Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Ukraiński (UK)
Przejdź do strony domowej biblioteki Uniwersytet Ekonomiczny we Wrocławiu Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaUniwersytet Ekonomiczny we Wrocławiu

Wyszukujesz frazę ""Mice, Knockout"" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-20 z 498
Tytuł:
Zbtb40 Deficiency Leads to Morphological and Phenotypic Abnormalities of Spermatocytes and Spermatozoa and Causes Male Infertility.
Autorzy:
Cui Y; The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha 410013, China.; The Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha 410013, China.; The Manufacture-Based Learning & Research Demonstration Center for Human Reproductive Health New Technology of Hunan Normal University, Changsha 410013, China.
Zhou M; The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha 410013, China.
He Q; The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha 410013, China.
He Z; The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha 410013, China.; The Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha 410013, China.; The Manufacture-Based Learning & Research Demonstration Center for Human Reproductive Health New Technology of Hunan Normal University, Changsha 410013, China.
Pokaż więcej
Źródło:
Cells [Cells] 2023 Apr 26; Vol. 12 (9). Date of Electronic Publication: 2023 Apr 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Infertility, Male*/genetics
Spermatocytes*
DNA-Binding Proteins*/genetics
Animals ; Humans ; Male ; Mice ; Mice, Knockout ; Semen ; Spermatozoa ; Testis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Time-restricted feeding mitigates obesity through adipocyte thermogenesis.
Autorzy:
Hepler C; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Weidemann BJ; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Waldeck NJ; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Marcheva B; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Cedernaes J; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Thorne AK; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Kobayashi Y; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Nozawa R; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Newman MV; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Gao P; Robert H. Lurie Cancer Center Metabolomics Core, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Shao M; Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ramsey KM; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Gupta RK; Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Bass J; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Pokaż więcej
Źródło:
Science (New York, N.Y.) [Science] 2022 Oct 21; Vol. 378 (6617), pp. 276-284. Date of Electronic Publication: 2022 Oct 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Adipocytes*/metabolism
Creatine*/metabolism
Obesity*/etiology
Obesity*/prevention & control
Thermogenesis*/genetics
Circadian Clocks*
Circadian Rhythm*
Diet, High-Fat*/adverse effects
DNA-Binding Proteins*/genetics
Transcription Factors*/genetics
Animals ; Mice ; ARNTL Transcription Factors/genetics ; Time Factors ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A cardiac-null mutation of Prdm16 causes hypotension in mice with cardiac hypertrophy via increased nitric oxide synthase 1.
Autorzy:
Kang JO; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Korea.
Ha TW; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Korea.
Jung HU; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea.
Lim JE; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Korea.
Oh B; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Korea.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2022 Jul 21; Vol. 17 (7), pp. e0267938. Date of Electronic Publication: 2022 Jul 21 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Heart Failure*/etiology
Hypotension*/complications
Hypotension*/genetics
Hypotension*/metabolism
Nitric Oxide Synthase Type I*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Animals ; Cardiomegaly/etiology ; Female ; Humans ; Loss of Function Mutation ; Mice ; Mice, Knockout ; Myocardium/metabolism ; Nitric Oxide/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Addressing the role of PKD3 in the T cell compartment with knockout mice.
Autorzy:
Koutník J; Institute of Cell Genetics, Medical University Innsbruck, Innsbruck, Austria.
Neururer V; Institute of Cell Genetics, Medical University Innsbruck, Innsbruck, Austria.; Apoptosis, Cancer, and Development Laboratory, Equipe labellisée 'La Ligue', LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Université de Lyon, Université Claude Bernard Lyon1, 69008, Lyon, France.
Gruber T; Institute of Cell Genetics, Medical University Innsbruck, Innsbruck, Austria.
Peer S; Institute of Cell Genetics, Medical University Innsbruck, Innsbruck, Austria.
Hermann-Kleiter N; Institute of Cell Genetics, Medical University Innsbruck, Innsbruck, Austria.
Olson WJ; Institute of Cell Genetics, Medical University Innsbruck, Innsbruck, Austria.; Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
Labi V; Institute of Developmental Immunology, Medical University Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Leitges M; Division of BioMedical Sciences, Faculty of Medicine, Craig L Dobbin Genetics Research Centre, Memorial University of Newfoundland Health Science Centre, 300 Prince Philip Drive, St. John's, NF, A1B 3V6, Canada.
Baier G; Institute of Cell Genetics, Medical University Innsbruck, Innsbruck, Austria.
Siegmund K; Institute of Cell Genetics, Medical University Innsbruck, Innsbruck, Austria. .
Pokaż więcej
Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2022 Apr 19; Vol. 20 (1), pp. 54. Date of Electronic Publication: 2022 Apr 19.
Typ publikacji:
Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't
MeSH Terms:
T-Lymphocytes*/metabolism
DNA-Activated Protein Kinase/*metabolism
DNA-Binding Proteins/*metabolism
Animals ; CD4-Positive T-Lymphocytes ; Mice ; Mice, Knockout ; Receptors, Antigen, T-Cell/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
Autorzy:
Seo SH; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Kim E; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Lee SH; CK Regeon Inc., Seoul, Republic of Korea.
Lee YH; Department of Internal Medicine, Yonsei University, Seoul, Republic of Korea.
Han DH; Department of surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Go H; Korea Mouse Phenotyping Center, Seoul National University, Seoul, Republic of Korea.
Seong JK; Korea Mouse Phenotyping Center, Seoul National University, Seoul, Republic of Korea.
Choi KY; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.; CK Regeon Inc., Seoul, Republic of Korea.
Pokaż więcej
Źródło:
Clinical and translational medicine [Clin Transl Med] 2022 Apr; Vol. 12 (4), pp. e742.
Typ publikacji:
Journal Article
MeSH Terms:
DNA-Binding Proteins*/antagonists & inhibitors
DNA-Binding Proteins*/metabolism
Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/drug therapy
Diabetes Mellitus, Type 2*/genetics
Transcription Factors*/antagonists & inhibitors
Transcription Factors*/metabolism
Adipocytes/metabolism ; Adipose Tissue/metabolism ; Animals ; Humans ; Mice ; Mice, Knockout ; Obesity/complications ; Obesity/drug therapy ; Obesity/genetics ; Wnt Signaling Pathway
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice.
Autorzy:
Frederick NM; Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA.; Northwestern University Interdepartmental Neuroscience Program, Northwestern University, Evanston, Illinois, 60208, USA.
Pooler MM; Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA.
Shah P; Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA.
Didonna A; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, 94158, USA.
Opal P; Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA.; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA.
Pokaż więcej
Źródło:
Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2021 Dec; Vol. 8 (12), pp. 2302-2308. Date of Electronic Publication: 2021 Nov 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Binding Proteins*/genetics
Dopamine Agonists/*pharmacology
Dopamine Antagonists/*pharmacology
Dystonia Musculorum Deformans/*metabolism
Receptors, Dopamine D2/*metabolism
Animals ; Disease Models, Animal ; Dystonia Musculorum Deformans/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Dopamine D1/agonists ; Receptors, Dopamine D1/antagonists & inhibitors ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/drug effects
SCR Disease Name:
Dystonia 6, torsion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.
Autorzy:
Khang R; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.
Jo A; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.
Kang H; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.
Kim H; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.
Kwag E; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.
Lee JY; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.
Koo O; Laboratory Animal Research Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; ToolGen, Seoul, 08501, South Korea.
Park J; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, South Korea.
Kim HK; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, South Korea.
Jo DG; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, South Korea.; Biomedical Institute for Convergence, Sungkyunkwan University, Suwon, 16419, South Korea.
Hwang I; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.
Ahn JY; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea.
Lee Y; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea.
Choi JY; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea.
Lee YS; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea.; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea.
Shin JH; Department of Pharmacology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea. .; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea. .; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Nov 23; Vol. 11 (1), pp. 22745. Date of Electronic Publication: 2021 Nov 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ataxia/*pathology
DNA-Binding Proteins/*metabolism
Gait Disorders, Neurologic/*pathology
Nerve Tissue Proteins/*physiology
Phospholipase D/*antagonists & inhibitors
Purkinje Cells/*pathology
Animals ; Ataxia/etiology ; DNA-Binding Proteins/administration & dosage ; DNA-Binding Proteins/genetics ; Gait Disorders, Neurologic/etiology ; Humans ; Male ; Mice ; Mice, Knockout ; Nerve Tissue Proteins/administration & dosage ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Purkinje Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice.
Autorzy:
van Thiel BS; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
van der Linden J; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.; Department of Experimental Cardiology, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Ridwan Y; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Garrelds IM; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Vermeij M; Department of Pathology, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Clahsen-van Groningen MC; Department of Pathology, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Qadri F; Max Delbrück Center, 13125 Berlin, Germany.
Alenina N; Max Delbrück Center, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.
Bader M; Max Delbrück Center, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.; Charité-University Medicine, 10117 Berlin, Germany.; Institute for Biology, University of Lübeck, 23562 Lübeck, Germany.
Roks AJM; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Danser AHJ; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Essers J; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.; Department of Radiation Oncology, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
van der Pluijm I; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus University Medical Center, 3015GD Rotterdam, The Netherlands.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 18; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 18.
Typ publikacji:
Journal Article
MeSH Terms:
Aging/*genetics
Angiotensin II/*genetics
DNA-Binding Proteins/*genetics
Endonucleases/*genetics
Glomerulosclerosis, Focal Segmental/*genetics
Progeria/*genetics
Renal Insufficiency, Chronic/*genetics
Renin/*genetics
Aging/metabolism ; Aging/pathology ; Angiotensin II/metabolism ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Animals ; DNA Damage ; DNA Repair ; DNA-Binding Proteins/deficiency ; Disease Models, Animal ; Endonucleases/deficiency ; Female ; Gene Expression Regulation ; Glomerular Filtration Rate ; Glomerulosclerosis, Focal Segmental/metabolism ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Kidney/metabolism ; Kidney/pathology ; Losartan/pharmacology ; Male ; Mice ; Mice, Knockout ; Progeria/metabolism ; Progeria/pathology ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; Renin/metabolism ; Renin-Angiotensin System/genetics ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MORC3, a novel MIWI2 association partner, as an epigenetic regulator of piRNA dependent transposon silencing in male germ cells.
Autorzy:
Kojima-Kita K; Department of Pathology, Medical School, Osaka University, Yamada-oka 2-2 Suita, Osaka, 565-0871, Japan. .
Kuramochi-Miyagawa S; Department of Pathology, Medical School, Osaka University, Yamada-oka 2-2 Suita, Osaka, 565-0871, Japan.; Graduate School of Frontier Biosciences, Osaka University, Yamada-oka 2-2 Suita, Osaka, 565-0871, Japan.
Nakayama M; Laboratory of Medical Omics Research, Department of Frontier Research and Development, Kazusa DNA Research Institute, Kisarazu, Chiba, 292-0818, Japan.
Miyata H; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1 Suita, Osaka, 565-0871, Japan.
Jacobsen SE; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.; Department of Biological Chemistry, University of California, Los Angeles, CA, 90095, USA.; Department of Howard Hughes Medical Institute, University of California, Los Angeles, CA, 90095, USA.
Ikawa M; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1 Suita, Osaka, 565-0871, Japan.
Koseki H; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.
Nakano T; Department of Pathology, Medical School, Osaka University, Yamada-oka 2-2 Suita, Osaka, 565-0871, Japan. .; Graduate School of Frontier Biosciences, Osaka University, Yamada-oka 2-2 Suita, Osaka, 565-0871, Japan. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Oct 14; Vol. 11 (1), pp. 20472. Date of Electronic Publication: 2021 Oct 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Developmental*
Adenosine Triphosphatases/*metabolism
DNA Methylation/*genetics
DNA-Binding Proteins/*metabolism
Germ Cells/*metabolism
Testis/*metabolism
Animals ; DNA Transposable Elements ; Epigenomics ; Female ; Germ Cells/growth & development ; Male ; Mice, Knockout ; Mice, Transgenic ; RNA, Small Interfering ; Retroelements ; Testis/growth & development ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
AIM2 deletion enhances blood-brain barrier integrity in experimental ischemic stroke.
Autorzy:
Xu SY; Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China.; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Bian HJ; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Shu S; Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China.; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.; Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China.; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China.
Xia SN; Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China.
Gu Y; Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China.
Zhang MJ; Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China.; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.; Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China.; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China.
Xu Y; Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China.; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.; Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China.; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China.
Cao X; Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China.; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.; Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.; Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China.; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China.
Pokaż więcej
Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2021 Oct; Vol. 27 (10), pp. 1224-1237. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood-Brain Barrier/*pathology
DNA-Binding Proteins/*genetics
Ischemic Stroke/*genetics
Ischemic Stroke/*pathology
Animals ; Electric Impedance ; Endothelial Cells ; Glucose/deficiency ; Hypoxia/pathology ; Infarction, Middle Cerebral Artery/pathology ; Intercellular Adhesion Molecule-1/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nervous System Diseases/etiology ; Nervous System Diseases/physiopathology ; Reperfusion Injury/pathology ; STAT3 Transcription Factor/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells.
Autorzy:
Sadegh C; Department of Stem Cell and Regenerative Biology, Center for Brain Science, and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America.; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Ebina W; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America.; Division of Hematology/Oncology, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, United States of America.
Arvanites AC; Department of Stem Cell and Regenerative Biology, and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America.
Davidow LS; Department of Stem Cell and Regenerative Biology, and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America.
Rubin LL; Department of Stem Cell and Regenerative Biology, and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America.
Macklis JD; Department of Stem Cell and Regenerative Biology, Center for Brain Science, and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2021 Sep 02; Vol. 16 (9), pp. e0254113. Date of Electronic Publication: 2021 Sep 02 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Binding Proteins/*genetics
Mouse Embryonic Stem Cells/*cytology
Neocortex/*cytology
Nerve Tissue Proteins/*genetics
Neurons/*cytology
Sirtuin 1/*antagonists & inhibitors
Animals ; Cell Differentiation ; Cells, Cultured ; DNA-Binding Proteins/metabolism ; Mice ; Mice, Knockout ; Mouse Embryonic Stem Cells/metabolism ; Neocortex/metabolism ; Nerve Tissue Proteins/metabolism ; Neurons/metabolism ; RNA, Messenger/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The zinc finger/RING domain protein Unkempt regulates cognitive flexibility.
Autorzy:
Vinsland E; Maurice Wohl Clinical Neuroscience Institute, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solnavägen 9, 17177, Stockholm, Sweden.
Baskaran P; Maurice Wohl Clinical Neuroscience Institute, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.
Mihaylov SR; Maurice Wohl Clinical Neuroscience Institute, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.
Hobbs C; Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, SE1 1UL, UK.
Wood H; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, 16 De Crespigny Park, London, PO82SE5 8AF, UK.
Bouybayoune I; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
Shah K; Department of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall 1415A - MURN, Riverside, CA, 92521, USA.
Houart C; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
Tee AR; Cancer and Genetics Building, Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park Way, Cardiff, CF14 4XN, UK.
Murn J; Department of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall 1415A - MURN, Riverside, CA, 92521, USA.
Fernandes C; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, 16 De Crespigny Park, London, PO82SE5 8AF, UK.; MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 4th Floor, New Hunt's House, London, SE1 1UL, UK.
Bateman JM; Maurice Wohl Clinical Neuroscience Institute, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK. joseph_.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Aug 11; Vol. 11 (1), pp. 16299. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Cognition/*physiology
DNA-Binding Proteins/*metabolism
Malformations of Cortical Development/*metabolism
Zinc Fingers/*physiology
Animals ; Cerebellum/metabolism ; Drosophila/metabolism ; HeLa Cells ; Hippocampus/metabolism ; Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurogenesis/physiology ; Signal Transduction/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo.
Autorzy:
Kuroda R; Department of Biochemistry, Jichi Medical University, Shimotsuke, Tochigi, Japan.; Department of Neurosurgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Tominaga K; Department of Biochemistry, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Kasashima K; Department of Biochemistry, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Kuroiwa K; Department of Biochemistry, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Sakashita E; Department of Biochemistry, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Hayakawa H; Core Center of Research Apparatus, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Kouki T; Department of Anatomy, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Ohno N; Department of Anatomy, Jichi Medical University, Shimotsuke, Tochigi, Japan.; Division of Ultrastructural Research, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.
Kawai K; Department of Neurosurgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Endo H; Department of Biochemistry, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2021 Jul 28; Vol. 16 (7), pp. e0255355. Date of Electronic Publication: 2021 Jul 28 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Oxidative Stress*
Brain/*pathology
DNA-Binding Proteins/*genetics
Mitochondria/*metabolism
Mitochondrial Proteins/*genetics
Transcription Factors/*genetics
Animals ; Brain/growth & development ; Brain/metabolism ; Cell Differentiation ; Cells, Cultured ; DNA, Mitochondrial/metabolism ; DNA-Binding Proteins/deficiency ; Down-Regulation ; Electron Transport Chain Complex Proteins/genetics ; Electron Transport Chain Complex Proteins/metabolism ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/cytology ; Microglia/metabolism ; Mitochondrial Proteins/deficiency ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neurogenesis ; Reactive Oxygen Species/metabolism ; Transcription Factors/deficiency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
No effect of deleted in malignant brain tumors 1 deficiency on chemotherapy induced murine intestinal mucositis.
Autorzy:
Nexoe AB; Department of Molecular Medicine, Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark.; Department of Gastroenterology, Odense University Hospital, Odense, Denmark.
Pedersen AA; Department of Molecular Medicine, Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark.
von Huth S; Department of Molecular Medicine, Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark.; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
Sorensen GL; Department of Molecular Medicine, Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark.
Holmskov U; Department of Molecular Medicine, Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark.
Jiang PP; Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
Detlefsen S; Department of Pathology, Odense University Hospital, Odense, Denmark.
Husby S; Hans Christian Andersen Children's Hospital, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark.
Rathe M; Hans Christian Andersen Children's Hospital, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark. .; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Jul 19; Vol. 11 (1), pp. 14687. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*adverse effects
Calcium-Binding Proteins/*genetics
DNA-Binding Proteins/*genetics
Mucositis/*chemically induced
Mucositis/*genetics
Tumor Suppressor Proteins/*genetics
Animals ; Disease Models, Animal ; Doxorubicin/adverse effects ; Enteritis/chemically induced ; Enteritis/genetics ; Enteritis/pathology ; Female ; Genetic Predisposition to Disease ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Intestines/drug effects ; Intestines/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mucositis/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
NUPR1 interacts with eIF2α and is required for resolution of the ER stress response in pancreatic tissue.
Autorzy:
Borrello MT; Centre de Recherche en Cancérologie de Marseille, INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.
Santofimia-Castaño P; Centre de Recherche en Cancérologie de Marseille, INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.
Bocchio M; INMED (INSERM U1249), Turing Center for Living Systems, Aix-Marseille University, Marseille, France.
Listi A; Centre de Recherche en Cancérologie de Marseille, INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.
Fraunhoffer N; Centre de Recherche en Cancérologie de Marseille, INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.
Soubeyran P; Centre de Recherche en Cancérologie de Marseille, INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.
Chevet E; INSERM U1242, Proteostasis and Cancer Team, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1, Rennes, France.
Pin C; Centre de Recherche en Cancérologie de Marseille, INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.; Departments of Pediatrics, Oncology, and Physiology and Pharmacology, Schulich School of Medicine, University of Western Ontario, Children's Health Research Institute, London, ON, Canada.
Iovanna J; Centre de Recherche en Cancérologie de Marseille, INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.
Pokaż więcej
Źródło:
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (13), pp. 4081-4097. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
DNA-Binding Proteins/*genetics
Endoplasmic Reticulum Stress/*genetics
Eukaryotic Initiation Factor-2/*genetics
Neoplasm Proteins/*genetics
Pancreas/*metabolism
Unfolded Protein Response/*genetics
Acinar Cells/metabolism ; Acinar Cells/ultrastructure ; Animals ; Blotting, Western ; Cell Line, Tumor ; DNA-Binding Proteins/metabolism ; Eukaryotic Initiation Factor-2/metabolism ; Humans ; Mice, Knockout ; Microscopy, Electron, Transmission ; Neoplasm Proteins/metabolism ; Pancreas/cytology ; Pancreas/ultrastructure ; Protein Binding ; Reverse Transcriptase Polymerase Chain Reaction ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Jazf1 acts as a regulator of insulin-producing β-cell differentiation in induced pluripotent stem cells and glucose homeostasis in mice.
Autorzy:
Park SJ; School of Life Science, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea.; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu, Korea.
Kwon W; School of Life Science, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea.; Division of Biotechnology, DGIST, Daegu, Korea.
Park S; Core Protein Resources Center, DGIST, Daegu, Korea.; Department of Brain and Cognitive Sciences, DGIST, Daegu, Korea.
Jeong J; Core Protein Resources Center, DGIST, Daegu, Korea.; Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Kim D; School of Life Science, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea.
Jang S; School of Life Science, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea.
Kim SY; School of Life Science, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea.
Sung Y; Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea.
Kim MO; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju, Korea.
Choi SK; Division of Biotechnology, DGIST, Daegu, Korea.; Core Protein Resources Center, DGIST, Daegu, Korea.
Ryoo ZY; School of Life Science, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea.
Pokaż więcej
Źródło:
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (14), pp. 4412-4427. Date of Electronic Publication: 2021 Apr 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Differentiation*
Homeostasis*
Co-Repressor Proteins/*physiology
DNA-Binding Proteins/*physiology
Glucose/*metabolism
Induced Pluripotent Stem Cells/*cytology
Insulin/*metabolism
Insulin-Secreting Cells/*cytology
Animals ; Cells, Cultured ; Female ; Induced Pluripotent Stem Cells/metabolism ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Organogenesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice.
Autorzy:
Hains DS; Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.
Polley S; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Liang D; Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.
Saxena V; Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.
Arregui S; Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.
Ketz J; The Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Barr-Beare E; Brown University, Providence, Rhode Island, USA.
Rawson A; Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.
Spencer JD; The Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Cohen A; The Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Hansen PL; Lundbeckfonden Center of Excellence NanoCAN, University of Southern Denmark, Odense, Denmark.; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Tuttolomondo M; Lundbeckfonden Center of Excellence NanoCAN, University of Southern Denmark, Odense, Denmark.; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Casella C; Lundbeckfonden Center of Excellence NanoCAN, University of Southern Denmark, Odense, Denmark.; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Ditzel HJ; Lundbeckfonden Center of Excellence NanoCAN, University of Southern Denmark, Odense, Denmark.; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Oncology, Odense University Hospital, Odense, Denmark.
Cohen D; Emergency Department, Nationwide Children's Hospital, Columbus, Ohio, USA.
Hollox EJ; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Schwaderer AL; Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.
Pokaż więcej
Źródło:
Clinical and translational medicine [Clin Transl Med] 2021 Jul; Vol. 11 (7), pp. e477.
Typ publikacji:
Letter; Research Support, N.I.H., Extramural
MeSH Terms:
Calcium-Binding Proteins/*genetics
DNA-Binding Proteins/*genetics
Tumor Suppressor Proteins/*genetics
Urinary Tract Infections/*pathology
Animals ; Anti-Bacterial Agents/therapeutic use ; Calcium-Binding Proteins/deficiency ; Case-Control Studies ; Child ; DNA Copy Number Variations ; DNA-Binding Proteins/deficiency ; Disease Models, Animal ; Genetic Predisposition to Disease ; Humans ; Mice ; Mice, Knockout ; Risk Factors ; Tumor Suppressor Proteins/deficiency ; Urinary Tract/metabolism ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/genetics
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors.
Autorzy:
Gao Y; Department of Biochemistry and Molecular Biology, College of Natural Science, Michigan State University, East Lansing, MI, USA.
Duque-Wilckens N; Department of Physiology, College of Natural Science, Michigan State University, East Lansing, MI, USA.
Aljazi MB; Department of Biochemistry and Molecular Biology, College of Natural Science, Michigan State University, East Lansing, MI, USA.
Wu Y; Department of Biochemistry and Molecular Biology, College of Natural Science, Michigan State University, East Lansing, MI, USA.
Moeser AJ; Department of Physiology, College of Natural Science, Michigan State University, East Lansing, MI, USA.; Gastrointestinal Stress Biology Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, East Lansing, MI, USA.
Mias GI; Department of Biochemistry and Molecular Biology, College of Natural Science, Michigan State University, East Lansing, MI, USA.; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.
Robison AJ; Department of Physiology, College of Natural Science, Michigan State University, East Lansing, MI, USA.
He J; Department of Biochemistry and Molecular Biology, College of Natural Science, Michigan State University, East Lansing, MI, USA. .
Pokaż więcej
Źródło:
Communications biology [Commun Biol] 2021 Jun 18; Vol. 4 (1), pp. 756. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Autism Spectrum Disorder/*genetics
Brain/*growth & development
Brain/*metabolism
DNA-Binding Proteins/*genetics
Histone-Lysine N-Methyltransferase/*genetics
Intellectual Disability/*genetics
Animals ; Autism Spectrum Disorder/metabolism ; Disease Models, Animal ; Embryonic Development/genetics ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Analysis of the role of Purα in the pathogenesis of Alzheimer's disease based on RNA-seq and ChIP-seq.
Autorzy:
Shi X; Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Ren S; Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Zhang B; Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Guo S; Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
He W; Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Yuan C; Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Yang X; Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China.
Ig-Lzevbekhai K; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sun T; Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Wang Q; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang, China. .
Cui J; Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Jun 09; Vol. 11 (1), pp. 12178. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*pathology
Chromatin Immunoprecipitation Sequencing/*methods
DNA-Binding Proteins/*metabolism
Hippocampus/*pathology
Nerve Tissue Proteins/*metabolism
Neurons/*pathology
RNA-Seq/*methods
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Animals ; DNA-Binding Proteins/genetics ; Hippocampus/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Tissue Proteins/genetics ; Neurons/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death.
Autorzy:
Foster AD; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.; Harry Perkins Institute of Medical Research, University of Western Australia, Crawley, WA, Australia.
Flynn LL; Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Nedlands, WA, 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Health Research Building, Discovery Way, Murdoch, WA, 6150, Australia.
Cluning C; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Cheng F; Department of Biomedical Sciences, Macquarie University, Sydney, Australia.
Davidson JM; Department of Biomedical Sciences, Macquarie University, Sydney, Australia.
Lee A; Department of Biomedical Sciences, Macquarie University, Sydney, Australia.
Polain N; Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Nedlands, WA, 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Health Research Building, Discovery Way, Murdoch, WA, 6150, Australia.
Mejzini R; Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Nedlands, WA, 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Health Research Building, Discovery Way, Murdoch, WA, 6150, Australia.
Farrawell N; School of Biological Sciences, University of Wollongong, Wollongong, 2522, Australia.
Yerbury JJ; School of Biological Sciences, University of Wollongong, Wollongong, 2522, Australia.
Layfield R; School of Life Sciences, University of Nottingham, Nottingham, UK.
Akkari PA; Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Nedlands, WA, 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Health Research Building, Discovery Way, Murdoch, WA, 6150, Australia.
Rea SL; Harry Perkins Institute of Medical Research, University of Western Australia, Crawley, WA, Australia. .; Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Nedlands, WA, 6009, Australia. .; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Health Research Building, Discovery Way, Murdoch, WA, 6150, Australia. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Jun 01; Vol. 11 (1), pp. 11474. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Protein Aggregates*
Proteolysis*
DNA-Binding Proteins/*metabolism
Neurons/*metabolism
Sequestosome-1 Protein/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Cell Death ; Cell Line ; DNA-Binding Proteins/genetics ; Frontotemporal Lobar Degeneration/genetics ; Frontotemporal Lobar Degeneration/metabolism ; Mice ; Mice, Knockout ; Sequestosome-1 Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 498

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies