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Wyszukujesz frazę ""Mice, Inbred BALB C"" wg kryterium: Temat


Tytuł :
Impact of mouse strain and sex when modeling radiation necrosis.
Autorzy :
Boria AJ; School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Hampton Hall 1263A, West Lafayette, IN, USA.
Perez-Torres CJ; School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Hampton Hall 1263A, West Lafayette, IN, USA. .; Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA. .
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Źródło :
Radiation oncology (London, England) [Radiat Oncol] 2020 Jun 03; Vol. 15 (1), pp. 141. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Mice, Inbred BALB C*
Mice, Inbred C57BL*
Radiation Injuries, Experimental/*epidemiology
Radiation Injuries, Experimental/*genetics
Animals ; Brain/pathology ; Brain/radiation effects ; Female ; Male ; Mice ; Necrosis
Czasopismo naukowe
Tytuł :
Cisatracurium regulates the CXCR4/let-7a-5p axis to inhibit colorectal cancer progression by suppressing TGF-β/SMAD2/3 signalling.
Autorzy :
Xia YZ; Department of Anesthesiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, PR China.
Shan GF; Department of Anesthesiology, Funing People's Hospital of Jiangsu Province Yancheng, 224400, Jiangsu Province, PR China.
Yang H; Animal Facility & Laboratory Animal Model Department, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, PR China.
Zha J; Department of Anesthesiology, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou, 215153, Jiangsu province, PR China.
Wang L; Department of Anesthesiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, PR China.
Chen JM; Department of Anesthesiology, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou, 215153, Jiangsu province, PR China. Electronic address: .
Zhang XS; Department of Anesthesiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, PR China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Apr 25; Vol. 339, pp. 109424. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Atracurium/*analogs & derivatives
Colorectal Neoplasms/*drug therapy
Colorectal Neoplasms/*genetics
MicroRNAs/*genetics
Receptors, CXCR4/*genetics
Signal Transduction/*drug effects
Animals ; Atracurium/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; HCT116 Cells ; Heterografts/drug effects ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Signal Transduction/genetics ; Smad2 Protein/genetics ; Smad3 Protein/genetics ; Transforming Growth Factor beta/metabolism ; Up-Regulation/drug effects ; Up-Regulation/genetics ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Perfluorooctanesulfonate and perfluorooctanoate exacerbate airway inflammation in asthmatic mice and in vitro.
Autorzy :
Yang M; Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Li LY; Guangzhou Key Laboratory of Otorhinolaryngology, Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Qin XD; Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Ye XY; Guangzhou Key Laboratory of Otorhinolaryngology, Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yu S; Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Bao Q; Guangzhou Key Laboratory of Otorhinolaryngology, Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Sun L; Guangzhou Key Laboratory of Otorhinolaryngology, Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Wang ZB; Department of Environmental Health Sciences, Laboratory of Human Environmental Epigenomes, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA.
Bloom MS; Departments of Environmental Health Sciences and Epidemiology & Biostatistics, University at Albany School of Public Health, Albany, USA.
Jalava P; Department of Environmental and Biological Science, University of Eastern Finland, Kuopio, Finland.
Hu LW; Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Yu HY; Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Zeng XW; Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Yang BY; Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Dong GH; Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: .
Li CW; Guangzhou Key Laboratory of Otorhinolaryngology, Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Apr 20; Vol. 766, pp. 142365. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Asthma*/chemically induced
Fluorocarbons*/toxicity
Alkanesulfonic Acids ; Animals ; Caprylates ; Inflammation/chemically induced ; Lung ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
Intranasal administration of a recombinant RBD vaccine induced protective immunity against SARS-CoV-2 in mouse.
Autorzy :
Du Y; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Xu Y; Guangdong South China Vaccine, Guangzhou, China.
Feng J; Guangdong South China Vaccine, Guangzhou, China.
Hu L; Sino-French Hoffmann Institute of Immunology, State Key Laboratory of Respiratory Disease, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, China.
Zhang Y; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Zhang B; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Guo W; Guangdong South China Vaccine, Guangzhou, China.
Mai R; Guangdong South China Vaccine, Guangzhou, China.
Chen L; Guangdong South China Vaccine, Guangzhou, China.
Fang J; Sino-French Hoffmann Institute of Immunology, State Key Laboratory of Respiratory Disease, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, China.
Zhang H; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China. Electronic address: .
Peng T; Guangdong South China Vaccine, Guangzhou, China; Sino-French Hoffmann Institute of Immunology, State Key Laboratory of Respiratory Disease, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, China. Electronic address: .
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Źródło :
Vaccine [Vaccine] 2021 Apr 15; Vol. 39 (16), pp. 2280-2287. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Administration, Intranasal*
Antibodies, Viral/*blood
COVID-19/*prevention & control
COVID-19 Vaccines/*administration & dosage
Animals ; Antibodies, Neutralizing/blood ; Immunoglobulin G/blood ; Mice ; Mice, Inbred BALB C ; Vaccines, Subunit/administration & dosage ; Vaccines, Synthetic/administration & dosage
Czasopismo naukowe
Tytuł :
Enterovirus 71 induces autophagy in mice via mTOR inhibition and ERK pathway activation.
Autorzy :
Wang B; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Zhu Y; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Liu L; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Wang B; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Chen M; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Wang J; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Yang L; School of Medicine, Dalian University, Dalian 116622, China. Electronic address: .
Liu J; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119188. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*physiology
Enterovirus A, Human/*metabolism
Enterovirus Infections/*metabolism
MAP Kinase Signaling System/*physiology
TOR Serine-Threonine Kinases/*antagonists & inhibitors
TOR Serine-Threonine Kinases/*metabolism
Animals ; Animals, Newborn ; Cell Line, Tumor ; Enterovirus Infections/pathology ; Enzyme Activation/physiology ; Female ; Humans ; Male ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Autorzy :
Chen J; Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, PR China.
Zhang W; Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, PR China.
Pan C; Department of Chemistry, Shantou University Medical College, Shantou, Guangdong, PR China.
Fan J; Department of Plastic and Reconstructive Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, PR China. Electronic address: .
Zhong X; Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, PR China. Electronic address: .
Tang S; Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119185. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cell Cycle Checkpoints/*drug effects
Diterpenes, Kaurane/*pharmacology
Melanoma/*metabolism
Transcription Factor RelA/*metabolism
Animals ; Antineoplastic Agents/therapeutic use ; Apoptosis/physiology ; Cell Cycle Checkpoints/physiology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; Diterpenes, Kaurane/therapeutic use ; Dose-Response Relationship, Drug ; Humans ; Melanoma/drug therapy ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Transcription Factor RelA/antagonists & inhibitors ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Microvesicles mediate sorafenib resistance in liver cancer cells through attenuating p53 and enhancing FOXM1 expression.
Autorzy :
Jaffar Ali D; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, Jiangsu 210096, China.
He C; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China.
Xu H; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China.
Kumaravel S; Department of Medical Physiology, College of Medicine, Texas A & M Health Science Center, College Station, TX 77843, United States of America.
Sun B; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China.
Zhou Y; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Liu R; Department of Genetic Engineering, College of Natural Science, University of Suwon, Kyunggi-Do 445-743, Republic of Korea.
Xiao Z; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119149. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Cell-Derived Microparticles/*metabolism
Drug Resistance, Neoplasm/*physiology
Forkhead Box Protein M1/*biosynthesis
Liver Neoplasms/*metabolism
Sorafenib/*pharmacology
Tumor Suppressor Protein p53/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm/drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Sorafenib/therapeutic use ; Tumor Suppressor Protein p53/antagonists & inhibitors ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions.
Autorzy :
Gheware A; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Dholakia D; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Kannan S; Center for High Computing, CSIR- Central Leather Research Institute (CLRI), Chennai, 600020, India.
Panda L; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Rani R; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Pattnaik BR; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India.
Jain V; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Parekh Y; CSIR-Center for Cellular and Molecular Biology, Annexe-II, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, India.
Enayathullah MG; CSIR-Center for Cellular and Molecular Biology, Annexe-II, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, India.
Bokara KK; CSIR-Center for Cellular and Molecular Biology, Annexe-II, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Subramanian V; Center for High Computing, CSIR- Central Leather Research Institute (CLRI), Chennai, 600020, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Mukerji M; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India.; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India.; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Agrawal A; Center for Translational Research in Lung Disease, CSIR- IGIB, Delhi, 110007, India. .; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. .
Prasher B; Genomics and Molecular Medicine, Council of Scientific and Industrial Research -Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, 110007, India. .; CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics) CSIR-IGIB, Delhi, 110007, India. .; Centre of Excellence for Applied Development of Ayurveda, Prakriti and Genomics, CSIR's Ayurgenomics Unit-TRISUTRA (Translational Research and Innovative Science ThRoughAyurgenomics), CSIR- IGIB, Delhi, 110007, India. .; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. .
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Źródło :
Respiratory research [Respir Res] 2021 Apr 06; Vol. 22 (1), pp. 99. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Justicia*/chemistry
Anti-Inflammatory Agents/*pharmacology
COVID-19/*drug therapy
Hypoxia/*drug therapy
Lung/*drug effects
Plant Extracts/*pharmacology
Pneumonia/*prevention & control
Pulmonary Fibrosis/*drug therapy
Sepsis/*drug therapy
Animals ; Anti-Inflammatory Agents/isolation & purification ; Bleomycin ; COVID-19/metabolism ; COVID-19/virology ; Cecum/microbiology ; Cecum/surgery ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Hypoxia-Inducible Factor-Proline Dioxygenases/genetics ; Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism ; Inflammation Mediators/metabolism ; Ligation ; Lung/metabolism ; Lung/microbiology ; Lung/pathology ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Plant Extracts/isolation & purification ; Pneumonia/genetics ; Pneumonia/metabolism ; Pneumonia/microbiology ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Sepsis/genetics ; Sepsis/metabolism ; Sepsis/microbiology ; Transcriptome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Ainsliaea fragrans champ. Extract prevents cervicitis in BALB/c mice and regulates MyD88-NF-κB signaling pathway in MALP-2-stimulated RAW264.7 cells.
Autorzy :
Lin X; Institute of Pharmaceutical Science, China Pharmaceutical University, NO. 24 TongJiaXiang St., Nanjing City, 210009, Jiangsu Province, China. Electronic address: .
An X; Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, NO. 155 HanZhong Rd., Nanjing, 210029, Jiangsu Province, China. Electronic address: .
Wang L; Institute of Pharmaceutical Science, China Pharmaceutical University, NO. 24 TongJiaXiang St., Nanjing City, 210009, Jiangsu Province, China. Electronic address: .
Zhang J; Institute of Pharmaceutical Science, China Pharmaceutical University, NO. 24 TongJiaXiang St., Nanjing City, 210009, Jiangsu Province, China. Electronic address: .
Abuduwaili A; School of Pharmacy, China Pharmaceutical University, NO. 24 TongJiaXiang St., Nanjing City, 210009, Jiangsu Province, China. Electronic address: .
Wang H; Department of Natural Medicinal Chemistry, China Pharmaceutical University, NO. 24 TongJiaXiang St., Nanjing City, 210009 Jiangsu Province, China. Electronic address: .
Yan M; Institute of Pharmaceutical Science, China Pharmaceutical University, NO. 24 TongJiaXiang St., Nanjing City, 210009, Jiangsu Province, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Apr 06; Vol. 269, pp. 113684. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Drugs, Chinese Herbal/*therapeutic use
Lipopeptides/*toxicity
Myeloid Differentiation Factor 88/*antagonists & inhibitors
NF-kappa B/*antagonists & inhibitors
Uterine Cervicitis/*chemically induced
Uterine Cervicitis/*prevention & control
Animals ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; Female ; Macrophage Activation/drug effects ; Macrophage Activation/physiology ; Mice ; Mice, Inbred BALB C ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; RAW 264.7 Cells ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Uterine Cervicitis/metabolism
Czasopismo naukowe
Tytuł :
Mapping and role of T cell response in SARS-CoV-2-infected mice.
Autorzy :
Zhuang Z; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Lai X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Sun J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chen Z; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhang Z; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Dai J; Guangzhou Customs District Technology Center, Guangzhou, China.
Liu D; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Li Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Li F; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wang Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhu A; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wang J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yang W; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Huang J; Guangzhou Customs District Technology Center, Guangzhou, China.
Li X; Guangzhou Customs District Technology Center, Guangzhou, China.
Hu L; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Wen L; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhuo J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhang Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chen D; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Li S; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Huang S; Guangzhou Customs District Technology Center, Guangzhou, China.
Shi Y; Guangzhou Customs District Technology Center, Guangzhou, China.
Zheng K; Guangzhou Customs District Technology Center, Guangzhou, China.
Zhong N; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhao J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhou D; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Zhao J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Institute of Infectious Disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou, China.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2021 Apr 05; Vol. 218 (4).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*immunology
Epitopes, T-Lymphocyte/*immunology
Host-Pathogen Interactions/*physiology
T-Lymphocytes/*immunology
T-Lymphocytes/*virology
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antibodies, Neutralizing/blood ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/virology ; Chlorocebus aethiops ; Cross Reactions ; Epitope Mapping ; Interferon Type I/immunology ; Interferon Type I/metabolism ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Middle East Respiratory Syndrome Coronavirus/immunology ; SARS Virus/immunology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Vero Cells
Czasopismo naukowe
Tytuł :
Sex-dependent modulation of immune development in mice by secretory IgA-coated Lactobacillus reuteri isolated from breast milk.
Autorzy :
Qi C; Institute of Nutrition and Health, Qingdao University, Qingdao 266071, PR China.
Ding M; School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China.
Li S; Guangzhou Fine Nutrition Research Center, Guangzhou, 510700, PR China.
Zhou Q; Department of Neonatology, The Affiliated Wuxi Maturity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, PR China.
Li D; Institute of Nutrition and Health, Qingdao University, Qingdao 266071, PR China.
Yu R; Department of Neonatology, The Affiliated Wuxi Maturity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, PR China. Electronic address: .
Sun J; Institute of Nutrition and Health, Qingdao University, Qingdao 266071, PR China. Electronic address: .
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Źródło :
Journal of dairy science [J Dairy Sci] 2021 Apr; Vol. 104 (4), pp. 3863-3875. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Lactobacillus reuteri*
Probiotics*
Animals ; Female ; Humans ; Immunoglobulin A, Secretory ; Male ; Mice ; Mice, Inbred BALB C ; Milk, Human
Czasopismo naukowe
Tytuł :
The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer.
Autorzy :
Fujii A; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.; Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masuda T; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Iwata M; Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan.
Tobo T; Department of Clinical Laboratory Medicine, Kyushu University Beppu Hospital, Oita, Japan.
Wakiyama H; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Koike K; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Kosai K; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Nakano T; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Kuramitsu S; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Kitagawa A; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Sato K; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Kouyama Y; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Shimizu D; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Matsumoto Y; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
Utsunomiya T; Department of Surgery, Oita Prefectural Hospital, Oita, Japan.
Ohtsuka T; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, Kagoshima, Japan.
Yamanishi Y; Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan.
Nakamura M; Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Mimori K; Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Apr; Vol. 112 (4), pp. 1655-1668. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Pancreatic Ductal/*genetics
GTPase-Activating Proteins/*genetics
Pancreatic Neoplasms/*genetics
Animals ; Carcinoma, Pancreatic Ductal/pathology ; Cell Cycle/genetics ; Cell Line, Tumor ; DNA Copy Number Variations/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Genes, erbB-1/genetics ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Pancreatic Neoplasms/pathology ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Isolation and characterization of two novel reassortant H5N6 avian influenza viruses from waterfowl in eastern China.
Autorzy :
Yang F; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Xiao Y; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Liu F; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Yao H; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Wu N; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Wu H; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. .
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Źródło :
Archives of virology [Arch Virol] 2021 Apr; Vol. 166 (4), pp. 1197-1201. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Animals, Wild/*virology
Birds/*virology
Influenza A virus/*isolation & purification
Influenza in Birds/*virology
Reassortant Viruses/*isolation & purification
Animals ; China/epidemiology ; Genetic Variation ; Genome, Viral/genetics ; Genotype ; Influenza A virus/genetics ; Influenza A virus/immunology ; Influenza A virus/pathogenicity ; Mice ; Mice, Inbred BALB C ; Phylogeny ; RNA, Viral/genetics ; Reassortant Viruses/genetics ; Reassortant Viruses/immunology ; Reassortant Viruses/pathogenicity ; Viral Proteins/genetics ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
The quinazoline derivative, 04NB-03, induces cell cycle arrest and apoptosis in hepatocellular carcinoma cells in a reactive oxygen species-dependent manner.
Autorzy :
Wang R; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Zhu Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Chen J; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Wang Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Song X; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Wu Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Jin F; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, China. Electronic address: .
Wang Y; Guangzhou Jinan Biomedicine Research and Development Center, Key Laboratory of Bioengineering Medicine of Guangdong Province, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, 510632, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Apr 01; Vol. 338, pp. 109371. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*pathology
Cell Cycle Checkpoints/*drug effects
Liver Neoplasms/*pathology
Quinazolines/*pharmacology
Reactive Oxygen Species/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Inhibitory Concentration 50 ; M Phase Cell Cycle Checkpoints/drug effects ; Mice, Inbred BALB C ; Mice, Nude ; Quinazolines/chemistry
Czasopismo naukowe
Tytuł :
Evaluation of protection induced by in vitro maturated BMDCs presenting CD8 T cell stimulating peptides after a heterologous vaccination regimen in BALB/c model against Leishmania major.
Autorzy :
Shermeh AS; Immunotherapy and Leishmania Vaccine Research Department, Pasteur Institute of Iran, Tehran, Iran.
Zahedifard F; Immunotherapy and Leishmania Vaccine Research Department, Pasteur Institute of Iran, Tehran, Iran.
Habibzadeh S; Immunotherapy and Leishmania Vaccine Research Department, Pasteur Institute of Iran, Tehran, Iran.
Taheri T; Immunotherapy and Leishmania Vaccine Research Department, Pasteur Institute of Iran, Tehran, Iran.
Rafati S; Immunotherapy and Leishmania Vaccine Research Department, Pasteur Institute of Iran, Tehran, Iran.
Seyed N; Immunotherapy and Leishmania Vaccine Research Department, Pasteur Institute of Iran, Tehran, Iran. Electronic address: .
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 Apr; Vol. 223, pp. 108082. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Protozoan Vaccines*
Bone Marrow Cells/*immunology
CD8-Positive T-Lymphocytes/*immunology
Dendritic Cells/*immunology
Leishmania major/*immunology
Leishmaniasis, Cutaneous/*prevention & control
Amino Acid Sequence ; Animals ; CD4-Positive T-Lymphocytes/immunology ; Cytokines/metabolism ; Epitopes/chemistry ; Epitopes/immunology ; Female ; Mice ; Mice, Inbred BALB C ; Nitric Oxide/metabolism ; Proteome/chemistry ; Vaccines, DNA
Czasopismo naukowe
Tytuł :
Protection of melatonin against long-term radon exposure-caused lung injury.
Autorzy :
Wu Q; School of Public Health, Medical College of Soochow University, Suzhou, China.
Fang L; Shanghai Minhang District Center for Disease Prevention and Control, Shanghai, China.
Yang Y; School of Public Health, Medical College of Soochow University, Suzhou, China.
Wang A; Medical College, Soochow University, Suzhou, China.
Chen X; School of Public Health, Medical College of Soochow University, Suzhou, China.
Sun J; School of Public Health, Medical College of Soochow University, Suzhou, China.
Wan J; Medical College, Soochow University, Suzhou, China.
Hong C; Medical College, Soochow University, Suzhou, China.
Tong J; School of Public Health, Medical College of Soochow University, Suzhou, China.
Tao S; School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China.
Tian H; School of Public Health, Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Apr; Vol. 36 (4), pp. 472-483. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article
MeSH Terms :
Air Pollutants, Radioactive/*toxicity
Antioxidants/*pharmacology
Lung Injury/*prevention & control
Melatonin/*pharmacology
Radiation Injuries, Experimental/*prevention & control
Radon/*toxicity
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Epithelial Cells/radiation effects ; Humans ; Inhalation Exposure/adverse effects ; Lung/drug effects ; Lung/pathology ; Lung/radiation effects ; Lung Injury/metabolism ; Lung Injury/pathology ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mice, Inbred BALB C ; Mitochondria/metabolism ; Oxidative Stress/drug effects ; Radiation Injuries, Experimental/metabolism ; Radiation Injuries, Experimental/pathology ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
BNT162b vaccines protect rhesus macaques from SARS-CoV-2.
Autorzy :
Vogel AB; BioNTech, Mainz, Germany.
Kanevsky I; Pfizer, Pearl River, NY, USA.
Che Y; Pfizer, Groton, CT, USA.
Swanson KA; Pfizer, Pearl River, NY, USA.
Muik A; BioNTech, Mainz, Germany.
Vormehr M; BioNTech, Mainz, Germany.
Kranz LM; BioNTech, Mainz, Germany.
Walzer KC; BioNTech, Mainz, Germany.
Hein S; BioNTech, Mainz, Germany.
Güler A; BioNTech, Mainz, Germany.
Loschko J; Pfizer, Pearl River, NY, USA.
Maddur MS; Pfizer, Pearl River, NY, USA.
Ota-Setlik A; Pfizer, Pearl River, NY, USA.
Tompkins K; Pfizer, Pearl River, NY, USA.
Cole J; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Lui BG; BioNTech, Mainz, Germany.
Ziegenhals T; BioNTech, Mainz, Germany.
Plaschke A; BioNTech, Mainz, Germany.
Eisel D; BioNTech, Mainz, Germany.
Dany SC; BioNTech, Mainz, Germany.
Fesser S; BioNTech, Mainz, Germany.
Erbar S; BioNTech, Mainz, Germany.
Bates F; BioNTech, Mainz, Germany.
Schneider D; BioNTech, Mainz, Germany.
Jesionek B; BioNTech, Mainz, Germany.
Sänger B; BioNTech, Mainz, Germany.
Wallisch AK; BioNTech, Mainz, Germany.
Feuchter Y; BioNTech, Mainz, Germany.
Junginger H; BioNTech, Mainz, Germany.
Krumm SA; BioNTech, Mainz, Germany.
Heinen AP; BioNTech, Mainz, Germany.
Adams-Quack P; BioNTech, Mainz, Germany.
Schlereth J; BioNTech, Mainz, Germany.
Schille S; BioNTech, Mainz, Germany.
Kröner C; BioNTech, Mainz, Germany.
de la Caridad Güimil Garcia R; BioNTech, Mainz, Germany.
Hiller T; BioNTech, Mainz, Germany.
Fischer L; BioNTech, Mainz, Germany.
Sellers RS; Pfizer, Pearl River, NY, USA.
Choudhary S; Pfizer, Pearl River, NY, USA.
Gonzalez O; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Vascotto F; TRON-Translational Oncology at the University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Gutman MR; VCA SouthPaws Veterinary Specialists and Emergency Center, Fairfax, VA, USA.
Fontenot JA; New Iberia Research Center, New Iberia, LA, USA.
Hall-Ursone S; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Brasky K; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Griffor MC; Pfizer, Groton, CT, USA.
Han S; Pfizer, Groton, CT, USA.
Su AAH; BioNTech, Mainz, Germany.
Lees JA; Pfizer, Groton, CT, USA.
Nedoma NL; Pfizer, Groton, CT, USA.
Mashalidis EH; Pfizer, Groton, CT, USA.
Sahasrabudhe PV; Pfizer, Groton, CT, USA.
Tan CY; Pfizer, Pearl River, NY, USA.
Pavliakova D; Pfizer, Pearl River, NY, USA.
Singh G; Pfizer, Pearl River, NY, USA.
Fontes-Garfias C; University of Texas Medical Branch, Galveston, TX, USA.
Pride M; Pfizer, Pearl River, NY, USA.
Scully IL; Pfizer, Pearl River, NY, USA.
Ciolino T; Pfizer, Pearl River, NY, USA.
Obregon J; Pfizer, Pearl River, NY, USA.
Gazi M; Texas Biomedical Research Institute, San Antonio, TX, USA.
Carrion R Jr; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Alfson KJ; Texas Biomedical Research Institute, San Antonio, TX, USA.
Kalina WV; Pfizer, Pearl River, NY, USA.
Kaushal D; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Shi PY; University of Texas Medical Branch, Galveston, TX, USA.
Klamp T; BioNTech, Mainz, Germany.
Rosenbaum C; BioNTech, Mainz, Germany.
Kuhn AN; BioNTech, Mainz, Germany.
Türeci Ö; BioNTech, Mainz, Germany.
Dormitzer PR; Pfizer, Pearl River, NY, USA.
Jansen KU; Pfizer, Pearl River, NY, USA.
Sahin U; BioNTech, Mainz, Germany. .; TRON-Translational Oncology at the University Medical Centre of the Johannes Gutenberg University, Mainz, Germany. .
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Źródło :
Nature [Nature] 2021 Apr; Vol. 592 (7853), pp. 283-289. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
COVID-19/*immunology
COVID-19/*prevention & control
COVID-19 Vaccines/*immunology
SARS-CoV-2/*immunology
Aging/immunology ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antigens, Viral/chemistry ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; COVID-19/blood ; COVID-19/therapy ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/chemistry ; COVID-19 Vaccines/genetics ; Cell Line ; Clinical Trials as Topic ; Female ; Humans ; Immunization, Passive ; Internationality ; Macaca mulatta/immunology ; Macaca mulatta/virology ; Male ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Protein Multimerization ; RNA, Viral/analysis ; Respiratory System/immunology ; Respiratory System/virology ; SARS-CoV-2/chemistry ; SARS-CoV-2/genetics ; Solubility ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology ; Vaccination ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/chemistry ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology
SCR Protocol :
COVID-19 serotherapy
Czasopismo naukowe
Tytuł :
Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma.
Autorzy :
Zhao L; Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Chen H; Department of General Surgery, Shandong University Affiliated Shandong Provincial Hospital, Jinan 250021, China.
Lu L; Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Zhao C; Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Malichewe CV; Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Wang L; Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Guo X; Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: .
Zhang X; Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 01; Vol. 270, pp. 119113. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Glioma/*metabolism
Neuropilin-1/*metabolism
Peptides/*pharmacology
Angiogenesis Inhibitors/pharmacology ; Animals ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/physiology ; Cell Line, Tumor ; China ; Drug Delivery Systems/methods ; Drug Screening Assays, Antitumor/methods ; Endothelial Cells/metabolism ; Female ; Glioma/drug therapy ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunotherapy ; Liposomes/therapeutic use ; Mice, Inbred BALB C ; Mice, Nude ; Signal Transduction/physiology ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Czasopismo naukowe
Tytuł :
HIF-1α downregulation of miR-433-3p in adipocyte-derived exosomes contributes to NPC progression via targeting SCD1.
Autorzy :
Yin H; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Qiu X; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Shan Y; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
You B; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Xie L; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Zhang P; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Zhao J; Department of Paediatrics, Affiliated Hospital of Nantong University, Nantong, China.
You Y; Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.; Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Apr; Vol. 112 (4), pp. 1457-1470. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Adipocytes/*pathology
Down-Regulation/*genetics
Exosomes/*genetics
Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
MicroRNAs/*genetics
Nasopharyngeal Carcinoma/*genetics
Nasopharyngeal Neoplasms/*genetics
Stearoyl-CoA Desaturase/*genetics
Animals ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Hypoxia/genetics ; Hypoxia/pathology ; Lipid Metabolism/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/pathology ; Promoter Regions, Genetic/genetics
Czasopismo naukowe
Tytuł :
Mineral trioxide aggregate (MTA) inhibits osteoclastogenesis and osteoclast activation through calcium and aluminum activities.
Autorzy :
Rezende TMB; Programa de Pós-graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brazil. .; Curso de Odontologia, Universidade Católica de Brasília, Brasília, DF, Brazil. .; Programa de Pós-graduação em Ciências da Saúde, Universidade de Brasília, Brasília, DF, Brazil. .
Ribeiro Sobrinho AP; Departamento de Odontologia Restauradora, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Vieira LQ; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Sousa MGDC; Programa de Pós-graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brazil.
Kawai T; Department of Oral Science and Translational Research, College of Dental Medicine, NOVA Southeastern University, Fort Lauderdale, FL, USA.; Cell Therapy Institute, Center for Collaborative Research, NOVA Southeastern University, Fort Lauderdale, FL, USA.
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Źródło :
Clinical oral investigations [Clin Oral Investig] 2021 Apr; Vol. 25 (4), pp. 1805-1814. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Resorption*
Osteoclasts*
Aluminum/pharmacology ; Aluminum Compounds ; Animals ; Brazil ; Calcium ; Calcium Compounds ; Cell Differentiation ; Drug Combinations ; Mice ; Mice, Inbred BALB C ; Osteogenesis ; Oxides ; RANK Ligand/pharmacology ; Silicates
Czasopismo naukowe

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