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Tytuł :
Humanized Mice for Infectious and Neurodegenerative disorders.
Autorzy :
Dash PK; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Gorantla S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Poluektova L; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Hasan M; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Waight E; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Zhang C; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Markovic M; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Edagwa B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Machhi J; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Olson KE; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Wang X; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mosley RL; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Kevadiya B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Gendelman HE; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .
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Źródło :
Retrovirology [Retrovirology] 2021 Jun 05; Vol. 18 (1), pp. 13. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Disease Models, Animal*
Immunity, Innate*
Mice, SCID*
Neurodegenerative Diseases/*immunology
Animals ; HIV-1/immunology ; Mice
Czasopismo naukowe
Tytuł :
Nutrient supplements from selected botanicals mediated immune modulation of the tumor microenvironment and antitumor mechanism.
Autorzy :
Chen HM; Department of Oncological Sciences, Icahn School of Medicine At Mount Sinai, New York, 10029, USA.; Immunotherapy Research Center, Houston Methodist Research Institute, Houston, TX, 77030, USA.; Cancer Center, Houston Methodist Research Institute, Houston, 77030, USA.
Sun L; Department of Ophthalmology, Columbia University, New York, 10027, USA.
Pan PY; Department of Oncological Sciences, Icahn School of Medicine At Mount Sinai, New York, 10029, USA.; Immunotherapy Research Center, Houston Methodist Research Institute, Houston, TX, 77030, USA.; Cancer Center, Houston Methodist Research Institute, Houston, 77030, USA.
Wang LH; Institute of Integrated Medicine and Chinese Medical Research Center, China Medical University, Taichung, 40402, Taiwan, ROC. .
Chen SH; Department of Oncological Sciences, Icahn School of Medicine At Mount Sinai, New York, 10029, USA. .; Immunotherapy Research Center, Houston Methodist Research Institute, Houston, TX, 77030, USA. .; Cancer Center, Houston Methodist Research Institute, Houston, 77030, USA. .; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine Graduate School of Medical Sciences, New York, USA. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Dec; Vol. 70 (12), pp. 3435-3449. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*immunology
Carcinoma, Non-Small-Cell Lung/*therapy
Lung Neoplasms/*immunology
Lung Neoplasms/*therapy
Nutrients/*immunology
Plant Extracts/*immunology
Tumor Microenvironment/*immunology
Animals ; Dietary Supplements ; Disease Models, Animal ; Immune Tolerance/immunology ; Immunity/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Mice, Transgenic ; Monocytes/immunology ; Myeloid Cells/immunology ; Myeloid-Derived Suppressor Cells/immunology ; Neoplasm Recurrence, Local/immunology ; Th1 Cells/immunology ; Th17 Cells/immunology
Czasopismo naukowe
Tytuł :
The effect of Gö6976 on chronic myeloid leukemia in vitro and in vivo.
Autorzy :
Cao ZR; The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, People's Republic of China.
Chen XP; The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, People's Republic of China.
Feng M; Neuroscience Research Center, Chongqing Medical University, Chongqing, People's Republic of China.
Hou YL; Zhoukou Union Osteological Hospital, Zhoukou, People's Republic of China.
Li Y; The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, People's Republic of China.
Hu XL; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, People's Republic of China.
Huang ZL; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, People's Republic of China.
Hu J; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, People's Republic of China.
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Źródło :
Hematology (Amsterdam, Netherlands) [Hematology] 2021 Dec; Vol. 26 (1), pp. 543-551.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Carbazoles/*pharmacology
Cell Proliferation/*drug effects
Imatinib Mesylate/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Animals ; Carbazoles/agonists ; Drug Agonism ; Humans ; Imatinib Mesylate/agonists ; K562 Cells ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred NOD ; Mice, SCID ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
R4 RGS proteins suppress engraftment of human hematopoietic stem/progenitor cells by modulating SDF-1/CXCR4 signaling.
Autorzy :
Chan KYY; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Zhang C; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Wong YTS; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Zhang XB; Department of Medicine, Loma Linda University, Loma Linda, CA.
Wang CC; Department of Obstetrics and Gynaecology.
Ng WH; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Fok SP; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Tang PMK; Department of Anatomical and Cellular Pathology.
Kang W; Department of Anatomical and Cellular Pathology.
Feng B; School of Biomedical Sciences.
Poon ENY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Lee KY; Hong Kong Red Cross Blood Transfusion Service, Yau Ma Tei, Hong Kong.
Lee CK; Hong Kong Red Cross Blood Transfusion Service, Yau Ma Tei, Hong Kong.
Chen C; Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China; and.
Leung TY; Department of Obstetrics and Gynaecology.
Ng MHL; Department of Anatomical and Cellular Pathology.
To KF; Department of Anatomical and Cellular Pathology.
Wang H; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Lam HS; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Ng PC; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Yuen PMP; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Li K; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Leung AWK; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Li CK; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong.
Leung KT; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong.
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Źródło :
Blood advances [Blood Adv] 2021 Nov 09; Vol. 5 (21), pp. 4380-4392.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
RGS Proteins*/genetics
Animals ; Antigens, CD34 ; Hematopoietic Stem Cells ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Receptors, CXCR4/genetics
Czasopismo naukowe
Tytuł :
IL-10 induces IgG4 production in NOD-scid Il2rγ mice humanized by engraftment of peripheral blood mononuclear cells.
Autorzy :
Cevhertas L; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.; Department of Medical Immunology, Institute of Health Sciences, Bursa Uludag University, Bursa, Turkey.
Ma S; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.; Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Stanic B; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Ochsner U; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Jansen K; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Ferstl R; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.; Christine Kühne Center for Allergy Research and Education (CK-CARE, Davos, Switzerland.
Frei R; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.; Christine Kühne Center for Allergy Research and Education (CK-CARE, Davos, Switzerland.
Chijioke O; Cellular Immunotherapy, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Münz C; Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Zhang L; Department of Otolaryngology Head and Neck surgery and department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
O'Mahony L; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Akdis M; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
van de Veen W; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
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Źródło :
Allergy [Allergy] 2021 Nov; Vol. 76 (11), pp. 3525-3529. Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-10*
Leukocytes, Mononuclear*
Animals ; Immunoglobulin G ; Mice ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID
Raport
Tytuł :
NK cell receptor and ligand composition influences the clearance of SARS-CoV-2.
Autorzy :
Hsieh WC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Genome and Systems Biology Degree Program, National Taiwan University, Taipei, Taiwan.
Lai EY; Institute of Statistical Science, and.
Liu YT; Institute of Information Science, Academia Sinica, Taipei, Taiwan.
Wang YF; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Tzeng YS; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Cui L; Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of Medicine, Stanford, California, USA.
Lai YJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Solomont School of Nursing, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, Massachusetts, USA.
Huang HC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Huang JH; Institute of Information Science, Academia Sinica, Taipei, Taiwan.; National Institute for Basic Biology, Okazaki, Aichi, Japan.
Ni HC; Institute of Information Science, Academia Sinica, Taipei, Taiwan.
Tsai DY; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Liang JJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Liao CC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Lu YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Jiang L; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Liu MT; Centers for Disease Control, Taipei, Taiwan.
Wang JT; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chang SY; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chen CY; Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Tsai HC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chang YM; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Wernig G; Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of Medicine, Stanford, California, USA.
Li CW; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Lin KI; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Lin YL; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan.
Tsai HK; Institute of Information Science, Academia Sinica, Taipei, Taiwan.
Huang YT; Genome and Systems Biology Degree Program, National Taiwan University, Taipei, Taiwan.; Institute of Statistical Science, and.; Department of Mathematics, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
Chen SY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Genome and Systems Biology Degree Program, National Taiwan University, Taipei, Taiwan.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Nov 01; Vol. 131 (21).
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*immunology
COVID-19/*virology
Killer Cells, Natural/*immunology
Receptors, Natural Killer Cell/*immunology
SARS-CoV-2/*immunology
Adolescent ; Adult ; Aged ; Animals ; Antigens, Differentiation, T-Lymphocyte/immunology ; Cell Adhesion Molecules/immunology ; Cohort Studies ; Cytotoxicity, Immunologic ; Female ; Heterografts ; Host Microbial Interactions/immunology ; Humans ; Immunophenotyping ; In Vitro Techniques ; Ligands ; Male ; Mice ; Mice, SCID ; Middle Aged ; NK Cell Lectin-Like Receptor Subfamily D/immunology ; Pandemics ; Receptors, Immunologic/immunology ; Receptors, Virus/immunology ; Viral Load ; Young Adult
Czasopismo naukowe
Tytuł :
3,3'-Diselenodipropionic acid (DSePA) induces reductive stress in A549 cells triggering p53-independent apoptosis: A novel mechanism for diselenides.
Autorzy :
Gandhi VV; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India; Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
Gandhi KA; Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi, Mumbai, India.
Kumbhare LB; Chemistry Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
Goda JS; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India; Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi, Mumbai, India.
Gota V; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India; Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi, Mumbai, India.
Priyadarsini KI; UM-DAE Centre for Excellence in Basic Sciences, Kalina Campus, Mumbai, 400098, India.
Kunwar A; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India; Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Mumbai, 400085, India. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 Nov 01; Vol. 175, pp. 1-17. Date of Electronic Publication: 2021 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Tumor Suppressor Protein p53*/genetics
A549 Cells ; Animals ; Cell Line, Tumor ; Endoplasmic Reticulum Stress ; Humans ; Mice ; Mice, SCID ; Propionates ; Reactive Oxygen Species/metabolism ; Selenium Compounds
Czasopismo naukowe
Tytuł :
Ultrasound augments on-demand breast tumor radiosensitization and apoptosis through a tri-responsive combinatorial delivery theranostic platform.
Autorzy :
Bhardwaj P; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India. .
Goda JS; Department of Radiation Oncology, Tata Memorial Centre, Mumbai, & Homi Bhabha National Institute, Maharashtra, India. .
Pai V; Department of Radiation Oncology, Tata Memorial Centre, Mumbai, & Homi Bhabha National Institute, Maharashtra, India. .
Chaudhari P; Animal house facility, Tata Memorial Centre, Mumbai, & Homi Bhabha National Institute, Maharashtra, India.
Mohanty B; Animal house facility, Tata Memorial Centre, Mumbai, & Homi Bhabha National Institute, Maharashtra, India.
Pai T; Department of Pathology, Tata Memorial Centre, Mumbai, & Homi Bhabha National Institute, Maharashtra, India.
Vishwakarma K; Department of Radiation Oncology, Tata Memorial Centre, Mumbai, & Homi Bhabha National Institute, Maharashtra, India. .
Thorat R; Animal house facility, Tata Memorial Centre, Mumbai, & Homi Bhabha National Institute, Maharashtra, India.
Wadasadawala T; Department of Radiation Oncology, Tata Memorial Centre, Mumbai, & Homi Bhabha National Institute, Maharashtra, India. .
Banerjee R; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India. .
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Źródło :
Nanoscale [Nanoscale] 2021 Oct 21; Vol. 13 (40), pp. 17077-17092. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Precision Medicine*
Triple Negative Breast Neoplasms*/diagnostic imaging
Triple Negative Breast Neoplasms*/drug therapy
Animals ; Apoptosis ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Positron Emission Tomography Computed Tomography ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Impact of Dose, Duration, and Immune Status on Efficacy of Ultrashort Telacebec Regimens in Mouse Models of Buruli Ulcer.
Autorzy :
Komm O; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7, Baltimore, Maryland, USA.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; First Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Almeida DV; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7, Baltimore, Maryland, USA.
Converse PJ; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7, Baltimore, Maryland, USA.
Omansen TF; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; First Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nuermberger EL; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins Universitygrid.21107.35grid.471401.7, Baltimore, Maryland, USA.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Oct 18; Vol. 65 (11), pp. e0141821. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Buruli Ulcer*/drug therapy
Mycobacterium ulcerans*
Animals ; Imidazoles ; Mice ; Mice, Inbred BALB C ; Mice, SCID ; Piperidines ; Pyridines
Czasopismo naukowe
Tytuł :
Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo.
Autorzy :
Koval A; Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, 1206, Geneva, Switzerland.
Bassanini I; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, 20133, Milano, Italy; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta', Consiglio Nazonale delle Ricerche, 20131, Milano, Italy.
Xu J; Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, 1206, Geneva, Switzerland; Department of Biomedical Sciences, Faculty of Biology and Medicine, 1011, University of Lausanne, Lausanne, Switzerland.
Tonelli M; Dipartimento di Farmacia, Università di Genova, 16132, Genova, Italy.
Boido V; Dipartimento di Farmacia, Università di Genova, 16132, Genova, Italy.
Sparatore F; Dipartimento di Farmacia, Università di Genova, 16132, Genova, Italy.
Amant F; Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven and Department of Oncology, 3000, Leuven, Belgium; Centre for Gynecologic Oncology Amsterdam (CGOA), Antoni Van Leeuwenhoek-Netherlands Cancer Institute (AvL-NKI), University Medical Center (UMC), 1066, Amsterdam, the Netherlands.
Annibali D; Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
Leucci E; Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, 3000, Leuven, Belgium; Trace, LKI Leuven Cancer Institute, KU Leuven, 3000, Leuven, Belgium.
Sparatore A; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, 20133, Milano, Italy. Electronic address: .
Katanaev VL; Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, 1206, Geneva, Switzerland; School of Biomedicine, Far Eastern Federal University, 690922, Vladivostok, Russia. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113562. Date of Electronic Publication: 2021 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Clofazimine/*pharmacology
Phenazines/*pharmacology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Clofazimine/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Molecular Structure ; Phenazines/chemical synthesis ; Phenazines/chemistry ; Solubility ; Structure-Activity Relationship ; Water/chemistry ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Tytuł :
Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain.
Autorzy :
Bhan A; Division of Neurosurgery, Beckman Research Institute, City of Hope Medical Center, 1500 E. Duarte Rd, Duarte, CA, 91010, USA. .
Ansari K; Division of Neurosurgery, Beckman Research Institute, City of Hope Medical Center, 1500 E. Duarte Rd, Duarte, CA, 91010, USA.; Celcuity LLC, Minneapolis, MN, 55446, USA.
Chen MY; Division of Neurosurgery, Beckman Research Institute, City of Hope Medical Center, 1500 E. Duarte Rd, Duarte, CA, 91010, USA.
Jandial R; Division of Neurosurgery, Beckman Research Institute, City of Hope Medical Center, 1500 E. Duarte Rd, Duarte, CA, 91010, USA.
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Źródło :
Scientific reports [Sci Rep] 2021 Oct 15; Vol. 11 (1), pp. 16866. Date of Electronic Publication: 2021 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain Neoplasms/*drug therapy
Breast Neoplasms/*drug therapy
Induced Pluripotent Stem Cells/*drug effects
Lapatinib/*pharmacology
Neoplasm Metastasis/*pathology
Receptor, ErbB-2/*drug effects
Animals ; Antineoplastic Agents/pharmacology ; Brain Neoplasms/secondary ; Breast Neoplasms/pathology ; Drug Carriers/pharmacology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Mice, Inbred NOD ; Mice, SCID ; Quinazolines/pharmacology ; Receptor, ErbB-2/metabolism
Czasopismo naukowe
Tytuł :
Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline.
Autorzy :
Sullivan JR; Department of Microbiology & Immunology, McGill University, Montréal, Canada.; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada.; McGill International TB Centre, Montréal, Canada.
Lupien A; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada.; McGill International TB Centre, Montréal, Canada.
Kalthoff E; Department of Biochemistry, McGill University, Montréal, Canada.; Centre de Recherche en Biologie Structural, McGill University, Montréal, Canada.
Hamela C; Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.
Taylor L; Clinical Proteomics Platform, Research Institute of the McGill University Health Centre, Montréal, Canada.
Munro KA; Department of Biochemistry, McGill University, Montréal, Canada.; Centre de Recherche en Biologie Structural, McGill University, Montréal, Canada.
Schmeing TM; Department of Biochemistry, McGill University, Montréal, Canada.; Centre de Recherche en Biologie Structural, McGill University, Montréal, Canada.
Kremer L; Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.; INSERM, IRIM, Montpellier, France.
Behr MA; Department of Microbiology & Immunology, McGill University, Montréal, Canada.; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada.; McGill International TB Centre, Montréal, Canada.; Department of Medicine, McGill University Health Centre, Montréal, Canada.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Oct 12; Vol. 17 (10), pp. e1009965. Date of Electronic Publication: 2021 Oct 12 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mycobacterium Infections, Nontuberculous*
Antitubercular Agents/*pharmacology
Mycobacterium abscessus/*drug effects
Valine/*analogs & derivatives
Animals ; Drug Therapy, Combination/methods ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Valine/pharmacology ; Zebrafish
Czasopismo naukowe
Tytuł :
sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis.
Autorzy :
Zhao Y; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.; Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
Yang X; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
Li S; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
Zhang B; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
Li S; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
Wang X; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
Wang Y; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
Jia C; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China.
Chang Y; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China. .
Wei W; Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Ministry of Education, Hefei, 230032, China. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Oct 09; Vol. 12 (1), pp. 535. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthritis, Experimental*
Mesenchymal Stem Cell Transplantation*
Animals ; Apoptosis ; Autophagy ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł :
Molecular Imaging of Human Skeletal Myoblasts (huSKM) in Mouse Post-Infarction Myocardium.
Autorzy :
Fiedorowicz K; Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Wargocka-Matuszewska W; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02-089 Warsaw, Poland.
Ambrożkiewicz KA; Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Rugowska A; Faculty of Biology, Institute of Human Biology and Evolution, Adam Mickiewicz University, 60-479 Poznan, Poland.
Cheda Ł; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02-089 Warsaw, Poland.
Fiedorowicz M; Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Zimna A; Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Drabik M; Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Borkowski S; Institute of Radioelectronics and Multimedia Technology, Warsaw University of Technology, 00-665 Warsaw, Poland.
Świątkiewicz M; Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Bogorodzki P; Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.; Institute of Radioelectronics and Multimedia Technology, Warsaw University of Technology, 00-665 Warsaw, Poland.
Grieb P; Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Hamankiewicz P; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02-089 Warsaw, Poland.
Kolanowski TJ; Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Rozwadowska N; Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Kozłowska U; Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Klimczak A; Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
Kolasiński J; Kolasiński Clinic, Hair Clinic Poznan, 62-020 Swarzędz, Poland.
Rogulski Z; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02-089 Warsaw, Poland.
Kurpisz M; Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 08; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Mesenchymal Stem Cells/*cytology
Molecular Imaging/*methods
Myoblasts, Skeletal/*cytology
Myocardial Infarction/*pathology
Myocardium/*pathology
Animals ; Disease Models, Animal ; Genes, Reporter ; Humans ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Myoblasts, Skeletal/metabolism ; Myocardial Infarction/metabolism ; Myocardium/metabolism
Czasopismo naukowe
Tytuł :
Human Adipose-Derived Mesenchymal Stem Cells Ameliorate Elastase-Induced Emphysema in Mice by Mesenchymal-Epithelial Transition.
Autorzy :
Fujioka N; Department of Respiratory Medicine, Nara Medical University, Kashihara, Nara, Japan.
Kitabatake M; Department of Immunology, Nara Medical University, Kashihara, Nara, Japan.
Ouji-Sageshima N; Department of Immunology, Nara Medical University, Kashihara, Nara, Japan.
Ibaraki T; Department of Respiratory Medicine, Nara Medical University, Kashihara, Nara, Japan.
Kumamoto M; Department of Respiratory Medicine, Nara Medical University, Kashihara, Nara, Japan.
Fujita Y; Department of Respiratory Medicine, Nara Medical University, Kashihara, Nara, Japan.
Hontsu S; Department of Respiratory Medicine, Nara Medical University, Kashihara, Nara, Japan.
Yamauchi M; Department of Respiratory Medicine, Nara Medical University, Kashihara, Nara, Japan.
Yoshikawa M; Department of Respiratory Medicine, Nara Medical University, Kashihara, Nara, Japan.
Muro S; Department of Respiratory Medicine, Nara Medical University, Kashihara, Nara, Japan.
Ito T; Department of Immunology, Nara Medical University, Kashihara, Nara, Japan.
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Źródło :
International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2021 Oct 08; Vol. 16, pp. 2783-2793. Date of Electronic Publication: 2021 Oct 08 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Emphysema*
Mesenchymal Stem Cells*
Pulmonary Disease, Chronic Obstructive*/chemically induced
Pulmonary Disease, Chronic Obstructive*/therapy
Pulmonary Emphysema*/chemically induced
Pulmonary Emphysema*/genetics
Pulmonary Emphysema*/therapy
Animals ; Disease Models, Animal ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, SCID ; Pancreatic Elastase ; Swine
Czasopismo naukowe
Tytuł :
Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis.
Autorzy :
Pernigoni N; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Zagato E; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Calcinotto A; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Troiani M; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Mestre RP; Medical Oncology Unit, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.
Calì B; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Attanasio G; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Troisi J; Theoreo Srl, Montecorvino Pugliano, 84090 Salerno, Italy.
Minini M; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Mosole S; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Revandkar A; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Pasquini E; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Elia AR; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Bossi D; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Rinaldi A; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Rescigno P; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Turin, Italy.
Flohr P; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
Hunt J; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
Neeb A; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
Buroni L; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
Guo C; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
Welti J; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
Ferrari M; Medical Oncology Unit, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.
Grioni M; Cellular Immunology Unit, IRCCS Ospedale San Raffaele, 20100 Milan, Italy.
Gauthier J; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Florida College of Medicine, Gainesville, FL, USA.
Gharaibeh RZ; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Florida College of Medicine, Gainesville, FL, USA.
Palmisano A; Experimental Imaging Center, San Raffaele Scientific Institute, 20100 Milan, Italy.; School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.
Lucchini GM; Clinical Microbiology Unit, Ente Ospedaliero Cantonale, EOC, CH-6500 Bellinzona, Switzerland.
D'Antonio E; Medical Oncology Unit, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.
Merler S; Department of Medicine, Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy.; Section of Oncology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Bolis M; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.; Computational Oncology Unit, Department of Oncology, Istituto di Ricerche Farmacologiche 'Mario Negri' IRCCS, 20156 Milano, Italy.
Grassi F; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.
Esposito A; Experimental Imaging Center, San Raffaele Scientific Institute, 20100 Milan, Italy.; School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.
Bellone M; Cellular Immunology Unit, IRCCS Ospedale San Raffaele, 20100 Milan, Italy.
Briganti A; Division of Oncology, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy.
Rescigno M; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Milan, Italy.
Theurillat JP; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.
Jobin C; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Florida College of Medicine, Gainesville, FL, USA.; Department of Infectious Diseases and Immunology, University of Florida College of Medicine, Gainesville, FL, USA.; Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA.
Gillessen S; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.; Medical Oncology Unit, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.
de Bono J; Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
Alimonti A; Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.; Department of Medicine, Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy.; Department of Health Sciences and Technology, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Oct 08; Vol. 374 (6564), pp. 216-224. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Host Microbial Interactions*
Androgens/*biosynthesis
Bacteria/*metabolism
Gastrointestinal Microbiome/*physiology
Prostatic Neoplasms, Castration-Resistant/*metabolism
Prostatic Neoplasms, Castration-Resistant/*microbiology
Aged ; Aged, 80 and over ; Androgen Antagonists/therapeutic use ; Animals ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/genetics ; Cell Line, Tumor ; Fecal Microbiota Transplantation ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; Neoplasms, Experimental ; Prevotella/metabolism ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Symbiosis ; Xenograft Model Antitumor Assays
SCR Organism :
Prevotella stercorea
Czasopismo naukowe
Tytuł :
Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias.
Autorzy :
Suryawanshi GW; Department of Microbiology, Immunology and Molecular Genetics, University of California, 615 Charles E. Young Dr. South, BSRB, Rm 173, Los Angeles, CA, 90095, USA.; UCLA AIDS Institute, Los Angeles, CA, 90095, USA.
Arokium H; Department of Microbiology, Immunology and Molecular Genetics, University of California, 615 Charles E. Young Dr. South, BSRB, Rm 173, Los Angeles, CA, 90095, USA.; UCLA AIDS Institute, Los Angeles, CA, 90095, USA.
Kim S; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Center for Retrovirus Research, The Ohio State University, Columbus, OH, 43210, USA.; Infectious Disease Institute, The Ohio State University, Columbus, OH, 43210, USA.
Khamaikawin W; School of Nursing, University of California, Los Angeles, CA, 90095, USA.; Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
Lin S; School of Nursing, University of California, Los Angeles, CA, 90095, USA.
Shimizu S; School of Nursing, University of California, Los Angeles, CA, 90095, USA.
Chupradit K; School of Nursing, University of California, Los Angeles, CA, 90095, USA.
Lee Y; Department of Microbiology, Immunology and Molecular Genetics, University of California, 615 Charles E. Young Dr. South, BSRB, Rm 173, Los Angeles, CA, 90095, USA.; UCLA AIDS Institute, Los Angeles, CA, 90095, USA.
Xie Y; Department of Microbiology, Immunology and Molecular Genetics, University of California, 615 Charles E. Young Dr. South, BSRB, Rm 173, Los Angeles, CA, 90095, USA.; UCLA AIDS Institute, Los Angeles, CA, 90095, USA.
Guan X; Department of Microbiology, Immunology and Molecular Genetics, University of California, 615 Charles E. Young Dr. South, BSRB, Rm 173, Los Angeles, CA, 90095, USA.; UCLA AIDS Institute, Los Angeles, CA, 90095, USA.
Suryawanshi V; Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA, 90089, USA.
Presson AP; Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, 84108, USA.; Department of Biostatistics, University of California, Los Angeles, 90095, USA.
An DS; UCLA AIDS Institute, Los Angeles, CA, 90095, USA.; School of Nursing, University of California, Los Angeles, CA, 90095, USA.
Chen ISY; Department of Microbiology, Immunology and Molecular Genetics, University of California, 615 Charles E. Young Dr. South, BSRB, Rm 173, Los Angeles, CA, 90095, USA. .; UCLA AIDS Institute, Los Angeles, CA, 90095, USA. .; Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Oct 07; Vol. 12 (1), pp. 528. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells*
Animals ; Disease Models, Animal ; Hematopoiesis ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID
Czasopismo naukowe
Tytuł :
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).
Autorzy :
Huang Q; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Zhong Y; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Li B; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Ouyang S; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Deng L; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Mo J; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Shi S; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Lv N; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Wu R; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Liu P; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Hu W; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Zhang X; Guangdong Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address: .
Wang Y; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 05; Vol. 221, pp. 113525. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Pyridines/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Molecular Docking Simulation ; Molecular Structure ; Pyridines/chemical synthesis ; Pyridines/chemistry ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma.
Autorzy :
Castelli R; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43124, Parma, Italy.
Taranto S; Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, via Branze 39, I-25123, Brescia, Italy.
Furiassi L; Dipartimento di Scienze Biomolecolari, Università, degli Studi di Urbino 'Carlo Bo', Piazza Rinascimento 6, I-61029, Urbino, Italy.
Bozza N; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43124, Parma, Italy.
Marseglia G; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43124, Parma, Italy.
Ferlenghi F; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43124, Parma, Italy.
Rivara S; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43124, Parma, Italy. Electronic address: .
Retini M; Dipartimento di Scienze Biomolecolari, Università, degli Studi di Urbino 'Carlo Bo', Piazza Rinascimento 6, I-61029, Urbino, Italy.
Bedini A; Dipartimento di Scienze Biomolecolari, Università, degli Studi di Urbino 'Carlo Bo', Piazza Rinascimento 6, I-61029, Urbino, Italy.
Spadoni G; Dipartimento di Scienze Biomolecolari, Università, degli Studi di Urbino 'Carlo Bo', Piazza Rinascimento 6, I-61029, Urbino, Italy.
Matarazzo S; Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, via Branze 39, I-25123, Brescia, Italy.
Ronca R; Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, via Branze 39, I-25123, Brescia, Italy.
Presta M; Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, via Branze 39, I-25123, Brescia, Italy.
Mor M; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43124, Parma, Italy.
Giacomini A; Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, via Branze 39, I-25123, Brescia, Italy.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 05; Vol. 221, pp. 113529. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Fibroblast Growth Factors/*antagonists & inhibitors
Multiple Myeloma/*drug therapy
Animals ; Antineoplastic Agents ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cholesterol/analogs & derivatives ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Fibroblast Growth Factors/metabolism ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Molecular Structure ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Human Liver Stem Cell Derived Extracellular Vesicles Alleviate Kidney Fibrosis by Interfering with the β-Catenin Pathway through miR29b.
Autorzy :
Kholia S; Department of Medical Sciences, University of Torino, 10126 Torino, Italy.; Molecular Biotechnology Centre, University of Torino, 10126 Torino, Italy.
Herrera Sanchez MB; Molecular Biotechnology Centre, University of Torino, 10126 Torino, Italy.; 2i3T Società Per la Gestione Dell'incubatore di Imprese e per il Trasferimento Tecnologico Scarl, University of Torino, 10126 Torino, Italy.
Deregibus MC; Molecular Biotechnology Centre, University of Torino, 10126 Torino, Italy.; 2i3T Società Per la Gestione Dell'incubatore di Imprese e per il Trasferimento Tecnologico Scarl, University of Torino, 10126 Torino, Italy.
Sassoè-Pognetto M; Department of Neurosciences, University of Torino, 10126 Torino, Italy.
Camussi G; Department of Medical Sciences, University of Torino, 10126 Torino, Italy.
Brizzi MF; Department of Medical Sciences, University of Torino, 10126 Torino, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 05; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Extracellular Vesicles/*physiology
Fibrosis/*prevention & control
Kidney Diseases/*prevention & control
Liver/*cytology
Stem Cells/*cytology
beta Catenin/*metabolism
Animals ; Apoptosis ; Biomarkers/metabolism ; Cell Proliferation ; Cells, Cultured ; Disease Models, Animal ; Female ; Fibrosis/etiology ; Fibrosis/metabolism ; Fibrosis/pathology ; Gene Expression Regulation ; Humans ; Kidney Diseases/etiology ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Liver/metabolism ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; MicroRNAs/genetics ; Stem Cells/metabolism ; beta Catenin/genetics
Czasopismo naukowe

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