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Tytuł:
Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease.
Autorzy:
Fang Z; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Shen G; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Wang Y; Department of VIP Medical Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Hong F; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Tang X; Physical Examination Center, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Zeng Y; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Zhang T; Department of Clinical Laboratory, Guangzhou First People's Hospital, Guangzhou, 510080, China.
Liu H; Guangdong Key Laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Li Y; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Wang J; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Zhang J; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Gao A; Department of Health Sciences, College of Health Solutions, Arizona State University, Tempe, USA.
Qi W; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Yang X; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. .; Guangdong Engineering & Technology Research Center for Gene Manipulation and Biomacromolecular Products, Sun Yat-Sen University, Guangzhou, 510080, China. .
Zhou T; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. .; Guangdong Province Key Laboratory of Diabetology, Guangzhou, 510080, China. .
Gao G; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. .; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. .
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Źródło:
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Mar 12; Vol. 9 (1), pp. 66. Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/genetics
Non-alcoholic Fatty Liver Disease*/metabolism
Serpins*
Humans ; Mice ; Rats ; Animals ; Inflammation/metabolism ; Mice, Transgenic
Czasopismo naukowe
Tytuł:
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
Autorzy:
Xu H; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
Qiu Q; Department of Genetics, Penn Epigenetics Institute, Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hu P; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Ministry of Education), Shanghai Ocean University, Shanghai, China.
Hoxha K; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jang E; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
O'Reilly M; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kim C; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
He Z; Interdisciplinary Research Center On Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China.; University of the Chinese Academy of Sciences, Beijing, 100049, China.
Marotta N; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Changolkar L; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zhang B; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wu H; Department of Genetics, Penn Epigenetics Institute, Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Schellenberg GD; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kraemer B; Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, 98195, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, 98104, USA.
Luk KC; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lee EB; Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Trojanowski JQ; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Brunden KR; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lee VM; Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło:
Acta neuropathologica [Acta Neuropathol] 2024 Mar 12; Vol. 147 (1), pp. 55. Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Tauopathies*/pathology
Alzheimer Disease*/pathology
Mice ; Humans ; Animals ; Brain/pathology ; tau Proteins/metabolism ; Neurons/pathology ; Mice, Transgenic ; Mammals/metabolism ; Adaptor Proteins, Signal Transducing/metabolism
Czasopismo naukowe
Tytuł:
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12.
Autorzy:
Sepulveda J; Department of Pharmacology & Physiology, Georgetown University, Washington, DC, 20007, USA.
Kim JY; Department of Neuroscience, Georgetown University, Washington, DC, 20007, USA.
Binder J; Department of Neuroscience, Georgetown University, Washington, DC, 20007, USA.
Vicini S; Department of Pharmacology & Physiology, Georgetown University, Washington, DC, 20007, USA.
Rebeck GW; Department of Neuroscience, Georgetown University, Washington, DC, 20007, USA. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2024 Mar 11; Vol. 19 (1), pp. 24. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Amyloid beta-Peptides*/metabolism
Animals ; Mice ; Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology ; Apolipoprotein E3/genetics ; Apolipoprotein E3/metabolism ; Apolipoprotein E4/genetics ; Apolipoprotein E4/metabolism ; Brain/metabolism ; Genotype ; Mice, Transgenic ; Microglia/metabolism
Czasopismo naukowe
Tytuł:
Evidence for disrupted copper availability in human spinal cord supports Cu (atsm) as a treatment option for sporadic cases of ALS.
Autorzy:
Hilton JBW; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia.
Kysenius K; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia.
Liddell JR; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia.
Mercer SW; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia.
Paul B; School of Geography, Earth and Atmospheric Sciences, The University of Melbourne, Victoria, 3010, Australia.; Elemental Scientific Lasers, LLC, 685 Old Buffalo Trail, Bozeman, MT, 59715, USA.
Beckman JS; Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA.
McLean CA; Department of Anatomical Pathology, The Alfred Hospital, Victoria, 3004, Australia.
White AR; Mental Health Program, Department of Cell and Molecular Biology, Queensland Institute of Biomedical Research Berghofer, Herston, QLD, 4006, Australia.
Donnelly PS; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, 3010, Australia.
Bush AI; Melbourne Dementia Research Centre, The University of Melbourne and Florey Institute of Neuroscience and Mental Health, Victoria, 3010, Australia.
Hare DJ; Atomic Medicine Initiative, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Roberts BR; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Crouch PJ; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 11; Vol. 14 (1), pp. 5929. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/metabolism
Neurodegenerative Diseases*/metabolism
Thiosemicarbazones*
Coordination Complexes*
Humans ; Mice ; Animals ; Copper/metabolism ; Superoxide Dismutase/metabolism ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism ; Mice, Transgenic ; Spinal Cord/metabolism ; Ceruloplasmin/metabolism ; Disease Models, Animal
SCR Disease Name:
Amyotrophic lateral sclerosis 1
Czasopismo naukowe
Tytuł:
PCDHA9 as a candidate gene for amyotrophic lateral sclerosis.
Autorzy:
Zhong J; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100101, China.
Wang C; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disease, Beijing, 100053, China. .
Zhang D; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100101, China.
Yao X; Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Zhao Q; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Huang X; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Lin F; Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Xue C; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100101, China.
Wang Y; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100101, China.
He R; Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Li XY; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disease, Beijing, 100053, China.
Li Q; Shenzhen Clabee Biotechnology Incorporation, Shenzhen, 518057, China.
Wang M; Shanghai Key Laboratory of Birth Defects, Division of Neonatology, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, 201102, China.
Zhao S; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100101, China.
Afridi SK; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100101, China.
Zhou W; Shanghai Key Laboratory of Birth Defects, Division of Neonatology, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, 201102, China.
Wang Z; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disease, Beijing, 100053, China.
Xu Y; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, China. .
Xu Z; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China. .; University of Chinese Academy of Sciences, Beijing, 100101, China. .
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Źródło:
Nature communications [Nat Commun] 2024 Mar 11; Vol. 15 (1), pp. 2189. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/metabolism
Neurodegenerative Diseases*/metabolism
Humans ; Mice ; Animals ; Aged ; Mice, Transgenic ; Motor Neurons/metabolism ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł:
Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss.
Autorzy:
Lei HY; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Pi GL; Department of Traditional Chinese Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
He T; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xiong R; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Lv JR; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Liu JL; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wu DQ; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Li MZ; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Shi K; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Li SH; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yu NN; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Gao Y; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yu HL; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wei LY; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wang X; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhou QZ; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zou PL; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhou JY; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Liu YZ; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Shen NT; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yang J; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Ke D; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wang Q; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Liu GP; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yang XF; Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, Guangdong, China.
Wang JZ; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226000, Jiangsu, China. .
Yang Y; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .
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Źródło:
Military Medical Research [Mil Med Res] 2024 Mar 11; Vol. 11 (1), pp. 16. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Humans ; Male ; Mice ; Animals ; Mice, Transgenic ; Proteomics ; Hippocampus/metabolism ; Hippocampus/pathology ; Memory Disorders/metabolism
Czasopismo naukowe
Tytuł:
Updates on mouse models of Alzheimer's disease.
Autorzy:
Zhong MZ; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Biology, College of Arts and Science, Boston University, Boston, MA, 02215, USA.
Peng T; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Science Research Program, Scarsdale High School, New York, NY, 10583, USA.
Duarte ML; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Research & Development, James J Peters VA Medical Center, Bronx, NY, 10468, USA. .
Wang M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. .; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. .
Cai D; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Research & Development, James J Peters VA Medical Center, Bronx, NY, 10468, USA. .; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Department of Neurology, N. Bud Grossman Center for Memory Research and Care, The University of Minnesota, Minneapolis, MN, 55455, USA. .; Geriatric Research Education & Clinical Center (GRECC), The Minneapolis VA Health Care System, Minneapolis, MN, 55417, USA. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2024 Mar 11; Vol. 19 (1), pp. 23. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/pathology
Neurodegenerative Diseases*
Male ; Female ; Humans ; Mice ; Animals ; tau Proteins/genetics ; Amyloid beta-Protein Precursor/genetics ; Mice, Transgenic ; Disease Models, Animal ; Amyloid beta-Peptides
Czasopismo naukowe
Tytuł:
Endothelium-targeted Ddx24 conditional knockout exacerbates ConA-induced hepatitis in mice due to vascular hyper-permeability.
Autorzy:
Gan H; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.
Cai J; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.
Li L; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.
Zheng X; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.
Yan L; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.
Hu X; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.
Zhao N; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.
Li B; Department of Ophthalmology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China. Electronic address: .
He J; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China. Electronic address: .
Wang D; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China. Electronic address: .
Pang P; Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Mar 10; Vol. 129, pp. 111618. Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*/metabolism
Hepatitis*
Animals ; Mice ; Concanavalin A/toxicity ; Endothelium/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic
Czasopismo naukowe
Tytuł:
FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
Autorzy:
Kodavati M; Division of DNA Repair Research within the Center for Neuroregeneration, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
Wang H; Division of DNA Repair Research within the Center for Neuroregeneration, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
Guo W; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.; Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; INSERM, UMR-S1118, Mécanismes Centraux et Périphériques de la Neurodégénérescence, Université de Strasbourg, CRBS, Strasbourg, France.
Mitra J; Division of DNA Repair Research within the Center for Neuroregeneration, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
Hegde PM; Division of DNA Repair Research within the Center for Neuroregeneration, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
Provasek V; Division of DNA Repair Research within the Center for Neuroregeneration, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.; College of Medicine, Texas A&M University, College Station, TX, USA.
Rao VHM; Division of DNA Repair Research within the Center for Neuroregeneration, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
Vedula I; Center for Bioenergetics, Houston Methodist Research Institute, Houston, TX, USA.
Zhang A; Center for Bioenergetics, Houston Methodist Research Institute, Houston, TX, USA.; Department of Medicine, Houston Methodist, Weill Cornell Medicine affiliate, Houston, TX, USA.
Mitra S; Division of DNA Repair Research within the Center for Neuroregeneration, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
Tomkinson AE; Departments of Internal Medicine, and Molecular Genetics and Microbiology and University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA.
Hamilton DJ; Center for Bioenergetics, Houston Methodist Research Institute, Houston, TX, USA.; Department of Medicine, Houston Methodist, Weill Cornell Medicine affiliate, Houston, TX, USA.
Van Den Bosch L; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.
Hegde ML; Division of DNA Repair Research within the Center for Neuroregeneration, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA. .; Department of Neuroscience, Weill Cornell Medical College, New York, NY, USA. .
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Źródło:
Nature communications [Nat Commun] 2024 Mar 09; Vol. 15 (1), pp. 2156. Date of Electronic Publication: 2024 Mar 09.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/metabolism
Motor Neuron Disease*
Mitochondrial Diseases*
Humans ; Animals ; Mice ; Ligases/metabolism ; Mutation ; Mice, Transgenic ; DNA, Mitochondrial/genetics ; RNA-Binding Protein FUS/genetics ; RNA-Binding Protein FUS/metabolism
Czasopismo naukowe
Tytuł:
TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration.
Autorzy:
Creus-Muncunill J; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Haure-Mirande JV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Mattei D; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Bons J; Buck Institute for Research on Aging, Novato, CA, USA.
Ramirez AV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Hamilton BW; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Corwin C; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Chowdhury S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Schilling B; Buck Institute for Research on Aging, Novato, CA, USA.
Ellerby LM; Buck Institute for Research on Aging, Novato, CA, USA.
Ehrlich ME; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Mar 08; Vol. 21 (1), pp. 66. Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/metabolism
Mice ; Animals ; Humans ; Microglia/metabolism ; Gliosis/genetics ; Gliosis/metabolism ; Proteomics ; Corpus Striatum/metabolism ; Disease Models, Animal ; Mice, Transgenic ; Membrane Proteins/metabolism ; Adaptor Proteins, Signal Transducing/metabolism
Czasopismo naukowe
Tytuł:
Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice.
Autorzy:
Nowicka N; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Zglejc-Waszak K; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Juranek J; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Korytko A; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Wąsowicz K; Department of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Chmielewska-Krzesińska M; Department of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Wojtkiewicz J; Department of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medium, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
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Źródło:
PloS one [PLoS One] 2024 Mar 08; Vol. 19 (3), pp. e0299567. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/genetics
Amyotrophic Lateral Sclerosis*/metabolism
Amyotrophic Lateral Sclerosis*/pathology
Neurodegenerative Diseases*
Superoxide Dismutase-1*/genetics
Superoxide Dismutase-1*/metabolism
Animals ; Humans ; Mice ; Disease Models, Animal ; Disease Progression ; Mice, Transgenic ; Prospective Studies ; Receptor for Advanced Glycation End Products/genetics ; Signal Transduction ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł:
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria.
Autorzy:
Foss S; Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.
Sakya SA; Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.
Aguinagalde L; Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Lustig M; Section for Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Shaughnessy J; Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Cruz AR; Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Scheepmaker L; Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Mathiesen L; Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Ruso-Julve F; Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.
Anthi AK; Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.
Gjølberg TT; Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.
Mester S; Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.
Bern M; Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.
Evers M; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
Bratlie DB; Infection Immunology, Norwegian Institute of Public Health, Oslo, Norway.
Michaelsen TE; Infection Immunology, Norwegian Institute of Public Health, Oslo, Norway.; Department of Chemical Pharmacy, School of Pharmacy, University of Oslo, Oslo, Norway.
Schlothauer T; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Munich, Germany.
Sok D; International AIDS Vaccine Initiative (IAVI), New York, NY, USA.
Bhattacharya J; Antibody Translational Research Program, Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
Leusen J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
Valerius T; Section for Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Ram S; Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Rooijakkers SHM; Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Sandlie I; Department of Biosciences, University of Oslo, Oslo, Norway.
Andersen JT; Department of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. .; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway. .; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway. .
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Źródło:
Nature communications [Nat Commun] 2024 Mar 07; Vol. 15 (1), pp. 2007. Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, Fc*
Neoplasms*/therapy
Neoplasms*/drug therapy
Mice ; Animals ; Humans ; Immunoglobulin G ; Half-Life ; Anti-Bacterial Agents/therapeutic use ; Gram-Negative Bacteria/metabolism ; Gram-Positive Bacteria/metabolism ; Mice, Transgenic ; Antibodies, Monoclonal ; Histocompatibility Antigens Class I/metabolism
Czasopismo naukowe
Tytuł:
Neuronal Protection by Ha-RAS-GTPase Signaling through Selective Downregulation of Plasmalemmal Voltage-Dependent Anion Channel-1.
Autorzy:
Neumann S; Department of Biochemistry II-Molecular Neurobiochemistry, Faculty of Chemistry and Biochemistry, Ruhr-Universität Bochum, 44801 Bochum, Germany.
Kuteykin-Teplyakov K; Department of Biochemistry II-Molecular Neurobiochemistry, Faculty of Chemistry and Biochemistry, Ruhr-Universität Bochum, 44801 Bochum, Germany.
Heumann R; Department of Biochemistry II-Molecular Neurobiochemistry, Faculty of Chemistry and Biochemistry, Ruhr-Universität Bochum, 44801 Bochum, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 06; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Voltage-Dependent Anion Channels*/metabolism
Neurodegenerative Diseases*/metabolism
Mice ; Animals ; Neuroprotection ; ras Proteins/metabolism ; Down-Regulation ; Voltage-Dependent Anion Channel 1/metabolism ; Cell Membrane/metabolism ; Mice, Transgenic ; RNA, Messenger/metabolism ; Voltage-Dependent Anion Channel 2/metabolism
Czasopismo naukowe
Tytuł:
Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation.
Autorzy:
Cho M; Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Han JK; Brain Science Institute, Korea Institute of Science and Technology, 5. Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.
Suh J; Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kim JJ; Department of Electronics Engineering, Pusan National University, 2, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan, 46241, Republic of Korea.
Ryu JR; Department of Anatomy, College of Medicine, Korea University, 17-gil Koryodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Min IS; Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Sang M; Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Lim S; Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kim TS; Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kim K; Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kang K; Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Hwang K; School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Kim K; Brain Science Institute, Korea Institute of Science and Technology, 5. Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.
Hong EB; Center for Brain Function, Korea Institute of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.
Nam MH; Center for Brain Function, Korea Institute of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.
Kim J; School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Song YM; School of Electrical Engineering and Computer Science (EECS), Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
Lee GJ; Department of Electronics Engineering, Pusan National University, 2, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan, 46241, Republic of Korea. .
Cho IJ; Department of Convergence Medicine, College of Medicine, Korea University, 17-gil Koryodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. .; Department of Anatomy, College of Medicine, Korea University, 7-gil Koryodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. .
Yu KJ; Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. .; Department of Electrical and Electronic Engineering, YU-Korea Institute of Science and Technology (KIST) Institute, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea. .
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Źródło:
Nature communications [Nat Commun] 2024 Mar 06; Vol. 15 (1), pp. 2000. Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Absorbable Implants*
Central Nervous System Depressants*
Animals ; Mice ; Optogenetics ; Artifacts ; Brain ; Electronics ; Mice, Transgenic
Czasopismo naukowe
Tytuł:
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1.
Autorzy:
Xie X; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Lan Q; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200032, China.
Zhao J; University of Chinese Academy of Sciences, Beijing, 100049, China.; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhang S; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Liu L; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhang Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Xu W; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200032, China.
Shao M; University of Chinese Academy of Sciences, Beijing, 100049, China.; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Peng J; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Xia S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200032, China.
Zhu Y; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhang K; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xian Lin Road, Jiangsu, 210023, Nanjing, China.
Zhang X; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhang R; University of Chinese Academy of Sciences, Beijing, 100049, China.; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Li J; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xian Lin Road, Jiangsu, 210023, Nanjing, China.
Dai W; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Ge Z; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xian Lin Road, Jiangsu, 210023, Nanjing, China.
Hu S; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Yu C; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Wang J; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Ma D; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Zheng M; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xian Lin Road, Jiangsu, 210023, Nanjing, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China.
Yang H; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Xiao G; University of Chinese Academy of Sciences, Beijing, 100049, China.; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Rao Z; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Lu L; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200032, China.
Zhang L; University of Chinese Academy of Sciences, Beijing, 100049, China. .; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China. .
Bai F; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. .
Zhao Y; National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, 518112, China. .
Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200032, China. .
Liu H; Drug Discovery and Design Center, State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. .; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xian Lin Road, Jiangsu, 210023, Nanjing, China. .; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China. .
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Źródło:
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Mar 06; Vol. 9 (1), pp. 54. Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatitis C, Chronic*
COVID-19*
Humans ; Animals ; Mice ; Rats ; Dogs ; Calpain ; Cathepsin L ; Antiviral Agents/pharmacology ; COVID-19 Vaccines ; Disease Models, Animal ; Mice, Transgenic ; Anti-Inflammatory Agents
Czasopismo naukowe
Tytuł:
Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT 7 R.
Autorzy:
Jeong JH; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Lee H; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Kim D; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Park E; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Woo J; Research Animal Resource Center, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Cho Y; Research Animal Resource Center, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Keum G; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Lee A; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Kang T; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Kim J; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Choo H; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Lee S; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
Jeon B; Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seongbuk-gu, Seoul 02792, Republic of Korea.
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Źródło:
ACS chemical neuroscience [ACS Chem Neurosci] 2024 Mar 06; Vol. 15 (5), pp. 1026-1041. Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Autism Spectrum Disorder*
Biphenyl Compounds*
Animals ; Mice ; Serotonin ; beta-Arrestins ; Signal Transduction ; Mice, Transgenic ; GTP-Binding Proteins ; Disease Models, Animal ; Microfilament Proteins ; Nerve Tissue Proteins
Czasopismo naukowe
Tytuł:
D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning.
Autorzy:
Zachry JE; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Kutlu MG; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Yoon HJ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Leonard MZ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Chevée M; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Patel DD; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Gaidici A; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Kondev V; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Thibeault KC; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Bethi R; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Tat J; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Melugin PR; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Isiktas AU; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA; Department of Neuroscience, Yale University, New Haven, CT 06520, USA.
Joffe ME; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Cai DJ; Nash Family Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA.
Conn PJ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Grueter BA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Calipari ES; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: .
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Źródło:
Neuron [Neuron] 2024 Mar 06; Vol. 112 (5), pp. 835-849.e7. Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, Dopamine D1*/metabolism
Medium Spiny Neurons*
Mice ; Animals ; Mice, Transgenic ; Nucleus Accumbens/physiology ; Neurons/physiology ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł:
On the Inadequacy of the Current Transgenic Animal Models of Alzheimer's Disease: The Path Forward.
Autorzy:
Volloch V; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Rits-Volloch S; Division of Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 04; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Mice ; Animals ; Amyloid beta-Protein Precursor/metabolism ; Mice, Transgenic ; Amyloid beta-Peptides/metabolism ; Disease Models, Animal
Czasopismo naukowe
Tytuł:
LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression.
Autorzy:
Lubben N; Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Brynildsen JK; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Webb CM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Li HL; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Leyns CEG; Neuroscience Discovery, Merck & Co., Inc., Boston, MA, 02115, USA.
Changolkar L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zhang B; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Meymand ES; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
O'Reilly M; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Madaj Z; Bioinformatics and Biostatistics Core, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA.
DeWeerd D; Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Fell MJ; Neuroscience Discovery, Merck & Co., Inc., Boston, MA, 02115, USA.
Lee VMY; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Bassett DS; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Santa Fe Institute, Santa Fe, NM, 87501, USA.
Henderson MX; Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA. .; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2024 Mar 04; Vol. 13 (1), pp. 13. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
Brain*
Dopaminergic Neurons*
Animals ; Humans ; Mice ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Lewy Bodies ; Mice, Transgenic ; Mutation/genetics
Czasopismo naukowe
Tytuł:
MiR-203 improves cardiac dysfunction by targeting PARP1-NAD axis in aging murine.
Autorzy:
Zhao L; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Tang P; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Lin Y; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Du M; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Li H; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Jiang L; Department of Pharmacy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Xu H; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Sun H; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Han J; Department of Pharmacy, Caoxian People's Hospital, Heze, China.
Sun Z; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Xu R; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Lou H; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Chen Z; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.
Kopylov P; Department of Preventive and Emergency Cardiology, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Liu X; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.; National Key Laboratory of Frigid Zone Cardiovascular Diseases (NKLFZCD), Harbin, China.; Research Unit of Noninfectious Chronic Diseases in Frigid Zone, Chinese Academy of Medical Sciences, Harbin, China.
Zhang Y; Department of Pharmacology (State-Province Key Laboratories of Biomedicine- Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China.; National Key Laboratory of Frigid Zone Cardiovascular Diseases (NKLFZCD), Harbin, China.; Research Unit of Noninfectious Chronic Diseases in Frigid Zone, Chinese Academy of Medical Sciences, Harbin, China.; Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin, China.
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Źródło:
Aging cell [Aging Cell] 2024 Mar; Vol. 23 (3), pp. e14063. Date of Electronic Publication: 2023 Dec 14.
Typ publikacji:
Journal Article
MeSH Terms:
MicroRNAs*/genetics
MicroRNAs*/metabolism
Heart Diseases*
Mice ; Humans ; Animals ; Aged ; NAD/metabolism ; Aging/genetics ; Aging/metabolism ; Myocytes, Cardiac/metabolism ; Cellular Senescence/genetics ; Mice, Transgenic ; Poly (ADP-Ribose) Polymerase-1/genetics
Czasopismo naukowe

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