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Tytuł :
HepaCAM‑PIK3CA axis regulates the reprogramming of glutamine metabolism to inhibit prostate cancer cell proliferation.
Autorzy :
He Z; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), School of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Gao Y; Department of Laboratory Diagnosis, People's Hospital of Chongqing Banan District, Chongqing 401320, P.R. China.
Li T; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), School of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Yu C; Center for Clinical Molecular Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China.
Ou L; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), School of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Luo C; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), School of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
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Źródło :
International journal of oncology [Int J Oncol] 2022 Apr; Vol. 60 (4). Date of Electronic Publication: 2022 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation/*genetics
Glutamine/*metabolism
Signal Transduction/*genetics
Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor/metabolism ; Cell Proliferation/physiology ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Disease Models, Animal ; Glutamine/genetics ; Male ; Mice ; Mice, Nude/genetics ; Mice, Nude/metabolism ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/prevention & control
Czasopismo naukowe
Tytuł :
Ring finger protein 6 enhances chemo-resistance by transcriptionally activating proliferating cell nuclear antigen expression and attenuating DNA damage in lung adenocarcinoma.
Autorzy :
Sun Y; Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China; School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Sun H; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Qi Y; Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China; School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Pan M; Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai, China; Shanghai Key Laboratory of Biliary Tract Disease, Shanghai, China.
An N; Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China; School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Leng X; Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China; School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Liu Y; Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai, China; Shanghai Key Laboratory of Biliary Tract Disease, Shanghai, China.
Chen Z; Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2022 May 28; Vol. 534, pp. 215609. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma of Lung*/drug therapy
Adenocarcinoma of Lung*/genetics
DNA-Binding Proteins*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Animals ; Cisplatin/pharmacology ; DNA Damage ; Drug Resistance, Neoplasm/genetics ; Humans ; Male ; Mice ; Mice, Nude ; Proliferating Cell Nuclear Antigen/genetics
Czasopismo naukowe
Tytuł :
A novel protein encoded by ZCRB1-induced circHEATR5B suppresses aerobic glycolysis of GBM through phosphorylation of JMJD5.
Autorzy :
Song J; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang, 110004, China.; Liaoning Medical Surgery and Rehabilitation Robot Technology Engineering Research Center, Shenyang, 110004, China.
Zheng J; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang, 110004, China.; Liaoning Medical Surgery and Rehabilitation Robot Technology Engineering Research Center, Shenyang, 110004, China.
Liu X; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang, 110004, China.; Liaoning Medical Surgery and Rehabilitation Robot Technology Engineering Research Center, Shenyang, 110004, China.
Dong W; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang, 110004, China.; Liaoning Medical Surgery and Rehabilitation Robot Technology Engineering Research Center, Shenyang, 110004, China.
Yang C; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang, 110004, China.; Liaoning Medical Surgery and Rehabilitation Robot Technology Engineering Research Center, Shenyang, 110004, China.
Wang D; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang, 110004, China.; Liaoning Medical Surgery and Rehabilitation Robot Technology Engineering Research Center, Shenyang, 110004, China.
Ruan X; Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, 110122, China.
Zhao Y; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang, 110004, China.; Liaoning Medical Surgery and Rehabilitation Robot Technology Engineering Research Center, Shenyang, 110004, China.
Liu L; Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, 110122, China.
Wang P; Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, 110122, China.
Zhang M; Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, 110122, China.
Liu Y; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China. .; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang, 110004, China. .; Liaoning Medical Surgery and Rehabilitation Robot Technology Engineering Research Center, Shenyang, 110004, China. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 May 10; Vol. 41 (1), pp. 171. Date of Electronic Publication: 2022 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Glioblastoma*/genetics
Glioblastoma*/metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Glycolysis ; Humans ; In Situ Hybridization, Fluorescence ; Mice ; Mice, Nude ; Phosphorylation ; RNA, Circular/genetics
Czasopismo naukowe
Tytuł :
Synthetic polymer material modified by d-peptide and its targeted application in the treatment of non-small cell lung cancer.
Autorzy :
Song L; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, PR China.
Chen XW; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Rd, Shanghai 201203, PR China; Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, PR China.
Liu Y; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Rd, Shanghai 201203, PR China; Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, PR China.
Wang H; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, PR China; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Rd, Shanghai 201203, PR China. Electronic address: .
Li JQ; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Rd, Shanghai 201203, PR China; Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, PR China. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2022 May 10; Vol. 619, pp. 121651. Date of Electronic Publication: 2022 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
Nanoparticles*
Animals ; Cell Line, Tumor ; Docetaxel/pharmacology ; Drug Delivery Systems ; Liposomes ; Mice ; Mice, Nude ; Peptides ; Polymers ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Exosomal AFAP1-AS1 binds to microRNA-15a-5p to promote the proliferation, migration, and invasion of ectopic endometrial stromal cells in endometriosis.
Autorzy :
Wang X; Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, NO.139 Renmin Road, Changsha, Hunan, 410000, PR China.
Zhang M; Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, NO.139 Renmin Road, Changsha, Hunan, 410000, PR China.; Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310006, PR China.
Jiang L; Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, NO.139 Renmin Road, Changsha, Hunan, 410000, PR China.
Fang X; Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, NO.139 Renmin Road, Changsha, Hunan, 410000, PR China.
Zhang T; Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, NO.139 Renmin Road, Changsha, Hunan, 410000, PR China. .
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Źródło :
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2022 May 05; Vol. 20 (1), pp. 77. Date of Electronic Publication: 2022 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Endometriosis*/genetics
Endometriosis*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
RNA, Long Noncoding*/genetics
Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Female ; Humans ; Mice ; Mice, Nude ; Stromal Cells/metabolism ; Transcription Factors
Czasopismo naukowe
Tytuł :
Combination of berberine and low glucose inhibits gastric cancer through the PP2A/GSK3β/MCL-1 signaling pathway.
Autorzy :
Peng Z; Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wangmu T; Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li L; Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Han G; Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huang D; Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yi P; Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2022 May 05; Vol. 922, pp. 174918. Date of Electronic Publication: 2022 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/pharmacology
Berberine*/pharmacology
Berberine*/therapeutic use
Stomach Neoplasms*/pathology
Animals ; Apoptosis ; Glucose/pharmacology ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Mice ; Mice, Nude ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Myeloid Cell Leukemia Sequence 1 Protein/therapeutic use ; Signal Transduction
Czasopismo naukowe
Tytuł :
CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling.
Autorzy :
Zhu L; Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China.
Yang X; Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China.
Feng J; Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China.
Mao J; Zhengzhou Tobacco Research Institute of China National Tobacco Company, Zhengzhou, 450001, China.
Zhang Q; Zhengzhou Tobacco Research Institute of China National Tobacco Company, Zhengzhou, 450001, China.
He M; Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China.
Mi Y; Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China.
Mei Y; Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China.
Jin G; Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China.
Zhang H; Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China. .
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Źródło :
Journal of translational medicine [J Transl Med] 2022 May 04; Vol. 20 (1), pp. 194. Date of Electronic Publication: 2022 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation/genetics ; Cytochrome P-450 CYP2E1/genetics ; Cytochrome P-450 CYP2E1/metabolism ; Dishevelled Proteins/genetics ; Dishevelled Proteins/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Nude ; Reactive Oxygen Species/metabolism ; Wnt Signaling Pathway/genetics ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Nanogels loading curcumin in situ through microemulsion photopolymerization for enhancement of antitumor effects.
Autorzy :
Peng Y; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China. .
Yu S; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China. .
Wang Z; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China. .
Huang P; Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, P. R. China. .
Wang W; Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, P. R. China. .
Xing J; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China. .
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Źródło :
Journal of materials chemistry. B [J Mater Chem B] 2022 May 04; Vol. 10 (17), pp. 3293-3302. Date of Electronic Publication: 2022 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Curcumin*/chemistry
Animals ; Apoptosis ; HeLa Cells ; Humans ; Mice ; Mice, Nude ; Nanogels
Czasopismo naukowe
Tytuł :
Synthesis, characterisation and evaluation of hyperbranched N -(2-hydroxypropyl) methacrylamides for transport and delivery in pancreatic cell lines in vitro and in vivo .
Autorzy :
Anane-Adjei AB; Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK. .
Fletcher NL; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. .; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia.
Cavanagh RJ; Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK. .
Houston ZH; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. .; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia.
Crawford T; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. .
Pearce AK; Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK. .
Taresco V; Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK. .
Ritchie AA; School of Medicine, University of Nottingham, NG7 2RD, UK.
Clarke P; School of Medicine, University of Nottingham, NG7 2RD, UK.
Grabowska AM; School of Medicine, University of Nottingham, NG7 2RD, UK.
Gellert PR; Product Technology & Development, Operations, AstraZeneca, Macclesfield, UK.
Ashford MB; Advanced Drug Delivery, Pharmaceutical Sciences, R&D AstraZeneca, Macclesfield, UK.
Kellam B; Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK. .
Thurecht KJ; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. .; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia.
Alexander C; Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK. .
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Źródło :
Biomaterials science [Biomater Sci] 2022 May 04; Vol. 10 (9), pp. 2328-2344. Date of Electronic Publication: 2022 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasms*
Prodrugs*
Acrylamides ; Animals ; Cell Line ; Cell Line, Tumor ; Humans ; Mice ; Mice, Nude ; Polymers
Czasopismo naukowe
Tytuł :
Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma.
Autorzy :
Zhang T; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Cui Y; Hepatobiliary Surgery Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Wu Y; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Meng J; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Han L; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Zhang J; Department of Physiology and Pathophysiology, Tianjin Key Laboratory of Cell Homeostasis and Major Diseases, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Zhang C; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Yang C; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Chen L; Hepatobiliary Surgery Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Bai X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Zhang K; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Wu K; Laboratory of Mitochondrial Biology and Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland, USA.
Sack MN; Laboratory of Mitochondrial Biology and Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland, USA.
Wang L; Department of Physiology and Pathophysiology, Tianjin Key Laboratory of Cell Homeostasis and Major Diseases, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Zhu L; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
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Źródło :
Clinical and translational medicine [Clin Transl Med] 2022 May; Vol. 12 (5), pp. e852.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/enzymology
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Glutaminase*/genetics
Glutaminase*/metabolism
Liver Neoplasms*/enzymology
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Mitochondrial Proteins*/metabolism
Nerve Tissue Proteins*/metabolism
Acetylation ; Animals ; Humans ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Mice, Nude ; Mitochondria, Liver/metabolism
Czasopismo naukowe
Tytuł :
Atorvastatin regulates the migration and invasion of prostate cancer through the epithelial-mesenchymal transformation and matrix metalloproteinase pathways.
Autorzy :
Zhu Z; Department of Andrology, The First Hospital of Jilin University, Changchun, Jilin, China.
Cao Y; Department of Andrology, The First Hospital of Jilin University, Changchun, Jilin, China.
Liu L; Department of Andrology, The First Hospital of Jilin University, Changchun, Jilin, China.
Zhao Z; Department of Andrology, The First Hospital of Jilin University, Changchun, Jilin, China.
Yin H; Department of Neuroelectrophysiology, Dalian Municipal Central Hospital, Dalian, Liaoning, China.
Wang H; Department of Andrology, The First Hospital of Jilin University, Changchun, Jilin, China. .
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Źródło :
Investigative and clinical urology [Investig Clin Urol] 2022 May; Vol. 63 (3), pp. 350-358.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*
Prostatic Neoplasms*/pathology
Animals ; Atorvastatin/pharmacology ; Atorvastatin/therapeutic use ; Caspase 3/pharmacology ; Caspase 3/therapeutic use ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Male ; Matrix Metalloproteinases ; Mice ; Mice, Nude ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; bcl-2-Associated X Protein/metabolism ; bcl-2-Associated X Protein/pharmacology
Czasopismo naukowe
Tytuł :
Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease.
Autorzy :
Kubota Y; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.; Division of Internal Medicine, Department of Medical Oncology, Showa University School of Medicine, Tokyo, Japan.
Han Q; AntiCancer Inc., San Diego, CA, U.S.A.
Hozumi C; AntiCancer Inc., San Diego, CA, U.S.A.; Anticancer Japan, Narita, Japan.
Masaki N; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Yamamoto J; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Aoki Y; AntiCancer Inc., San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Tsunoda T; Division of Internal Medicine, Department of Medical Oncology, Showa University School of Medicine, Tokyo, Japan.
Hoffman RM; AntiCancer Inc., San Diego, CA, U.S.A.; .; Department of Surgery, University of California, San Diego, CA, U.S.A.
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Źródło :
Anticancer research [Anticancer Res] 2022 May; Vol. 42 (5), pp. 2567-2572.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols*/therapeutic use
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/pathology
Animals ; CA-19-9 Antigen ; Carbon-Sulfur Lyases ; Disease Models, Animal ; Female ; Fluorouracil/therapeutic use ; Humans ; Irinotecan/therapeutic use ; Leucovorin/therapeutic use ; Methionine ; Mice ; Mice, Nude ; Oxaliplatin ; Xenograft Model Antitumor Assays
SCR Disease Name :
Pancreatic Carcinoma
Czasopismo naukowe
Tytuł :
Circ_0020123 promotes NSCLC tumorigenesis via up-regulating KIAA1522 expression through miR-940.
Autorzy :
Fan Y; Department of Thoracic Surgery, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
Wang Q; Department of Thoracic Surgery, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
Shi M; Department of Thoracic Surgery, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
Ju G; Department of Thoracic Surgery, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
Lu H; Department of Thoracic Surgery, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
Zheng L; Department of Scientific, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
Chen J; Department of Clinical Laboratory, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
Zhou X; Department of Thoracic Surgery, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
Xiao T; Department of Thoracic Surgery, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
Chen S; Department of Thoracic Surgery, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu Province, China.
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Źródło :
Cell cycle (Georgetown, Tex.) [Cell Cycle] 2022 May; Vol. 21 (9), pp. 894-907. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/metabolism
Lung Neoplasms*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic ; Mice ; Mice, Nude ; RNA, Circular/genetics
Czasopismo naukowe
Tytuł :
Blue light irradiation inhibits the growth of colon cancer and activation of cancer‑associated fibroblasts.
Autorzy :
Yoshimoto T; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Shimada M; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Tokunaga T; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Nakao T; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Nishi M; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Takasu C; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Kashihara H; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Wada Y; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Okikawa S; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Yoshikawa K; Department of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
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Źródło :
Oncology reports [Oncol Rep] 2022 May; Vol. 47 (5). Date of Electronic Publication: 2022 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cancer-Associated Fibroblasts*/radiation effects
Colonic Neoplasms*/genetics
Light*
Animals ; B7-H1 Antigen/metabolism ; Cell Movement/radiation effects ; Cell Proliferation/radiation effects ; HCT116 Cells ; Humans ; Mice ; Mice, Nude ; Rod Opsins/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C.
Autorzy :
Zhang H; The Affiliated Nanhua Hospital, Department of Hematology, Hengyang Medical School, University of South China, Hengyang, China.
Huang T; The Affiliated Nanhua Hospital, Department of Pain Treatment, Hengyang Medical School, University of South China, Hengyang, China.
Yuan S; The Affiliated Nanhua Hospital, Department of Hematology, Hengyang Medical School, University of South China, Hengyang, China.
Long Y; The Affiliated Nanhua Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, China.
Tan S; The Affiliated Nanhua Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, China.
Niu G; The Affiliated Nanhua Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, China.
Zhang P; The Affiliated Nanhua Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, China.
Yang M; The Affiliated Nanhua Hospital, Department of Oncology, Hengyang Medical School, University of South China, Hengyang, China.
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Źródło :
Thoracic cancer [Thorac Cancer] 2022 May; Vol. 13 (9), pp. 1406-1418. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
3' Untranslated Regions ; Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; Mice ; Mice, Nude ; Microfilament Proteins ; RNA, Circular/genetics
Czasopismo naukowe
Tytuł :
Al-MPS Obstructs EMT in Breast Cancer by Inhibiting Lipid Metabolism via miR-215-5p/SREBP1.
Autorzy :
Wu CL; Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Xu LL; Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Peng J; Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Zhang DH; Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
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Źródło :
Endocrinology [Endocrinology] 2022 May 01; Vol. 163 (5).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms*/genetics
Breast Neoplasms*/pathology
MicroRNAs*/metabolism
Alkalies/metabolism ; Alkalies/pharmacology ; Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lipid Metabolism/genetics ; Mice ; Mice, Nude ; Polysaccharides/pharmacology
Czasopismo naukowe
Tytuł :
Mechanical force-sensitive lncRNA SNHG8 inhibits osteogenic differentiation by regulating EZH2 in hPDLSCs.
Autorzy :
Zhang Z; Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Wenhua Xi Road No. 44-1 Wenhua Road West, 250012, Jinan, Shandong, China.
He Q; Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Wenhua Xi Road No. 44-1 Wenhua Road West, 250012, Jinan, Shandong, China.
Yang S; Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Wenhua Xi Road No. 44-1 Wenhua Road West, 250012, Jinan, Shandong, China.
Zhao X; Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Wenhua Xi Road No. 44-1 Wenhua Road West, 250012, Jinan, Shandong, China.
Li X; Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Wenhua Xi Road No. 44-1 Wenhua Road West, 250012, Jinan, Shandong, China.
Wei F; Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Wenhua Xi Road No. 44-1 Wenhua Road West, 250012, Jinan, Shandong, China. Electronic address: .
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Źródło :
Cellular signalling [Cell Signal] 2022 May; Vol. 93, pp. 110285. Date of Electronic Publication: 2022 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Osteogenesis*/genetics
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Animals ; Cell Differentiation ; Cells, Cultured ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Mice ; Mice, Nude ; Periodontal Ligament ; Rats
Czasopismo naukowe
Tytuł :
TRIM66 hastens the malignant progression of non-small cell lung cancer via modulating MMP9-mediated TGF-β/SMAD pathway.
Autorzy :
Chen W; Department of Respiratory, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, PR China.
Zhang Y; Department of General Practice, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, PR China.
Fang Z; Department of Respiratory, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, PR China.
Qi W; Department of Cardiothoracic Surgery, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, PR China.
Xu Y; Department of Oncology, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, PR China. Electronic address: .
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Źródło :
Cytokine [Cytokine] 2022 May; Vol. 153, pp. 155831. Date of Electronic Publication: 2022 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/pathology
Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Matrix Metalloproteinase 9/metabolism ; Mice ; Mice, Nude ; Smad Proteins/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Exosomal MMP-1 transfers metastasis potential in triple-negative breast cancer through PAR1-mediated EMT.
Autorzy :
Zhu Y; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Tao Z; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Chen Y; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Pharmacy, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Lin S; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Zhu M; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Ji W; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
Liu X; Division of Surgical Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Li T; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. .; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. .
Hu X; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. .; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. .
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Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2022 May; Vol. 193 (1), pp. 65-81. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/pathology
Triple Negative Breast Neoplasms*/pathology
Matrix Metalloproteinase 1/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Female ; Humans ; Matrix Metalloproteinase 1/genetics ; Matrix Metalloproteinase 1/pharmacology ; Mice ; Mice, Nude ; Neoplasm Metastasis ; Receptor, PAR-1/genetics ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Circ_0008035 promotes the progression of gastric cancer via the regulation of miR-1256/CEACAM6 axis.
Autorzy :
Chu C; Department of Gastrointestinal Surgery, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.
Liu X; Department of Gastrointestinal Surgery, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.
Zhao Z; Department of Gastrointestinal Surgery, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.
Shi Z; Department of Gastrointestinal Surgery, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.
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Źródło :
Cell cycle (Georgetown, Tex.) [Cell Cycle] 2022 May; Vol. 21 (10), pp. 1091-1102. Date of Electronic Publication: 2022 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, CD*/genetics
Antigens, CD*/metabolism
Cell Adhesion Molecules*/genetics
Cell Adhesion Molecules*/metabolism
GPI-Linked Proteins*/genetics
GPI-Linked Proteins*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
RNA, Circular*/genetics
RNA, Circular*/metabolism
Stomach Neoplasms*/genetics
Stomach Neoplasms*/metabolism
Stomach Neoplasms*/pathology
Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Disease Progression ; Mice ; Mice, Nude ; Signal Transduction
Czasopismo naukowe

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