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Tytuł:
E3 Ubiquitin Ligase Uhrf2 Knockout Reveals a Critical Role in Social Behavior and Synaptic Plasticity in the Hippocampus.
Autorzy:
Zhuang Y; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Li C; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Zhao F; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Yan Y; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Pan H; National Health Commission (NHC) Key Laboratory of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai 200032, China.
Zhan J; National Health Commission (NHC) Key Laboratory of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai 200032, China.
Behnisch T; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 26; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Hippocampus*/metabolism
Neuronal Plasticity*/genetics
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Animals ; Mice ; Memory Disorders/metabolism ; Mice, Knockout ; Social Behavior ; Ubiquitin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice.
Autorzy:
Franco TM; Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo 04039-032, Brazil.
Tavares MR; Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo 04039-032, Brazil.
Novaes LS; Department of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de São Paulo, Sao Paulo 05508-000, Brazil.
Munhoz CD; Department of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de São Paulo, Sao Paulo 05508-000, Brazil.
Peixoto-Santos JE; Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo 04039-032, Brazil.
Araujo RC; Department of Biophysics, Federal University of Sao Paulo, Sao Paulo 04039-032, Brazil.
Donato J Jr; Department of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de São Paulo, Sao Paulo 05508-000, Brazil.
Bader M; Max-Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125 Berlin, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, 10117 Berlin, Germany.; Institute for Biology, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.
Wasinski F; Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo 04039-032, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 25; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Receptor, Bradykinin B2*/genetics
Receptor, Bradykinin B2*/metabolism
Tyrosine 3-Monooxygenase*/genetics
Mice ; Male ; Female ; Animals ; Bradykinin/pharmacology ; Receptor, Bradykinin B1/metabolism ; Body Weight ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling.
Autorzy:
Nakayama Y; Laboratory of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan.
Masuda Y; Laboratory of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan.
Mukae T; Laboratory of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan.
Mikami T; Laboratory of Biochemistry, Kobe Pharmaceutical University, Kobe, Japan.
Shimizu R; Laboratory of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan.
Kondo N; Laboratory of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan.
Kitagawa H; Laboratory of Biochemistry, Kobe Pharmaceutical University, Kobe, Japan.
Itoh N; Kyoto University Graduate School of Pharmaceutical Science, Kyoto, Japan.
Konishi M; Laboratory of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan. .
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Źródło:
Communications biology [Commun Biol] 2024 Jan 25; Vol. 7 (1), pp. 129. Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anemia*
Iron*/metabolism
Animals ; Mice ; Macrophages/metabolism ; Mice, Knockout ; Phagocytosis/physiology ; Receptors, IgG/metabolism ; Spleen/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Nerve Tissue Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MiR-31-5p regulates the neuroinflammatory response via TRAF6 in neuropathic pain.
Autorzy:
Liu Y; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20080, China.
Wang L; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20080, China.
Zhou C; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20080, China.
Yuan Y; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20080, China.
Fang B; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20080, China.
Lu K; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20080, China.
Xu F; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20080, China. .
Chen L; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20080, China. .
Huang L; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20080, China. .
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Źródło:
Biology direct [Biol Direct] 2024 Jan 24; Vol. 19 (1), pp. 10. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MicroRNAs*/genetics
Neuralgia*/genetics
Animals ; Mice ; Inflammation/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; TNF Receptor-Associated Factor 6/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
Autorzy:
Zhang Y; Department of Molecular and Cellular Physiology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan. .
Li N; Department of Molecular and Cellular Physiology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Kobayashi S; Department of Molecular and Cellular Physiology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Jan 22; Vol. 22 (1), pp. 58. Date of Electronic Publication: 2024 Jan 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms:
Muscle, Smooth, Vascular*
Paxillin*
rho-Associated Kinases*
Animals ; Humans ; Mice ; Actins ; Mice, Knockout ; Myosin Light Chains ; Phosphorylcholine/analogs & derivatives ; Sphingosine/analogs & derivatives
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Benefits and Caveats in the Use of Retinal Pigment Epithelium-Specific Cre Mice.
Autorzy:
Kocherlakota S; Laboratory of Cell Metabolism, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
Baes M; Laboratory of Cell Metabolism, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 20; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Retinal Pigment Epithelium*/metabolism
Macular Degeneration*/genetics
Macular Degeneration*/metabolism
Mice ; Animals ; Retina ; Photoreceptor Cells ; Proteins/metabolism ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Distinct Alterations in Dendritic Spine Morphology in the Absence of β-Neurexins.
Autorzy:
Mohrmann L; Institute of Anatomy and Molecular Neurobiology, University Münster, 48149 Münster, Germany.
Seebach J; Institute of Anatomy and Molecular Neurobiology, University Münster, 48149 Münster, Germany.
Missler M; Institute of Anatomy and Molecular Neurobiology, University Münster, 48149 Münster, Germany.
Rohlmann A; Institute of Anatomy and Molecular Neurobiology, University Münster, 48149 Münster, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 20; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Neurexins*
Dendritic Spines*/metabolism
Mice ; Animals ; Synapses/metabolism ; Neurons/metabolism ; Synaptic Transmission/physiology ; Hippocampus/metabolism ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
L-Lactate Treatment at 24 h and 48 h after Acute Experimental Stroke Is Neuroprotective via Activation of the L-Lactate Receptor HCA 1 .
Autorzy:
Geiseler SJ; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, 0316 Oslo, Norway.
Hadzic A; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, 0316 Oslo, Norway.
Lambertus M; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, 0316 Oslo, Norway.
Forbord KM; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, 0316 Oslo, Norway.
Sajedi G; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, 0316 Oslo, Norway.
Liesz A; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, 81377 Munich, Germany.; Graduate School of Systemic Neurosciences Munich, 82152 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
Morland C; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, 0316 Oslo, Norway.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Lactic Acid*/pharmacology
Stroke*/drug therapy
Humans ; Mice ; Animals ; Brain/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Knockout of the Tnfa Gene Decreases Influenza Virus-Induced Histological Reactions in Laboratory Mice.
Autorzy:
Savenkova DA; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.; Novosibirsk State University, Pirogova 2, Novosibirsk 630090, Russia.
Gudymo AS; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.
Korablev AN; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Lavrentieva 10, Novosibirsk 630090, Russia.
Taranov OS; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.
Bazovkina DV; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Lavrentieva 10, Novosibirsk 630090, Russia.
Danilchenko NV; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.
Perfilyeva ON; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.
Ivleva EK; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.
Moiseeva AA; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.
Bulanovich YA; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.
Roshchina EV; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.
Serova IA; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Lavrentieva 10, Novosibirsk 630090, Russia.
Battulin NR; Novosibirsk State University, Pirogova 2, Novosibirsk 630090, Russia.; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Lavrentieva 10, Novosibirsk 630090, Russia.
Kulikova EA; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Lavrentieva 10, Novosibirsk 630090, Russia.
Yudkin DV; State Research Center of Virology and Biotechnology 'Vector', Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being (FBRI SRC VB 'Vector', Rospotrebnadzor), Koltsovo 630559, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 18; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Influenza A virus*
Tumor Necrosis Factor-alpha*/genetics
Orthomyxoviridae Infections*/pathology
Animals ; Mice ; Cytokines/genetics ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development.
Autorzy:
Röthe J; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Kraft R; Carl-Ludwig-Institute for Physiology, Medical Faculty, Leipzig University, Leipzig, Germany.
Ricken A; Institute of Anatomy, Medical Faculty, Leipzig University, Leipzig, Germany.
Kaczmarek I; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Matz-Soja M; Medical Department II - Gastroenterology, Hepatology, Infectious Diseases, Pneumology, University Medical Center, Leipzig, Germany.; Division of Hepatology, Clinic and Polyclinic for Oncology, Gastroenterology, Hepatology, Infectious Diseases, and Pneumology, University Hospital, Leipzig, Germany.
Winter K; Institute of Anatomy, Medical Faculty, Leipzig University, Leipzig, Germany.
Dietzsch AN; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Buchold J; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Ludwig MG; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Liebscher I; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Schöneberg T; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Thor D; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany. .
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Źródło:
Communications biology [Commun Biol] 2024 Jan 16; Vol. 7 (1), pp. 104. Date of Electronic Publication: 2024 Jan 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Islets of Langerhans*/metabolism
Humans ; Animals ; Mice ; Somatostatin/metabolism ; Insulin/metabolism ; Lung/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Mice, Knockout ; Glucose/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lymphocyte-Specific Protein 1 Regulates Expression and Stability of Endothelial Nitric Oxide Synthase.
Autorzy:
Smeir M; Department of Anatomy, Physiology and Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.
Chumala P; Department of Medicine, Canadian Center for Rural and Agricultural Health, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada.
Katselis GS; Department of Medicine, Canadian Center for Rural and Agricultural Health, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada.
Liu L; Department of Anatomy, Physiology and Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.
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Źródło:
Biomolecules [Biomolecules] 2024 Jan 15; Vol. 14 (1). Date of Electronic Publication: 2024 Jan 15.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*
Nitric Oxide Synthase Type III*/genetics
Nitric Oxide Synthase Type III*/metabolism
Microfilament Proteins*/metabolism
Animals ; Humans ; Mice ; Adenoviridae ; Genome-Wide Association Study ; Lymphocytes ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice.
Autorzy:
Hao Q; Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Henning SM; Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Magyar CE; Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Said J; Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Zhong J; VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.; Department of Internal Medicine, School of Medicine, University of California, Riverside, CA 92521, USA.
Rettig MB; Departments of Medicine and Urology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Vadgama JV; Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Wang P; Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.; Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
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Źródło:
Biomolecules [Biomolecules] 2024 Jan 14; Vol. 14 (1). Date of Electronic Publication: 2024 Jan 14.
Typ publikacji:
Journal Article
MeSH Terms:
Furans*
Lignans*/pharmacology
Lignans*/therapeutic use
Prostatic Neoplasms*/drug therapy
Prostatic Neoplasms*/prevention & control
Animals ; Male ; Mice ; Chemoprevention ; Mice, Knockout ; Phosphatidylinositol 3-Kinases ; Prostate/drug effects ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Tensins ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Tea
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PKD1L1 Is Involved in Congenital Chylothorax.
Autorzy:
Whitchurch JB; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Campus, Oxfordshire OX11 0RD, UK.
Schneider S; Department of Neonatology and Paediatric Intensive Care, University Hospital Bonn Center of Paediatrics, 53127 Bonn, Germany.; Institute of Human Genetics, University Hospital Bonn, 53127 Bonn, Germany.
Hilger AC; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, 91054 Erlangen, Germany.
Köllges R; Department of Neonatology and Paediatric Intensive Care, University Hospital Bonn Center of Paediatrics, 53127 Bonn, Germany.; Institute of Human Genetics, University Hospital Bonn, 53127 Bonn, Germany.
Stegmann JD; Department of Neonatology and Paediatric Intensive Care, University Hospital Bonn Center of Paediatrics, 53127 Bonn, Germany.; Institute of Human Genetics, University Hospital Bonn, 53127 Bonn, Germany.
Waffenschmidt L; Institute of Human Genetics, University Hospital Bonn, 53127 Bonn, Germany.; Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, 91054 Erlangen, Germany.
Dyer L; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Campus, Oxfordshire OX11 0RD, UK.
Thiele H; Cologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Dhabhai B; Genome & Computational Biology Lab, Department of Biotechnology, Mohanlal Sukhadia University, Udaipur 313001, India.
Dakal TC; Genome & Computational Biology Lab, Department of Biotechnology, Mohanlal Sukhadia University, Udaipur 313001, India.
Müller A; Department of Neonatology and Paediatric Intensive Care, University Hospital Bonn Center of Paediatrics, 53127 Bonn, Germany.
Norris DP; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Campus, Oxfordshire OX11 0RD, UK.
Reutter HM; Institute of Human Genetics, University Hospital Bonn, 53127 Bonn, Germany.; Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, 91054 Erlangen, Germany.
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Źródło:
Cells [Cells] 2024 Jan 12; Vol. 13 (2). Date of Electronic Publication: 2024 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chylothorax*/genetics
Animals ; Female ; Humans ; Mice ; Pregnancy ; Fetus ; Genetic Diseases, X-Linked ; Hydrops Fetalis ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice, Knockout
SCR Disease Name:
Chylothorax, congenital
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deficiency in astrocyte CCL2 production reduces neuroimmune control of Toxoplasma gondii infection.
Autorzy:
Orchanian SB; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America.; Institute for Immunology, University of California, Irvine, Irvine, California, United States of America.
Still K; Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America.
Harris TH; Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia, United States of America.
Lodoen MB; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America.; Institute for Immunology, University of California, Irvine, Irvine, California, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2024 Jan 11; Vol. 20 (1), pp. e1011710. Date of Electronic Publication: 2024 Jan 11 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Toxoplasma*/metabolism
Toxoplasmosis*/metabolism
Animals ; Humans ; Mice ; Astrocytes/metabolism ; Brain/metabolism ; Chemokine CCL2/metabolism ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice.
Autorzy:
Bai X; Ministry of Education Key Laboratory of Molecular and Cellular BiologyHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, Hebei, China.
Wang B; Ministry of Education Key Laboratory of Molecular and Cellular BiologyHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, Hebei, China.
Cui Y; Ministry of Education Key Laboratory of Molecular and Cellular BiologyHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, Hebei, China.
Tian S; Ministry of Education Key Laboratory of Molecular and Cellular BiologyHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, Hebei, China.
Zhang Y; Ministry of Education Key Laboratory of Molecular and Cellular BiologyHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, Hebei, China.
You L; Ministry of Education Key Laboratory of Molecular and Cellular BiologyHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, Hebei, China.
Chang YZ; Ministry of Education Key Laboratory of Molecular and Cellular BiologyHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, Hebei, China. .
Gao G; Ministry of Education Key Laboratory of Molecular and Cellular BiologyHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, Hebei, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Jan 09; Vol. 21 (1), pp. 15. Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*
Central Nervous System Diseases*
Animals ; Humans ; Mice ; Atrophy ; Brain ; Hepcidins/genetics ; Hippocampus ; Iron ; Memory Disorders/genetics ; Mice, Knockout
Czasopismo naukowe
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Tytuł:
Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease.
Autorzy:
Okaya T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Kawasaki T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Sato S; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.; Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba 260-8670, Japan.
Koyanagi Y; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Tatsumi K; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Hatano R; Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Ohnuma K; Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Morimoto C; Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Kasuya Y; Department of Biomedical Science, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Hasegawa Y; Department of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.
Ohara O; Department of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.
Suzuki T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.; Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba 260-8670, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 06; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Hypertension, Pulmonary*/chemically induced
Hypertension, Pulmonary*/genetics
Lung Diseases, Interstitial*/chemically induced
Lung Diseases, Interstitial*/genetics
Osteochondrodysplasias*
Humans ; Animals ; Mice ; Dipeptidyl Peptidase 4/genetics ; Phosphatidylinositol 3-Kinases ; Bleomycin/toxicity ; Mice, Knockout ; Transforming Growth Factor beta/genetics
SCR Disease Name:
Smith-McCort Dysplasia
Czasopismo naukowe
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Tytuł:
5-HT 2A Receptor Knockout Mice Show Sex-Dependent Differences following Acute Noribogaine Administration.
Autorzy:
Villalba S; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET-Universidad Austral, Mariano Acosta 1611, Buenos Aires B1629WWA, Argentina.; Departamento de Fisiología, Biología Molecular y Celular Prof. Héctor Maldonado, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET), Facultad de Ciencias Exactas, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.
González B; Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Avenida General Flores 2124, Montevideo 11800, Uruguay.
Junge S; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET-Universidad Austral, Mariano Acosta 1611, Buenos Aires B1629WWA, Argentina.; Departamento de Fisiología, Biología Molecular y Celular Prof. Héctor Maldonado, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET), Facultad de Ciencias Exactas, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.
Bernardi A; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET-Universidad Austral, Mariano Acosta 1611, Buenos Aires B1629WWA, Argentina.; Departamento de Fisiología, Biología Molecular y Celular Prof. Héctor Maldonado, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET), Facultad de Ciencias Exactas, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.
González J; Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Avenida General Flores 2125, Montevideo 11800, Uruguay.
Fagúndez C; Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Avenida General Flores 2124, Montevideo 11800, Uruguay.
Torterolo P; Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Avenida General Flores 2125, Montevideo 11800, Uruguay.
Carrera I; Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Avenida General Flores 2124, Montevideo 11800, Uruguay.
Urbano FJ; Departamento de Fisiología, Biología Molecular y Celular Prof. Héctor Maldonado, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET), Facultad de Ciencias Exactas, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.
Bisagno V; Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET-Universidad Austral, Mariano Acosta 1611, Buenos Aires B1629WWA, Argentina.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 05; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
Ibogaine*/pharmacology
Female ; Male ; Animals ; Mice ; Mice, Knockout ; Receptor, Serotonin, 5-HT2A/genetics ; N-Methylaspartate ; Serotonin ; Glutamic Acid ; RNA, Messenger
Czasopismo naukowe
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Tytuł:
SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice.
Autorzy:
Huang M; Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Chow CH; Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Gurdita A; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Donald K. Johnson Eye Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Harada H; Donald K. Johnson Eye Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Pham Truong VQB; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Donald K. Johnson Eye Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Eide S; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Sun HS; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Department of Anatomy, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Feng ZP; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Monnier PP; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Donald K. Johnson Eye Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.; Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, M5T 3A9, Canada.
Wallace VA; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Donald K. Johnson Eye Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.; Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, M5T 3A9, Canada.
Sugita S; Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Toronto, ON, M5T 0S8, Canada. .; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada. .
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Źródło:
Communications biology [Commun Biol] 2024 Jan 05; Vol. 7 (1), pp. 34. Date of Electronic Publication: 2024 Jan 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Qb-SNARE Proteins*/metabolism
Qc-SNARE Proteins*/metabolism
Synaptosomal-Associated Protein 25*/metabolism
Photoreceptor Cells, Vertebrate*/cytology
Photoreceptor Cells, Vertebrate*/metabolism
Animals ; Mice ; Biological Transport ; Cytoskeleton ; Glutamic Acid ; Mice, Knockout ; RNA, Messenger
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding.
Autorzy:
Tomita S; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Nakanishi N; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. .
Ogata T; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.; Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Higuchi Y; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Sakamoto A; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Tsuji Y; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Suga T; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Matoba S; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
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Źródło:
Communications biology [Commun Biol] 2024 Jan 05; Vol. 7 (1), pp. 40. Date of Electronic Publication: 2024 Jan 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Caveolin 1*/genetics
Caveolin 1*/metabolism
Hypertension, Pulmonary*
Signal Transduction*
Membrane Proteins*/genetics
Membrane Proteins*/metabolism
RNA-Binding Proteins*/genetics
RNA-Binding Proteins*/metabolism
Animals ; Mice ; Endothelial Cells ; Mice, Knockout ; Pulmonary Arterial Hypertension
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.
Autorzy:
Norris AC; Department of Biological Sciences, Vanderbilt University, 465 21St Ave S, Nashville, TN, 37212, USA.
Yazlovitskaya EM; Department of Biological Sciences, Vanderbilt University, 465 21St Ave S, Nashville, TN, 37212, USA.
Zhu L; Division of Endocrinology, Diabetes and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA.
Rose BS; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA.
May JC; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA.
Gibson-Corley KN; Division of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
McLean JA; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA.
Stafford JM; Division of Endocrinology, Diabetes and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA.; Tennessee Valley Healthcare System, Veterans Affairs, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Graham TR; Department of Biological Sciences, Vanderbilt University, 465 21St Ave S, Nashville, TN, 37212, USA. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 03; Vol. 14 (1), pp. 343. Date of Electronic Publication: 2024 Jan 03.
Typ publikacji:
Journal Article
MeSH Terms:
Dyslipidemias*/genetics
Dyslipidemias*/metabolism
Insulin Resistance*/physiology
Animals ; Female ; Male ; Mice ; Cholesterol/metabolism ; Diet, High-Fat ; Lipid Metabolism/genetics ; Liver/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Triglycerides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 61-80 z 23231

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