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Wyszukujesz frazę ""Mexiletine"" wg kryterium: Temat

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Wyświetlanie 1-20 z 1090
Tytuł:
Blockers of Skeletal Muscle Na v 1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back.
Autorzy:
De Bellis M; Section of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy.
Boccanegra B; Section of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy.
Cerchiara AG; Section of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy.
Imbrici P; Section of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy.
De Luca A; Section of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 03; Vol. 24 (1). Date of Electronic Publication: 2023 Jan 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Mexiletine*/pharmacology
Mexiletine*/therapeutic use
Myotonia*/drug therapy
NAV1.4 Voltage-Gated Sodium Channel*/metabolism
Voltage-Gated Sodium Channel Blockers*/pharmacology
Voltage-Gated Sodium Channel Blockers*/therapeutic use
Humans ; Muscle, Skeletal/drug effects ; Syndrome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double-blind placebo-controlled cross-over study.
Autorzy:
Ruijs TQ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.
Koopmans IW; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.
de Kam ML; Centre for Human Drug Research, Leiden, The Netherlands.
Tannemaat MR; Leiden University Medical Centre, Leiden, The Netherlands.
Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.
Heuberger JAAC; Centre for Human Drug Research, Leiden, The Netherlands.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Dec; Vol. 15 (12), pp. 2971-2981. Date of Electronic Publication: 2022 Oct 25.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Mexiletine*/pharmacology
Mexiletine*/therapeutic use
Muscles*
Male ; Humans ; Cross-Over Studies ; Double-Blind Method ; Biomarkers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial.
Autorzy:
Yamada S; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hashizume A; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hijikata Y; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Inagaki T; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ito D; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kishimoto Y; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kinoshita F; Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.
Hirakawa A; Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Shimizu S; Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.
Nakamura T; First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Katsuno M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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Źródło:
Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2022 Nov; Vol. 9 (11), pp. 1702-1714. Date of Electronic Publication: 2022 Oct 08.
Typ publikacji:
Randomized Controlled Trial; Observational Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mexiletine*/pharmacology
Mexiletine*/therapeutic use
Bulbo-Spinal Atrophy, X-Linked*/drug therapy
Bulbo-Spinal Atrophy, X-Linked*/complications
Humans ; Pressure ; Tongue ; Muscle Weakness ; Paresis/complications
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications.
Autorzy:
Ingleby-Talecki L; GSK Global Non-Clinical Safety, Collegeville, Pennsylvania, USA.
van Dijkman SC; GSK Clinical Pharmacology Modelling and Simulation, Brentford, UK.
Oosterholt SP; GSK Clinical Pharmacology Modelling and Simulation, Brentford, UK.
Della Pasqua O; GSK Clinical Pharmacology Modelling and Simulation, Brentford, UK.
Winter C; GSK Clinical Safety and Pharmacovigilance, Brentford, UK.
Cunnington M; GSK Epidemiology, Value Evidence & Outcomes, Stevenage, UK.
Rebar L; GSK US Regulatory Affairs, Collegeville, Pennsylvania, USA.
Forero-Schwanhaeuser S; GSK, US Medical Affairs, Philadelphia, Pennsylvania, USA.
Patel V; Former GSK Employee, Collegeville, Pennsylvania, USA.
Cooper JA; GSK General Medicines, Brentford, UK.
Bahinski A; GSK Global Non-Clinical Safety, Collegeville, Pennsylvania, USA.
Chaudhary KW; GSK Global Non-Clinical Safety, Collegeville, Pennsylvania, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Aug; Vol. 15 (8), pp. 1978-1989. Date of Electronic Publication: 2022 May 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mexiletine*/pharmacology
Sodium Channels*/metabolism
Anticonvulsants/pharmacology ; Flecainide/pharmacology ; HEK293 Cells ; Humans ; Lamotrigine/pharmacology ; Sodium Channel Blockers/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Human-induced pluripotent stem cell-derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs.
Autorzy:
Gomez-Galeno J; Human BioMolecular Research Institute, San Diego, CA, USA.
Okolotowicz K; Department of Medicine, Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Johnson M; Human BioMolecular Research Institute, San Diego, CA, USA.
McKeithan WL; Department of Medicine, Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Mercola M; Department of Medicine, Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Cashman JR; Human BioMolecular Research Institute, San Diego, CA, USA.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2021 Aug; Vol. 9 (4), pp. e00828.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Induced Pluripotent Stem Cells/*cytology
Mexiletine/*analogs & derivatives
Mexiletine/*pharmacokinetics
Myocytes, Cardiac/*metabolism
Animals ; Behavior, Animal/drug effects ; Cells, Cultured ; Female ; Humans ; Liver/metabolism ; Long QT Syndrome ; Male ; Mexiletine/adverse effects ; Mice, Inbred BALB C ; Rats, Sprague-Dawley ; Seizures/chemically induced ; Mice ; Rats
SCR Disease Name:
Long Qt Syndrome 3
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Characterisation of mexiletine's translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart.
Autorzy:
Hesketh LM; Cardiovascular Division, Faculty of Life Sciences and Medicine, The Rayne Institute, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Wilder CDE; Cardiovascular Division, Faculty of Life Sciences and Medicine, The Rayne Institute, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Ranadive NN; Cardiovascular Division, Faculty of Life Sciences and Medicine, The Rayne Institute, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Lytra G; Cardiovascular Division, Faculty of Life Sciences and Medicine, The Rayne Institute, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Qazimi P; Cardiovascular Division, Faculty of Life Sciences and Medicine, The Rayne Institute, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Munro JS; Cardiovascular Division, Faculty of Life Sciences and Medicine, The Rayne Institute, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Ahdi N; Cardiovascular Division, Faculty of Life Sciences and Medicine, The Rayne Institute, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Curtis MJ; Cardiovascular Division, Faculty of Life Sciences and Medicine, The Rayne Institute, King's College London, St Thomas' Hospital, London, SE1 7EH, UK. .
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Źródło:
Scientific reports [Sci Rep] 2020 May 21; Vol. 10 (1), pp. 8397. Date of Electronic Publication: 2020 May 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Arrhythmia Agents/*pharmacology
Mexiletine/*pharmacology
Myocardial Ischemia/*complications
Ventricular Fibrillation/*drug therapy
Animals ; Anti-Arrhythmia Agents/administration & dosage ; Anti-Arrhythmia Agents/adverse effects ; Dose-Response Relationship, Drug ; Electrocardiography ; Heart/drug effects ; Male ; Mexiletine/administration & dosage ; Mexiletine/adverse effects ; Myocardial Ischemia/physiopathology ; Organ Culture Techniques ; Rats, Wistar ; Ventricular Fibrillation/etiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chiral Discrimination of Mexiletine Enantiomers by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors and Experimental Design Method Optimization.
Autorzy:
Cârcu-Dobrin M; Department of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology 'George Emil Palade' of Târgu Mureș, 540142 Târgu Mureș, Romania.
Hancu G; Department of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology 'George Emil Palade' of Târgu Mureș, 540142 Târgu Mureș, Romania.
Papp LA; Department of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology 'George Emil Palade' of Târgu Mureș, 540142 Târgu Mureș, Romania.
Fülöp I; Department of Toxicology and Biopharmacy, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology 'George Emil Palade' of Târgu Mureș, 540142 Târgu Mureș, Romania.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Aug 31; Vol. 27 (17). Date of Electronic Publication: 2022 Aug 31.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclodextrins*/chemistry
Electrophoresis, Capillary/methods ; Mexiletine ; Research Design ; Stereoisomerism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mexiletine effectively prevented refractory Torsades de Pointes and ventricular fibrillation in a patient with congenital type 2 long QT syndrome.
Autorzy:
Nakashima R; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takase S; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kai K; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sakamoto K; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tsutsui H; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
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Źródło:
Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2022 Jul; Vol. 33 (7), pp. 1592-1595. Date of Electronic Publication: 2022 May 08.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Long QT Syndrome*/complications
Long QT Syndrome*/diagnosis
Long QT Syndrome*/drug therapy
Torsades de Pointes*/diagnosis
Torsades de Pointes*/etiology
Adult ; Arrhythmias, Cardiac ; DNA-Binding Proteins ; Electrocardiography ; Female ; Humans ; Mexiletine/therapeutic use ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/etiology ; Ventricular Fibrillation/prevention & control
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effectiveness and safety of mexiletine versus placebo in patients with myotonia: a systematic review and meta-analysis
Autorzy:
Elettreby, Abdelrahman MohammedAff1, Aff2, IDs1007202407412z_cor1
Elnaga, Ahmed Abdullah AboAff1, Aff2
Alsaied, Mohamed AhmedAff1, Aff2
Ewis, Dalia KamalAff2, Aff3
Sharkawy, Aya MohammedAff2, Aff4
Fareed, RahmaAff2, Aff5
Alderbi, Gehad MagdyAff2, Aff5
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Źródło:
Neurological Sciences. :1-13
Czasopismo naukowe
Szczegóły
Tytuł:
Improving the understanding of how patients with non-dystrophic myotonia are selected for myotonia treatment with mexiletine (NaMuscla): outcomes of treatment impact using a European Delphi panel.
Autorzy:
Chapman, Ann-Marie (AUTHOR)
Schurer, Marieke (AUTHOR)
Weijers, Laure (AUTHOR)
Omar, Amer (AUTHOR)
Lee, Hiba (AUTHOR)
Weidenfeller, Alla Zozulya (AUTHOR)
Ellis, Crispin (AUTHOR)
Sonecha, Shaneil (AUTHOR)
Schneider-Gold, Christiane (AUTHOR)
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Źródło:
BMC Neurology. 12/1/2021, Vol. 21 Issue 1, p1-16. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sodium channel blockers in the management of long QT syndrome types 3 and 2: A system review and meta-analysis.
Autorzy:
Yang Y; School of Clinical Medicine, Tsinghua University, Beijing, China.
Lv TT; Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Li SY; School of Clinical Medicine, Tsinghua University, Beijing, China.
Zhang P; School of Clinical Medicine, Tsinghua University, Beijing, China.; Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
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Źródło:
Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2021 Nov; Vol. 32 (11), pp. 3057-3067. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Long QT Syndrome*/diagnosis
Long QT Syndrome*/drug therapy
Long QT Syndrome*/genetics
Sodium Channel Blockers*/therapeutic use
Adrenergic beta-Antagonists/therapeutic use ; Electrocardiography ; Flecainide/therapeutic use ; Humans ; Mexiletine/therapeutic use ; Ranolazine/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Are antiarrhythmic agents indicated in premature ventricular complex‐induced cardiomyopathy and when?
Autorzy:
Kantharia, Bharat K.
Shah, Arti N.
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Temat:
PATIENT selection
CARDIOMYOPATHIES
PATIENT safety
TREATMENT effectiveness
CALCIUM antagonists
AMIODARONE
ARRHYTHMIA
MEXILETINE
DRUG efficacy
ADRENERGIC beta blockers
FLECAINIDE
CATHETER ablation
MYOCARDIAL depressants
PROPAFENONE
DISEASE complications
Źródło:
Journal of Cardiovascular Electrophysiology; Mar2024, Vol. 35 Issue 3, p574-582, 9p
Czasopismo naukowe
Szczegóły
Tytuł:
Green electrochemical nanosensor platform design for mexiletine detection based on Citrus reticulata peel-mediated iron nanoparticles and quantum dots and investigation of the adsorption mechanism by the DFT-D3 method.
Autorzy:
Kucuk, Ipek
Kanbes-Dindar, Cigdem
Unal, Didem Nur
Bozal-Palabiyik, Burcin
Karayel, Arzu
Uslu, Bengi
Pokaż więcej
Temat:
MANDARIN orange
CARBON electrodes
QUANTUM dots
IRON
MEXILETINE
FOURIER transform infrared spectroscopy
ELECTRON transport
Źródło:
New Journal of Chemistry; 2/28/2024, Vol. 48 Issue 8, p3729-3740, 12p
Czasopismo naukowe
Szczegóły
Tytuł:
Mexiletine or catheter ablation after amiodarone failure in the VANISH trial.
Autorzy:
Deyell MW; Heart Rhythm Services, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Steinberg C; Institut Universitaire de Cardiologie et Pneumologie de Québec, Universite Laval, Quebec City, Quebec, Canada.
Doucette S; Department of Medicine, QEII Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada.
Parkash R; Department of Medicine, QEII Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada.
Nault I; Institut Universitaire de Cardiologie et Pneumologie de Québec, Universite Laval, Quebec City, Quebec, Canada.
Gray C; Department of Medicine, QEII Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada.
Essebag V; McGill University Health Centre and Hôpital Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
Gardner M; Department of Medicine, QEII Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada.
Sterns LD; Royal Jubilee Hospital, Victoria, British Columbia, Canada.
Healey JS; Population Health Research Institute, Hamilton, Ontario, Canada.
Hruczkowski T; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.
Rivard L; Institut de Cardiologie de Montréal, Montreal, Quebec, Canada.
Leong-Sit P; Heart Rhythm Service, University Hospital, Western University, London, Ontario, Canada.
Nery PB; University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Sapp JL; Department of Medicine, QEII Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada.
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Źródło:
Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2018 Apr; Vol. 29 (4), pp. 603-608. Date of Electronic Publication: 2018 Feb 01.
Typ publikacji:
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Catheter Ablation*/adverse effects
Drug Substitution*
Amiodarone/*administration & dosage
Anti-Arrhythmia Agents/*administration & dosage
Heart Rate/*drug effects
Mexiletine/*administration & dosage
Myocardial Ischemia/*complications
Tachycardia, Ventricular/*surgery
Action Potentials/drug effects ; Aged ; Amiodarone/adverse effects ; Anti-Arrhythmia Agents/adverse effects ; Female ; Humans ; Male ; Mexiletine/adverse effects ; Middle Aged ; Myocardial Ischemia/diagnosis ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/physiopathology ; Time Factors ; Treatment Failure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of intramolecular hydrogen bonding on nuclear magnetic resonance, electron paramagnetic resonance and molecular docking studies: Mexiletine molecule
Autorzy:
Tasdemir, Halil UgurAff1, IDs0089402405838y_cor1
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Źródło:
Journal of Molecular Modeling: Computational Chemistry - Life Science - Advanced Materials - New Methods. 30(2)
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 1090

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