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Wyszukujesz frazę ""Mice, Knockout"" wg kryterium: Temat


Tytuł :
Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice.
Autorzy :
Si Y; Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China.
Guo C; Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China; Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegne, Netherlands.
Xiao F; Department of Prosthodontics, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China.
Mei B; Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China. Electronic address: .
Meng B; Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China. Electronic address: .
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Źródło :
Behavioural brain research [Behav Brain Res] 2022 Feb 10; Vol. 418, pp. 113652. Date of Electronic Publication: 2021 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mice, Knockout*
Behavior, Animal/*physiology
Feeding Behavior/*physiology
Presenilin-1/*genetics
Presenilin-2/*genetics
Animals ; Female ; Male ; Mice
Czasopismo naukowe
Tytuł :
A novel model of myocardial infarction based on atherosclerosis in mice.
Autorzy :
Wang J; Tianjin Medical University, Tianjin, China; Department of Cardiology, General Hospital of Huabei Petroleum Administration Bureau, Renqiu, Hebei, China.
Shan S; Department of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. Electronic address: .
Lyu A; Department of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Wan Y; Department of Biology, Providence College, Providence, RI, 02918, USA.
Zhang J; Department of Cardiology, Cangzhou Central Hospital, Cangzhou Teaching Hospital of Tianjin Medical University, Cangzhou, Hebei, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Oct 22; Vol. 576, pp. 100-107. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Diet, High-Fat*
Disease Models, Animal*
Atherosclerosis/*pathology
Dyslipidemias/*physiopathology
Mice, Knockout, ApoE/*genetics
Myocardial Infarction/*pathology
Animals ; Atherosclerosis/metabolism ; Disease Progression ; Female ; Mice ; Mice, Inbred C57BL ; Mice, Knockout, ApoE/metabolism ; Myocardial Infarction/metabolism
Czasopismo naukowe
Tytuł :
Rapid generation of conditional knockout mice using the CRISPR-Cas9 system and electroporation for neuroscience research.
Autorzy :
Nishizono H; Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan. .; Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, 33458, USA. .
Hayano Y; Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, 33458, USA.
Nakahata Y; Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, 33458, USA.
Ishigaki Y; Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.
Yasuda R; Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, 33458, USA. .
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Źródło :
Molecular brain [Mol Brain] 2021 Sep 23; Vol. 14 (1), pp. 148. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CRISPR-Cas Systems*
Mice, Knockout*
Electroporation/*methods
Gene Editing/*methods
Gene Targeting/*methods
Neurosciences/*methods
Animals ; Base Sequence ; Calcium-Calmodulin-Dependent Protein Kinase Type 1/genetics ; Embryo Transfer ; Exons/genetics ; Gene Editing/economics ; Gene Targeting/economics ; Integrases ; Mice ; Mice, Inbred C57BL ; Neurosciences/economics ; Transgenes
Czasopismo naukowe
Tytuł :
Inducible Slc4a11 Knockout Triggers Corneal Edema Through Perturbation of Corneal Endothelial Pump.
Autorzy :
Ogando DG; Vision Science Program, School of Optometry, Indiana University, Bloomington, Indiana, United States.
Shyam R; Vision Science Program, School of Optometry, Indiana University, Bloomington, Indiana, United States.
Kim ET; Vision Science Program, School of Optometry, Indiana University, Bloomington, Indiana, United States.
Wang YC; Vision Science Program, School of Optometry, Indiana University, Bloomington, Indiana, United States.
Liu CY; Vision Science Program, School of Optometry, Indiana University, Bloomington, Indiana, United States.
Bonanno JA; Vision Science Program, School of Optometry, Indiana University, Bloomington, Indiana, United States.
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2021 Jun 01; Vol. 62 (7), pp. 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Corneal Edema*/genetics
Corneal Edema*/metabolism
Corneal Edema*/physiopathology
Disease Models, Animal*
Mice, Knockout*/genetics
Mice, Knockout*/metabolism
Anion Transport Proteins/*genetics
Symporters/*genetics
Animals ; Anion Transport Proteins/metabolism ; Endothelium, Corneal/physiology ; Mice ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Fibroblast growth factor 21 reverses high-fat diet-induced impairment of vascular function via the anti-oxidative pathway in ApoE knockout mice.
Autorzy :
Huang WP; Division of Cardiology, Cheng Hsin General Hospital, Taipei, Taiwan.; Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chen CY; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Lin TW; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Kuo CS; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Huang HL; National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Huang PH; Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Lin SJ; Division of Cardiology, Cheng Hsin General Hospital, Taipei, Taiwan.; Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Apr; Vol. 26 (8), pp. 2451-2461. Date of Electronic Publication: 2022 Mar 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diet, High-Fat*/adverse effects
Endothelium, Vascular*/metabolism
Animals ; Apolipoproteins E ; Fibroblast Growth Factors ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Knockout, ApoE ; Nitric Oxide Synthase Type III/metabolism ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
STAT-1 Knockout Mice as a Model for Wild-Type Sudan Virus (SUDV).
Autorzy :
Escaffre O; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Juelich TL; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Neef N; XTR Toxicologic Pathology Services LLC, Sterling, VA 20165, USA.
Massey S; Office of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Smith J; Office of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Brasel T; Office of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; The Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Smith JK; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Kalveram B; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Zhang L; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Perez D; Texas A&M University Division of Research, Texas A&M University, College Station, TX 77843, USA.
Ikegami T; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; The Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Freiberg AN; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; The Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Comer JE; Office of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; The Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Institute of Translational Sciences, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
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Źródło :
Viruses [Viruses] 2021 Jul 17; Vol. 13 (7). Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Models, Animal*
Mice, Knockout*
Ebolavirus/*genetics
STAT1 Transcription Factor/*genetics
Amides/therapeutic use ; Animals ; Antibodies, Viral/blood ; Antiviral Agents/therapeutic use ; Ebolavirus/classification ; Ebolavirus/drug effects ; Ebolavirus/pathogenicity ; Female ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/virology ; Male ; Mice ; Pyrazines/therapeutic use ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Hyperlipidemic hypersensitivity to lethal microbial inflammation and its reversal by selective targeting of nuclear transport shuttles.
Autorzy :
Liu Y; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Health Care System, Nashville, TN, USA.
Zienkiewicz J; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Health Care System, Nashville, TN, USA.
Boyd KL; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Smith TE; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Health Care System, Nashville, TN, USA.
Xu ZQ; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Health Care System, Nashville, TN, USA.
Hawiger J; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. .; Department of Veterans Affairs, Tennessee Valley Health Care System, Nashville, TN, USA. .; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA. .; Vanderbilt University Medical Center, 21st Avenue South, T-1218, MCN, Nashville, TN, 37232, USA. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jun 07; Vol. 11 (1), pp. 11907. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Mice, Knockout*
Cell Nucleus/*metabolism
Hyperlipidemias/*metabolism
Inflammation/*metabolism
Signal Transduction/*physiology
Active Transport, Cell Nucleus/physiology ; Animals ; Cell-Penetrating Peptides/metabolism ; Cytokines/metabolism ; Female ; HEK293 Cells ; Hep G2 Cells ; Humans ; Inflammation/chemically induced ; Inflammation/microbiology ; Karyopherins/metabolism ; Lipopolysaccharides ; Mice ; Mice, Inbred C57BL ; RAW 264.7 Cells ; Sterol Regulatory Element Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Efficiency comparison of B6(Cg)-Tyr /J and C57BL/6NTac embryos as hosts for the generation of knockout mice.
Autorzy :
Ma Y; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
He L; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
Xiang L; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
Zhang J; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
Wang J; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
Zhu W; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
Cao W; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
Zhu Y; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
Gao M; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
Zhou F; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China.
Liu Z; CAM-SU Genomic Resource Center, Soochow University, Suzhou, 215123, Jiang Su, China. .
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Źródło :
Transgenic research [Transgenic Res] 2021 Jun; Vol. 30 (3), pp. 275-281. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Embryo Transfer*
Blastocyst/*metabolism
Mice, Knockout/*genetics
Mouse Embryonic Stem Cells/*transplantation
Animals ; Embryo, Mammalian ; Germ Cells/growth & development ; Mice ; Mice, Knockout/growth & development ; Microinjections ; Mouse Embryonic Stem Cells/cytology
Czasopismo naukowe
Tytuł :
[Effects of CACNA1H gene knockout on autistic-like behaviors and the morphology of hippocampal neurons in mice].
Autorzy :
Jiao C; Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Wang JM; Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Kuang HX; Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Wu ZH; Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Liu T; Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.; Center for Experimental Medicine, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
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Źródło :
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2022 Apr 18; Vol. 54 (2), pp. 209-216.
Typ publikacji :
Journal Article
MeSH Terms :
Autistic Disorder*/genetics
Calcium Channels, T-Type*/genetics
Animals ; Gene Knockout Techniques ; Hippocampus ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons
Czasopismo naukowe
Tytuł :
Nrf2 attenuates the innate immune response after experimental myocardial infarction.
Autorzy :
Bromage DI; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK. Electronic address: .
Trevelin SC; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Huntington J; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Yang VX; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Muthukumar A; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Mackie SJ; School of Cancer and Pharmaceutical Sciences, SGDP Centre, King's College London, Memory Lane, London, SE5 8AF, UK.
Sawyer G; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Zhang X; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Santos CXC; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Safinia N; MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Smyrnias I; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK; School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, GU2 7AL, UK.
Giacca M; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Ivetic A; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Shah AM; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 May 28; Vol. 606, pp. 10-16. Date of Electronic Publication: 2022 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Myocardial Infarction*/metabolism
Ventricular Remodeling*/physiology
Animals ; Cytokines/metabolism ; Disease Models, Animal ; Immunity, Innate ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myocardium/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Tytuł :
Effects of repetitive training on learning and memory performance of TLR2 KO mice.
Autorzy :
Bae HJ; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Kim J; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Bae HJ; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Park K; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Yang X; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Cho YJ; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Jung SY; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Park SJ; School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.
Ryu JH; Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: .
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Źródło :
Behavioural brain research [Behav Brain Res] 2022 May 24; Vol. 426, pp. 113836. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cognition*
Toll-Like Receptor 2*/genetics
Toll-Like Receptor 2*/metabolism
Animals ; Hippocampus/metabolism ; Humans ; Maze Learning ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Reversal Learning/physiology
Czasopismo naukowe
Tytuł :
Exploration of group II metabotropic glutamate receptor modulation in mouse models of Rett syndrome and MECP2 Duplication syndrome.
Autorzy :
Vermudez SAD; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Buch A; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Weiss K; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA.
Gogliotti RG; Department of Molecular Pharmacology and Neuroscience, Loyola University Chicago, IL, 60660, USA.
Niswender CM; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN, 37232, USA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, 37232, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2022 May 15; Vol. 209, pp. 109022. Date of Electronic Publication: 2022 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Mental Retardation, X-Linked*/genetics
Receptors, Metabotropic Glutamate*/metabolism
Rett Syndrome*/drug therapy
Rett Syndrome*/genetics
Rett Syndrome*/metabolism
Animals ; Disease Models, Animal ; Humans ; Methyl-CpG-Binding Protein 2/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
SCR Disease Name :
Lubs X-linked mental retardation syndrome
Czasopismo naukowe
Tytuł :
Loss of CRMP1 and CRMP2 results in migration defects of Purkinje cells in the X lobule of the mouse cerebellum.
Autorzy :
Akinaga S; Department of Life Science and Medical Bio-Science, Waseda University, Shinjuku-ku, Tokyo 162-8480 Japan.
Harada S; Department of Life Science and Medical Bio-Science, Waseda University, Shinjuku-ku, Tokyo 162-8480 Japan.
Takahashi M; Department of Life Science and Medical Bio-Science, Waseda University, Shinjuku-ku, Tokyo 162-8480 Japan.
Kaneko A; Department of Life Science and Medical Bio-Science, Waseda University, Shinjuku-ku, Tokyo 162-8480 Japan.
Kolattukudy P; Biomolecular Science Center, University of Central Florida, Biomolecular Science, Orlando, FL 32816, USA.
Goshima Y; Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Ohshima T; Department of Life Science and Medical Bio-Science, Waseda University, Shinjuku-ku, Tokyo 162-8480 Japan. Electronic address: .
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Źródło :
Brain research [Brain Res] 2022 May 15; Vol. 1783, pp. 147846. Date of Electronic Publication: 2022 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neurogenesis*
Purkinje Cells*/physiology
Animals ; Cell Movement ; Cerebellum ; Mammals ; Mice ; Mice, Knockout ; Phosphorylation
Czasopismo naukowe
Tytuł :
Vitamin C alleviates alcoholic liver injury by suppressing neutrophil infiltration in senescence marker protein 30-knockout mice irrespective of its antioxidant effects.
Autorzy :
Baek SM; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Lee SW; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Lee YJ; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Choi SK; Core Protein Resources Center, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea.
Kim HY; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea; Core Protein Resources Center, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea.
Seo MS; Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.
Sung SE; Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.
Lee AR; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Kim TU; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Han SH; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Media and Communication, Hanyang University, Seoul 04763, Republic of Korea.
Son JH; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Park SJ; Laboratory of Veterinary Histology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Kim TH; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Jeong KS; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
Park JK; Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea; Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2022 May 15; Vol. 297, pp. 120228. Date of Electronic Publication: 2021 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants*/metabolism
Antioxidants*/pharmacology
Liver Diseases, Alcoholic*/drug therapy
Liver Diseases, Alcoholic*/metabolism
Animals ; Ascorbic Acid/pharmacology ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophil Infiltration
Czasopismo naukowe
Tytuł :
Vascular smooth muscle ROCK1 contributes to hypoxia-induced pulmonary hypertension development in mice.
Autorzy :
Penumatsa KC; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Singhal AA; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Warburton RR; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Bear MD; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Bhedi CD; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Nasirova S; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Wilson JL; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Qi G; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Preston IR; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Hill NS; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Fanburg BL; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA.
Kim YB; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA, 02115, USA.
Toksoz D; Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, 800 Washington St., Boston, MA, 02111, USA. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 May 14; Vol. 604, pp. 137-143. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Pulmonary Arterial Hypertension*/genetics
rho-Associated Kinases*/genetics
rho-Associated Kinases*/metabolism
rho-Associated Kinases*/physiology
Animals ; Hypertrophy, Right Ventricular/genetics ; Hypoxia/complications ; Mice ; Mice, Knockout ; Muscle, Smooth, Vascular/enzymology ; Myocytes, Smooth Muscle/metabolism ; Pulmonary Artery/metabolism
Czasopismo naukowe
Tytuł :
Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2-Deficient Hearts.
Autorzy :
van Opbergen CJM; The Leon Charney Division of Cardiology, New York University Grossmann School of Medicine (C.J.M.v.O., J.-C.K., M.C., M.D.).
Bagwan N; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (N.B., S.R.M., A.L.).
Maurya SR; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (N.B., S.R.M., A.L.).
Kim JC; The Leon Charney Division of Cardiology, New York University Grossmann School of Medicine (C.J.M.v.O., J.-C.K., M.C., M.D.).
Smith AN; Department of Chemistry & Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN (A.N.S., J.N.J.).
Blackwell DJ; Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN (D.J.B., B.C.K.).
Johnston JN; Department of Chemistry & Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN (A.N.S., J.N.J.).
Knollmann BC; Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN (D.J.B., B.C.K.).
Cerrone M; The Leon Charney Division of Cardiology, New York University Grossmann School of Medicine (C.J.M.v.O., J.-C.K., M.C., M.D.).
Lundby A; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (N.B., S.R.M., A.L.).
Delmar M; The Leon Charney Division of Cardiology, New York University Grossmann School of Medicine (C.J.M.v.O., J.-C.K., M.C., M.D.).
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Źródło :
Circulation [Circulation] 2022 May 10; Vol. 145 (19), pp. 1480-1496. Date of Electronic Publication: 2022 May 01.
Typ publikacji :
Journal Article
MeSH Terms :
Arrhythmogenic Right Ventricular Dysplasia*/genetics
Plakophilins*/genetics
Sarcoplasmic Reticulum*/metabolism
Animals ; Arrhythmias, Cardiac ; Calcium/metabolism ; Calcium Signaling ; Humans ; Isoproterenol/pharmacology ; Mice ; Mice, Knockout ; Myocytes, Cardiac/metabolism ; Physical Conditioning, Animal/adverse effects ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism
Czasopismo naukowe
Tytuł :
Mrgprb2 gene plays a role in the anaphylactoid reactions induced by Houttuynia cordata injection.
Autorzy :
Sun X; School of Pharmacy, Jiangsu University, Zhenjiang, 212000, China.
Lv W; School of Pharmacy, Jiangsu University, Zhenjiang, 212000, China. Electronic address: .
Wang Y; School of Pharmacy, Jiangsu University, Zhenjiang, 212000, China. Electronic address: .
Zhang X; School of Pharmacy, Jiangsu University, Zhenjiang, 212000, China. Electronic address: .
Ouyang Z; School of Pharmacy, Jiangsu University, Zhenjiang, 212000, China. Electronic address: .
Yin R; School of Pharmacy, Jiangsu University, Zhenjiang, 212000, China. Electronic address: .
Wei Y; School of Pharmacy, Jiangsu University, Zhenjiang, 212000, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2022 May 10; Vol. 289, pp. 115053. Date of Electronic Publication: 2022 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Anaphylaxis/*etiology
Drugs, Chinese Herbal/*toxicity
Houttuynia/*chemistry
Receptors, G-Protein-Coupled/*genetics
Anaphylaxis/genetics ; Animals ; Cell Degranulation/drug effects ; Drugs, Chinese Herbal/administration & dosage ; Female ; Histamine Release/drug effects ; Male ; Mast Cells/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; p-Methoxy-N-methylphenethylamine/toxicity
Czasopismo naukowe
Tytuł :
Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury.
Autorzy :
Dai M; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Peng W; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China; Institute of Rare Diseases, West China Hospital of Sichuan University, Chengdu, 610041, China.
Zhang T; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhao Q; Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Ma X; Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Cheng Y; Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wang C; Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Li F; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; Laboratory of Metabolomics and Drug-induced Liver Injury, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2022 May 10; Vol. 289, pp. 115090. Date of Electronic Publication: 2022 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical and Drug Induced Liver Injury/*etiology
PPAR alpha/*genetics
Plant Extracts/*toxicity
Tripterygium/*chemistry
Animals ; Chemical and Drug Induced Liver Injury/genetics ; Diterpenes/chemistry ; Diterpenes/toxicity ; Epoxy Compounds/chemistry ; Epoxy Compounds/toxicity ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Pentacyclic Triterpenes/chemistry ; Pentacyclic Triterpenes/toxicity ; Phenanthrenes/chemistry ; Phenanthrenes/toxicity ; Plant Extracts/chemistry ; Tablets
Czasopismo naukowe
Tytuł :
Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell-specific manner.
Autorzy :
Avalos A; The Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Tietsort JT; The Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Suwankitwat N; The Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Woods JD; Seattle Children's Research Institute, Seattle, Washington, USA.
Jackson SW; Seattle Children's Research Institute, Seattle, Washington, USA.
Christodoulou A; The Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Morrill C; The Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Liggitt HD; The Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Zhu C; Department of Immunology, Microarray and Immune Phenotyping Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Li QZ; Department of Immunology, Microarray and Immune Phenotyping Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Bui KK; The Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Park H; The Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Iritani BM; The Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
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Źródło :
JCI insight [JCI Insight] 2022 May 09; Vol. 7 (9). Date of Electronic Publication: 2022 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing*/immunology
Autoantibodies*
Autoimmune Diseases*
B-Lymphocytes*/immunology
Immunity, Humoral*
Actins ; Animals ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
AAV-delivered diacylglycerol kinase DGKk achieves long-term rescue of fragile X syndrome mouse model.
Autorzy :
Habbas K; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Médecine Translationelle et Neurogénétique, Centre National de la Recherche Scientifique (CNRS UMR7104), Institut National de la Santé et de la Recherche Médicale (INSERM U1258), Université de Strasbourg, Illkirch, France.
Cakil O; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Médecine Translationelle et Neurogénétique, Centre National de la Recherche Scientifique (CNRS UMR7104), Institut National de la Santé et de la Recherche Médicale (INSERM U1258), Université de Strasbourg, Illkirch, France.
Zámbó B; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Médecine Translationelle et Neurogénétique, Centre National de la Recherche Scientifique (CNRS UMR7104), Institut National de la Santé et de la Recherche Médicale (INSERM U1258), Université de Strasbourg, Illkirch, France.
Tabet R; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Médecine Translationelle et Neurogénétique, Centre National de la Recherche Scientifique (CNRS UMR7104), Institut National de la Santé et de la Recherche Médicale (INSERM U1258), Université de Strasbourg, Illkirch, France.
Riet F; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), PHENOMIN-ICS, Centre National de la Recherche Scientifique (CNRS UMR7104), Institut National de la Santé et de la Recherche Médicale (INSERM U1258), Université de Strasbourg, Illkirch, France.
Dembele D; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Médecine Translationelle et Neurogénétique, Centre National de la Recherche Scientifique (CNRS UMR7104), Institut National de la Santé et de la Recherche Médicale (INSERM U1258), Université de Strasbourg, Illkirch, France.
Mandel JL; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Médecine Translationelle et Neurogénétique, Centre National de la Recherche Scientifique (CNRS UMR7104), Institut National de la Santé et de la Recherche Médicale (INSERM U1258), Université de Strasbourg, Illkirch, France.
Hocquemiller M; Lysogene, Neuilly-sur-Seine, France.
Laufer R; Lysogene, Neuilly-sur-Seine, France.
Piguet F; NeuroGenCell, INSERM U1127, Paris Brain Institute (ICM), Sorbonne University, CNRS, AP-HP, University Hospital Pitié-Salpêtrière, Paris, France.
Moine H; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Médecine Translationelle et Neurogénétique, Centre National de la Recherche Scientifique (CNRS UMR7104), Institut National de la Santé et de la Recherche Médicale (INSERM U1258), Université de Strasbourg, Illkirch, France.
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Źródło :
EMBO molecular medicine [EMBO Mol Med] 2022 May 09; Vol. 14 (5), pp. e14649. Date of Electronic Publication: 2022 Apr 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fragile X Syndrome*/genetics
Fragile X Syndrome*/metabolism
Fragile X Syndrome*/therapy
Animals ; Diacylglycerol Kinase/genetics ; Diacylglycerol Kinase/metabolism ; Disease Models, Animal ; Fragile X Mental Retardation Protein/genetics ; Fragile X Mental Retardation Protein/metabolism ; Mice ; Mice, Knockout
Czasopismo naukowe

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