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Wyszukujesz frazę ""Mice, Transgenic"" wg kryterium: Temat

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Tytuł:
Common human genetic variants of APOE impact murine COVID-19 mortality.
Autorzy:
Ostendorf BN; Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA. .; Department of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany. .; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. .; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine, Berlin, Germany. .
Patel MA; Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Bilanovic J; Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Carrasco SE; Laboratory of Comparative Pathology, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and Rockefeller University, New York, NY, USA.
Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Tavazoie SF; Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA. .
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Źródło:
Nature [Nature] 2022 Nov; Vol. 611 (7935), pp. 346-351. Date of Electronic Publication: 2022 Sep 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Apolipoproteins E*/genetics
COVID-19*/genetics
COVID-19*/mortality
COVID-19*/virology
Human Genetics*
Mice, Transgenic*/genetics
Mice, Transgenic*/virology
SARS-CoV-2*/pathogenicity
Animals ; Humans ; Male ; Mice ; Apolipoprotein E2/genetics ; Apolipoprotein E3/genetics ; Apolipoprotein E4/genetics ; Prospective Studies ; Disease Models, Animal
Czasopismo naukowe
Szczegóły
Tytuł:
Development of a humanized HLA-A30 transgenic mouse model.
Autorzy:
Zhu MM; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Niu BW; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Liu LL; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Yang H; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Qin BY; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Peng XH; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Chen LX; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Liu Y; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Wang C; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Ren XN; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Xu CH; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Zhou XH; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
Li F; Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Shanghai, China.
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Źródło:
Animal models and experimental medicine [Animal Model Exp Med] 2022 Dec; Vol. 5 (4), pp. 350-361. Date of Electronic Publication: 2022 Jul 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
HLA-A Antigens*
Mice, Transgenic*
Animals ; Humans ; Influenza A Virus, H1N1 Subtype ; Mice
Czasopismo naukowe
Szczegóły
Tytuł:
Stable Transgenic Mouse Strain with Enhanced Photoactivatable Cre Recombinase for Spatiotemporal Genome Manipulation.
Autorzy:
Li H; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.; Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China.
Wu Y; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Qiu Y; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Li X; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Guan Y; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Cao X; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Liu M; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Zhang D; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Huang S; Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Brain Functional Genomics, East China Normal University, Shanghai, 200062, China.
Lin L; Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Brain Functional Genomics, East China Normal University, Shanghai, 200062, China.
Hui L; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Ma X; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Liu M; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Zhang X; Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China.
Wang L; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Li D; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Dec; Vol. 9 (34), pp. e2201352. Date of Electronic Publication: 2022 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mice, Transgenic*
Mice ; Animals
Czasopismo naukowe
Szczegóły
Tytuł:
The human EF1a promoter does not provide expression of the transgene in mice.
Autorzy:
Battulin N; Laboratory of Developmental Genetics, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 630090. .; Institute of Genetic Technologies, Novosibirsk State University, Novosibirsk, Russia, 630090. .
Korablev A; Laboratory of Developmental Genetics, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 630090.
Ryzhkova A; Laboratory of Developmental Genetics, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 630090.
Smirnov A; Laboratory of Developmental Genetics, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 630090.
Kabirova E; Laboratory of Developmental Genetics, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 630090.
Khabarova A; Laboratory of Developmental Genetics, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 630090.
Lagunov T; Laboratory of Developmental Genetics, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 630090.
Serova I; Laboratory of Developmental Genetics, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 630090.
Serov O; Laboratory of Developmental Genetics, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, 630090.
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Źródło:
Transgenic research [Transgenic Res] 2022 Oct; Vol. 31 (4-5), pp. 525-535. Date of Electronic Publication: 2022 Aug 12.
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin-Converting Enzyme 2*/genetics
Mice, Transgenic*
Animals ; COVID-19 ; Disease Models, Animal ; Humans ; Mice ; Peptide Elongation Factor 1/genetics ; Promoter Regions, Genetic ; SARS-CoV-2/genetics ; Transgenes
Czasopismo naukowe
Szczegóły
Tytuł:
Bifidobacterium breve HNXY26M4 Attenuates Cognitive Deficits and Neuroinflammation by Regulating the Gut-Brain Axis in APP/PS1 Mice.
Autorzy:
Zhu G; College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Zhao J; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China.; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China.
Wang G; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China.; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China.
Chen W; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China.
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Źródło:
Journal of agricultural and food chemistry [J Agric Food Chem] 2023 Mar 22; Vol. 71 (11), pp. 4646-4655. Date of Electronic Publication: 2023 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Bifidobacterium breve*/genetics
Neurodegenerative Diseases*
Neuroprotective Agents*
Cognitive Dysfunction*/drug therapy
Cognitive Dysfunction*/microbiology
Alzheimer Disease*/genetics
Alzheimer Disease*/microbiology
Mice ; Animals ; Brain-Gut Axis ; Neuroinflammatory Diseases ; Cognition ; Mice, Transgenic
Czasopismo naukowe
Szczegóły
Tytuł:
Pteris laeta Wall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis via Activating the Wnt Signaling Pathway.
Autorzy:
Shi YS; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; Academy of Integrative Medicine, Dalian Medical University, Dalian 116044, China.
Chen JC; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Lin BH; The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510920, China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Wang RN; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; College of Basic Medical Sciences, Dalian Medical University, Dalian 116600, China.
Zhao J; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; College of Basic Medical Sciences, Dalian Medical University, Dalian 116600, China.
Li S; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; College of Basic Medical Sciences, Dalian Medical University, Dalian 116600, China.
Zhang Y; The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510920, China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.; Chiba University, Matsudo 2718501, Japan.
Zhang XF; The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510920, China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
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Źródło:
Journal of agricultural and food chemistry [J Agric Food Chem] 2023 Mar 22; Vol. 71 (11), pp. 4586-4598. Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:
Journal Article
MeSH Terms:
Pteris*/metabolism
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Mice ; Animals ; Wnt Signaling Pathway ; Mice, Transgenic ; Disease Models, Animal ; Neurogenesis ; Hippocampus ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Human Resistin Induces Cardiac Dysfunction in Pulmonary Hypertension.
Autorzy:
Lin Q; Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD.
Kumar S; Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD.
Kariyawasam U; Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD.
Yang X; Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD.; Department of Anesthesiology Qilu Hospital, Cheeloo College of Medicine, Shandong University Jinan China.
Yang W; Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD.; Department of Cardiovascular Medicine Xiangya Hospital, Central South University Changsha China.
Skinner JT; Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD.
Gao WD; Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD.
Johns RA; Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD.
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Źródło:
Journal of the American Heart Association [J Am Heart Assoc] 2023 Mar 21; Vol. 12 (6), pp. e027621. Date of Electronic Publication: 2023 Mar 16.
Typ publikacji:
Journal Article
MeSH Terms:
Hypertension, Pulmonary*
Pulmonary Arterial Hypertension*/complications
Ventricular Dysfunction, Right*/complications
Mice ; Animals ; Humans ; Resistin ; Cytokines ; Mice, Transgenic ; Familial Primary Pulmonary Hypertension ; Hypertrophy, Right Ventricular ; Inflammation ; Ventricular Remodeling
Czasopismo naukowe
Szczegóły
Tytuł:
Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load.
Autorzy:
Oroszi T; Department of Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands. .; Research Center for Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary. .
Geerts E; Department of Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
Rajadhyaksha R; Department of Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
Nyakas C; Research Center for Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary.; Department of Morphology and Physiology, Health Science Faculty, Semmelweis Univesity, Budapest, Hungary.
van Heuvelen MJG; Department of Human Movement Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van der Zee EA; Department of Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
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Źródło:
Behavioral and brain functions : BBF [Behav Brain Funct] 2023 Mar 20; Vol. 19 (1), pp. 5. Date of Electronic Publication: 2023 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*/metabolism
Alzheimer Disease*/genetics
Alzheimer Disease*/therapy
Alzheimer Disease*/metabolism
Mice ; Male ; Animals ; Mice, Transgenic ; Amyloid beta-Protein Precursor/metabolism ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Vibration/therapeutic use ; Hippocampus/pathology ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer's disease.
Autorzy:
Wijesinghe P; Department of Ophthalmology & Visual Sciences, Faculty of Medicine, The University of British Columbia, Eye Care Centre, Vancouver, Canada.
Xi J; Department of Ophthalmology & Visual Sciences, Faculty of Medicine, The University of British Columbia, Eye Care Centre, Vancouver, Canada.
Cui J; Department of Ophthalmology & Visual Sciences, Faculty of Medicine, The University of British Columbia, Eye Care Centre, Vancouver, Canada.
Campbell M; Department of Ophthalmology & Visual Sciences, Faculty of Medicine, The University of British Columbia, Eye Care Centre, Vancouver, Canada.
Pham W; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Centre, Nashville, TN, USA.; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Matsubara JA; Department of Ophthalmology & Visual Sciences, Faculty of Medicine, The University of British Columbia, Eye Care Centre, Vancouver, Canada .; Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, Canada.
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Źródło:
Life science alliance [Life Sci Alliance] 2023 Mar 20; Vol. 6 (6). Date of Electronic Publication: 2023 Mar 20 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
MicroRNAs*/genetics
Mice ; Animals ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Szczegóły
Tytuł:
Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity.
Autorzy:
Zhai Y; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Chen L; School of Medicine, Shanghai University, Shanghai 200444, China.
Zhao Q; Clinical Systems Biology Laboratories, Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China.
Zheng ZH; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Chen ZN; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Bian H; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Yang X; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Lu HY; Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an 710032, China.
Lin P; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Chen X; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Chen R; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Sun HY; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Fan LN; State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.
Zhang K; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Wang B; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Sun XX; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Feng Z; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Zhu YM; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Zhou JS; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Chen SR; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Zhang T; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Chen SY; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Chen JJ; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Zhang K; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Wang Y; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Chang Y; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Zhang R; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Zhang B; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Wang LJ; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Li XM; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
He Q; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Yang XM; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Nan G; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Xie RH; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Yang L; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Yang JH; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.; Clinical Systems Biology Laboratories, Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China.
Zhu P; Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. eabg2482. Date of Electronic Publication: 2023 Mar 17.
Typ publikacji:
Journal Article
MeSH Terms:
Autoimmunity*
Autoimmune Diseases*
Mice ; Animals ; Cysteine ; Mice, Transgenic ; Peptides ; HLA-DRB1 Chains/genetics ; Autoantibodies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production.
Autorzy:
Afram E; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.
Lauritzen I; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.
Bourgeois A; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.
El Manaa W; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.
Duplan E; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.
Chami M; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.
Valverde A; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.; Fonds de Dotation CLINATEC, 17 rue des Martyrs, Bat 43, 38054, Grenoble, France.
Charlotte B; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.
Pardossi-Piquard R; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France. .
Checler F; Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team Labeled 'Laboratory of Excellence (Labex) DISTALZ', 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France. .
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Źródło:
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2023 Mar 17; Vol. 80 (4), pp. 97. Date of Electronic Publication: 2023 Mar 17.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Extracellular Vesicles*/metabolism
Mice ; Animals ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Plaque, Amyloid ; Mice, Transgenic ; Endosomes/metabolism ; Amyloid beta-Peptides/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Deletion of Sod1 in Motor Neurons Exacerbates Age-Related Changes in Axons and Neuromuscular Junctions in Mice.
Autorzy:
Pollock N; Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, and MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Liverpool, L7 8TX, UK.
Macpherson PC; Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109 MI.
Staunton CA; Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, and MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Liverpool, L7 8TX, UK.
Hemmings K; Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, and MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Liverpool, L7 8TX, UK.
Davis CS; Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109 MI.
Owen ED; Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, and MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Liverpool, L7 8TX, UK.
Vasilaki A; Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, and MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Liverpool, L7 8TX, UK.
Van Remmen H; Oklahoma Medical Research Foundation (OMRF), Oklahoma City, 73104, OK.
Richardson A; University of Oklahoma Health Science Center (OUHSC), Oklahoma City, 73104, OK.
McArdle A; Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, and MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Liverpool, L7 8TX, UK.
Brooks SV; Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109 MI.
Jackson MJ; Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, and MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Liverpool, L7 8TX, UK .
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Źródło:
ENeuro [eNeuro] 2023 Mar 17; Vol. 10 (3). Date of Electronic Publication: 2023 Mar 17 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Muscle, Skeletal*/physiology
Neuromuscular Junction*/metabolism
Mice ; Animals ; Motor Neurons/metabolism ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism ; Axons/metabolism ; Mice, Transgenic ; Superoxide Dismutase/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy.
Autorzy:
Xiong M; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Division of Biology and Biomedical Sciences (DBBS), Washington University School of Medicine, St. Louis, MO, 63110, USA.; Present Address: Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.
Wang C; Institute for Brain Science and Disease, Chongqing Medical University, Chongqing, 400016, China.
Gratuze M; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Present address: Institute of Neurophysiopathology (INP UMR7051), CNRS, Aix-Marseille Université, Marseille, 13005, France.
Saadi F; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Bao X; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Bosch ME; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Lee C; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Jiang H; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Serrano JR; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Gonzales ER; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Kipnis M; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2023 Mar 16; Vol. 18 (1), pp. 17. Date of Electronic Publication: 2023 Mar 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebral Amyloid Angiopathy*/metabolism
Alzheimer Disease*/metabolism
Mice ; Animals ; Apolipoprotein E4/genetics ; Apolipoprotein E4/metabolism ; Astrocytes/metabolism ; Gliosis/metabolism ; Amyloid beta-Peptides/metabolism ; Apolipoproteins E/metabolism ; Brain/metabolism ; Mice, Transgenic ; Plaque, Amyloid/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lactobacillaceae improve cognitive dysfunction via regulating gut microbiota and suppressing Aβ deposits and neuroinflammation in APP/PS1 mice.
Autorzy:
Wu Y; College of Biochemical Engineering, Beijing Union University, Beijing, China.
Niu X; College of Biochemical Engineering, Beijing Union University, Beijing, China.
Li P; College of Biochemical Engineering, Beijing Union University, Beijing, China.
Tong T; College of Biochemical Engineering, Beijing Union University, Beijing, China.
Wang Q; College of Biochemical Engineering, Beijing Union University, Beijing, China.
Zhang M; Department of Physics and Astronomy, University of Manitoba, Winnipeg, Canada.; Sino Canada Health Engineering Research Institute, Hefei, China.
Li Y; Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Liu J; Internal Trade Food Science and Technology (Beijing) Co., Ltd, Beijing, China.
Li Z; College of Biochemical Engineering, Beijing Union University, Beijing, China. .
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Źródło:
Archives of microbiology [Arch Microbiol] 2023 Mar 16; Vol. 205 (4), pp. 118. Date of Electronic Publication: 2023 Mar 16.
Typ publikacji:
Journal Article
MeSH Terms:
Gastrointestinal Microbiome*
Neurodegenerative Diseases*
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Cognitive Dysfunction*/drug therapy
Cognitive Dysfunction*/pathology
Mice ; Humans ; Animals ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/therapeutic use ; Mice, Transgenic ; Neuroinflammatory Diseases ; Lactobacillaceae ; Disease Models, Animal
Czasopismo naukowe
Szczegóły
Tytuł:
A rare human variant that disrupts GPR10 signalling causes weight gain in mice.
Autorzy:
Talbot F; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Feetham CH; Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Mokrosiński J; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Lawler K; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Keogh JM; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Henning E; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Mendes de Oliveira E; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Ayinampudi V; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Saeed S; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Inserm UMR1283, CNRS UMR8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, 59000, France.; Université de Lille, Lille, 59000, France.
Bonnefond A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Inserm UMR1283, CNRS UMR8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, 59000, France.; Université de Lille, Lille, 59000, France.
Arslan M; School of Life Sciences, Forman Christian College, Lahore, Pakistan.
Yeo GSH; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Froguel P; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Inserm UMR1283, CNRS UMR8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, 59000, France.; Université de Lille, Lille, 59000, France.
Bechtold DA; Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Adamson A; Genome Editing Unit, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Humphreys N; Genome Editing Unit, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Barroso I; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; Exeter Centre of Excellence for Diabetes Research (ExCEED), University of Exeter Medical School, Exeter, UK.
Luckman SM; Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. .
Farooqi IS; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. .
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Źródło:
Nature communications [Nat Commun] 2023 Mar 15; Vol. 14 (1), pp. 1450. Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Obesity*/genetics
Receptors, G-Protein-Coupled*/genetics
Receptors, G-Protein-Coupled*/metabolism
Animals ; Humans ; Mice ; Energy Metabolism ; Mice, Transgenic ; Signal Transduction ; Weight Gain/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model.
Autorzy:
Fukunaka A; Laboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan. .
Shimura M; Department of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. .; RIKEN SPring-8 Center, Kouto, Hyogo, Japan. .
Ichinose T; Inorganic Analysis Laboratories, Toray Research Center, Inc., Otsu, Shiga, Japan.
Pereye OB; Laboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Nakagawa Y; Laboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Tamura Y; Laboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Mizutani W; Laboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Inoue R; Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Inoue T; Department of Materials Physics, Nagoya University, Nagoya, Japan.
Tanaka Y; Graduate School of Engineering, Osaka University, Osaka, Japan.
Sato T; Laboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Saitoh T; Laboratory of Bio-Response Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Fukada T; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
Nishida Y; Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Miyatsuka T; Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Department of Endocrinology, Diabetes, and Metabolism, Kitasato University Hospital, Sagamihara, Kanagawa, Japan.
Shirakawa J; Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Watada H; Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Matsuyama S; RIKEN SPring-8 Center, Kouto, Hyogo, Japan.; Department of Materials Physics, Nagoya University, Nagoya, Japan.; Graduate School of Engineering, Osaka University, Osaka, Japan.
Fujitani Y; Laboratory of Developmental Biology and Metabolism, Institute for Molecularand Cellular Regulation, Gunma University, Maebashi, Gunma, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 15; Vol. 13 (1), pp. 3484. Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Islets of Langerhans*/metabolism
Insulin-Secreting Cells*/metabolism
Diabetes Mellitus, Type 2*/metabolism
Humans ; Mice ; Animals ; Islet Amyloid Polypeptide/metabolism ; Zinc/metabolism ; Iron/metabolism ; Mice, Transgenic ; Amyloid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DNA Aβ42 immunization via needle-less Jet injection in mice and rabbits as potential immunotherapy for Alzheimer's disease.
Autorzy:
Lambracht-Washington D; Department of Neurology, UT Southwestern Medical Center Dallas, TX, USA. Electronic address: .
Fu M; Department of Neurology, UT Southwestern Medical Center Dallas, TX, USA. Electronic address: .
Wight-Carter M; Animal Resource Center, UT Southwestern Medical Center Dallas, TX, USA. Electronic address: .
Riegel M; Animal Resource Center, UT Southwestern Medical Center Dallas, TX, USA; University of Kansas, Lawrence, KS, USA. Electronic address: .
Hynan LS; Departments of Population and Data Sciences (Biostatistics) & Psychiatry, UT Southwestern Medical Center Dallas, TX, USA. Electronic address: .
Rosenberg RN; Department of Neurology, UT Southwestern Medical Center Dallas, TX, USA. Electronic address: .
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Źródło:
Journal of the neurological sciences [J Neurol Sci] 2023 Mar 15; Vol. 446, pp. 120564. Date of Electronic Publication: 2023 Jan 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Amyloid beta-Peptides*/metabolism
Alzheimer Disease*
Mice ; Rabbits ; Animals ; Plaque, Amyloid ; Peptide Fragments ; Immunotherapy ; Brain/metabolism ; Cytokines ; Immunization/methods ; Injections, Jet ; DNA ; Mice, Transgenic ; Disease Models, Animal ; Mammals/genetics ; Mammals/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence.
Autorzy:
Fox ME; Departments of Anesthesiology and Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: .
Wulff AB; Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland.
Franco D; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
Choi EY; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
Calarco CA; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
Engeln M; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
Turner MD; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
Chandra R; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
Rhodes VM; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
Thompson SM; Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.
Ament SA; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.
Lobo MK; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: .
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Źródło:
Biological psychiatry [Biol Psychiatry] 2023 Mar 15; Vol. 93 (6), pp. 489-501. Date of Electronic Publication: 2022 Aug 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Fentanyl*/metabolism
Analgesics, Opioid*
Mice ; Male ; Female ; Animals ; Nucleus Accumbens/physiology ; Neurons/metabolism ; Mice, Inbred C57BL ; Receptors, Dopamine D1/metabolism ; Mice, Transgenic
Czasopismo naukowe
Szczegóły
Tytuł:
Dorsomedial prefrontal hypoexcitability underlies lost empathy in frontotemporal dementia.
Autorzy:
Phillips HL; Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA; Neuroscience Graduate Program, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
Dai H; Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
Choi SY; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Jansen-West K; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Zajicek AS; Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA; Neuroscience Graduate Program, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
Daly L; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA; Neuroscience Program, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Gao FB; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA; Neuroscience Program, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Yao WD; Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA; Neuroscience Graduate Program, State University of New York Upstate Medical University, Syracuse, NY 13210, USA; Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: .
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Źródło:
Neuron [Neuron] 2023 Mar 15; Vol. 111 (6), pp. 797-806.e6. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Frontotemporal Dementia*/genetics
Alzheimer Disease*/genetics
Amyotrophic Lateral Sclerosis*/genetics
Mice ; Animals ; Empathy ; DNA Repeat Expansion ; Mice, Transgenic ; C9orf72 Protein/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use.
Autorzy:
Teague CD; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Picone JA; Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Wright WJ; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania.
Browne CJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Silva GM; Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Futamura R; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Minier-Toribio A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Estill ME; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Ramakrishnan A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Martinez-Rivera FJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Godino A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Parise EM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Schmidt KH; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Pulido NV; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Lorsch ZS; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Kim JH; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia.
Shen L; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Neve RL; Gene Delivery Technology Core, Massachusetts General Hospital, Cambridge, Massachusetts.
Dong Y; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania.
Nestler EJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Hamilton PJ; Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia. Electronic address: .
Pokaż więcej
Źródło:
Biological psychiatry [Biol Psychiatry] 2023 Mar 15; Vol. 93 (6), pp. 502-511. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptation, Physiological*/genetics
Cocaine*/pharmacology
Cocaine*/metabolism
Cocaine-Related Disorders*/genetics
Medium Spiny Neurons*/metabolism
Promoter Regions, Genetic*
Transcription Factors*/genetics
Transcription Factors*/metabolism
Animals ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Nucleus Accumbens ; Receptors, Dopamine D1/genetics ; Receptors, Dopamine D1/metabolism
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 55914

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