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Tytuł:
Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.
Autorzy:
Vilskersts R; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rigas Stradins University, LV-1007 Riga, Latvia.
Kigitovica D; Department of Internal Diseases, Faculty of Medicine, Rigas Stradins University, LV-1007 Riga, Latvia.; Department of Nephrology, Pauls Stradins Clinical University Hospital, LV-1012 Riga, Latvia.
Korzh S; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Videja M; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rigas Stradins University, LV-1007 Riga, Latvia.
Vilks K; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.; Department of Molecular Biology, Faculty of Biology, University of Latvia, LV-1050 Riga, Latvia.
Cirule H; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Skride A; Department of Internal Diseases, Faculty of Medicine, Rigas Stradins University, LV-1007 Riga, Latvia.; Department of Rare Diseases, Pauls Stradins Clinical University Hospital, LV-1012 Riga, Latvia.
Makrecka-Kuka M; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Liepinsh E; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Dambrova M; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rigas Stradins University, LV-1007 Riga, Latvia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 21; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Cardiotonic Agents/*pharmacology
Methylhydrazines/*pharmacology
Animals ; COVID-19/complications ; Cardiotonic Agents/therapeutic use ; Cardiotoxicity/drug therapy ; Disease Models, Animal ; Endothelium/drug effects ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Heart Ventricles/drug effects ; Hydrogen Peroxide/metabolism ; Lung/drug effects ; Male ; Methylhydrazines/therapeutic use ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Oxygen Saturation/drug effects ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Reperfusion Injury/drug therapy ; Stroke Volume/drug effects ; Ventricular Dysfunction, Left/drug therapy ; Ventricular Dysfunction, Right/drug therapy ; COVID-19 Drug Treatment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Normalization of heart rate variability with taurine and meldonium complex in post-infarction patients with type 2 diabetes mellitus.
Autorzy:
Belikova J; Department of Internal Medicine No 4, Bogomolets National Medical University, Kyiv, Ukraine.
Lizogub V; Department of Internal Medicine No 4, Bogomolets National Medical University, Kyiv, Ukraine.
Kuzminets A; Department of the Therapy, Infectious Disease and Dermatology Postgraduate Education, Bogomolets National Medical University, Kyiv, Ukraine.
Lavrenchuk I; Department of the Therapy, Infectious Disease and Dermatology Postgraduate Education, Bogomolets National Medical University, Kyiv, Ukraine.
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Źródło:
Journal of medicine and life [J Med Life] 2019 Jul-Sep; Vol. 12 (3), pp. 290-295.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Diabetes Mellitus, Type 2/*drug therapy
Diabetes Mellitus, Type 2/*physiopathology
Heart Rate/*physiology
Methylhydrazines/*therapeutic use
Myocardial Infarction/*complications
Taurine/*therapeutic use
Aged ; Female ; Humans ; Male ; Methylhydrazines/pharmacology ; Middle Aged ; Taurine/pharmacology ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats.
Autorzy:
Đurašević S; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Ružičić A; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Lakić I; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Tosti T; Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.
Đurović S; Institute of General and Physical Chemistry, University of Belgrade, 11000 Belgrade, Serbia.
Glumac S; School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Pejić S; Vinča Institute of Nuclear Sciences-National Institute of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Todorović A; Vinča Institute of Nuclear Sciences-National Institute of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Drakulić D; Vinča Institute of Nuclear Sciences-National Institute of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Stanković S; Centre for Medical Biochemistry, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.; Faculty of Medical Sciences, University of Kragujevac, 550601 Kragujevac, Serbia.
Jasnić N; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Đorđević J; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Todorović Z; School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; University Medical Centre 'Bežanijska Kosa', 11080 Belgrade, Serbia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 21; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Lipopolysaccharides/*pharmacology
Methylhydrazines/*pharmacology
Sepsis/*chemically induced
Sepsis/*drug therapy
Animals ; Apoptosis/drug effects ; Disease Models, Animal ; Inflammation/drug therapy ; Male ; Myocardium/pathology ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2-mediated Transport.
Autorzy:
Liepinsh E; Latvian Institute of Organic Synthesis, Riga, Latvia.
Makarova E; Latvian Institute of Organic Synthesis, Riga, Latvia.
Sevostjanovs E; Latvian Institute of Organic Synthesis, Riga, Latvia.
Hartmane D; Latvian Institute of Organic Synthesis, Riga, Latvia.
Cirule H; Latvian Institute of Organic Synthesis, Riga, Latvia.
Zharkova-Malkova O; Latvian Institute of Organic Synthesis, Riga, Latvia.
Grinberga S; Latvian Institute of Organic Synthesis, Riga, Latvia.
Dambrova M; Latvian Institute of Organic Synthesis, Riga, Latvia.; Faculty of Pharmacy, Riga Stradins University, Riga, Latvia.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2017 May; Vol. 120 (5), pp. 450-456. Date of Electronic Publication: 2017 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Betaine/*analogs & derivatives
Carnitine/*administration & dosage
Methylhydrazines/*pharmacokinetics
Organic Cation Transport Proteins/*metabolism
Animals ; Betaine/administration & dosage ; Betaine/pharmacokinetics ; Betaine/pharmacology ; Biological Transport/drug effects ; Carnitine/pharmacokinetics ; Carnitine/pharmacology ; Furosemide/administration & dosage ; Furosemide/pharmacology ; Male ; Methylhydrazines/pharmacology ; Mice ; Organic Cation Transport Proteins/antagonists & inhibitors ; Solute Carrier Family 22 Member 5 ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats.
Autorzy:
Đurašević S; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Ružičić A; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Lakić I; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Tosti T; Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.
Đurović S; Institute of General and Physical Chemistry, University of Belgrade, 11000 Belgrade, Serbia.
Glumac S; School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Pavlović S; Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Borković-Mitić S; Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Grigorov I; Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Stanković S; Centre for Medical Biochemistry, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.; Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Jasnić N; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Đorđević J; Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Todorović Z; School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; University Medical Centre 'Bežanijska kosa', University of Belgrade, 11000 Belgrade, Serbia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 08; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 08.
Typ publikacji:
Journal Article
MeSH Terms:
Feces/*microbiology
Methylhydrazines/*pharmacology
Sepsis/*prevention & control
Adrenal Glands/drug effects ; Animals ; Anti-Inflammatory Agents/pharmacology ; Apoptosis ; Biomarkers ; Epinephrine/metabolism ; Fatty Acids/metabolism ; Inflammation ; Lipid Metabolism/drug effects ; Lipid Peroxidation ; Lipidomics ; Male ; Norepinephrine/metabolism ; Oxidative Stress ; Oxygen/chemistry ; Rats ; Rats, Sprague-Dawley ; Temperature ; Treatment Outcome ; Triglycerides/metabolism ; Troponin T/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The effects of meldonium on the acute ischemia/reperfusion liver injury in rats.
Autorzy:
Đurašević S; Faculty of Biology, University of Belgrade, 16 Studentski Trg, 11000, Belgrade, Republic of Serbia. .
Stojković M; Faculty of Medicine, University of Belgrade, Belgrade, Republic of Serbia.
Sopta J; Faculty of Medicine, University of Belgrade, Belgrade, Republic of Serbia.
Pavlović S; Institute for Biological Research 'Siniša Stanković' - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Republic of Serbia.
Borković-Mitić S; Institute for Biological Research 'Siniša Stanković' - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Republic of Serbia.
Ivanović A; Institute for Biological Research 'Siniša Stanković' - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Republic of Serbia.
Jasnić N; Faculty of Biology, University of Belgrade, 16 Studentski Trg, 11000, Belgrade, Republic of Serbia.
Tosti T; Faculty of Chemistry, University of Belgrade, Belgrade, Republic of Serbia.
Đurović S; Institute of General and Physical Chemistry, University of Belgrade, Belgrade, Republic of Serbia.
Đorđević J; Faculty of Biology, University of Belgrade, 16 Studentski Trg, 11000, Belgrade, Republic of Serbia.
Todorović Z; Faculty of Medicine, University of Belgrade, Belgrade, Republic of Serbia.; University Medical Centre 'Bežanijska Kosa', University of Belgrade, Belgrade, Republic of Serbia.
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Źródło:
Scientific reports [Sci Rep] 2021 Jan 14; Vol. 11 (1), pp. 1305. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation/*drug effects
Liver/*metabolism
Liver Diseases/*drug therapy
Methylhydrazines/*pharmacology
Reperfusion Injury/*drug therapy
Acute Disease ; Animals ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Liver/pathology ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Male ; Rats ; Rats, Wistar ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Discovery of Highly Potent THP Derivatives as OCTN2 Inhibitors: From Structure-Based Virtual Screening to In Vivo Biological Activity.
Autorzy:
Di Cristo F; Elleva Pharma S.R.L., via Pietro Castellino 111, 80131 Naples, Italy.
Calarco A; Research Institute on Terrestrial Ecosystems (IRET)-CNR, Via Pietro Castellino 111, 80131 Naples, Italy.
Digilio FA; Research Institute on Terrestrial Ecosystems (IRET)-CNR, Via Pietro Castellino 111, 80131 Naples, Italy.
Sinicropi MS; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.
Rosano C; Proteomics and Mass Spectrometry Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genova, Italy.
Galderisi U; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Luigi Vanvitelli Campania University, Vico Luigi De Crecchio 1, 80138 Naples, Italy.
Melone MAB; Department of Advanced Medical and Surgical Sciences, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania 'Luigi Vanvitelli', via Sergio Pansini 5, 80131 Naples, Italy.
Saturnino C; Department of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Peluso G; Research Institute on Terrestrial Ecosystems (IRET)-CNR, Via Pietro Castellino 111, 80131 Naples, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 08; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 08.
Typ publikacji:
Journal Article
MeSH Terms:
Drosophila melanogaster/*drug effects
Huntington Disease/*drug therapy
Huntington Disease/*metabolism
Longevity/*drug effects
Methylhydrazines/*pharmacology
Solute Carrier Family 22 Member 5/*antagonists & inhibitors
Solute Carrier Family 22 Member 5/*metabolism
Animals ; Carnitine/metabolism ; Cell Line ; Cell Survival/drug effects ; Disease Models, Animal ; Drosophila melanogaster/genetics ; Drug Evaluation, Preclinical/methods ; Humans ; Mice ; Molecular Docking Simulation ; Protein Aggregation, Pathological/drug therapy ; Signal Transduction/drug effects ; Solute Carrier Family 22 Member 5/genetics ; Transfection ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Microencapsulation of mildronate in biodegradable and non-biodegradable polymers.
Autorzy:
Loca D; Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of Riga Technical University , Pulka 3/3, LV-1007, Riga , Latvia .
Sevostjanovs E
Makrecka M
Zharkova-Malkova O
Berzina-Cimdina L
Tupureina V
Sokolova M
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Źródło:
Journal of microencapsulation [J Microencapsul] 2014; Vol. 31 (3), pp. 246-53. Date of Electronic Publication: 2013 Oct 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiovascular Agents*/chemistry
Cardiovascular Agents*/pharmacokinetics
Cardiovascular Agents*/pharmacology
Lactic Acid*/chemistry
Lactic Acid*/pharmacokinetics
Lactic Acid*/pharmacology
Methylhydrazines*/chemistry
Methylhydrazines*/pharmacokinetics
Methylhydrazines*/pharmacology
Polymers*/chemistry
Polymers*/pharmacokinetics
Polymers*/pharmacology
Polystyrenes*/chemistry
Polystyrenes*/pharmacokinetics
Polystyrenes*/pharmacology
Animals ; Capsules ; Kinetics ; Male ; Polyesters ; Rabbits
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Effects of Meldonium on the Renal Acute Ischemia/Reperfusion Injury in Rats.
Autorzy:
Đurašević S; Faculty of Biology, University of Belgrade, 11158 Belgrade, Serbia.
Stojković M; School of Medicine, University of Belgrade, 11129 Belgrade, Serbia.
Bogdanović L; School of Medicine, University of Belgrade, 11129 Belgrade, Serbia.
Pavlović S; Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.
Borković-Mitić S; Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.
Grigorov I; Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.
Bogojević D; Institute for Biological Research 'Siniša Stanković'-National Institute of Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.
Jasnić N; Faculty of Biology, University of Belgrade, 11158 Belgrade, Serbia.
Tosti T; Faculty of Chemistry, University of Belgrade, 11158 Belgrade, Serbia.
Đurović S; Institute of General and Physical Chemistry, University of Belgrade, 11158 Belgrade, Serbia.
Đorđević J; Faculty of Biology, University of Belgrade, 11158 Belgrade, Serbia.
Todorović Z; School of Medicine, University of Belgrade, 11129 Belgrade, Serbia.; University Medical Centre 'Bežanijska kosa', University of Belgrade, 11080 Belgrade, Serbia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Nov 15; Vol. 20 (22). Date of Electronic Publication: 2019 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Kidney Injury/*drug therapy
Methylhydrazines/*therapeutic use
Reperfusion Injury/*drug therapy
Animals ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Male ; Norepinephrine/metabolism ; Oxidative Stress/drug effects ; Phosphorylation/drug effects ; Rats ; Rats, Wistar ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efficacy and safety of mildronate for acute ischemic stroke: a randomized, double-blind, active-controlled phase II multicenter trial.
Autorzy:
Zhu Y; Department of Neurology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhang G
Zhao J
Li D
Yan X
Liu J
Liu X
Zhao H
Xia J
Zhang X
Li Z
Zhang B
Guo Z
Feng L
Zhang Z
Qu F
Zhao G
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Źródło:
Clinical drug investigation [Clin Drug Investig] 2013 Oct; Vol. 33 (10), pp. 755-60.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Ischemia/*drug therapy
Cardiovascular Agents/*therapeutic use
Methylhydrazines/*therapeutic use
Stroke/*drug therapy
Aged ; Brain Ischemia/diagnosis ; Brain Ischemia/physiopathology ; Cardiovascular Agents/adverse effects ; Double-Blind Method ; Female ; Humans ; Male ; Methylhydrazines/adverse effects ; Middle Aged ; Stroke/diagnosis ; Stroke/physiopathology ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Nonlinear pharmacokinetic properties of mildronate capsules: a randomized, open-label, single- and multiple-dose study in healthy volunteers.
Autorzy:
Zhang J; Clinical Pharmacy Research Institute, The Second Xiangya Hospital, Central South University, Changsha, China.
Cai LJ
Yang J
Zhang QZ
Peng WX
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Źródło:
Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2013 Feb; Vol. 27 (1), pp. 120-8. Date of Electronic Publication: 2011 Jun 16.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Cardiotonic Agents/*pharmacokinetics
Enzyme Inhibitors/*pharmacokinetics
Methylhydrazines/*pharmacokinetics
gamma-Butyrobetaine Dioxygenase/*antagonists & inhibitors
Adult ; Calibration ; Capsules ; Cardiotonic Agents/administration & dosage ; Cardiotonic Agents/adverse effects ; Cardiotonic Agents/blood ; China ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/adverse effects ; Enzyme Inhibitors/blood ; Female ; Half-Life ; Humans ; Limit of Detection ; Male ; Metabolic Clearance Rate ; Methylhydrazines/administration & dosage ; Methylhydrazines/adverse effects ; Methylhydrazines/blood ; Reproducibility of Results ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rocket fuel for the quantification of S-nitrosothiols. Highly specific reduction of S-nitrosothiols to thiols by methylhydrazine.
Autorzy:
Wiesweg M; Institut für Physiologische Chemie, Universitätsklinikum Essen, Hufelandstrasse 55, 45 122 Essen, Germany.
Berchner-Pfannschmidt U
Fandrey J
Petrat F
de Groot H
Kirsch M
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Źródło:
Free radical research [Free Radic Res] 2013 Feb; Vol. 47 (2), pp. 104-15. Date of Electronic Publication: 2012 Dec 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cysteine/*analogs & derivatives
Methylhydrazines/*chemistry
S-Nitrosothiols/*chemistry
Sulfhydryl Compounds/*chemical synthesis
Ascorbic Acid/chemistry ; Biotin/chemistry ; Cysteine/analysis ; Cysteine/chemistry ; Cysteine/metabolism ; Glutathione/chemistry ; Magnetic Resonance Spectroscopy ; Methylhydrazines/metabolism ; Nitric Oxide/chemistry ; Nitric Oxide/metabolism ; Nitrosation ; Oxidation-Reduction ; Proteins/analysis ; Proteins/chemistry ; Proteins/metabolism ; Reactive Nitrogen Species ; Reactive Oxygen Species ; S-Nitrosothiols/analysis ; S-Nitrosothiols/metabolism ; Sulfhydryl Compounds/chemistry ; Sulfhydryl Compounds/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neuroprotective properties of mildronate, a small molecule, in a rat model of Parkinson's disease.
Autorzy:
Klusa VZ; Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga, Latvia.
Isajevs S
Svirina D
Pupure J
Beitnere U
Rumaks J
Svirskis S
Jansone B
Dzirkale Z
Muceniece R
Kalvinsh I
Vinters HV
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2010 Nov 09; Vol. 11 (11), pp. 4465-87. Date of Electronic Publication: 2010 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Methylhydrazines/*pharmacology
Neuroglia/*drug effects
Neurons/*drug effects
Neuroprotective Agents/*pharmacology
Parkinson Disease, Secondary/*metabolism
Animals ; Biomarkers/metabolism ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Corpus Striatum/cytology ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Glial Fibrillary Acidic Protein/genetics ; Glial Fibrillary Acidic Protein/metabolism ; Male ; Methylhydrazines/therapeutic use ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Neuroglia/metabolism ; Neurons/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Oxidopamine/toxicity ; Rats ; Rats, Wistar ; Receptor, Notch3 ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Substantia Nigra/cytology ; Substantia Nigra/drug effects ; Substantia Nigra/metabolism ; Tyrosine 3-Monooxygenase/genetics ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
Autorzy:
Liepinsh E; Latvian Institute of Organic Synthesis, Riga, Latvia. />Vilskersts R
Zvejniece L
Svalbe B
Skapare E
Kuka J
Cirule H
Grinberga S
Kalvinsh I
Dambrova M
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 Aug; Vol. 157 (8), pp. 1549-56. Date of Electronic Publication: 2009 Jul 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiovascular Agents/*therapeutic use
Diabetes Mellitus, Experimental/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*therapeutic use
Methylhydrazines/*therapeutic use
3-Hydroxybutyric Acid/metabolism ; Administration, Oral ; Animals ; Blood Glucose/metabolism ; Cardiovascular Agents/pharmacology ; Carnitine/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/physiopathology ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Disease Models, Animal ; Fructosamine/metabolism ; Heart/drug effects ; Heart/physiopathology ; Hyperalgesia/physiopathology ; Hyperalgesia/prevention & control ; Hypoglycemic Agents/pharmacology ; In Vitro Techniques ; Lipids/blood ; Male ; Methylhydrazines/pharmacology ; Myocardial Ischemia/physiopathology ; Myocardial Ischemia/prevention & control ; Pain Threshold ; Rats ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Protection of azidothymidine-induced cardiopathology in mice by mildronate, a mitochondria-targeted drug.
Autorzy:
Klusa V; Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga, Latvia. />Pupure J
Isajevs S
Rumaks J
Gordjushina V
Kratovska A
Taivans I
Svirskis S
Viksna L
Kalvinsh I
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2006 Oct; Vol. 99 (4), pp. 323-8.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Zidovudine*
Cardiovascular Agents/*therapeutic use
Heart Diseases/*prevention & control
Methylhydrazines/*therapeutic use
Mitochondria/*drug effects
Animals ; Cardiovascular Agents/pharmacology ; Disease Models, Animal ; Heart Diseases/chemically induced ; Methylhydrazines/pharmacology ; Mice ; Mice, Inbred ICR
Czasopismo naukowe
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Tytuł:
A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis.
Autorzy:
Lindquist C; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Bjørndal B; Department of Clinical Science, University of Bergen, Bergen, Norway.
Rossmann CR; Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria.
Svardal A; Department of Clinical Science, University of Bergen, Bergen, Norway.
Hallström S; Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria.
Berge RK; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
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Źródło:
PloS one [PLoS One] 2018 Mar 28; Vol. 13 (3), pp. e0194978. Date of Electronic Publication: 2018 Mar 28 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carnitine/*metabolism
Fatty Acids/*pharmacology
Liver/*metabolism
Mitochondria/*metabolism
Triglycerides/*blood
Animals ; Cardiovascular Agents/pharmacology ; Fatty Acids/chemistry ; Liver/drug effects ; Male ; Methylhydrazines/pharmacology ; Mitochondria/drug effects ; Oxidation-Reduction ; Rats ; Rats, Wistar
Czasopismo naukowe
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Tytuł:
Meldonium (Mildronate): A Performance-Enhancing Drug?
Autorzy:
Greenblatt HK; Tufts University School of Medicine, Boston, Massachusetts, 02111.
Greenblatt DJ; Tufts University School of Medicine, Boston, Massachusetts, 02111.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2016 May; Vol. 5 (3), pp. 167-9. Date of Electronic Publication: 2016 Apr 29.
Typ publikacji:
Editorial
MeSH Terms:
Methylhydrazines/*pharmacology
Doping in Sports ; Performance-Enhancing Substances
Opinia redakcyjna
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Tytuł:
Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction.
Autorzy:
Vilskersts R; Latvian Institute of Organic Synthesis, Riga, Latvia. />Zharkova-Malkova O
Mezhapuke R
Grinberga S
Cirule H
Dambrova M
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2013 Aug; Vol. 40 (8), pp. 518-24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Betaine/*analogs & derivatives
Carnitine/*metabolism
Carnitine/*pharmacology
Endothelium, Vascular/*metabolism
Glucose/*pharmacology
Animals ; Aorta/drug effects ; Aorta/metabolism ; Betaine/metabolism ; Cardiovascular Agents/administration & dosage ; Cardiovascular Agents/pharmacology ; Carnitine/administration & dosage ; Drug Therapy, Combination ; Glucose/administration & dosage ; Male ; Methylhydrazines/administration & dosage ; Methylhydrazines/pharmacology ; Rats ; Rats, Wistar
Czasopismo naukowe
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