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Tytuł:
Honokiol attenuate the arsenic trioxide-induced cardiotoxicity by reducing the myocardial apoptosis.
Autorzy:
Huang AL; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, People's Republic of China.; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Yang F; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, People's Republic of China.; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Cheng P; State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Liao DY; Department of Pathology, West China Hospital, Chengdu, Sichuan, People's Republic of China.
Zhou L; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, People's Republic of China.; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Ji XL; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, People's Republic of China.; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Peng DD; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, People's Republic of China.; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Zhang L; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, People's Republic of China.; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Cheng TT; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, People's Republic of China.; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Ma L; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, People's Republic of China.; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Xia XG; Department of Pathology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, People's Republic of China.; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2022 Apr; Vol. 10 (2), pp. e00914.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Arsenic Trioxide/*toxicity
Biphenyl Compounds/*pharmacology
Cardiotoxicity/*prevention & control
Lignans/*pharmacology
Animals ; Biphenyl Compounds/isolation & purification ; Cardiotoxicity/etiology ; Lignans/isolation & purification ; Magnolia/chemistry ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł:
TAMpepK Suppresses Metastasis through the Elimination of M2-Like Tumor-Associated Macrophages in Triple-Negative Breast Cancer.
Autorzy:
Lee C; Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea.; Cancer Immunology Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Korea.
Kim S; Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea.
Jeong C; Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea.
Cho I; Department of Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea.
Jo J; Department of Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea.
Han IH; Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea.
Bae H; Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 15; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Lymphatic Metastasis/*drug therapy
Melitten/*pharmacology
Peptides/*pharmacokinetics
Triple Negative Breast Neoplasms/*drug therapy
Tumor-Associated Macrophages/*drug effects
Animals ; Apoptosis/physiology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Lymphatic Metastasis/pathology ; Mice ; Mice, Inbred BALB C ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Phagocytosis/drug effects ; Phagocytosis/physiology ; Triple Negative Breast Neoplasms/metabolism ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/physiology ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/pathology
Czasopismo naukowe
Tytuł:
Fabrication of self-assembled peptide nanoparticles for in vitro assessment of cell apoptosis pathway and in vivo therapeutic efficacy.
Autorzy:
Rizvi SFA; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Mu S; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Zhao C; School of Pharmacy, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Zhang H; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China. .
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Źródło:
Mikrochimica acta [Mikrochim Acta] 2022 Jan 08; Vol. 189 (2), pp. 53. Date of Electronic Publication: 2022 Jan 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Apoptosis/*physiology
Nanoparticles/*chemistry
Peptides/*chemical synthesis
Peptides/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Cell Line, Tumor ; Glioblastoma ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Neoplasms, Experimental ; Prostatic Neoplasms ; Protein Conformation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Curcumin-coated gold nanoparticles attenuate doxorubicin-induced cardiotoxicity via regulating apoptosis in a mouse model.
Autorzy:
Sharifiaghdam Z; Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.; Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Dalouchi F; Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Sharifiaghdam M; Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences (TUMS, Tehran, Iran.; Laboratory of General Biochemistry & Physical Pharmacy, Ghent University, Ghent, Belgium.
Shaabani E; Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences (TUMS, Tehran, Iran.; Laboratory of General Biochemistry & Physical Pharmacy, Ghent University, Ghent, Belgium.
Ramezani F; Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Nikbakht F; Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Azizi Y; Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.; Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2022 Jan; Vol. 49 (1), pp. 70-83. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Metal Nanoparticles*
Apoptosis/*drug effects
Cardiotoxicity/*drug therapy
Cardiotoxins/*toxicity
Curcumin/*therapeutic use
Doxorubicin/*toxicity
Animals ; Cardiotoxicity/etiology ; Cardiotoxins/antagonists & inhibitors ; Doxorubicin/antagonists & inhibitors ; Gold ; Male ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron, Transmission ; Photoelectron Spectroscopy ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe
Tytuł:
Hsa_circ_0000527 Downregulation Suppresses the Development of Retinoblastoma by Modulating the miR-27a-3p/HDAC9 Pathway.
Autorzy:
Zuo X; Department of Ophthalmology, Xingtai People's Hospital, Xingtai, Hebei, China.
Fu C; Department of Cardiac Surgery, Xingtai Third Hospital, Xingtai, Hebei, China.
Xie J; Department of Ophthalmology, Xingtai People's Hospital, Xingtai, Hebei, China.
Wang X; Department of Ophthalmology, Xingtai People's Hospital, Xingtai, Hebei, China.
Yan Z; Department of Ophthalmology, Xingtai People's Hospital, Xingtai, Hebei, China.
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Źródło:
Current eye research [Curr Eye Res] 2022 Jan; Vol. 47 (1), pp. 115-126. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Apoptosis/*genetics
Histone Deacetylases/*genetics
MicroRNAs/*genetics
RNA, Neoplasm/*genetics
Repressor Proteins/*genetics
Retinal Neoplasms/*genetics
Retinoblastoma/*genetics
Animals ; Cell Line ; Cell Movement ; Cell Proliferation ; Cell Survival ; Down-Regulation ; Female ; Histone Deacetylases/biosynthesis ; Humans ; Mice ; Mice, Inbred BALB C ; MicroRNAs/biosynthesis ; RNA, Neoplasm/metabolism ; Repressor Proteins/biosynthesis ; Retinal Neoplasms/diagnosis ; Retinal Neoplasms/metabolism ; Retinoblastoma/diagnosis ; Retinoblastoma/metabolism
Czasopismo naukowe
Tytuł:
Radiosensitizer Effect of β-Apopicropodophyllin against Colorectal Cancer via Induction of Reactive Oxygen Species and Apoptosis.
Autorzy:
Kwon JH; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.; Division of Life Sciences, Korea University, Seoul 02841, Korea.
Lee NG; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.; Division of Life Sciences, Korea University, Seoul 02841, Korea.
Kang AR; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Song JY; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Hwang SG; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Um HD; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Kim J; Division of Life Sciences, Korea University, Seoul 02841, Korea.
Park JK; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 16; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 16.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Colorectal Neoplasms/*drug therapy
Podophyllin/*pharmacology
Radiation-Sensitizing Agents/*pharmacology
Reactive Oxygen Species/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Colorectal Neoplasms/metabolism ; HCT116 Cells ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł:
LOX-1 Regulates Neutrophil Apoptosis and Fungal Load in A. Fumigatus Keratitis.
Autorzy:
Li C; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
He K; Department of Ophthalmology, Zhejiang Quhua Hospital Quzhou, Zhejiang, China.
Yin M; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhang Q; Department of Ophthalmology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong, China.
Lin J; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Niu Y; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wang Q; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xu Q; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jiang N; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhao G; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
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Źródło:
Current eye research [Curr Eye Res] 2021 Dec; Vol. 46 (12), pp. 1800-1811. Date of Electronic Publication: 2021 Aug 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*genetics
Cornea/*microbiology
Eye Infections, Fungal/*microbiology
Fungi/*isolation & purification
Keratitis/*microbiology
Neutrophils/*pathology
Scavenger Receptors, Class E/*genetics
Animals ; Disease Models, Animal ; Eye Infections, Fungal/diagnosis ; Female ; Keratitis/diagnosis ; Mice ; Mice, Inbred BALB C ; Neutrophils/metabolism ; RNA/genetics ; Scavenger Receptors, Class E/biosynthesis
Czasopismo naukowe
Tytuł:
Preparation, Characterization, and Pharmacological Investigation of Withaferin-A Loaded Nanosponges for Cancer Therapy; In Vitro, In Vivo and Molecular Docking Studies.
Autorzy:
Shah HS; Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Nasrullah U; Institute of General Pharmacology and Toxicology, Goethe University Frankfurt am Main, 60596 Frankfurt am Main, Germany.
Zaib S; Department of Biochemistry, Faculty of Life Sciences, University of Central Punjab, Lahore 54590, Pakistan.
Usman F; Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 66000, Pakistan.
Khan A; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman.
Gohar UF; Institute of Industrial Biotechnology, Government College University, Lahore 54590, Pakistan.
Uddin J; Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.
Khan I; Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
Al-Harrasi A; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Nov 19; Vol. 26 (22). Date of Electronic Publication: 2021 Nov 19.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Docking Simulation*
Neoplasms*/drug therapy
Neoplasms*/metabolism
Neoplasms*/pathology
Apoptosis/*drug effects
Animals ; Calorimetry, Differential Scanning ; Female ; Humans ; MCF-7 Cells ; Mice ; Mice, Inbred BALB C ; Withania/chemistry ; Withanolides/chemistry ; Withanolides/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
JI017, a Complex Herbal Medication, Induces Apoptosis via the Nox4-PERK-CHOP Axis in Ovarian Cancer Cells.
Autorzy:
Kim T; Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Korea.
Ko SG; Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 12; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
NADPH Oxidase 4/*metabolism
Ovarian Neoplasms/*metabolism
Signal Transduction/*drug effects
Transcription Factor CHOP/*metabolism
eIF-2 Kinase/*metabolism
Animals ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mice, Inbred BALB C ; Mice, Nude ; NADPH Oxidase 4/genetics ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Plants, Medicinal/chemistry ; Signal Transduction/genetics ; Transcription Factor CHOP/genetics ; Xenograft Model Antitumor Assays/methods ; eIF-2 Kinase/genetics ; Mice
Czasopismo naukowe
Tytuł:
The disulfiram/copper complex induces apoptosis and inhibits tumour growth in human osteosarcoma by activating the ROS/JNK signalling pathway.
Autorzy:
Guo W; Department of Orthopaedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China.
Zhang X; Department of Orthopedic Surgery, Chongqing University Central Hospital, Chongqing 400000, China.
Lin L; Department of Orthopaedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China.
Wang H; Department of Orthopaedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China.
He E; Department of Orthopaedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China.
Wang G; Department of Orthopaedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China.
Zhao Q; Department of Orthopaedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100, Hai Ning Road, Shanghai 200080, China.
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Źródło:
Journal of biochemistry [J Biochem] 2021 Oct 11; Vol. 170 (2), pp. 275-287.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Copper/*pharmacology
Disulfiram/*pharmacology
MAP Kinase Signaling System/*drug effects
Osteosarcoma/*drug therapy
Reactive Oxygen Species/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Autophagy/drug effects ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Osteosarcoma/metabolism ; Osteosarcoma/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress.
Autorzy:
Shen Z; The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, 42 Baiziting, Nanjing, Jiangsu, 210009, China.; Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China.
Yin L; The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, 42 Baiziting, Nanjing, Jiangsu, 210009, China.
Zhou H; Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China.
Ji X; Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China.
Jiang C; Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China.
Zhu X; Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China.
He X; The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, 42 Baiziting, Nanjing, Jiangsu, 210009, China. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2021 Oct; Vol. 44 (5), pp. 1035-1049. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*genetics
Aurora Kinase A/*genetics
Carcinoma, Hepatocellular/*genetics
Cell Proliferation/*genetics
Endoplasmic Reticulum Stress/*genetics
Heat Shock Transcription Factors/*genetics
Liver Neoplasms/*genetics
Aminopyridines/administration & dosage ; Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apoptosis/drug effects ; Aurora Kinase A/antagonists & inhibitors ; Aurora Kinase A/metabolism ; Benzamides/administration & dosage ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Endoplasmic Reticulum Stress/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Heat Shock Transcription Factors/antagonists & inhibitors ; Heat Shock Transcription Factors/metabolism ; Hep G2 Cells ; Humans ; Indazoles/administration & dosage ; Kaplan-Meier Estimate ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Mice, Inbred BALB C ; Mice, Nude ; Pyrazoles/administration & dosage ; RNA Interference ; Xenograft Model Antitumor Assays/methods ; Mice
Czasopismo naukowe
Tytuł:
CD300a contributes to the resolution of articular inflammation triggered by MSU crystals by controlling neutrophil apoptosis.
Autorzy:
Valiate BVS; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Queiroz-Junior CM; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Levi-Schaffer F; Pharmacology and Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Galvão I; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Teixeira MM; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
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Źródło:
Immunology [Immunology] 2021 Oct; Vol. 164 (2), pp. 305-317. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, CD/*immunology
Apoptosis/*immunology
Inflammation/*immunology
Neutrophils/*immunology
Receptors, Immunologic/*immunology
Uric Acid/*immunology
Animals ; Cells, Cultured ; Gout/immunology ; Humans ; Interleukin-1beta/immunology ; Joints/immunology ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł:
Bioflavonoid-Induced Apoptosis and DNA Damage in Amastigotes and Promastigotes of Leishmania donovani : Deciphering the Mode of Action.
Autorzy:
Mehwish S; Department of Biotechnology, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.
Varikuti S; Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Ali Khan M; Department of Biotechnology, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.
Khan T; Department of Biotechnology, Faculty of Biological Sciences, University of Malakand, Chakdara 18800, Pakistan.
Khan IU; Department of Biotechnology, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.
Satoskar A; Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Elsayed Elserehy HA; Department of Zoology, College of Science, King Saud University, Riyad 11451, Saudi Arabia.
Ullah N; Department of Biotechnology, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 27; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 27.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
DNA Damage*
Antiprotozoal Agents/*pharmacology
Flavonoids/*pharmacology
Leishmania donovani/*growth & development
Leishmaniasis, Visceral/*pathology
Macrophages/*pathology
Animals ; Leishmania donovani/drug effects ; Leishmaniasis, Visceral/drug therapy ; Leishmaniasis, Visceral/genetics ; Leishmaniasis, Visceral/parasitology ; Macrophages/drug effects ; Macrophages/parasitology ; Mice ; Mice, Inbred BALB C ; Necrosis
Czasopismo naukowe
Tytuł:
Mechanism of TCONS_00147848 regulating apoptosis of nasal mucosa cells and alleviating allergic rhinitis through FOSL2-mediated JAK/STAT3 signaling pathway.
Autorzy:
Huang H; ENT Department, Inner Mongolia People's Hospital, Hohhot Inner Mongolia Autonomous Region, Hohhot, 010017, China.
Ren Y; Scientific Research Department, Inner Mongolia People's Hospital, Hohhot Inner Mongolia Autonomous Region, Hohhot, 010017, China.
Liang H; Scientific Research Department, Inner Mongolia People's Hospital, Hohhot Inner Mongolia Autonomous Region, Hohhot, 010017, China.
Liu X; ENT Department, Inner Mongolia People's Hospital, Hohhot Inner Mongolia Autonomous Region, Hohhot, 010017, China.
Nan J; Scientific Research Department, Inner Mongolia People's Hospital, Hohhot Inner Mongolia Autonomous Region, Hohhot, 010017, China.
Zhao H; Medical Department, Inner Mongolia People's Hospital, Hohhot Inner Mongolia Autonomous Region, Hohhot, 010017, China. .
Liu X; ENT Department, Inner Mongolia People's Hospital, Hohhot Inner Mongolia Autonomous Region, Hohhot, 010017, China. .
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Źródło:
Scientific reports [Sci Rep] 2021 Aug 06; Vol. 11 (1), pp. 15991. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Fos-Related Antigen-2/*antagonists & inhibitors
Janus Kinase 1/*metabolism
Nasal Mucosa/*pathology
RNA, Small Interfering/*genetics
Rhinitis, Allergic/*prevention & control
STAT3 Transcription Factor/*metabolism
Animals ; Fos-Related Antigen-2/genetics ; Janus Kinase 1/genetics ; Mice ; Mice, Inbred BALB C ; Nasal Mucosa/metabolism ; RNA, Small Interfering/administration & dosage ; Rhinitis, Allergic/etiology ; Rhinitis, Allergic/metabolism ; Rhinitis, Allergic/pathology ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł:
Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity.
Autorzy:
Doan P; Molecular Signaling Group, Faculty of Medicine and Health Technology, Tampere University, P.O. Box 553, 33101 Tampere, Finland.; BioMediTech Institute and Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33520 Tampere, Finland.; Science Center, Tampere University Hospital, Arvo Ylpön katu 34, 33520 Tampere, Finland.
Nguyen P; Molecular Signaling Group, Faculty of Medicine and Health Technology, Tampere University, P.O. Box 553, 33101 Tampere, Finland.; BioMediTech Institute and Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33520 Tampere, Finland.; Science Center, Tampere University Hospital, Arvo Ylpön katu 34, 33520 Tampere, Finland.
Murugesan A; Molecular Signaling Group, Faculty of Medicine and Health Technology, Tampere University, P.O. Box 553, 33101 Tampere, Finland.; BioMediTech Institute and Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33520 Tampere, Finland.; Department of Biotechnology, Lady Doak College, Thallakulam, Madurai 625002, India.
Candeias NR; Faculty of Engineering and Natural Sciences, Tampere University, P.O. Box 553, 33101 Tampere, Finland.
Yli-Harja O; BioMediTech Institute and Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33520 Tampere, Finland.; Science Center, Tampere University Hospital, Arvo Ylpön katu 34, 33520 Tampere, Finland.; Computational Systems Biology Group, Faculty of Medicine and Health Technology, Tampere University, P.O. Box 553, 33101 Tampere, Finland.; Institute for Systems Biology, 1441N 34th Street, Seattle, WA 98103, USA.
Kandhavelu M; Molecular Signaling Group, Faculty of Medicine and Health Technology, Tampere University, P.O. Box 553, 33101 Tampere, Finland.; BioMediTech Institute and Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33520 Tampere, Finland.; Science Center, Tampere University Hospital, Arvo Ylpön katu 34, 33520 Tampere, Finland.
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Źródło:
Cells [Cells] 2021 Aug 03; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Phenols/*pharmacology
Receptors, G-Protein-Coupled/*antagonists & inhibitors
Animals ; Antineoplastic Agents/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Calcium/metabolism ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Membrane Permeability/drug effects ; Cell Movement/drug effects ; Drug Synergism ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Mice ; Mice, Inbred BALB C ; Phenols/therapeutic use ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Reactive Oxygen Species/metabolism ; Receptors, G-Protein-Coupled/metabolism ; S Phase Cell Cycle Checkpoints/drug effects ; Temozolomide/pharmacology ; Temozolomide/therapeutic use
Czasopismo naukowe
Tytuł:
MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis.
Autorzy:
Yu T; Department of Hepatobiliary, Fuling Central Hospital of Chongqing City, Chongqing, China.
Yu J; Department of Hepatobiliary, Fuling Central Hospital of Chongqing City, Chongqing, China.
Lu L; Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Zhang Y; Precision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhou Y; Department of Hepatobiliary, Fuling Central Hospital of Chongqing City, Chongqing, China.
Zhou Y; Department of Hepatobiliary, Fuling Central Hospital of Chongqing City, Chongqing, China.
Huang F; Department of Radiology, Fuling Central Hospital of Chongqing City, Chongqing, China.
Sun L; Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guo Z; Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hou G; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. .
Dong Z; Precision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. .
Wang B; Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2021 Aug; Vol. 44 (4), pp. 821-834. Date of Electronic Publication: 2021 May 11.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Apoptosis Regulatory Proteins/*genetics
Carcinoma, Hepatocellular/*drug therapy
Drug Resistance, Neoplasm/*genetics
Liver Neoplasms/*drug therapy
MicroRNAs/*genetics
Phenylurea Compounds/*therapeutic use
Quinolines/*therapeutic use
RNA, Long Noncoding/*genetics
Animals ; Antineoplastic Agents/therapeutic use ; Apoptosis/genetics ; Apoptosis Regulatory Proteins/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Mice, Inbred BALB C ; Mice, Inbred NOD ; Mice, Knockout ; Mice, Nude ; Mice, SCID ; Xenograft Model Antitumor Assays/methods ; Mice
Czasopismo naukowe
Tytuł:
The Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis.
Autorzy:
Zhang X; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Xu J; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Marshall B; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Dong Z; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA.
Smith SB; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Department of Ophthamology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Zhang M; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 29; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 29.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*genetics
Caspase 12/*deficiency
Cytomegalovirus Retinitis/*enzymology
Immunity, Innate/*genetics
Muromegalovirus/*physiology
Retina/*enzymology
Retinal Neurons/*enzymology
Animals ; Caspase 12/genetics ; Cytomegalovirus Retinitis/genetics ; Cytomegalovirus Retinitis/virology ; Female ; In Situ Nick-End Labeling/methods ; Interferons/biosynthesis ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Retina/virology ; Retinal Neurons/virology ; Signal Transduction/genetics ; Tumor Suppressor Protein p53/metabolism ; Virus Replication/genetics
Czasopismo naukowe
Tytuł:
Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia.
Autorzy:
Cao H; Department of Hematology, Affiliated Hospital of Yan'an University, Yanan, 716000, China.
Wei W; Department of Neurosurgery, Affiliated Hospital of Yan'an University, Yanan, 716000, China.
Xu R; Department of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Cui X; Department of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 17; Vol. 11 (1), pp. 12742. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anemia, Aplastic/*drug therapy
Apoptosis/*drug effects
Ginsenosides/*pharmacology
Hematopoiesis/*drug effects
Mitochondria/*drug effects
bcl-2-Associated X Protein/*antagonists & inhibitors
Adult ; Anemia, Aplastic/pathology ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Ginsenosides/therapeutic use ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron, Transmission ; Middle Aged ; Mitochondria/ultrastructure ; Protein Transport ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł:
USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3.
Autorzy:
Chen W; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Song J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Liu S; Clinical Laboratory, Lishui Central Hospital, Lishui, 323000, China.
Tang B; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Shen L; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Zhu J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Fang S; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Wu F; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Zheng L; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Qiu R; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Chen C; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Gao Y; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Tu J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Zhao Z; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China. .
Ji J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2021 Jun 10; Vol. 28 (1), pp. 44. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Apoptosis/*genetics
Cholangiocarcinoma/*physiopathology
Hypoxia-Inducible Factor-Proline Dioxygenases/*genetics
Kinesins/*genetics
Ubiquitin Thiolesterase/*genetics
Animals ; Cholangiocarcinoma/genetics ; Female ; Humans ; Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism ; Kinesins/metabolism ; Mice ; Mice, Inbred BALB C ; Ubiquitin Thiolesterase/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł:
Ameliorative effects of eosinophil deficiency on immune response, endoplasmic reticulum stress, apoptosis, and autophagy in fungus-induced allergic lung inflammation.
Autorzy:
Wang S; Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jiang Z; Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Li L; Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhang J; Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhang C; Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Shao C; Department of Pulmonary Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. .; Department of Pulmonary Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, China. .
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Źródło:
Respiratory research [Respir Res] 2021 Jun 07; Vol. 22 (1), pp. 173. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Fungi*
Immunity*
Alveolitis, Extrinsic Allergic/*metabolism
Bronchoalveolar Lavage Fluid/*cytology
Endoplasmic Reticulum Stress/*immunology
Eosinophils/*pathology
Alveolitis, Extrinsic Allergic/microbiology ; Alveolitis, Extrinsic Allergic/pathology ; Animals ; Autophagy ; Disease Models, Animal ; Eosinophils/metabolism ; Female ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe

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