
Aspergillus/*classification
Cigarette Smoking/*metabolism
Lung/*metabolism
Lung Injury/*drug therapy
MAP Kinase Signaling System/*drug effects
Plant Extracts/*pharmacology
Pregnane X Receptor/*metabolism
Receptors, Aryl Hydrocarbon/*metabolism
Signal Transduction/*drug effects
Animals ; Cigarette Smoking/pathology ; Female ; Lung/pathology ; Lung Injury/metabolism ; Mice ; Plant Extracts/chemistry
SCR Organism :
Aspergillus cristatus
Czasopismo naukowe
Tytuł :
Mimicking of Phase I Metabolism Reactions of Molindone by HLM and Photocatalytic Methods with the Use of UHPLC-MS/MS.
Autorzy :
Gawlik M; Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
Savic V; Department of Organic Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Jovanovic M; Department of Organic Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Skibiński R; Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Mar 17; Vol. 25 (6). Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Light*
Metabolic Detoxication, Phase I*/radiation effects
Microsomes, Liver/*metabolism
Molindone/*metabolism
Tandem Mass Spectrometry/*methods
Biotransformation/radiation effects ; Catalysis/radiation effects ; Chromatography, High Pressure Liquid ; Humans ; Kinetics ; Metabolic Networks and Pathways/radiation effects ; Metabolome/radiation effects ; Microsomes, Liver/radiation effects ; Molindone/chemistry ; Multivariate Analysis ; Principal Component Analysis
Czasopismo naukowe
Tytuł :
Metabolism and pharmacokinetics of pharmaceuticals in cats (Felix sylvestris catus) and implications for the risk assessment of feed additives and contaminants.
Autorzy :
Lautz LS; Radboud University Nijmegen, Houtlaan 4, 6525 XZ Nijmegen, the Netherlands.
Jeddi MZ; European Food Safety Authority, Scientific Committee and Emerging Risks Unit, Via Carlo Magno, 1A, 43126 Parma, Italy.
Girolami F; University of Torino, Department of Veterinary Sciences, Largo P. Braccini 2, 10095 Grugliasco, Italy.
Nebbia C; University of Torino, Department of Veterinary Sciences, Largo P. Braccini 2, 10095 Grugliasco, Italy.
Dorne JLCM; European Food Safety Authority, Scientific Committee and Emerging Risks Unit, Via Carlo Magno, 1A, 43126 Parma, Italy. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Mar 01; Vol. 338, pp. 114-127. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Comparative Study; Journal Article; Review
MeSH Terms :
Food Contamination*
Animal Feed/*toxicity
Cytochrome P-450 Enzyme System/*metabolism
Glucuronosyltransferase/*metabolism
Xenobiotics/*pharmacokinetics
Animals ; Cats ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; No-Observed-Adverse-Effect Level ; Rats ; Risk Assessment ; Species Specificity ; Substrate Specificity ; Uncertainty ; Xenobiotics/administration & dosage ; Xenobiotics/toxicity
Czasopismo naukowe
Tytuł :
Toxicant exposure during pregnancy increases protective proteins in the dam and a sexually dimorphic response in the fetus.
Autorzy :
Rister AL; Department of Biology, East Carolina University, Greenville, NC 27858, USA. Electronic address: .
Amato CM; Department of Biology, East Carolina University, Greenville, NC 27858, USA.
Nash T; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695, USA.
McCoy MW; Department of Biology, East Carolina University, Greenville, NC 27858, USA.
Bereman M; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695, USA.
McCoy KA; Department of Biology, East Carolina University, Greenville, NC 27858, USA.
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Feb 15; Vol. 413, pp. 115407. Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteome*
Androgen Antagonists/*toxicity
Endocrine Disruptors/*toxicity
Liver/*drug effects
Oxazoles/*toxicity
Adenosine Triphosphate/metabolism ; Androgen Antagonists/metabolism ; Animals ; Endocrine Disruptors/metabolism ; Female ; Liver/embryology ; Liver/metabolism ; Male ; Maternal Exposure ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; Mice ; Oxazoles/metabolism ; Oxidative Phosphorylation ; Pregnancy ; Proteomics ; Sex Characteristics ; Sex Factors
Czasopismo naukowe
Tytuł :
In vitro phase I metabolism of vinclozolin by human liver microsomes.
Autorzy :
Cruz-Hurtado M; a Departamento de Toxicología , Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav) , Ciudad de México , México.
López-González ML; a Departamento de Toxicología , Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav) , Ciudad de México , México.
Mondragón V; b Centro de Excelencia de Agilent Technologies México , Ciudad de México , México.
Sierra-Santoyo A; a Departamento de Toxicología , Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav) , Ciudad de México , México.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Aug; Vol. 49 (8), pp. 895-904. Date of Electronic Publication: 2018 Dec 21.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Detoxication, Phase I*
Microsomes, Liver/*metabolism
Oxazoles/*metabolism
Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Humans ; Hydrolysis ; Male ; Metabolome/drug effects ; Microsomes, Liver/drug effects ; Oxazoles/chemistry ; Reference Standards ; Substrate Specificity/drug effects
Czasopismo naukowe
Tytuł :
Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.
Autorzy :
Potęga A; a Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry , Gdańsk University of Technology , Gdańsk , Poland.
Garwolińska D; b Department of Analytical Chemistry, Faculty of Chemistry , Gdańsk University of Technology , Gdańsk , Poland.
Nowicka AM; c Laboratory of Theory and Applications of Electrodes, Faculty of Chemistry , University of Warsaw , Warsaw , Poland.
Fau M; c Laboratory of Theory and Applications of Electrodes, Faculty of Chemistry , University of Warsaw , Warsaw , Poland.
Kot-Wasik A; b Department of Analytical Chemistry, Faculty of Chemistry , Gdańsk University of Technology , Gdańsk , Poland.
Mazerska Z; a Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry , Gdańsk University of Technology , Gdańsk , Poland.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Aug; Vol. 49 (8), pp. 922-934. Date of Electronic Publication: 2019 Jan 04.
Typ publikacji :
Journal Article
MeSH Terms :
Electrochemistry*
Mass Spectrometry*
Metabolic Detoxication, Phase I*
Metabolic Detoxication, Phase II*
Acridines/*metabolism
Antineoplastic Agents/*metabolism
Acridines/chemistry ; Animals ; Electrolysis ; Female ; Glutathione/metabolism ; Humans ; Male ; Microsomes, Liver/metabolism ; Oxidation-Reduction ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Multifunctional role of fucoidan, sulfated polysaccharides in human health and disease: A journey under the sea in pursuit of potent therapeutic agents.
Autorzy :
Pradhan B; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India.
Patra S; Department of Life Science, National Institute of Technology Rourkela, India.
Nayak R; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India.
Behera C; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India.
Dash SR; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India.
Nayak S; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India.
Sahu BB; Department of Life Science, National Institute of Technology Rourkela, India.
Bhutia SK; Department of Life Science, National Institute of Technology Rourkela, India. Electronic address: .
Jena M; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 01; Vol. 164, pp. 4263-4278. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aquatic Organisms/*chemistry
Polysaccharides/*chemistry
Sulfates/*chemistry
Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Chemical Fractionation/methods ; Disease Susceptibility ; Drug Discovery ; Health ; Humans ; Immunomodulation/drug effects ; Metabolic Detoxication, Phase I ; Molecular Structure ; Polysaccharides/isolation & purification ; Seaweed/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
In vitro-in vivo and cross-life stage extrapolation of uptake and biotransformation of benzo[a]pyrene in the fathead minnow (Pimephales promelas).
Autorzy :
Grimard C; Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Mangold-Döring A; Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Institute for Environmental Research (Biology V), RWTH Aachen University, Aachen, Germany.
Schmitz M; Department for Evolutionary Ecology and Environmental Toxicology, Goethe University Frankfurt, Frankfurt, Germany.
Alharbi H; Department of Plant Protection, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
Jones PD; Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; School of Environment and Sustainability, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Giesy JP; Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Department of Environmental Sciences, Baylor University, Waco, Texas, USA.
Hecker M; Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; School of Environment and Sustainability, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address: .
Brinkmann M; Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; School of Environment and Sustainability, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Global Institute for Water Security, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
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Źródło :
Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2020 Nov; Vol. 228, pp. 105616. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Benzo(a)pyrene/*toxicity
Cyprinidae/*metabolism
Larva/*drug effects
Water Pollutants, Chemical/*toxicity
Animals ; Benzo(a)pyrene/metabolism ; Biological Transport ; Computer Simulation ; Cyprinidae/growth & development ; Larva/metabolism ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; Toxicokinetics ; Water Pollutants, Chemical/metabolism
Czasopismo naukowe
Tytuł :
Coumarins and P450s, Studies Reported to-Date.
Autorzy :
Foroozesh M; Department of Chemistry, Xavier University of Louisiana, 1 Drexel Dr., New Orleans, LA 70125, USA. .
Sridhar J; Department of Chemistry, Xavier University of Louisiana, 1 Drexel Dr., New Orleans, LA 70125, USA. .
Goyal N; Department of Chemistry, Xavier University of Louisiana, 1 Drexel Dr., New Orleans, LA 70125, USA. .
Liu J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave., Memphis, TN 38163, USA. .
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2019 Apr 24; Vol. 24 (8). Date of Electronic Publication: 2019 Apr 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Metabolic Detoxication, Phase I*
Coumarins/*chemistry
Cytochrome P-450 Enzyme System/*chemistry
Xenobiotics/*chemistry
Coumarins/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Humans ; Models, Molecular ; Quantitative Structure-Activity Relationship ; Xenobiotics/metabolism
Czasopismo naukowe
Tytuł :
Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines: An update comprising flunitrazolam, norflurazepam, and 4'-chlorodiazepam (Ro5-4864).
Autorzy :
Moosmann B; Institute of Forensic Medicine, Forensic Toxicology, Kantonsspital St. Gallen, St. Gallen, Switzerland.; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Bisel P; Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg, Germany.
Westphal F; State Bureau of Criminal Investigation Schleswig-Holstein, Kiel, Germany.
Wilde M; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Hermann Staudinger Graduate School, University of Freiburg, Freiburg, Germany.
Kempf J; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Angerer V; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Auwärter V; Institute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
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Źródło :
Drug testing and analysis [Drug Test Anal] 2019 Mar; Vol. 11 (3), pp. 541-549. Date of Electronic Publication: 2019 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Detoxication, Phase I*
Benzodiazepines/*metabolism
Benzodiazepinones/*metabolism
Designer Drugs/*metabolism
Flurazepam/*analogs & derivatives
Microsomes, Liver/*metabolism
Biotransformation ; Chromatography, Liquid ; Flurazepam/metabolism ; Gas Chromatography-Mass Spectrometry ; Humans ; In Vitro Techniques ; Substance Abuse Detection/methods ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Suspect and non-target screening workflows to investigate the in vitro and in vivo metabolism of the synthetic cannabinoid 5Cl-THJ-018.
Autorzy :
Vervliet P; Toxicological Centre, University of Antwerp, Antwerp, Belgium.
Mortelé O; Toxicological Centre, University of Antwerp, Antwerp, Belgium.
Gys C; Toxicological Centre, University of Antwerp, Antwerp, Belgium.
Degreef M; Toxicological Centre, University of Antwerp, Antwerp, Belgium.
Lanckmans K; Universitair Ziekenhuis Brussel, Jette, Belgium.
Maudens K; Toxicological Centre, University of Antwerp, Antwerp, Belgium.
Covaci A; Toxicological Centre, University of Antwerp, Antwerp, Belgium.
van Nuijs ALN; Toxicological Centre, University of Antwerp, Antwerp, Belgium.
Lai FY; Toxicological Centre, University of Antwerp, Antwerp, Belgium.
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Źródło :
Drug testing and analysis [Drug Test Anal] 2019 Mar; Vol. 11 (3), pp. 479-491. Date of Electronic Publication: 2018 Oct 23.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Metabolic Detoxication, Phase I*
Metabolic Detoxication, Phase II*
Cannabinoids/*metabolism
Biotransformation ; Cannabinoids/pharmacokinetics ; Cannabinoids/urine ; Chromatography, Liquid ; Designer Drugs/metabolism ; Designer Drugs/pharmacokinetics ; Humans ; Microsomes, Liver/metabolism ; Middle Aged ; Tandem Mass Spectrometry ; Workflow
Czasopismo naukowe
Tytuł :
Adenosine Triphosphate-Binding Cassette Transporters Are Not Involved In the Detoxification of Azadirachta indica Extracts In Anopheles stephensi Larvae.
Autorzy :
Ferrari M
Negri A
Romeo C
Boccazzi IV
Nodari R
Habluetzel A
Molteni G
Corbett Y
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Źródło :
Journal of the American Mosquito Control Association [J Am Mosq Control Assoc] 2018 Dec; Vol. 34 (4), pp. 311-314.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metabolic Detoxication, Phase I*
ATP-Binding Cassette Transporters/*metabolism
Anopheles/*metabolism
Azadirachta/*chemistry
Insect Proteins/*metabolism
Plant Extracts/*chemistry
Animals ; Anopheles/growth & development ; Larva/metabolism
Czasopismo naukowe
Tytuł :
LC-ESI-MS/MS identification and characterization of ponatinib in vivo phase I and phase II metabolites.
Autorzy :
Attwa MW; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, Cairo 11562, Egypt. Electronic address: .
Kadi AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Darwish HW; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, Cairo 11562, Egypt.
Amer SM; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, Cairo 11562, Egypt.
AlRabiah H; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
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Źródło :
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2018 Oct; Vol. 485, pp. 144-151. Date of Electronic Publication: 2018 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Detoxication, Phase I*
Metabolic Detoxication, Phase II*
Imidazoles/*analysis
Imidazoles/*metabolism
Pyridazines/*analysis
Pyridazines/*metabolism
Animals ; Chromatography, Liquid ; Hydrolysis ; Male ; Models, Animal ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model.
Autorzy :
Park YM; Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, 66123 Saarbrücken, Germany.; Environmental Safety Group, Korea Institute of Science and Technology (KIST) Europe, 66123 Saarbrücken, Germany.
Meyer MR; Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, 66421 Homburg, Germany.
Müller R; Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, 66123 Saarbrücken, Germany.; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig Germany, 38124 Braunschweig, Germany.
Herrmann J; Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, 66123 Saarbrücken, Germany.; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig Germany, 38124 Braunschweig, Germany.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Sep 29; Vol. 25 (19). Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Cannabinoids/*administration & dosage
Cannabinoids/*metabolism
Zebrafish/*metabolism
Animals ; Cannabinoids/chemistry ; Cell Line ; Drug Administration Routes ; Humans ; Larva ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; Metabolic Networks and Pathways ; Metabolome ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Zebrafish/embryology
Czasopismo naukowe
Tytuł :
Catalpol coordinately regulates phase I and II detoxification enzymes of Triptolide through CAR and NRF2 pathways to reduce Triptolide-induced hepatotoxicity.
Autorzy :
Fu L; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhou L; Jiangsu Provincial Key Laboratory of Pharmacology and Safety Evaluation of Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Geng S; Jiangsu Provincial Key Laboratory of Pharmacology and Safety Evaluation of Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Sichuan Kelun Pharmaceutical CO., LTD., Chengdu 610071, China.
Li M; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Lu W; Jiangsu Provincial Key Laboratory of Pharmacology and Safety Evaluation of Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Lu Y; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China; Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210001, China.
Feng Z; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
Zhou X; The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Sep; Vol. 129, pp. 110379. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical and Drug Induced Liver Injury/*prevention & control
Cytochrome P-450 Enzyme System/*metabolism
Diterpenes/*metabolism
Glucuronosyltransferase/*metabolism
Hepatocytes/*drug effects
Iridoid Glucosides/*pharmacology
Liver/*drug effects
NF-E2-Related Factor 2/*metabolism
Phenanthrenes/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Cytochrome P-450 Enzyme System/genetics ; Disease Models, Animal ; Epoxy Compounds/metabolism ; Female ; Glucuronosyltransferase/genetics ; Hep G2 Cells ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Liver/enzymology ; Liver/pathology ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; NF-E2-Related Factor 2/genetics ; Rats, Sprague-Dawley ; Receptors, Cytoplasmic and Nuclear/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People.
Autorzy :
Wang LL; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Ren XX; Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China.
He Y; Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China.
Cui GF; Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China.
Wei ZW; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Jia J; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Cao J; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Liu Y; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Cong B; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China.; Department of Forensic Medicine, Hebei Medical University, Shijiazhuang, 050017, China.
Niu Y; Department of Criminal, The Ministry of Public Security, Beijing, 100038, China. .
Yun KM; School of Forensic Medicine, Shanxi Medical University, Taiyuan, 030001, China. .
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Źródło :
European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2020 Aug; Vol. 45 (4), pp. 477-485.
Typ publikacji :
Journal Article
MeSH Terms :
Diazepam/*pharmacokinetics
Hypnotics and Sedatives/*pharmacokinetics
Administration, Oral ; Adult ; Asian Continental Ancestry Group ; China ; Chromatography, High Pressure Liquid ; Diazepam/administration & dosage ; Diazepam/blood ; Female ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/blood ; Male ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; Models, Biological ; Solid Phase Extraction ; Tandem Mass Spectrometry ; Young Adult
Czasopismo naukowe
Tytuł :
Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo.
Autorzy :
Fang SQ; Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Huang J; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Pharmacology and Toxicology Division, Shanghai Institute of Food and Drug Control, Shanghai, China.
Zhang F; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ni HM; Department of Basic Theory of Traditional Chinese Medicine, College of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chen QL; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhu JR; Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Fu ZC; Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhu L; Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Qinghai Hospital of Traditional Chinese Medicine, Xining, China.
Hao WW; Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ge GB; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Qinghai Hospital of Traditional Chinese Medicine, Xining, China.
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Źródło :
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2020 Jul; Vol. 72 (7), pp. 979-989. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Microsomes, Liver*/drug effects
Microsomes, Liver*/metabolism
Cytochrome P-450 Enzyme Inhibitors/*pharmacokinetics
Drugs, Chinese Herbal/*pharmacokinetics
Pyridines/*pharmacokinetics
Animals ; Antineoplastic Agents/pharmacokinetics ; Cytochrome P-450 Enzyme System/metabolism ; Herb-Drug Interactions ; Humans ; Metabolic Detoxication, Phase I ; Mixed Function Oxygenases/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals.
Autorzy :
Meyer WK; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Jamison J; Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Richter R; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.
Woods SE; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Partha R; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Kowalczyk A; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Kronk C; Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Chikina M; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Bonde RK; Wetland and Aquatic Research Center, U.S. Geological Survey, Gainesville, FL, USA.
Crocker DE; Department of Biology, Sonoma State University, Rohnert Park, CA, USA.
Gaspard J; Pittsburgh Zoo and PPG Aquarium, Pittsburgh, PA, USA.
Lanyon JM; School of Biological Sciences, The University of Queensland, St. Lucia, QLD 4072, Australia.
Marsillach J; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.
Furlong CE; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Clark NL; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA. .; Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2018 Aug 10; Vol. 361 (6402), pp. 591-594.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cetacea*/blood
Cetacea*/classification
Cetacea*/genetics
Evolution, Molecular*
Lipid Metabolism*
Metabolic Detoxication, Phase I*
Aryldialkylphosphatase/*blood
Aryldialkylphosphatase/*genetics
Organophosphorus Compounds/*metabolism
Adaptation, Biological ; Animals ; Environmental Exposure ; Genetic Fitness ; Lipoproteins, HDL/metabolism ; Lipoproteins, LDL/metabolism ; Organophosphorus Compounds/toxicity ; Oxidation-Reduction ; Phylogeny ; Risk ; Selection, Genetic
Czasopismo naukowe
Tytuł :
Methylglyoxal - a signaling molecule in plant abiotic stress responses.
Autorzy :
Mostofa MG; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur 1706, Bangladesh. Electronic address: .
Ghosh A; Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh. Electronic address: .
Li ZG; School of Life Sciences, Yunnan Normal University, Kunming 650500, PR China. Electronic address: .
Siddiqui MN; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur 1706, Bangladesh. Electronic address: .
Fujita M; Laboratory of Plant Stress Responses, Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Miki, Kagawa 761-0795, Japan. Electronic address: .
Tran LP; Plant Stress Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam; Signaling Pathway Research Unit, RIKEN Center for Sustainable Resource Science, 1-7-22, Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2018 Jul; Vol. 122, pp. 96-109. Date of Electronic Publication: 2018 Mar 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Metabolic Detoxication, Phase I*
Pyruvaldehyde/*metabolism
Reactive Oxygen Species/*metabolism
Stress, Physiological/*genetics
Antioxidants/metabolism ; Calcium Signaling/genetics ; Gene Expression Regulation, Plant ; Glycation End Products, Advanced/metabolism ; Glycolysis/genetics ; Metabolic Networks and Pathways/genetics ; Plants/genetics ; Plants/metabolism ; Pyruvaldehyde/chemistry
Czasopismo naukowe
Tytuł :
Untargeted screening of phase I metabolism of combretastatin A4 by multi-tool analysis.
Autorzy :
Jaroch K; Department of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
Goryńska PZ; Department of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
Goryński K; Department of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
Stefański T; Department of Crystallography, Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.
Bojko B; Department of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland. Electronic address: .
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Źródło :
Talanta [Talanta] 2018 May 15; Vol. 182, pp. 22-31. Date of Electronic Publication: 2018 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Detoxication, Phase I*
Antineoplastic Agents, Phytogenic/*metabolism
Liver/*metabolism
Microsomes, Liver/*metabolism
Stilbenes/*metabolism
Tubulin Modulators/*metabolism
Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Biotransformation ; Chemical Precipitation ; Chromatography, Liquid/methods ; Humans ; Mass Spectrometry/methods ; Rats ; Solid Phase Microextraction/methods ; Stilbenes/chemistry ; Tubulin Modulators/chemistry
Czasopismo naukowe

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