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Tytuł :
[Generation and validation of inducible osteoblast-specific Stat3 knockout mice].
Autorzy :
Gong XY; Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology. Shanghai 200011, China. E-mail:.
Huang XR
Zhou SR
Yang YL
Xu HY
Jin AT
Dai QG
Jiang LY
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Źródło :
Shanghai kou qiang yi xue = Shanghai journal of stomatology [Shanghai Kou Qiang Yi Xue] 2020 Aug; Vol. 29 (4), pp. 337-342.
Typ publikacji :
Journal Article
MeSH Terms :
Mice, Knockout*
Osteoblasts*
STAT3 Transcription Factor*
Tooth Movement Techniques*
Animals ; Gene Knockout Techniques ; Mice ; RNA, Messenger
Czasopismo naukowe
Tytuł :
TIEG1 is upregulated in Lrp5/6-mediated valve osteogenesis.
Autorzy :
Rajamannan NM; Department of Cardiology, Most Sacred Heart of Jesus Cardiology and Valvular Institute, Sheboygan, Wisconsin.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
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Źródło :
Journal of cellular biochemistry [J Cell Biochem] 2019 Mar; Vol. 120 (3), pp. 3362-3366. Date of Electronic Publication: 2018 Sep 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Osteogenesis*
Aortic Valve Stenosis/*pathology
Calcinosis/*pathology
DNA-Binding Proteins/*physiology
Low Density Lipoprotein Receptor-Related Protein-5/*physiology
Low Density Lipoprotein Receptor-Related Protein-6/*metabolism
Mice, Knockout, ApoE/*physiology
Transcription Factors/*physiology
Animals ; Aortic Valve Stenosis/genetics ; Aortic Valve Stenosis/metabolism ; Calcinosis/genetics ; Calcinosis/metabolism ; Cell Differentiation ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; Female ; Hypercholesterolemia/genetics ; Hypercholesterolemia/metabolism ; Hypercholesterolemia/pathology ; Low Density Lipoprotein Receptor-Related Protein-6/genetics ; Male ; Mice ; Mice, Knockout ; Osteoblasts/metabolism ; Osteoblasts/pathology
Czasopismo naukowe
Tytuł :
MRI of Capn15 Knockout Mice and Analysis of Capn 15 Distribution Reveal Possible Roles in Brain Development and Plasticity.
Autorzy :
Zha C; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Farah CA; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Fonov V; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Rudko DA; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada; Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada.
Sossin WS; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2021 Jun 15; Vol. 465, pp. 128-141. Date of Electronic Publication: 2021 May 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calpain*/genetics
Calpain*/metabolism
Neurons*/metabolism
Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Magnetic Resonance Imaging ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.
Autorzy :
Monsivais D; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA. .; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, USA. .
Nagashima T; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.; Hanakoganei Ladies Clinic, Tokyo, Japan.
Prunskaite-Hyyryläinen R; Faculty of Biochemistry and Medicine, University of Oulu, Oulu, Finland.
Nozawa K; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, USA.
Shimada K; Research Institute for Microbial Disease, Osaka University, Osaka, Japan.
Tang S; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Hamor C; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Agno JE; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, USA.
Chen F; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Masand RP; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Young SL; Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA.
Creighton CJ; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
DeMayo FJ; National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Ikawa M; Research Institute for Microbial Disease, Osaka University, Osaka, Japan.
Lee SJ; Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; University of Connecticut School of Medicine, Department of Genetics and Genome Sciences, Farmington, CT, USA.
Matzuk MM; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA. .; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3386. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Embryo Implantation*
Bone Morphogenetic Proteins/*metabolism
Infertility, Female/*genetics
Activin Receptors, Type II/genetics ; Activin Receptors, Type II/metabolism ; Animals ; Biopsy ; Disease Models, Animal ; Endometrium/metabolism ; Endometrium/pathology ; Estrogens/metabolism ; Female ; Humans ; Mice ; Mice, Knockout ; Pregnancy ; Signal Transduction/physiology ; Smad1 Protein/analysis ; Smad1 Protein/genetics ; Smad1 Protein/metabolism ; Smad5 Protein/analysis ; Smad5 Protein/genetics ; Smad5 Protein/metabolism
Czasopismo naukowe
Tytuł :
β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity.
Autorzy :
Barella LF; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. .
Rossi M; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Pydi SP; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Meister J; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Jain S; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Cui Y; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Gavrilova O; Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Bethesda, MD, USA.
Fulgenzi G; Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.
Tessarollo L; Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.
Wess J; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3385. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*metabolism
Insulin-Secreting Cells/*pathology
Obesity/*metabolism
beta-Arrestin 1/*metabolism
Animals ; Blood Glucose/metabolism ; Cell Proliferation ; Diabetes Mellitus, Type 2/pathology ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Homeodomain Proteins/metabolism ; Humans ; Insulin Resistance ; Male ; Mice ; Mice, Knockout ; Obesity/etiology ; Obesity/pathology ; Trans-Activators/metabolism ; beta-Arrestin 1/genetics
Czasopismo naukowe
Tytuł :
Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength.
Autorzy :
Al-Barghouthi BM; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Mesner LD; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Calabrese GM; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Brooks D; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA.
Tommasini SM; Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA.
Bouxsein ML; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA.
Horowitz MC; Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA.
Rosen CJ; Maine Medical Center Research Institute, Scarborough, ME, USA.
Nguyen K; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Haddox S; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Farber EA; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Onengut-Gumuscu S; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Pomp D; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Farber CR; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA. .; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA, USA. .; Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3408. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Bone Density/*genetics
Osteoporosis/*genetics
Oxidoreductases Acting on Sulfur Group Donors/*genetics
Animals ; Cell Differentiation/genetics ; Collaborative Cross Mice ; Datasets as Topic ; Female ; Femur/physiology ; Fluoresceins/administration & dosage ; Fluorescent Dyes/administration & dosage ; Genome-Wide Association Study ; Glycosyltransferases/genetics ; Humans ; Male ; Mesenchymal Stem Cells ; Mice ; Mice, Knockout ; Osteoblasts ; Osteogenesis/genetics ; RNA-Seq ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Toll-like Receptor-4 (TLR4) Agonist-Based Intranasal Nanovaccine Delivery System for Inducing Systemic and Mucosal Immunity.
Autorzy :
Bakkari MA; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, South Dakota State University, Brookings, South Dakota 57007, United States.; College of Pharmacy, Jazan University, Jazan 45142, Kingdom of Saudi Arabia.
Valiveti CK; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, South Dakota State University, Brookings, South Dakota 57007, United States.
Kaushik RS; Department of Biology and Microbiology, South Dakota State University, Brookings, South Dakota57007, United States.
Tummala H; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, South Dakota State University, Brookings, South Dakota 57007, United States.
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Źródło :
Molecular pharmaceutics [Mol Pharm] 2021 Jun 07; Vol. 18 (6), pp. 2233-2241. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adjuvants, Immunologic/*pharmacology
COVID-19/*prevention & control
COVID-19 Vaccines/*administration & dosage
Drug Carriers/*pharmacology
Inulin/*pharmacology
Adjuvants, Immunologic/chemistry ; Administration, Intranasal ; Animals ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Vaccines/immunology ; Cells, Cultured ; Drug Carriers/chemistry ; Drug Evaluation, Preclinical ; Humans ; Immunity, Mucosal/drug effects ; Immunity, Mucosal/immunology ; Immunogenicity, Vaccine ; Inulin/chemistry ; Inulin/immunology ; Macrophages/drug effects ; Macrophages/immunology ; Male ; Mice ; Mice, Knockout ; Nanoparticles/chemistry ; Primary Cell Culture ; SARS-CoV-2/immunology ; Toll-Like Receptor 4/agonists ; Toll-Like Receptor 4/genetics
Czasopismo naukowe
Tytuł :
A functional motif of long noncoding RNA Nron against osteoporosis.
Autorzy :
Jin F; Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University, Guangzhou, China.; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China.
Li J; Department of Oral Implantology, School of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
Zhang YB; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China.
Liu X; Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University, Guangzhou, China.; Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Cai M; Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University, Guangzhou, China.; Department of Oral Implantology, School of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
Liu M; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China.
Li M; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ma C; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China.
Yue R; Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Zhu Y; Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Lai R; Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University, Guangzhou, China.
Wang Z; Department of Oral Implantology, School of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
Ji X; Department of Neurosurgery & China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
Wei H; Zeki Biotechnology & Pharmaceutical Co. Ltd, Beijing, China.
Dong J; Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Liu Z; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang Y; Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China. .
Sun Y; Department of Oral Implantology, School of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China. .
Wang X; Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University, Guangzhou, China. .; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 03; Vol. 12 (1), pp. 3319. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Osteoporosis/*genetics
Osteoporosis/*metabolism
RNA, Long Noncoding/*genetics
RNA, Long Noncoding/*metabolism
Animals ; Bone Diseases, Metabolic/etiology ; Bone Diseases, Metabolic/genetics ; Bone Diseases, Metabolic/metabolism ; Bone Resorption/genetics ; Bone Resorption/metabolism ; Bone Resorption/prevention & control ; Cullin Proteins/metabolism ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Female ; Femur/diagnostic imaging ; Femur/metabolism ; Femur/pathology ; Injections, Intravenous ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Osteoclasts/metabolism ; Osteoclasts/pathology ; Osteoporosis/therapy ; RNA, Long Noncoding/administration & dosage ; Ubiquitination ; Up-Regulation ; X-Ray Microtomography
Czasopismo naukowe
Tytuł :
STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer.
Autorzy :
Totten SP; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
Im YK; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
Cepeda Cañedo E; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Najyb O; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Nguyen A; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Hébert S; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Ahn R; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
Lewis K; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
Lebeau B; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
La Selva R; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
Sabourin V; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Martínez C; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Savage P; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Kuasne H; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Avizonis D; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Santos Martínez N; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Chabot C; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Aguilar-Mahecha A; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Goulet ML; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Dankner M; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Witcher M; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.
Petrecca K; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Basik M; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.
Pollak M; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.
Topisirovic I; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.
Lin R; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
Siegel PM; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Kleinman CL; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Department Human Genetics, McGill University, Montreal, QC, Canada.
Park M; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.
St-Pierre J; Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.
Ursini-Siegel J; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada. .; Division of Experimental Medicine, McGill University, Montreal, QC, Canada. .; Department of Biochemistry, McGill University, Montreal, QC, Canada. .; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 03; Vol. 12 (1), pp. 3299. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*drug therapy
Breast Neoplasms/*metabolism
Phenformin/*pharmacology
STAT1 Transcription Factor/*metabolism
Animals ; Antineoplastic Agents/administration & dosage ; Cell Line, Tumor ; Drug Synergism ; Electron Transport Complex I/antagonists & inhibitors ; Energy Metabolism/drug effects ; Female ; Glutathione/antagonists & inhibitors ; Glutathione/biosynthesis ; Humans ; Interferon-gamma/administration & dosage ; Interferon-gamma/deficiency ; Interferon-gamma/metabolism ; MCF-7 Cells ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Mice, SCID ; NAD(P)H Dehydrogenase (Quinone)/antagonists & inhibitors ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Naphthoquinones/administration & dosage ; Oxidative Stress/drug effects ; Phenformin/administration & dosage ; Poly I-C/administration & dosage ; Reactive Oxygen Species/metabolism ; STAT1 Transcription Factor/agonists ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
Autorzy :
Yamamoto Y; Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan.; Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Chino H; Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan.
Tsukamoto S; Laboratory Animal and Genome Sciences Section, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Ode KL; Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ueda HR; Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Osaka, Japan.
Mizushima N; Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 02; Vol. 12 (1), pp. 3292. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*genetics
Cilia/*metabolism
Microtubule-Associated Proteins/*genetics
Myosin Heavy Chains/*genetics
NIMA-Related Kinases/*genetics
Amino Acid Sequence ; Animals ; Brain/cytology ; Brain/metabolism ; Cell Line ; Cilia/genetics ; Female ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Expression Regulation ; Kidney/cytology ; Kidney/metabolism ; Liver/cytology ; Liver/metabolism ; Male ; Mice ; Mice, Knockout ; Microtubule-Associated Proteins/metabolism ; Muscle, Skeletal/cytology ; Muscle, Skeletal/metabolism ; Myocardium/cytology ; Myocardium/metabolism ; Myosin Heavy Chains/metabolism ; NIMA-Related Kinases/deficiency ; Protein Binding ; Sequence Alignment ; Sequence Homology, Amino Acid ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.
Autorzy :
Horisawa-Takada Y; Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan.
Kodera C; Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan.; Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Takemoto K; Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan.
Sakashita A; Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.
Horisawa K; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Maeda R; Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
Shimada R; Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan.
Usuki S; Liaison Laboratory Research Promotion Center, IMEG, Kumamoto University, Kumamoto, Japan.
Fujimura S; Liaison Laboratory Research Promotion Center, IMEG, Kumamoto University, Kumamoto, Japan.
Tani N; Liaison Laboratory Research Promotion Center, IMEG, Kumamoto University, Kumamoto, Japan.
Matsuura K; Department of Pluripotent Stem Cell Biology, IMEG, Kumamoto University, Kumamoto, Japan.
Akiyama T; Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan.
Suzuki A; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Niwa H; Department of Pluripotent Stem Cell Biology, IMEG, Kumamoto University, Kumamoto, Japan.
Tachibana M; Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
Ohba T; Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Katabuchi H; Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Namekawa SH; Department of Microbiology and Molecular Genetics, University of California, Davis, CA, USA.
Araki K; Institute of Resource Development and Analysis, and Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan.
Ishiguro KI; Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 01; Vol. 12 (1), pp. 3184. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomal Proteins, Non-Histone/*metabolism
Pachytene Stage/*genetics
Potassium Channels, Voltage-Gated/*metabolism
Spermatids/*cytology
Spermatogenesis/*genetics
Transcription Factors/*metabolism
Animals ; Chromatin Immunoprecipitation Sequencing ; Chromosomal Proteins, Non-Histone/genetics ; Disease Models, Animal ; Female ; Histone Deacetylase 1/metabolism ; Histone Deacetylase 2/metabolism ; Humans ; Infertility, Male/genetics ; Male ; Mice ; Mice, Knockout ; Oocytes/cytology ; Oocytes/metabolism ; Potassium Channels, Voltage-Gated/genetics ; RNA-Seq ; Spermatids/metabolism ; Transcription Factors/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.
Autorzy :
Zheng J; Department of Microbiology and Immunology and.
Meyerholz D; Pathology, University of Iowa, Iowa City, Iowa, USA.
Wong LR; Department of Microbiology and Immunology and.
Gelb M; Departments of Chemistry and Biochemistry, University of Washington, Seattle, Washington, USA.
Murakami M; Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Perlman S; Department of Microbiology and Immunology and.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Jun 01; Vol. 131 (11).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibody Formation*
Antibodies, Viral/*immunology
COVID-19/*immunology
Group II Phospholipases A2/*immunology
Middle East Respiratory Syndrome Coronavirus/*immunology
SARS Virus/*immunology
SARS-CoV-2/*immunology
Severe Acute Respiratory Syndrome/*immunology
Animals ; COVID-19/enzymology ; COVID-19/genetics ; Chlorocebus aethiops ; Group II Phospholipases A2/deficiency ; Mice ; Mice, Knockout ; Severe Acute Respiratory Syndrome/enzymology ; Severe Acute Respiratory Syndrome/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells.
Autorzy :
Roy S; Immuno-biology Laboratory, Translational Health Science & Technology Institute, Faridabad, Haryana, India.
Rizvi ZA; Immuno-biology Laboratory, Translational Health Science & Technology Institute, Faridabad, Haryana, India.
Clarke AJ; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Macdonald F; Institute of Immunology and Infection Research, University of Edinburgh, Scotland, UK.
Pandey A; Translational Health Science & Technology Institute, Faridabad, Haryana, India.
Zaiss DMW; Institute of Immunology and Infection Research, University of Edinburgh, Scotland, UK.
Simon AK; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Awasthi A; Immuno-biology Laboratory, Translational Health Science & Technology Institute, Faridabad, Haryana, India. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 01; Vol. 12 (1), pp. 3182. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ErbB Receptors/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Interleukin-9/*genetics
Melanoma, Experimental/*therapy
Skin Neoplasms/*therapy
T-Lymphocytes, Helper-Inducer/*immunology
Amphiregulin/metabolism ; Animals ; Cell Differentiation/immunology ; Female ; HEK293 Cells ; Healthy Volunteers ; Humans ; Immunotherapy, Adoptive/methods ; Melanoma, Experimental/immunology ; Mice ; Mice, Knockout ; Nitric Oxide Synthase Type II/genetics ; Primary Cell Culture ; RNA-Seq ; Signal Transduction/genetics ; Signal Transduction/immunology ; Skin Neoplasms/immunology ; Succinic Acid/metabolism ; T-Lymphocytes, Helper-Inducer/transplantation ; Transcriptional Activation/immunology
Czasopismo naukowe
Tytuł :
Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle.
Autorzy :
Betrie AH; Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.; Cardiovascular Therapeutics Unit, Department of Biochemistry and Pharmacology, The University of Melbourne, Victoria, Australia.; Department of Cardiovascular Surgery & Center for Basic Medical Research, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences; The Institute of Cardiovascular Diseases, Tianjin University, Tianjin; Center for Drug Development, Wannan Medical College, Wuhu, Anhui, China.
Brock JA; Department of Anatomy and Physiology, The University of Melbourne, Victoria, Australia.
Harraz OF; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.; Vermont Center for Cardiovascular and Brain Health, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Bush AI; Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
He GW; Department of Cardiovascular Surgery & Center for Basic Medical Research, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences; The Institute of Cardiovascular Diseases, Tianjin University, Tianjin; Center for Drug Development, Wannan Medical College, Wuhu, Anhui, China.
Nelson MT; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.; Vermont Center for Cardiovascular and Brain Health, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK.
Angus JA; Cardiovascular Therapeutics Unit, Department of Biochemistry and Pharmacology, The University of Melbourne, Victoria, Australia.
Wright CE; Cardiovascular Therapeutics Unit, Department of Biochemistry and Pharmacology, The University of Melbourne, Victoria, Australia. .
Ayton S; Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 01; Vol. 12 (1), pp. 3296. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium, Vascular/*metabolism
Muscle, Smooth, Vascular/*physiology
Sensory Receptor Cells/*metabolism
Vasodilation/*physiology
Zinc/*metabolism
Aged ; Animals ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Calcitonin Gene-Related Peptide/metabolism ; Calcium Channels, N-Type/metabolism ; Chelating Agents/pharmacology ; Cytoplasm/metabolism ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/innervation ; Ethylenediamines/pharmacology ; Female ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Muscle, Smooth, Vascular/drug effects ; Patch-Clamp Techniques ; Prostaglandin-Endoperoxide Synthases/metabolism ; Prostaglandins/metabolism ; Rats ; TRPA1 Cation Channel/genetics ; TRPA1 Cation Channel/metabolism ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
Histone deficiency and accelerated replication stress in T cell aging.
Autorzy :
Kim C; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California, USA.; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, California, USA.; Department of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, South Korea.
Jin J; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California, USA.; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, California, USA.
Ye Z; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California, USA.; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, California, USA.
Jadhav RR; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California, USA.; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, California, USA.
Gustafson CE; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California, USA.; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, California, USA.
Hu B; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California, USA.; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, California, USA.
Cao W; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California, USA.; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, California, USA.
Tian L; Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
Weyand CM; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California, USA.; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, California, USA.
Goronzy JJ; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, California, USA.; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, California, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Jun 01; Vol. 131 (11).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19/*immunology
Cellular Senescence/*immunology
Histones/*deficiency
MicroRNAs/*immunology
SARS-CoV-2/*immunology
T-Lymphocytes/*immunology
Animals ; COVID-19/genetics ; Cellular Senescence/genetics ; Female ; Histones/immunology ; Humans ; Male ; Mice, Knockout ; MicroRNAs/genetics ; SARS-CoV-2/genetics ; Sirtuin 1/genetics ; Sirtuin 1/immunology
Czasopismo naukowe
Tytuł :
The expression of STAT3 inhibited the NF-ΚB signalling pathway and reduced inflammatory responses in mice with viral myocarditis.
Autorzy :
Li Z; Department of Internal Medicine-Cardiovascular, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China.
Wang C; Department of Rheumatism Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Mao Y; Department of Internal Medicine-Cardiovascular, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Cui J; Department of Blood Specialty, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Wang X; Department of Internal Medicine-Cardiovascular, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Dang J; Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Wang S; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2021 Jun; Vol. 95, pp. 107534. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Enterovirus B, Human*
Coxsackievirus Infections/*immunology
Myocarditis/*immunology
NF-kappa B/*immunology
STAT3 Transcription Factor/*immunology
Animals ; Cytokines/immunology ; Male ; Mice, Inbred BALB C ; Mice, Knockout ; Myocarditis/genetics ; Myocardium/immunology ; STAT3 Transcription Factor/genetics ; Signal Transduction ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Talin1 regulates endometrial adhesive capacity through the Ras signaling pathway.
Autorzy :
Chen S; Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China; Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi 545005, China.
Liu B; Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Li J; Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi 545005, China.
Liao S; Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Bi Y; Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Huang W; Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Yuan L; Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Yang Y; Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: .
Qin A; Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 01; Vol. 274, pp. 119332. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Adhesion*
Embryo Implantation*
Abortion, Habitual/*pathology
Endometrium/*pathology
Talin/*metabolism
Talin/*physiology
ras Proteins/*metabolism
Abortion, Habitual/genetics ; Abortion, Habitual/metabolism ; Animals ; Apoptosis ; Cell Proliferation ; Cells, Cultured ; Endometrium/metabolism ; Female ; Gene Expression Regulation ; Humans ; Mice, Knockout ; Pregnancy ; Prognosis ; Talin/genetics ; ras Proteins/genetics
Czasopismo naukowe
Tytuł :
Novel XTENylated AWRK6 analog with hypoglycemic activity, and anti-HSV-2 potential in combination with double shRNA.
Autorzy :
Zhang X; Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai 519100, Guangdong, PR China.
Gao S; Department of Biochemistry and Molecular Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, Guangdong, PR China.
Liu M; Department of Biochemistry and Molecular Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, Guangdong, PR China.
Wei N; Department of Biochemistry and Molecular Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, Guangdong, PR China.
Zhang Q; Department of Biochemistry and Molecular Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, Guangdong, PR China.
Li X; Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai 519100, Guangdong, PR China.
Niu X; Department of Biochemistry and Molecular Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, Guangdong, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 01; Vol. 274, pp. 119313. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*therapy
Herpes Simplex/*therapy
Herpesvirus 2, Human/*drug effects
Obesity/*complications
Peptide Fragments/*pharmacology
Peptides/*pharmacology
RNA, Small Interfering/*administration & dosage
Animals ; Combined Modality Therapy ; Diabetes Mellitus, Experimental/etiology ; Diabetes Mellitus, Experimental/pathology ; Diet, High-Fat/adverse effects ; Herpes Simplex/genetics ; Herpes Simplex/virology ; Herpesvirus 2, Human/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Obese ; Peptide Fragments/chemistry ; Peptides/chemistry ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
Mouse bone marrow derived mesenchymal stem cells-secreted exosomal microRNA-125b-5p suppresses atherosclerotic plaque formation via inhibiting Map4k4.
Autorzy :
Lin F; Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518000, Guangdong, China. Electronic address: .
Zhang S; Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518000, Guangdong, China.
Liu X; Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518000, Guangdong, China.
Wu M; Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518000, Guangdong, China.
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Źródło :
Life sciences [Life Sci] 2021 Jun 01; Vol. 274, pp. 119249. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Bone Marrow/*metabolism
Exosomes/*metabolism
Mesenchymal Stem Cells/*metabolism
MicroRNAs/*genetics
Plaque, Atherosclerotic/*prevention & control
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Animals ; Exosomes/genetics ; Male ; Mesenchymal Stem Cells/cytology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Plaque, Atherosclerotic/etiology ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology
Czasopismo naukowe
Tytuł :
Samelisant (SUVN-G3031), a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy: pharmacological and neurochemical characterisation.
Autorzy :
Nirogi R; Suven Life Sciences Ltd., Hyderabad, India. .
Benade V; Suven Life Sciences Ltd., Hyderabad, India.
Daripelli S; Suven Life Sciences Ltd., Hyderabad, India.
Subramanian R; Suven Life Sciences Ltd., Hyderabad, India.
Kamuju V; Suven Life Sciences Ltd., Hyderabad, India.
Bhyrapuneni G; Suven Life Sciences Ltd., Hyderabad, India.
Muddana NR; Suven Life Sciences Ltd., Hyderabad, India.
Mekala VR; Suven Life Sciences Ltd., Hyderabad, India.
Petlu S; Suven Life Sciences Ltd., Hyderabad, India.
Jayarajan P; Suven Life Sciences Ltd., Hyderabad, India.
Badange R; Suven Life Sciences Ltd., Hyderabad, India.
Shinde A; Suven Life Sciences Ltd., Hyderabad, India.
Jasti V; Suven Life Sciences Ltd., Hyderabad, India.
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2021 Jun; Vol. 238 (6), pp. 1495-1511. Date of Electronic Publication: 2021 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Histamine Agonists/*pharmacology
Morpholines/*pharmacology
Narcolepsy/*drug therapy
Piperidines/*pharmacology
Animals ; Electroencephalography ; Histamine/metabolism ; Humans ; Male ; Methylhistamines/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Orexins/genetics ; Rats ; Rats, Wistar ; Sleep/drug effects ; Wakefulness/drug effects
Czasopismo naukowe

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