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Tytuł :
CD133+/CD166+ human gastric adenocarcinoma cells present the properties of neoplastic stem cells and emerge more malignant features.
Autorzy :
Ni T; Institute of Translational Medicine, Medical College, Yangzhou University, The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou 225001, China.
Wang H; Institute of Translational Medicine, Medical College, Yangzhou University, The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou 225001, China.
Zhan D; Institute of Translational Medicine, Medical College, Yangzhou University, The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou 225001, China.
Tao L; Department of Pharmacy, College of Medicine, Yangzhou University, Yangzhou, Jiangsu 225001, China.
Lv M; Department of Pharmacy, College of Medicine, Yangzhou University, Yangzhou, Jiangsu 225001, China.
Wang W; Institute of Translational Medicine, Medical College, Yangzhou University, The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou 225001, China.
Chu Z; Institute of Translational Medicine, Medical College, Yangzhou University, The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou 225001, China.
Zhou Z; Institute of Translational Medicine, Medical College, Yangzhou University, The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou 225001, China.
Sunagawa M; Department of Physiology, School of Medicine, Showa University, Tokyo 142, Japan.
Liu Y; Institute of Translational Medicine, Medical College, Yangzhou University, The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou 225001, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119021. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
AC133 Antigen/*metabolism
Activated-Leukocyte Cell Adhesion Molecule/*metabolism
Adenocarcinoma/*pathology
Neoplastic Stem Cells/*metabolism
Neoplastic Stem Cells/*pathology
Stomach Neoplasms/*pathology
Adenocarcinoma/metabolism ; Animals ; Biomarkers, Tumor/metabolism ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cell Self Renewal ; Drug Resistance, Neoplasm ; Humans ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Spheroids, Cellular/pathology ; Stomach Neoplasms/metabolism ; Tumor Stem Cell Assay
Czasopismo naukowe
Tytuł :
RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
Autorzy :
Li T; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Wang X; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Ju E; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
da Silva SR; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Chen L; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Zhang X; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Wei S; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Gao SJ; UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 16; Vol. 12 (1), pp. 1055. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Proteolysis*/drug effects
Ubiquitination*/drug effects
Carcinogenesis/*metabolism
Carcinogenesis/*pathology
Intracellular Signaling Peptides and Proteins/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Arginine/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Disease Progression ; Female ; Intercellular Signaling Peptides and Proteins/pharmacology ; Kinetics ; Lysine/metabolism ; Mice, Nude ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Tytuł :
Folliculin deficient renal cancer cells exhibit BRCA1 A complex expression impairment and sensitivity to PARP1 inhibitor olaparib.
Autorzy :
Zhang Q; Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
Xu Y; Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China.
Zhang Z; Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, China.
Li J; Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China.
Xia Q; Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
Chen Y; Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Feb 15; Vol. 769, pp. 145243. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
BRCA1 Protein/*metabolism
Carcinoma, Renal Cell/*metabolism
Estrone/*metabolism
Kidney Neoplasms/*metabolism
Phthalazines/*pharmacology
Piperazines/*pharmacology
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Animals ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Humans ; Kidney Neoplasms/pathology ; Mice ; Mice, Nude
Czasopismo naukowe
Tytuł :
FN1 promotes chondrocyte differentiation and collagen production via TGF-β/PI3K/Akt pathway in mice with femoral fracture.
Autorzy :
Zhang H; Outpatient Department, The Second Hospital of Jilin University, Changchun 130041, PR China.
Chen X; Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, PR China.
Xue P; Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, PR China.
Ma X; ICU, The Second Hospital of Jilin University, Changchun 130041, PR China.
Li J; Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun 130041, PR China. Electronic address: .
Zhang J; Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, PR China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Feb 15; Vol. 769, pp. 145253. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation/*physiology
Chondrocytes/*cytology
Collagen/*biosynthesis
Femoral Fractures/*metabolism
Fibronectins/*physiology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Chondrocytes/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Nude
Czasopismo naukowe
Tytuł :
The ATPase subunit of ATP6V1C1 inhibits autophagy and enhances radiotherapy resistance in esophageal squamous cell carcinoma.
Autorzy :
Yao X; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Center of Interventional Radiology and Vascular surgery, Department of Radiology, Zhongda hospital, Southeast university, Nanjing 210009, China.
Chen H; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xu B; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Lu J; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Gu J; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chen F; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ju M; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Sun X; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Feb 05; Vol. 768, pp. 145261. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*genetics
Esophageal Neoplasms/*genetics
Esophageal Squamous Cell Carcinoma/*genetics
Radiation Tolerance/*genetics
Vacuolar Proton-Translocating ATPases/*genetics
Animals ; Apoptosis/genetics ; Autophagy/physiology ; Cell Line, Tumor ; Cell Proliferation/genetics ; DNA Repair/genetics ; Esophageal Neoplasms/radiotherapy ; Esophageal Squamous Cell Carcinoma/radiotherapy ; Female ; Gene Silencing ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Radiation, Ionizing ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Effect of vitamin D on malignant behavior of non-small cell lung cancer cells.
Autorzy :
Songyang Y; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Song T; Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, China.
Shi Z; Human Biology Program, University of Toronto, ON M5S 3J6, Canada.
Li W; Renmin Hospital of Wuhan University, Department of Emergency, Wuhan, China.
Yang S; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.
Li D; Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Feb 05; Vol. 768, pp. 145309. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cisplatin/*administration & dosage
Lung Neoplasms/*drug therapy
Vitamin D/*administration & dosage
A549 Cells ; Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lung Neoplasms/metabolism ; Mice ; Mice, Nude ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Vitamin D/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
YYB-101, a Humanized Antihepatocyte Growth Factor Monoclonal Antibody, Inhibits Ovarian Cancer Cell Motility and Proliferation.
Autorzy :
Kim HJ; Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul, Republic of Korea.
Heo K; Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul, Republic of Korea .
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 671-678.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal, Humanized/*pharmacology
Antineoplastic Agents, Immunological/*pharmacology
Carcinoma, Ovarian Epithelial/*drug therapy
Cell Movement/*drug effects
Cell Proliferation/*drug effects
Hepatocyte Growth Factor/*antagonists & inhibitors
Ovarian Neoplasms/*drug therapy
Animals ; Apoptosis/drug effects ; Carcinoma, Ovarian Epithelial/metabolism ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Cytoskeleton/drug effects ; Cytoskeleton/metabolism ; Cytoskeleton/pathology ; Female ; Hepatocyte Growth Factor/metabolism ; Humans ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Proto-Oncogene Proteins c-met/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Urokinase-type Plasminogen Activator Is a Therapeutic Target for Overcoming Sorafenib Resistance in Hepatoma Cells.
Autorzy :
Osawa M; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Matsuda Y; Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata, Japan; .
Kinoshita Y; Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Wakai T; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 645-660.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Membrane Proteins/*metabolism
Protein Kinase Inhibitors/*pharmacology
Sorafenib/*pharmacology
Amiloride/pharmacology ; Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/enzymology ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Hep G2 Cells ; Humans ; Liver Neoplasms/enzymology ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Mice, Inbred BALB C ; Mice, Nude ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A Novel Orthotopic Mouse Model of Lung Metastasis Using Fluorescent Patient-derived Osteosarcoma Cells.
Autorzy :
Oshiro H; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.; Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Tome Y; Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan .
Miyake K; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Higuchi T; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Sugisawa N; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Park JH; AntiCancer Inc., San Diego, CA, U.S.A.
Zhang Z; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Razmjooei S; AntiCancer Inc., San Diego, CA, U.S.A.
Kanaya F; Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Nishida K; Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Hoffman RM; AntiCancer Inc., San Diego, CA, U.S.A.; .; Department of Surgery, University of California, San Diego, CA, U.S.A.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 635-640.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*pathology
Green Fluorescent Proteins/*metabolism
Lung Neoplasms/*secondary
Osteosarcoma/*secondary
Tibia/*pathology
Adolescent ; Animals ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Cell Tracking ; Female ; Green Fluorescent Proteins/genetics ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Mice, Nude ; Neoplasm Transplantation ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; Tibia/metabolism ; Transfection ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis.
Autorzy :
Xu Y; Department of Health Management, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wang Q; Department of Health Management, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Li X; Department of Health Management, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Chen Y; Department of Health Management, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xu G; Department of Health Management, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Feb; Vol. 36 (2), pp. 257-266. Date of Electronic Publication: 2020 Sep 20.
Typ publikacji :
Journal Article
MeSH Terms :
Ferroptosis/*drug effects
Itraconazole/*pharmacology
Nasopharyngeal Carcinoma/*drug therapy
Nasopharyngeal Neoplasms/*drug therapy
Neoplastic Stem Cells/*drug effects
Spheroids, Cellular/*drug effects
Animals ; Cell Line, Tumor ; Cell Survival/drug effects ; Female ; Humans ; Mice, Nude ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/pathology ; Neoplastic Stem Cells/pathology ; Radiation Tolerance/drug effects ; Spheroids, Cellular/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice.
Autorzy :
Bastaki S; Immunology research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Aravindhan S; Department of Electronics and Communication Engineering, AL-AMEEN ENGINEERING COLLEGE (Autonomous), Erode, Tamilnadu 638104, India. Electronic address: .
Ahmadpour Saheb N; Immunology research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Afsari Kashani M; Immunology research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Evgenievich Dorofeev A; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Karoon Kiani F; Immunology research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Jahandideh H; Immunology research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Beigi Dargani F; Immunology research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Aksoun M; Immunology research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nikkhoo A; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Masjedi A; Immunology research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahmoodpoor A; Department of Anesthesiology, School of Medicine, Imam Reza Medical Research & Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Ahmadi M; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Dolati S; Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Namvar Aghdash S; Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
Jadidi-Niaragh F; Immunology research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118847. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*antagonists & inhibitors
Breast Neoplasms/*therapy
Melanoma, Experimental/*therapy
Nanoparticles/*administration & dosage
Nanoparticles/*chemistry
RNA, Small Interfering/*genetics
STAT3 Transcription Factor/*antagonists & inhibitors
Animals ; Apoptosis ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Movement ; Cell Proliferation ; Chitosan/chemistry ; Disease Progression ; Female ; Gene Products, tat/chemistry ; Humans ; Hyaluronic Acid/chemistry ; Melanoma, Experimental/genetics ; Melanoma, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Circ-UBR1 facilitates proliferation, metastasis, and inhibits apoptosis in breast cancer by regulating the miR-1299/CCND1 axis.
Autorzy :
Zhang L; Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: .
Sun D; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhang J; Department of Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Tian Y; Department of Breast Surgery, Huaihe Hospital of Henan University, Kaifeng, Henan, China.
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118829. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Breast Neoplasms/*pathology
Cyclin D1/*metabolism
MicroRNAs/*genetics
RNA, Circular/*genetics
Ubiquitin-Protein Ligases/*genetics
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Movement ; Cell Proliferation ; Cyclin D1/genetics ; Disease Progression ; Female ; Humans ; Lymphatic Metastasis ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Prognosis ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Insulin-Induced Gene 2 Expression Is Associated with Breast Cancer Metastasis.
Autorzy :
Lu N; Department of Breast Medical Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China. Electronic address: .
Zhang M; Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin, China.
Lu L; Department of Pharmacy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Liu YZ; Department of Medicine, Tianjin Medical University General Hospital, Tianjin, China.
Liu XD; Department of Breast Medical Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.
Zhang HH; Department of Human Resources, Tianjin Hospital, Tianjin, China.
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Źródło :
The American journal of pathology [Am J Pathol] 2021 Feb; Vol. 191 (2), pp. 385-395. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*pathology
Intracellular Signaling Peptides and Proteins/*metabolism
Membrane Proteins/*metabolism
Neoplasm Metastasis/*genetics
Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Female ; Heterografts ; Humans ; Mice ; Mice, Nude ; Neoplasm Metastasis/pathology
Czasopismo naukowe
Tytuł :
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling.
Autorzy :
Sarma A; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Gajan A; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Kim S; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Gurdziel K; Genome Sciences Core, Wayne State University, Detroit, Michigan.
Mao G; Department of Chemical Engineering and Materials Science, Wayne State University College of Engineering, Detroit, Michigan.
Nangia-Makker P; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Shekhar MPV; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2021 Feb; Vol. 191 (2), pp. 368-384. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic/*physiology
Melanoma/*metabolism
Melanoma/*pathology
Ubiquitin-Conjugating Enzymes/*metabolism
Wnt Signaling Pathway/*physiology
Animals ; Cell Line ; Heterografts ; Humans ; Mice ; Mice, Nude ; Phenotype
Czasopismo naukowe
Tytuł :
cIAP2 via NF-κB signalling affects cell proliferation and invasion in hepatocellular carcinoma.
Autorzy :
Jiang XJ; Department of Hepatobiliary Surgery, Affiliated Putian Hospital of Putian College, 363100, Fujian, China.
Chen ZW; Department of Pathology, Affiliated Putian Hospital of Putian College, 363100, Fujian, China.
Zhao JF; Department of Hepatobiliary Surgery, Affiliated Putian Hospital of Putian College, 363100, Fujian, China.
Liao CX; Department of Hepatobiliary Surgery, Affiliated Putian Hospital of Putian College, 363100, Fujian, China.
Cai QH; Department of Hepatobiliary Surgery, Affiliated Putian Hospital of Putian College, 363100, Fujian, China. Electronic address: .
Lin J; Department of Pathology, Affiliated Putian Hospital of Putian College, 363100, Fujian, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118867. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Baculoviral IAP Repeat-Containing 3 Protein/*metabolism
Biomarkers, Tumor/*metabolism
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
NF-kappa B/*metabolism
Animals ; Apoptosis ; Baculoviral IAP Repeat-Containing 3 Protein/genetics ; Biomarkers, Tumor/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Movement ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; NF-kappa B/genetics ; Neoplasm Invasiveness ; Prognosis ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Oesophageal squamous cell carcinoma-associated IL-33 rewires macrophage polarization towards M2 via activating ornithine decarboxylase.
Autorzy :
Mai S; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Liu L; Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jiang J; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ren P; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Diao D; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wang H; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Cai K; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Feb; Vol. 54 (2), pp. e12960. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Esophageal Neoplasms/*pathology
Esophageal Squamous Cell Carcinoma/*pathology
Interleukin-33/*metabolism
Macrophages/*immunology
Ornithine Decarboxylase/*metabolism
Aged ; Animals ; Cell Differentiation ; Cell Line, Tumor ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/mortality ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism ; Macrophages/cytology ; Macrophages/metabolism ; Male ; Mice ; Mice, Nude ; Middle Aged ; Ornithine Decarboxylase/chemistry ; Ornithine Decarboxylase/genetics ; Polyamines/analysis ; Polyamines/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Tytuł :
Reversion from Methionine Addiction to Methionine Independence Results in Loss of Tumorigenic Potential of Highly-malignant Lung-cancer Cells.
Autorzy :
Yamamoto J; AntiCancer Inc, San Diego, CA, U.S.A.; .; Department of Surgery, University of California, San Diego, CA, U.S.A.; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Aoki Y; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Han Q; AntiCancer Inc, San Diego, CA, U.S.A.
Sugisawa N; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Sun YU; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Hamada K; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Nishino H; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Inubushi S; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Miyake K; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Matsuyama R; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Bouvet M; Department of Surgery, University of California, San Diego, CA, U.S.A.
Endo I; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan .
Hoffman RM; AntiCancer Inc, San Diego, CA, U.S.A.; .; Department of Surgery, University of California, San Diego, CA, U.S.A.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 641-643.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Transformation, Neoplastic/*metabolism
Lung Neoplasms/*metabolism
Methionine/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic/pathology ; Humans ; Lung Neoplasms/pathology ; Mice, Nude ; Signal Transduction ; Tumor Burden
Czasopismo naukowe
Tytuł :
[Ginsenoside 20(S)-Rg3 upregulates tumor suppressor VHL gene expression by suppressing DNMT3A-mediated promoter methylation in ovarian cancer cells].
Autorzy :
Wang L; Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.; Department of Gynecology, Lanzhou University Second Hospital, Lan Zhou 730030, China.
Han X; Department of Obstetrics and Gynecology, Shaanxi Provincial People's Hospital, Xi'an 710068, China.
Zheng X; the Second Affiliated Hospital of Zhejiang University School of medicine, Hangzhou 310009, China.
Zhou Y; Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Hou H; Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Chen W; Center for Laboratory Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Li X; Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Zhao L; Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
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Źródło :
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2021 Jan 30; Vol. 41 (1), pp. 100-106.
Typ publikacji :
Journal Article
MeSH Terms :
Ginsenosides*/pharmacology
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Animals ; Cell Line, Tumor ; DNA Methylation ; Female ; Gene Expression ; Humans ; Mice ; Mice, Nude ; Promoter Regions, Genetic ; Von Hippel-Lindau Tumor Suppressor Protein/genetics
Czasopismo naukowe
Tytuł :
Real-time interleaved spectroscopic photoacoustic and ultrasound (PAUS) scanning with simultaneous fluence compensation and motion correction.
Autorzy :
Jeng GS; Department of Bioengineering, University of Washington, Seattle, WA, USA.; Institute of Electronics, National Chiao Tung University, Hsinchu, Taiwan.
Li ML; Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan.; Institute of Photonics Technologies, National Tsing Hua University, Hsinchu, Taiwan.
Kim M; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Yoon SJ; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Pitre JJ Jr; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Li DS; Department of Chemical Engineering, University of Washington, Seattle, WA, USA.
Pelivanov I; Department of Bioengineering, University of Washington, Seattle, WA, USA. .
O'Donnell M; Department of Bioengineering, University of Washington, Seattle, WA, USA.
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Źródło :
Nature communications [Nat Commun] 2021 Jan 29; Vol. 12 (1), pp. 716. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Computer Systems*
Molecular Imaging/*methods
Photoacoustic Techniques/*methods
Spectrum Analysis/*methods
Animals ; Equipment Design ; Female ; Image Processing, Computer-Assisted ; Lasers ; Mice ; Mice, Nude ; Models, Animal ; Molecular Imaging/instrumentation ; Motion ; Optical Fibers ; Phantoms, Imaging ; Photoacoustic Techniques/instrumentation ; Spectrum Analysis/instrumentation ; Ultrasonography/instrumentation ; Ultrasonography/methods
Czasopismo naukowe
Tytuł :
NUPR1 is a critical repressor of ferroptosis.
Autorzy :
Liu J; The Third Affiliated Hospital, Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, 510600, Guangdong, China.
Song X; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Kuang F; The Third Affiliated Hospital, Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, 510600, Guangdong, China.
Zhang Q; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Xie Y; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Kang R; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Kroemer G; Université Paris Descartes, Sorbonne Paris Cité, 75006, Paris, France. .; Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France. .; Institut National de la Santé et de la Recherche Médicale, U1138, Paris, France. .; Université Pierre et Marie Curie, 75006, Paris, France. .; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, 94800, Villejuif, France. .; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015, Paris, France. .; Department of Women's and Children's Health, Karolinska University Hospital, 17176, Stockholm, Sweden. .
Tang D; The Third Affiliated Hospital, Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, 510600, Guangdong, China. .; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 28; Vol. 12 (1), pp. 647. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
DNA-Binding Proteins/*genetics
Ferroptosis/*genetics
Iron/*metabolism
Lipocalin-2/*genetics
Neoplasm Proteins/*genetics
Pancreatic Neoplasms/*genetics
Animals ; Cell Line, Tumor ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/metabolism ; Humans ; Kaplan-Meier Estimate ; Lipocalin-2/metabolism ; Mice, Knockout ; Mice, Nude ; Mice, Transgenic ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/metabolism ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/therapy ; Piperazines/pharmacology ; RNAi Therapeutics/methods ; Signal Transduction/genetics ; Thiazines/pharmacology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe

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