Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Mice, Mutant Strains"" wg kryterium: Temat


Tytuł :
Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice.
Autorzy :
Arimitsu N; Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
Mizukami Y; Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
Shimizu J; Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
Takai K; Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
Suzuki T; Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
Suzuki N; Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan. Electronic address: .
Pokaż więcej
Źródło :
Molecular and cellular neurosciences [Mol Cell Neurosci] 2021 Apr; Vol. 112, pp. 103614. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Adhesion Molecules, Neuronal/*physiology
Extracellular Matrix Proteins/*physiology
Hippocampus/*abnormalities
Mice, Mutant Strains/*abnormalities
Nerve Tissue Proteins/*physiology
Serine Endopeptidases/*physiology
Signal Transduction/*physiology
Animals ; Cell Adhesion Molecules, Neuronal/deficiency ; Cell Movement ; Enzyme Activation ; Extracellular Matrix Proteins/deficiency ; Genes, Recessive ; Hippocampus/embryology ; Hippocampus/metabolism ; Hippocampus/pathology ; Homozygote ; Mice ; Mice, Mutant Strains/genetics ; Mice, Mutant Strains/metabolism ; Nerve Tissue Proteins/biosynthesis ; Nerve Tissue Proteins/deficiency ; Nerve Tissue Proteins/genetics ; Neural Cell Adhesion Molecules/biosynthesis ; Neural Cell Adhesion Molecules/genetics ; Phenotype ; Phosphorylation ; Protein Processing, Post-Translational ; Proto-Oncogene Proteins c-akt/metabolism ; Serine Endopeptidases/deficiency ; Synapses/metabolism ; Transcription Factors/biosynthesis ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Modulation of tactile feedback for the execution of dexterous movement.
Autorzy :
Conner JM; Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Bohannon A; Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Igarashi M; Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Taniguchi J; Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Baltar N; Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Azim E; Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2021 Oct 15; Vol. 374 (6565), pp. 316-323. Date of Electronic Publication: 2021 Oct 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Feedback, Sensory*
Motor Skills/*physiology
Touch/*physiology
Animals ; Brain Stem/cytology ; Brain Stem/physiology ; Female ; Male ; Mice ; Mice, Mutant Strains ; Movement ; Neural Inhibition ; Optogenetics ; Somatosensory Cortex/physiology ; Vesicular Inhibitory Amino Acid Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
Autorzy :
Chen X; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Zhang Y; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Ren X; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Su Q; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Liu Y; School of Life Sciences & Research Center for Peptide Drugs, Yan'an University, Yan'an, Shaanxi, China.
Dang X; College of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an, Shaanxi, China.
Qin Y; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Yang X; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Xing Z; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Shen Y; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Wang Y; College of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an, Shaanxi, China.
Bai Z; School of Life Sciences & Research Center for Peptide Drugs, Yan'an University, Yan'an, Shaanxi, China.
Yeh ETH; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Wu H; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China. Electronic address: .
Qi Y; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China. Electronic address: .
Pokaż więcej
Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101183. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Second Messenger Systems*
Sumoylation*
Cysteine Endopeptidases/*metabolism
KCNQ2 Potassium Channel/*metabolism
KCNQ3 Potassium Channel/*metabolism
Amino Acid Motifs ; Animals ; Brain/metabolism ; Cysteine Endopeptidases/genetics ; KCNQ2 Potassium Channel/genetics ; KCNQ3 Potassium Channel/genetics ; Mice ; Mice, Mutant Strains ; Myocardium/metabolism ; Seizures/genetics ; Seizures/metabolism ; Ubiquitin-Activating Enzymes/genetics ; Ubiquitin-Activating Enzymes/metabolism
Czasopismo naukowe
Tytuł :
Tomato Bushy Stunt Virus Nanoparticles as a Platform for Drug Delivery to Shh-Dependent Medulloblastoma.
Autorzy :
Lico C; Laboratory of Biotechnology, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Tanno B; Laboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Marchetti L; Laboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Novelli F; Laboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Giardullo P; Laboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Arcangeli C; Laboratory of Health and Environment, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Pazzaglia S; Laboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Podda MS; Laboratory of Health and Environment, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Santi L; Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, Via S. Camillo De Lellis, 01100 Viterbo, Italy.
Bernini R; Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, Via S. Camillo De Lellis, 01100 Viterbo, Italy.
Baschieri S; Laboratory of Biotechnology, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Mancuso M; Laboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 29; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cerebellar Neoplasms*/drug therapy
Cerebellar Neoplasms*/genetics
Cerebellar Neoplasms*/metabolism
Cerebellar Neoplasms*/pathology
Doxorubicin*/chemistry
Doxorubicin*/pharmacology
Drug Delivery Systems*
Medulloblastoma*/drug therapy
Medulloblastoma*/genetics
Medulloblastoma*/metabolism
Medulloblastoma*/pathology
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Hedgehog Proteins/*metabolism
Neoplasm Proteins/*metabolism
Tombusvirus/*chemistry
Animals ; Hedgehog Proteins/genetics ; Mice ; Mice, Mutant Strains ; Neoplasm Proteins/genetics ; Tobacco/virology
Czasopismo naukowe
Tytuł :
Microplasma Treatment versus Negative Pressure Therapy for Promoting Wound Healing in Diabetic Mice.
Autorzy :
Shao PL; Department of Nursing, Asia University, Taichung 41354, Taiwan.
Liao JD; Engineered Materials for Biomedical Applications Laboratory, Department of Materials Science and Engineering, National Cheng Kung University, Tainan 70101, Taiwan.; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan 70101, Taiwan.
Wu SC; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Chen YH; Engineered Materials for Biomedical Applications Laboratory, Department of Materials Science and Engineering, National Cheng Kung University, Tainan 70101, Taiwan.
Wong TW; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.; Department of Biochemistry and Molecular Biology, College of Medicine, Center of Applied Nanomedicine, National Cheng Kung University, Tainan 70101, Taiwan.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 24; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*complications
Diabetes Mellitus, Experimental/*therapy
Negative-Pressure Wound Therapy/*methods
Plasma Gases/*therapeutic use
Skin/*injuries
Wound Healing/*physiology
Animals ; Desmoglein 1/metabolism ; In Vitro Techniques ; Ki-67 Antigen/metabolism ; Male ; Mice ; Mice, Mutant Strains ; Nitric Oxide/metabolism ; Plasma Skin Regeneration/methods ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Re-Epithelialization/physiology ; Regional Blood Flow/physiology ; Signal Transduction ; Skin/pathology ; Skin/physiopathology ; Smad Proteins/genetics ; Smad Proteins/metabolism ; Transforming Growth Factor beta/metabolism ; Wound Healing/genetics
Czasopismo naukowe
Tytuł :
Diverse inhibitory projections from the cerebellar interposed nucleus.
Autorzy :
Judd EN; Department of Physiology and Biophysics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, United States.
Lewis SM; Department of Physiology and Biophysics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, United States.
Person AL; Department of Physiology and Biophysics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, United States.
Pokaż więcej
Źródło :
ELife [Elife] 2021 Sep 20; Vol. 10. Date of Electronic Publication: 2021 Sep 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain Mapping/*methods
Cerebellar Nuclei/*physiology
Neurons/*physiology
Animals ; Cell Tracking/methods ; Female ; Male ; Mice ; Mice, Mutant Strains ; Neural Pathways/physiology ; Synapses/physiology
Czasopismo naukowe
Tytuł :
A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes.
Autorzy :
Segawa K; Laboratory of Biochemistry and Immunology, World Premier International Research Center, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Kikuchi A; Department of Pediatrics, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
Noji T; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Sugiura Y; Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan.
Hiraga K; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Suzuki C; Department of Cellular and Molecular Pharmacology and.; Department of Cellular and Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Haginoya K; Department of Pediatric Neurology, Takuto Rehabilitation Center for Children, Sendai, Miyagi, Japan.; Department of Pediatric Neurology, Miyagi Children's Hospital, Sendai, Miyagi, Japan.
Kobayashi Y; Department of Pediatric Neurology, Takuto Rehabilitation Center for Children, Sendai, Miyagi, Japan.; Department of Pediatrics, National Hospital Organization Sendai-Nishitaga Hospital, Sendai, Miyagi, Japan.
Matsunaga M; Laboratory of Biochemistry and Immunology, World Premier International Research Center, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Ochiai Y; Laboratory of Biochemistry and Immunology, World Premier International Research Center, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Yamada K; Laboratory of Biochemistry and Immunology, World Premier International Research Center, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Nishimura T; Laboratory of Biochemistry and Immunology, World Premier International Research Center, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Iwasawa S; Department of Pediatrics, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
Shoji W; Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Miyagi, Japan.
Sugihara F; Central Instrumentation Laboratory, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Nishino K; Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima, Japan.
Kosako H; Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima, Japan.
Ikawa M; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Uchiyama Y; Department of Cellular and Molecular Pharmacology and.; Department of Cellular and Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Suematsu M; Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan.
Ishikita H; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Kure S; Department of Pediatrics, Tohoku University School of Medicine, Sendai, Miyagi, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Nagata S; Laboratory of Biochemistry and Immunology, World Premier International Research Center, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.
Pokaż więcej
Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Sep 15; Vol. 131 (18).
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Point Mutation*
ATP Binding Cassette Transporter 1/*genetics
ATP-Binding Cassette Transporters/*genetics
ATP-Binding Cassette Transporters/*metabolism
Neurodegenerative Diseases/*genetics
Neurodegenerative Diseases/*metabolism
Phosphatidylcholines/*metabolism
ATP Binding Cassette Transporter 1/deficiency ; ATP Binding Cassette Transporter 1/metabolism ; ATP-Binding Cassette Transporters/chemistry ; Adult ; Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Brain/diagnostic imaging ; Cell Membrane/metabolism ; Female ; Genes, Lethal ; Heterozygote ; Humans ; Male ; Membrane Lipids/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Mutant Strains ; Molecular Dynamics Simulation ; Neurodegenerative Diseases/diagnostic imaging ; Phospholipid Transfer Proteins/genetics ; Phospholipid Transfer Proteins/metabolism ; Pregnancy
Czasopismo naukowe
Tytuł :
Resident cardiac macrophages mediate adaptive myocardial remodeling.
Autorzy :
Wong NR; Departmental of Medicine, Washington University School of Medicine.
Mohan J; Departmental of Medicine, Washington University School of Medicine.
Kopecky BJ; Departmental of Medicine, Washington University School of Medicine.
Guo S; Departmental of Medicine, Washington University School of Medicine.
Du L; Department of Anesthesiology, Washington University School of Medicine.
Leid J; Departmental of Medicine, Washington University School of Medicine.
Feng G; Departmental of Medicine, Washington University School of Medicine.
Lokshina I; Departmental of Medicine, Washington University School of Medicine.
Dmytrenko O; Departmental of Medicine, Washington University School of Medicine.
Luehmann H; Department of Radiology, Washington University School of Medicine.
Bajpai G; Departmental of Medicine, Washington University School of Medicine.
Ewald L; Departmental of Medicine, Washington University School of Medicine.
Bell L; Departmental of Medicine, Washington University School of Medicine.
Patel N; Departmental of Genetics, Washington University School of Medicine.
Bredemeyer A; Departmental of Medicine, Washington University School of Medicine.
Weinheimer CJ; Departmental of Medicine, Washington University School of Medicine.
Nigro JM; Departmental of Medicine, Washington University School of Medicine.
Kovacs A; Departmental of Medicine, Washington University School of Medicine.
Morimoto S; Department of Physical Therapy, International University of Health and Welfare, Japan.
Bayguinov PO; Department of Biochemistry, Washington University School of Medicine.
Fisher MR; Department of Biochemistry, Washington University School of Medicine.
Stump WT; Department of Biochemistry, Washington University School of Medicine.
Greenberg M; Department of Biochemistry, Washington University School of Medicine.
Fitzpatrick JAJ; Washington University Center for Cellular Imaging, Washington University School of Medicine; Departments of Neuroscience, Cell Biology & Physiology, and Biomedical Engineering, Washington University School of Medicine.
Epelman S; Toronto General Hospital Research Institute, University Health Network.
Kreisel D; Department of Pathology and Immunology, Washington University School of Medicine; Department of Surgery, Washington University School of Medicine.
Sah R; Departmental of Medicine, Washington University School of Medicine.
Liu Y; Department of Radiology, Washington University School of Medicine.
Hu H; Department of Anesthesiology, Washington University School of Medicine.
Lavine KJ; Departmental of Medicine, Washington University School of Medicine; Department of Pathology and Immunology, Washington University School of Medicine; Department of Developmental Biology, Washington University School of Medicine. Electronic address: .
Pokaż więcej
Źródło :
Immunity [Immunity] 2021 Sep 14; Vol. 54 (9), pp. 2072-2088.e7. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiomyopathy, Dilated/*metabolism
Macrophage Activation/*physiology
Macrophages/*metabolism
Ventricular Remodeling/*physiology
Animals ; Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/pathology ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mutation ; Myocardium/metabolism ; Troponin T/genetics
Czasopismo naukowe
Tytuł :
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.
Autorzy :
Maurano M; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA; Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA 98195, USA; Molecular and Cellular Biology Graduate Program, University of Washington School of Medicine, Seattle, WA 98195, USA.
Snyder JM; Department of Comparative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
Connelly C; Calico Life Sciences LLC, South San Francisco, CA 94080, USA.
Henao-Mejia J; Department of Pathology and Laboratory Medicine, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Sidrauski C; Calico Life Sciences LLC, South San Francisco, CA 94080, USA.
Stetson DB; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address: .
Pokaż więcej
Źródło :
Immunity [Immunity] 2021 Sep 14; Vol. 54 (9), pp. 1948-1960.e5. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Deaminase/*metabolism
Autoimmune Diseases of the Nervous System/*pathology
Nervous System Malformations/*pathology
Stress, Physiological/*physiology
eIF-2 Kinase/*metabolism
A549 Cells ; Animals ; Autoimmune Diseases of the Nervous System/genetics ; Autoimmune Diseases of the Nervous System/metabolism ; Disease Models, Animal ; HEK293 Cells ; Humans ; Mice ; Mice, Mutant Strains ; Mutation ; Nervous System Malformations/genetics ; Nervous System Malformations/metabolism
SCR Disease Name :
Aicardi-Goutieres syndrome
Czasopismo naukowe
Tytuł :
Marginating transitional B cells modulate neutrophils in the lung during inflammation and pneumonia.
Autorzy :
Podstawka J; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Sinha S; Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Hiroki CH; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Sarden N; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Granton E; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Labit E; Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Kim JH; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Andonegui G; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Lou Y; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Snarr BD; Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
Sheppard DC; Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.; Division of Infectious Diseases, McGill University Health Centre, Montreal, Quebec, Canada.; Department of Medical Microbiology, McGill University Health Centre, Montreal, Quebec, Canada.
Rosin NL; Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Biernaskie J; Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Yipp BG; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Pokaż więcej
Źródło :
The Journal of experimental medicine [J Exp Med] 2021 Sep 06; Vol. 218 (9). Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
B-Lymphocytes/*pathology
Lung/*pathology
Neutrophils/*pathology
Pneumonia/*pathology
Animals ; Aspergillosis/microbiology ; Aspergillosis/pathology ; B-Lymphocytes/physiology ; Capillaries/pathology ; Cell Adhesion ; Chemokine CXCL13/metabolism ; Integrin alpha5/metabolism ; Intravital Microscopy ; Lipoxins/metabolism ; Lung/blood supply ; Lung/diagnostic imaging ; Mice, Mutant Strains ; Pneumonia/diagnostic imaging ; Receptors, CXCR5/metabolism ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation.
Autorzy :
Li S; Department of Oncology of the First Affiliated Hospital, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Wang L; Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Xu Z; Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Huang Y; Department of Oncology of the First Affiliated Hospital, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xue R; Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yue T; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xu L; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Gong F; Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Bai S; Department of Oncology of the First Affiliated Hospital, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Wu Q; Department of Oncology of the First Affiliated Hospital, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Liu J; Department of Oncology of the First Affiliated Hospital, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Lin B; Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Zhang H; Department of Oncology of the First Affiliated Hospital, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xue Y; Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Xu P; Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Hou J; Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yang X; College of Biomedical Engineering, South-Central University for Nationalities, Wuhan, China.
Jin T; Department of Oncology of the First Affiliated Hospital, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Zhou R; Department of Oncology of the First Affiliated Hospital, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Lou J; Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Xu T; Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Bai L; Department of Oncology of the First Affiliated Hospital, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Pokaż więcej
Źródło :
The Journal of experimental medicine [J Exp Med] 2021 Sep 06; Vol. 218 (9). Date of Electronic Publication: 2021 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CARD Signaling Adaptor Proteins/*metabolism
Carrier Proteins/*metabolism
Glutathione Transferase/*metabolism
Inflammasomes/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Animals ; CARD Signaling Adaptor Proteins/genetics ; Carrier Proteins/genetics ; Endoplasmic Reticulum/metabolism ; Glutathione Transferase/genetics ; Macrophages/metabolism ; Macrophages/pathology ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Reactive Oxygen Species/metabolism ; Triglycerides/metabolism
Czasopismo naukowe
Tytuł :
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
Autorzy :
Fukuda K; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA.; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Okamura K; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA.
Riding RL; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA.
Fan X; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA.
Afshari K; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA.
Haddadi NS; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA.
McCauley SM; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA.
Guney MH; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA.
Luban J; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA.
Funakoshi T; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Yaguchi T; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Kawakami Y; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Khvorova A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA.; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA.
Fitzgerald KA; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA.
Harris JE; Department of Dermatology, University of Massachusetts Medical School, Worcester, MA.
Pokaż więcej
Źródło :
The Journal of experimental medicine [J Exp Med] 2021 Sep 06; Vol. 218 (9). Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cancer Vaccines/*immunology
DNA-Binding Proteins/*immunology
Melanoma/*pathology
Melanoma, Experimental/*immunology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Cancer Vaccines/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Dendritic Cells/immunology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Melanoma/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mice, Transgenic ; Middle Aged ; Tumor Microenvironment/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy.
Autorzy :
Spaulding EL; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 04469, USA.
Hines TJ; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Bais P; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Tadenev ALD; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Schneider R; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Jewett D; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Pattavina B; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Pratt SL; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Neuroscience Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Morelli KH; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 04469, USA.
Stum MG; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Hill DP; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Gobet C; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Pipis M; MRC Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
Reilly MM; MRC Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
Jennings MJ; Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Horvath R; Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Bai Y; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Shy ME; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Alvarez-Castelao B; Max Planck Institute for Brain Research, Frankfurt, Germany.
Schuman EM; Max Planck Institute for Brain Research, Frankfurt, Germany.
Bogdanik LP; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Storkebaum E; Department of Molecular Neurobiology, Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands.
Burgess RW; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 04469, USA.; Neuroscience Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2021 Sep 03; Vol. 373 (6559), pp. 1156-1161. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Stress, Physiological*/drug effects
Stress, Physiological*/genetics
Stress, Physiological*/physiology
Charcot-Marie-Tooth Disease/*metabolism
Glycine-tRNA Ligase/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Tyrosine-tRNA Ligase/*metabolism
Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Animals ; Charcot-Marie-Tooth Disease/genetics ; Charcot-Marie-Tooth Disease/physiopathology ; Disease Models, Animal ; Female ; Gene Deletion ; Genes, Dominant ; Glycine-tRNA Ligase/genetics ; Male ; Mice ; Mice, Mutant Strains ; Motor Neurons/physiology ; Protein Biosynthesis ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/genetics ; Spinal Cord/physiopathology ; Transcriptome ; Tyrosine-tRNA Ligase/genetics
Czasopismo naukowe
Tytuł :
Improving Right Ventricular Function by Increasing BMP Signaling with FK506.
Autorzy :
Boehm M; Division of Pulmonary and Critical Care Medicine, Department of Medicine.; Vera Moulton Wall Center for Pulmonary Vascular Disease.; Cardio-Pulmonary Institute, Justus-Liebig-University Giessen, German Center for Lung Research (DZL), Giessen, Germany.
Tian X; Division of Pulmonary and Critical Care Medicine, Department of Medicine.; Vera Moulton Wall Center for Pulmonary Vascular Disease.
Ali MK; Division of Pulmonary and Critical Care Medicine, Department of Medicine.; Vera Moulton Wall Center for Pulmonary Vascular Disease.
Mao Y; Division of Pulmonary and Critical Care Medicine, Department of Medicine.; Vera Moulton Wall Center for Pulmonary Vascular Disease.
Ichimura K; Division of Pulmonary and Critical Care Medicine, Department of Medicine.; Vera Moulton Wall Center for Pulmonary Vascular Disease.
Zhao M; Division of Cardiology, Department of Pediatrics.; Cardiovascular Institute, and.
Kuramoto K; Division of Pulmonary and Critical Care Medicine, Department of Medicine.; Vera Moulton Wall Center for Pulmonary Vascular Disease.
Dannewitz Prosseda S; Division of Pulmonary and Critical Care Medicine, Department of Medicine.; Vera Moulton Wall Center for Pulmonary Vascular Disease.
Fajardo G; Division of Cardiology, Department of Pediatrics.; Cardiovascular Institute, and.
Dufva MJ; Department of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado; and.; Department of Pediatrics, Section of Cardiology, Children's Hospital Colorado, Anschutz Medical Campus, Aurora, Colorado.
Qin X; Cardiovascular Institute, and.; Department of Cardiovascular Medicine, Stanford University, Stanford, California.
Kheyfets VO; Department of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado; and.; Department of Pediatrics, Section of Cardiology, Children's Hospital Colorado, Anschutz Medical Campus, Aurora, Colorado.
Bernstein D; Division of Cardiology, Department of Pediatrics.; Cardiovascular Institute, and.
Reddy S; Division of Cardiology, Department of Pediatrics.; Cardiovascular Institute, and.
Metzger RJ; Vera Moulton Wall Center for Pulmonary Vascular Disease.; Division of Cardiology, Department of Pediatrics.; Cardiovascular Institute, and.
Zamanian RT; Division of Pulmonary and Critical Care Medicine, Department of Medicine.; Vera Moulton Wall Center for Pulmonary Vascular Disease.; Cardiovascular Institute, and.
Haddad F; Cardiovascular Institute, and.; Department of Cardiovascular Medicine, Stanford University, Stanford, California.
Spiekerkoetter E; Division of Pulmonary and Critical Care Medicine, Department of Medicine.; Vera Moulton Wall Center for Pulmonary Vascular Disease.; Cardiovascular Institute, and.
Pokaż więcej
Źródło :
American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2021 Sep; Vol. 65 (3), pp. 272-287.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Bone Morphogenetic Protein Receptors, Type II/*metabolism
Bone Morphogenetic Proteins/*metabolism
Pulmonary Arterial Hypertension/*metabolism
Signal Transduction/*drug effects
Tacrolimus/*pharmacology
Ventricular Function, Right/*drug effects
Animals ; Bone Morphogenetic Protein Receptors, Type II/genetics ; Bone Morphogenetic Proteins/genetics ; Fibroblasts/metabolism ; Fibrosis ; Humans ; Male ; Mice ; Mice, Mutant Strains ; Myocardium/metabolism ; Pulmonary Arterial Hypertension/drug therapy ; Pulmonary Arterial Hypertension/genetics ; Signal Transduction/genetics ; Ventricular Function, Right/genetics
Czasopismo naukowe
Tytuł :
Neutrophil elastase-regulated macrophage sheddome/secretome and phagocytic failure.
Autorzy :
Ma J; Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.
Kummarapurugu AB; Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.
Hawkridge A; Department of Pharmaceutics/Department of Pharmacotherapy & Outcomes Science, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia.
Ghosh S; Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Zheng S; Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.
Voynow JA; Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.
Pokaż więcej
Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 Sep 01; Vol. 321 (3), pp. L555-L565. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phagocytosis*
Leukocyte Elastase/*metabolism
Lysosomes/*metabolism
Macrophages/*metabolism
Phagosomes/*metabolism
Adolescent ; Adult ; Animals ; Child ; Child, Preschool ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Female ; Humans ; Leukocyte Elastase/genetics ; Lysosomes/genetics ; Lysosomes/pathology ; Macrophages/physiology ; Male ; Mice ; Mice, Mutant Strains ; Phagosomes/genetics ; Phagosomes/pathology ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice.
Autorzy :
Caliz AD; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Yoo HJ; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Vertii A; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Dolan AC; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Tournier C; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Davis RJ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Keaney JF Jr; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Kant S; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 29; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cytokines/*metabolism
MAP Kinase Kinase 7/*metabolism
Animals ; Cell Movement ; Cells, Cultured ; Inflammation/metabolism ; Lipopolysaccharides/pharmacology ; MAP Kinase Kinase 4/genetics ; MAP Kinase Kinase 4/metabolism ; MAP Kinase Kinase 7/genetics ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/physiology ; Macrophages/drug effects ; Macrophages/physiology ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
ZFP36L2 Role in Thyroid Functionality.
Autorzy :
Albano F; IEOS-CNR, 80131 Naples, Italy.; Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Tucci V; Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy.
Blackshear PJ; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.; Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Reale C; Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Roberto L; Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Russo F; Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Marotta P; Stazione Zoologica Anton Dohrn, 80121 Napoli, Italy.
Porreca I; Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.
Colella M; Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.; Department of Science and Technology, University of Sannio, 82100 Benevento, Italy.
Mallardo M; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy.
de Felice M; IEOS-CNR, 80131 Naples, Italy.; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy.
Ambrosino C; Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy.; Department of Science and Technology, University of Sannio, 82100 Benevento, Italy.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 29; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 29.
Typ publikacji :
Journal Article
MeSH Terms :
Thyroid Gland/*physiology
Tristetraprolin/*physiology
Animals ; Apoptosis/physiology ; Cell Line ; Cell Survival ; Female ; Gene Deletion ; Gene Expression Regulation ; Mice, Inbred C57BL ; Mice, Mutant Strains ; PAX8 Transcription Factor/genetics ; Rats ; Receptor, Notch1/metabolism ; Thyroid Gland/cytology ; Thyroid Gland/drug effects ; Thyrotropin/pharmacology ; Tristetraprolin/genetics
Czasopismo naukowe
Tytuł :
The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals.
Autorzy :
Torrillas de la Cal A; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos, 45071 Toledo, Spain.
Paniagua-Torija B; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos, 45071 Toledo, Spain.
Arevalo-Martin A; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos, 45071 Toledo, Spain.
Faulkes CG; School of Biological & Chemical Sciences, Queen Mary University of London, London E1 4NS, UK.
Jiménez AJ; Departamento de Biología Celular, Genética y Fisiología, Universidad de Málaga, Campus de Teatinos, 29071 Malaga, Spain.; Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Malaga, Spain.
Ferrer I; Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, 08908 L'Hospitalet de Llobregat, Spain.
Molina-Holgado E; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos, 45071 Toledo, Spain.
Garcia-Ovejero D; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos, 45071 Toledo, Spain.
Pokaż więcej
Źródło :
Cells [Cells] 2021 Aug 28; Vol. 10 (9). Date of Electronic Publication: 2021 Aug 28.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ependyma/*cytology
Spinal Cord/*cytology
Adolescent ; Adult ; Animals ; Biomarkers/metabolism ; Cell Proliferation ; Ependyma/metabolism ; Female ; Humans ; Macaca mulatta ; Male ; Mice, Mutant Strains ; Middle Aged ; Mole Rats ; Pan troglodytes ; Point Mutation ; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins/genetics ; Species Specificity ; Spinal Canal/cytology ; Spinal Canal/metabolism ; Spinal Cord/metabolism ; Spinal Cord Injuries/metabolism ; Spinal Cord Injuries/pathology ; Young Adult
Czasopismo naukowe
Tytuł :
Notch1 haploinsufficiency in mice accelerates adipogenesis.
Autorzy :
Yamaguchi K; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hayashi M; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Uchida Y; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Cheng XW; Department of Cardiology/Hypertension and Heart Center, Yanbian University Hospital, Yanji, Jilin, China.; Department of Community Health and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nakayama T; Department of Blood Transfusion, Aichi Medical University Hospital, Nagakute, Japan.
Matsushita T; Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan.; Department of Blood Transfusion, Nagoya University Hospital, Nagoya, Japan.
Murohara T; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takeshita K; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. .; Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan. .; Department of Clinical Laboratory, Saitama Medical Centre, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, Japan. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2021 Aug 18; Vol. 11 (1), pp. 16761. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipogenesis*
Cell Proliferation*
Haploinsufficiency*
Signal Transduction*
Adipose Tissue, White/*metabolism
Receptor, Notch1/*metabolism
3T3-L1 Cells ; Animals ; Diet, High-Fat ; Mice ; Mice, Mutant Strains ; Receptor, Notch1/genetics
Czasopismo naukowe
Tytuł :
Cation leak underlies neuronal excitability in an HCN1 developmental and epileptic encephalopathy.
Autorzy :
Bleakley LE; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
McKenzie CE; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Soh MS; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Forster IC; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Pinares-Garcia P; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Sedo A; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Kathirvel A; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Churilov L; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.; Melbourne Medical School, University of Melbourne, Parkville, Victoria 3010, Australia.
Jancovski N; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Maljevic S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Berkovic SF; Department of Medicine, Epilepsy Research Centre, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia.
Scheffer IE; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.; Department of Medicine, Epilepsy Research Centre, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia.; Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Victoria 3052, Australia.
Petrou S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Santoro B; Department of Neuroscience, The Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Reid CA; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.; Department of Medicine, Epilepsy Research Centre, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia.
Pokaż więcej
Źródło :
Brain : a journal of neurology [Brain] 2021 Aug 17; Vol. 144 (7), pp. 2060-2073.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Brain Diseases/*metabolism
Epilepsy/*metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
Neurons/*metabolism
Potassium Channels/*metabolism
Animals ; Brain Diseases/genetics ; Epilepsy/genetics ; Female ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Male ; Mice ; Mice, Mutant Strains ; Mutation ; Neurons/pathology ; Potassium Channels/genetics ; Pyramidal Cells/metabolism ; Xenopus laevis
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies