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Wyświetlanie 41-60 z 2283
Tytuł:
Functional Dysregulations in CA1 Hippocampal Networks of a 3-Hit Mouse Model of Schizophrenia.
Autorzy:
Percelay S; UNICAEN, INSERM, COMETE, CYCERON, CHU Caen, Normandie Université, 14000 Caen, France.
Billard JM; UNICAEN, INSERM, COMETE, CYCERON, CHU Caen, Normandie Université, 14000 Caen, France.
Freret T; UNICAEN, INSERM, COMETE, CYCERON, CHU Caen, Normandie Université, 14000 Caen, France.
Andrieux A; Inserm U1216, CEA, Grenoble Institut Neurosciences, Université Grenoble Alpes, 38000 Grenoble, France.
Boulouard M; UNICAEN, INSERM, COMETE, CYCERON, CHU Caen, Normandie Université, 14000 Caen, France.
Bouet V; UNICAEN, INSERM, COMETE, CYCERON, CHU Caen, Normandie Université, 14000 Caen, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 05; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
Long-Term Potentiation*
Synaptic Transmission*
Theta Rhythm*
CA1 Region, Hippocampal/*physiopathology
Schizophrenia/*physiopathology
Animals ; CA1 Region, Hippocampal/pathology ; Disease Models, Animal ; Humans ; Mice ; Mice, Mutant Strains ; Schizophrenia/genetics ; Schizophrenia/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.
Autorzy:
Song Y; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Shan L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. .; Department of Medicine, Pathology and Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.
Gbyli R; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Liu W; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Strowig T; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Helmholtz Centre for Infection Research, Braunschweig, Germany.
Patel A; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Fu X; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Shenzhen Children's Hospital, Shenzhen, People's Republic of China.
Wang X; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Hematology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Xu ML; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Gao Y; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Qin A; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Bruscia EM; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Tebaldi T; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
Biancon G; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Mamillapalli P; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Urbonas D; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Eynon E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Gonzalez DG; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Chen J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Krause DS; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
Alderman J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Halene S; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA. .; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. .; Howard Hughes Medical Institute, Yale University, New Haven, CT, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Mar 05; Vol. 371 (6533), pp. 1019-1025.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood Circulation*
Disease Models, Animal*
Mice*
Anemia, Sickle Cell/*blood
Erythrocytes/*cytology
Erythropoiesis/*physiology
Animals ; Cytokines/metabolism ; Erythropoiesis/genetics ; Female ; Gene Deletion ; Hematopoietic Stem Cells/cytology ; Humans ; Hydrolases/genetics ; Liver/physiology ; Mice, Mutant Strains ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity.
Autorzy:
Xu K; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
Yin N; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Peng M; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Stamatiades EG; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Institute of Microbiology, Infectious Diseases and Immunology, Charité University Medical Centre, 12203 Berlin, Germany.
Shyu A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Li P; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Zhang X; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Do MH; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
Wang Z; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
Capistrano KJ; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Chou C; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Levine AG; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
Rudensky AY; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Li MO; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. .; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Jan 22; Vol. 371 (6527), pp. 405-410.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Glycolysis*
CD8-Positive T-Lymphocytes/*immunology
Lactate Dehydrogenase 5/*metabolism
Phosphatidylinositol 3-Kinase/*metabolism
Animals ; CD8-Positive T-Lymphocytes/enzymology ; Forkhead Box Protein O1/metabolism ; Humans ; Lactate Dehydrogenase 5/genetics ; Listeria monocytogenes ; Listeriosis/enzymology ; Listeriosis/immunology ; Mice ; Mice, Mutant Strains ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Warburg Effect, Oncologic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated.
Autorzy:
Zhang Y; Department of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. .; Department of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. .; Translational Musculoskeletal Research Center (TMRC), Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA. .
Tian Z; Department of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Gerard D; Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA.
Yao L; Department of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.; Department of Orthopaedics/Sports Medicine and Joint Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Shofer FS; Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Cs-Szabo G; Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA.
Qin L; Department of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Pacifici M; Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, USA.
Enomoto-Iwamoto M; Department of Orthopedics, University of Maryland, Baltimore, MD, USA.
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Źródło:
Scientific reports [Sci Rep] 2021 Jan 19; Vol. 11 (1), pp. 1804. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Expression*
ADAM Proteins/*genetics
Antigens, CD/*genetics
Inflammation/*genetics
Intervertebral Disc/*metabolism
Membrane Proteins/*genetics
Animals ; Mice ; Mice, Mutant Strains ; Proteolysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alteration of Neural Stem Cell Functions in Ataxia and Male Sterility Mice: A Possible Role of β-Tubulin Glutamylation in Neurodegeneration.
Autorzy:
Sheikh AM; Department of Laboratory Medicine, Shimane University Faculty of Medicine, 89-1 Enya Cho, Izumo 693-8501, Japan.
Yano S; Department of Laboratory Medicine, Shimane University Faculty of Medicine, 89-1 Enya Cho, Izumo 693-8501, Japan.
Tabassum S; Department of Laboratory Medicine, Shimane University Faculty of Medicine, 89-1 Enya Cho, Izumo 693-8501, Japan.
Omura K; Department of Organ Pathology, Shimane University Faculty of Medicine, 89-1 Enya Cho, Izumo 693-8501, Japan.
Araki A; Department of Organ Pathology, Shimane University Faculty of Medicine, 89-1 Enya Cho, Izumo 693-8501, Japan.
Mitaki S; Department of Neurology, Shimane University Faculty of Medicine, 89-1 Enya Cho, Izumo 693-8501, Japan.
Ito Y; Department of Neurology, Shimane University Faculty of Medicine, 89-1 Enya Cho, Izumo 693-8501, Japan.
Huang S; Department of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgangdong Road, Guangzhou 510260, China.
Nagai A; Department of Neurology, Shimane University Faculty of Medicine, 89-1 Enya Cho, Izumo 693-8501, Japan.
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Źródło:
Cells [Cells] 2021 Jan 14; Vol. 10 (1). Date of Electronic Publication: 2021 Jan 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ataxia/*metabolism
Heredodegenerative Disorders, Nervous System/*metabolism
Infertility, Male/*metabolism
Neural Stem Cells/*metabolism
Tubulin/*metabolism
Animals ; Ataxia/genetics ; Ataxia/pathology ; Female ; Glutamine/genetics ; Glutamine/metabolism ; Heredodegenerative Disorders, Nervous System/genetics ; Heredodegenerative Disorders, Nervous System/pathology ; Infertility, Male/genetics ; Infertility, Male/pathology ; Male ; Mice ; Mice, Mutant Strains ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Neural Stem Cells/pathology ; Tubulin/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The role of β 2 integrin in dendritic cell migration during infection.
Autorzy:
Altorki T; Faculty of Biology, Medicine and Health, Lydia Becker Institute of Immunology and Inflammation, Manchester Academic Health Science Centre, A.V. Hill Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.; Present address: Faculty of Medical Applied Sciences, Department of Medical Laboratory Sciences, King Abdul-Aziz University, Jeddah, Saudi Arabia.
Muller W; Faculty of Biology, Medicine and Health, Lydia Becker Institute of Immunology and Inflammation, Manchester Academic Health Science Centre, A.V. Hill Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Brass A; Faculty of Biology, Medicine and Health, Division of Informatics, Imaging and Data Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Cruickshank S; Faculty of Biology, Medicine and Health, Lydia Becker Institute of Immunology and Inflammation, Manchester Academic Health Science Centre, A.V. Hill Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK. .
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Źródło:
BMC immunology [BMC Immunol] 2021 Jan 06; Vol. 22 (1), pp. 2. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD18 Antigens/*immunology
Cell Movement/*immunology
Dendritic Cells/*immunology
Animals ; CD18 Antigens/deficiency ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Trichuriasis/immunology ; Trichuris
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells.
Autorzy:
Shivaraju M; Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.; Departments of Internal Medicine and Pediatrics, Pulmonary and Critical Care Division, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Chitta UK; Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
Grange RMH; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Jain IH; Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Present address: Department of Physiology, University of California San Francisco, San Francisco, CA 94158, USA.
Capen D; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Liao L; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Xu J; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Ichinose F; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Zapol WM; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Mootha VK; Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Rajagopal J; Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA. .; Departments of Internal Medicine and Pediatrics, Pulmonary and Critical Care Division, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Jan 01; Vol. 371 (6524), pp. 52-57.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Differentiation*
Hypoxia/*pathology
Neuroendocrine Cells/*physiology
Oxygen/*physiology
Stem Cells/*physiology
Trachea/*cytology
Anaerobiosis ; Animals ; Calcitonin Gene-Related Peptide/metabolism ; Calcitonin Gene-Related Peptide/pharmacology ; Calcitonin Receptor-Like Protein/metabolism ; Cell Count ; Gene Deletion ; Humans ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; Mice, Mutant Strains ; Neuroendocrine Cells/cytology ; Prolyl Hydroxylases/metabolism ; Stem Cells/cytology ; Stem Cells/drug effects ; Trans-Activators/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mapping molar shapes on signaling pathways.
Autorzy:
Morita W; Department of Anthropology, National Museum of Nature and Science, Tsukuba, Ibaraki, Japan.
Morimoto N; Laboratory of Physical Anthropology, Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Kyoto, Japan.
Jernvall J; Institute of Biotechnology and Department of Geosciences and Geography, University of Helsinki, Helsinki, Finland.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2020 Dec 14; Vol. 16 (12), pp. e1008436. Date of Electronic Publication: 2020 Dec 14 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Anatomic*
Signal Transduction*
Molar/*anatomy & histology
Animals ; Biological Evolution ; Machine Learning ; Mice ; Mice, Mutant Strains ; Phylogeny
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer.
Autorzy:
Krishna S; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Lowery FJ; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Copeland AR; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Bahadiroglu E; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mukherjee R; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jia L; National Institutes of Health Library, National Institutes of Health, Bethesda, MD 20892, USA.
Anibal JT; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Sachs A; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Adebola SO; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Gurusamy D; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yu Z; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Hill V; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Gartner JJ; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Li YF; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Parkhurst M; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Paria B; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Kvistborg P; Division of Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Kelly MC; Single Cell Analysis Facility, Cancer Research Technology Program, Frederick National Laboratory, Bethesda, MD 20892, USA.
Goff SL; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Altan-Bonnet G; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Robbins PF; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. .
Rosenberg SA; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2020 Dec 11; Vol. 370 (6522), pp. 1328-1334.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:
CD8-Positive T-Lymphocytes/*immunology
Immunotherapy, Adoptive/*methods
Lymphocytes, Tumor-Infiltrating/*transplantation
Melanoma/*therapy
Skin Neoplasms/*therapy
Animals ; Antigens, CD/analysis ; Antigens, Differentiation, T-Lymphocyte/analysis ; Apyrase/analysis ; CD8-Positive T-Lymphocytes/chemistry ; Female ; Humans ; Lectins, C-Type/analysis ; Melanoma/immunology ; Mice ; Mice, Mutant Strains ; Skin Neoplasms/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An investigation into the impact of deleting one copy of the glutaredoxin-2 gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet.
Autorzy:
Gill R; Department of Biochemistry, Faculty of Science, Memorial University of Newfoundland, St. John's, Canada.
Mallay S; Department of Biochemistry, Faculty of Science, Memorial University of Newfoundland, St. John's, Canada.
Young A; Department of Biochemistry, Faculty of Science, Memorial University of Newfoundland, St. John's, Canada.
Mailloux RJ; Department of Biochemistry, Faculty of Science, Memorial University of Newfoundland, St. John's, Canada.; The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Sainte-Anne-de-Bellevue, Canada.
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Źródło:
Redox report : communications in free radical research [Redox Rep] 2020 Dec; Vol. 25 (1), pp. 87-94.
Typ publikacji:
Journal Article
MeSH Terms:
Diet, High-Fat/*adverse effects
Glutaredoxins/*genetics
Mitochondria, Muscle/*metabolism
Weight Gain/*genetics
Animals ; Energy Metabolism/genetics ; Female ; Glutaredoxins/metabolism ; Hydrogen Peroxide/metabolism ; Male ; Mice, Mutant Strains ; Mitochondria, Liver/metabolism ; Mitochondria, Liver/physiology ; Mitochondria, Muscle/physiology ; Oxidative Stress/genetics ; Superoxides/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD signaling.
Autorzy:
Okur MN; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Fang EF; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Department of Clinical Molecular Biology, University of Oslo and The Akershus University Hospital, Lørenskog, Norway.
Fivenson EM; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Tiwari V; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Croteau DL; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Bohr VA; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Danish Center for Healthy Aging, University of Copenhagen, Copenhagen N, Denmark.
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Źródło:
Aging cell [Aging Cell] 2020 Dec; Vol. 19 (12), pp. e13268. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cockayne Syndrome/*metabolism
DNA Helicases/*metabolism
DNA Repair Enzymes/*metabolism
Mitochondria/*metabolism
NAD/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
Transcription Factors/*metabolism
AMP-Activated Protein Kinases/metabolism ; Aging, Premature/genetics ; Aging, Premature/metabolism ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Cerebellum/metabolism ; Cockayne Syndrome/genetics ; Cockayne Syndrome/pathology ; DNA Helicases/deficiency ; DNA Helicases/genetics ; DNA Repair Enzymes/deficiency ; DNA Repair Enzymes/genetics ; Disease Models, Animal ; Humans ; Longevity/genetics ; Longevity/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mitochondria/pathology ; Oligonucleotide Array Sequence Analysis ; Poly-ADP-Ribose Binding Proteins/deficiency ; Poly-ADP-Ribose Binding Proteins/genetics ; Signal Transduction ; Transcription Factors/deficiency ; Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain.
Autorzy:
Kawamura A; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan.
Abe Y; Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku, Tokyo, 160-8582, Japan.
Seki F; Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, 160-8582, Japan.; Live Imaging Center, Central Institute for Experimental Animals, Kawasaki, Kanagawa, 210-0821, Japan.
Katayama Y; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan.
Nishiyama M; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan.
Takata N; Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku, Tokyo, 160-8582, Japan.
Tanaka KF; Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku, Tokyo, 160-8582, Japan.
Okano H; Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, 160-8582, Japan.
Nakayama KI; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan. .
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Źródło:
Molecular brain [Mol Brain] 2020 Nov 23; Vol. 13 (1), pp. 160. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*pathology
Brain/*physiopathology
DNA-Binding Proteins/*genetics
Mutation/*genetics
Nerve Net/*physiopathology
Oligodendroglia/*metabolism
Animals ; Behavior, Animal ; Brain/diagnostic imaging ; Cell Lineage ; Diffusion Tensor Imaging ; Heterozygote ; Mice ; Mice, Mutant Strains ; Social Behavior
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau.
Autorzy:
Darwich NF; Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Phan JM; Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Kim B; Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Suh E; Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Papatriantafyllou JD; Medical Center of Athens, Memory Disorders Clinic and Day Care Center for Third Age 'IASIS,' Athens, Greece.
Changolkar L; Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Nguyen AT; Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
O'Rourke CM; Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
He Z; Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Porta S; Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Gibbons GS; Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Luk KC; Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Papageorgiou SG; First University Department of Neurology, Eginiteio University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Grossman M; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Massimo L; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Irwin DJ; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
McMillan CT; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Nasrallah IM; Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Toro C; NIH Undiagnosed Diseases Program, National Human Genome Research Institute, MD, USA.
Aguirre GK; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Van Deerlin VM; Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Lee EB; Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2020 Nov 20; Vol. 370 (6519). Date of Electronic Publication: 2020 Oct 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Protein Aggregates*
Alzheimer Disease/*metabolism
Alzheimer Disease/*pathology
Protein Aggregation, Pathological/*genetics
Valosin Containing Protein/*metabolism
tau Proteins/*metabolism
Animals ; Aspartic Acid/genetics ; Gene Knock-In Techniques ; Genes, Dominant ; Glycine/genetics ; Humans ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mutation ; Neurofibrillary Tangles/genetics ; Neurofibrillary Tangles/metabolism ; Phosphorylation ; Valosin Containing Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage.
Autorzy:
Tashkandi MM; Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, 700 Albany Street; W-202B, Boston, MA, 02118, USA.
Alsaqer SF; Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, 700 Albany Street; W-202B, Boston, MA, 02118, USA.
Alhousami T; Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, 700 Albany Street; W-202B, Boston, MA, 02118, USA.
Ali F; Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, 700 Albany Street; W-202B, Boston, MA, 02118, USA.
Wu YC; Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, 700 Albany Street; W-202B, Boston, MA, 02118, USA.
Shin J; Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, 700 Albany Street; W-202B, Boston, MA, 02118, USA.
Mehra P; Department of Oral and Maxillofacial Surgery, Boston University Henry M. Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA, 02118, USA.
Wolford LM; Texas A&M University College of Dentistry, Baylor University Medical Center, Dallas, TX, USA.
Gerstenfeld LC; Department of Orthopedic Surgery, School of Medicine, Boston University, Boston, MA, USA.
Goldring MB; Hospital for Special Surgery Research Institute, Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, 10021, USA.
Bais MV; Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, 700 Albany Street; W-202B, Boston, MA, 02118, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Nov 19; Vol. 10 (1), pp. 20179. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Aggrecans/*metabolism
Amino Acid Oxidoreductases/*metabolism
Cartilage, Articular/*pathology
Osteoarthritis/*pathology
Temporomandibular Joint Disorders/*metabolism
Adenoviridae/genetics ; Aged ; Amino Acid Oxidoreductases/administration & dosage ; Amino Acid Oxidoreductases/genetics ; Animals ; Cartilage, Articular/metabolism ; Cartilage, Articular/transplantation ; Chondrocytes/metabolism ; Collagen/genetics ; Disease Models, Animal ; Female ; Gene Regulatory Networks ; Humans ; Male ; Metabolism/genetics ; Mice, Mutant Strains ; Mice, Nude ; Middle Aged ; Osteoarthritis/metabolism ; Sex Characteristics ; Temporomandibular Joint Disorders/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice.
Autorzy:
Watanabe S; Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Iwata Y; Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Fukushima H; Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Saito K; Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Tanaka Y; Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Hasegawa Y; Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Akiyama M; Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
Sugiura K; Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2020 Nov 19; Vol. 10 (1), pp. 20149. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-1/*genetics
Neutrophils/*pathology
Psoriasis/*genetics
Psoriasis/*pathology
Administration, Topical ; Animals ; Cells, Cultured ; Chemokines/genetics ; Cytokines/genetics ; Disease Models, Animal ; Extracellular Traps ; Imiquimod/administration & dosage ; Imiquimod/toxicity ; Interleukin-1/metabolism ; Macrophages, Peritoneal/pathology ; Macrophages, Peritoneal/physiology ; Male ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Ornithine/analogs & derivatives ; Ornithine/pharmacology ; Psoriasis/chemically induced ; Psoriasis/drug therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2.
Autorzy:
Jeon SH; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Kim N; Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Ju YJ; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Gee MS; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Lee D; Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Lee JK; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 10; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Abscisic Acid/*pharmacology
Membrane Proteins/*metabolism
Memory Disorders/*drug therapy
Neurodegenerative Diseases/*drug therapy
Phosphate-Binding Proteins/*metabolism
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Animals ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/pathology ; Disease Models, Animal ; Female ; Humans ; Male ; Memory Disorders/metabolism ; Memory Disorders/pathology ; Mice ; Mice, Mutant Strains ; Mice, Transgenic ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; PPAR gamma/metabolism ; Plant Growth Regulators/pharmacology ; Presenilin-1/genetics ; Presenilin-1/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fifty years of the asebia mouse: origins, insights and contemporary developments.
Autorzy:
Schneider MR; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
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Źródło:
Experimental dermatology [Exp Dermatol] 2015 May; Vol. 24 (5), pp. 340-1. Date of Electronic Publication: 2015 Mar 09.
Typ publikacji:
Historical Article; Journal Article
MeSH Terms:
Mice, Mutant Strains*
Alopecia/*history
Sebaceous Glands/*abnormalities
Alopecia/genetics ; Animals ; Disease Models, Animal ; History, 20th Century ; Mice ; Stearoyl-CoA Desaturase/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice.
Autorzy:
Han KA; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Korea.
Yoon TH; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Korea.
Shin J; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Korea.
Um JW; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Korea.; Core Protein Resources Center, DGIST, Daegu, 42988, Korea.
Ko J; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Korea. .
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Źródło:
Molecular autism [Mol Autism] 2020 Oct 30; Vol. 11 (1), pp. 87. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cooperative Behavior*
Social Dominance*
Microfilament Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Animals ; Brain/pathology ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Neurons/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance.
Autorzy:
Chhabra NF; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Amarie OV; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.
Wu M; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Amend AL; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Rubey M; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Gradinger D; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Irmler M; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.
Beckers J; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Chair of Experimental Genetics, Center of Life and Food Sciences, Weihenstephan, Technische Universität München, Freising, Germany.
Rathkolb B; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Ludwig-Maximilians-Universität München, Gene Center, Chair for Molecular Animal Breeding and Biotechnology, Munich, Germany.
Wolf E; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Ludwig-Maximilians-Universität München, Gene Center, Chair for Molecular Animal Breeding and Biotechnology, Munich, Germany.
Feuchtinger A; Helmholtz Zentrum München, Research Unit Analytical Pathology, Neuherberg, Germany.
Huypens P; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Teperino R; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Rozman J; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Przemeck GKH; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Hrabě de Angelis M; Helmholtz Zentrum München, Institute of Experimental Genetics and German Mouse Clinic, Neuherberg, Germany. .; German Center for Diabetes Research (DZD), Neuherberg, Germany. .; Chair of Experimental Genetics, Center of Life and Food Sciences, Weihenstephan, Technische Universität München, Freising, Germany. .
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Źródło:
Communications biology [Commun Biol] 2020 Oct 30; Vol. 3 (1), pp. 628. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Circadian Rhythm/*genetics
Glucose/*metabolism
Insulin Secretion/*genetics
Insulin-Secreting Cells/*physiology
PAX6 Transcription Factor/*genetics
Animals ; Blood Glucose/genetics ; Circadian Rhythm/physiology ; Gene Expression Regulation ; Glucose/genetics ; Liver/metabolism ; Liver/physiology ; Male ; Mice, Inbred C3H ; Mice, Mutant Strains ; Mutation ; Optic Nerve/abnormalities ; PAX6 Transcription Factor/metabolism ; Retina/ultrastructure ; Retinal Ganglion Cells/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains.
Autorzy:
Kecskés A; Department of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research Group, University of Pécs, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.
Pohóczky K; Department of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research Group, University of Pécs, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; Department of Pharmacology, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary.
Kecskés M; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; Institute of Physiology, Medical School & Szentágothai Research Centre, University of Pécs, H-7624 Pécs, Hungary.
Varga ZV; Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.; HCEMM-SU Cardiometabolic Immunology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.
Kormos V; Department of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research Group, University of Pécs, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.
Szőke É; Department of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research Group, University of Pécs, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; ALGONIST Biotechnologies GmbH, A-1030 Wien, Austria.
Henn-Mike N; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; Institute of Physiology, Medical School & Szentágothai Research Centre, PTE-NAP Molecular Neuroendocrinology Research Group, University of Pécs, H-7624 Pécs, Hungary.
Fehér M; Department of Neurosurgery, Kaposi Mór Teaching Hospital, H-7400 Kaposvár, Hungary.
Kun J; Department of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research Group, University of Pécs, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; Bioinformatics Research Group, Genomics and Bioinformatics Core Facility, Szentágothai Research Centre University of Pécs, H-7624 Pécs, Hungary.
Gyenesei A; Bioinformatics Research Group, Genomics and Bioinformatics Core Facility, Szentágothai Research Centre University of Pécs, H-7624 Pécs, Hungary.
Renner É; Human Brain Tissue Bank, Semmelweis University, H-1089 Budapest, Hungary.
Palkovits M; Human Brain Tissue Bank, Semmelweis University, H-1089 Budapest, Hungary.
Ferdinandy P; Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.; Pharmahungary Group, H-6720 Szeged, Hungary.
Ábrahám IM; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; Institute of Physiology, Medical School & Szentágothai Research Centre, PTE-NAP Molecular Neuroendocrinology Research Group, University of Pécs, H-7624 Pécs, Hungary.
Gaszner B; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; Department of Anatomy, Medical School, Research Group for Mood Disorders, University of Pécs, H-7624 Pécs, Hungary.
Helyes Z; Department of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, Molecular Pharmacology Research Group, University of Pécs, H-7624 Pécs, Hungary.; Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; ALGONIST Biotechnologies GmbH, A-1030 Wien, Austria.; PharmInVivo Ltd., H-7629 Pécs, Hungary.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 21; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Analgesics/*pharmacology
Brain/*metabolism
Neurons/*metabolism
Receptors, Somatostatin/*genetics
Receptors, Somatostatin/*metabolism
Affect/physiology ; Animals ; Brain/cytology ; Butanes/pharmacology ; CHO Cells ; Cricetulus ; Electrophysiology/methods ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Molecular Targeted Therapy ; Naphthalenes/pharmacology ; Neurons/drug effects ; Receptors, Somatostatin/agonists ; Sulfones/pharmacology ; Vesicular Glutamate Transport Protein 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 41-60 z 2283

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