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Tytuł:
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice.
Autorzy:
Kiani Shabestari S; Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA.
Morabito S; Mathematical, Computational and System Biology (MCSB) Program, UC Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA.
Danhash EP; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA.
McQuade A; Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA.
Sanchez JR; Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA.
Miyoshi E; Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA.
Chadarevian JP; Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA.
Claes C; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA.
Coburn MA; Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA.
Hasselmann J; Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA.
Hidalgo J; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA.
Tran KN; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA.
Martini AC; Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA; Department of Pathology & Laboratory Medicine, UC Irvine, Irvine, CA 92697, USA.
Chang Rothermich W; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA.
Pascual J; Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA; Department of Pathology & Laboratory Medicine, UC Irvine, Irvine, CA 92697, USA.
Head E; Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA; Department of Pathology & Laboratory Medicine, UC Irvine, Irvine, CA 92697, USA.
Hume DA; Mater Research Institute-University of Queensland, Brisbane, Australia.
Pridans C; University of Edinburgh Centre for Inflammation Research, Edinburgh, UK; Simons Initiative for the Developing Brain Centre, University of Edinburgh, Edinburgh, UK; The Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh, UK.
Davtyan H; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA.
Swarup V; Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA.
Blurton-Jones M; Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2022 Jun 14; Vol. 39 (11), pp. 110961.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Cerebral Amyloid Angiopathy*/complications
Cerebral Amyloid Angiopathy*/pathology
Microglia*/metabolism
Amyloid beta-Peptides/metabolism ; Animals ; Brain/metabolism ; Disease Models, Animal ; Humans ; Induced Pluripotent Stem Cells ; Membrane Glycoproteins ; Mice ; Mice, Transgenic ; Plaque, Amyloid/pathology ; Receptors, Immunologic
Czasopismo naukowe
Szczegóły
Tytuł:
PBMSCs transplantation facilitates functional recovery after spinal cord injury by regulating microglia/macrophages plasticity.
Autorzy:
Pang QM; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China; Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Qian NN; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Zou WH; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Yang YC; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Chen H; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Zhang M; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Zhang Q; Department of Human Anatomy, Zunyi Medical University, Zunyi, Guizhou, China. Electronic address: .
Ao J; Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Zhang T; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China; Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China. Electronic address: .
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Źródło:
Transplant immunology [Transpl Immunol] 2022 Jun; Vol. 72, pp. 101592. Date of Electronic Publication: 2022 Mar 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Microglia*/metabolism
Microglia*/pathology
Spinal Cord Injuries*/drug therapy
Spinal Cord Injuries*/pathology
Animals ; Anti-Inflammatory Agents/therapeutic use ; Cytokines/metabolism ; Interleukin-6/genetics ; Macrophages/pathology ; Rats ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Gadolinium chloride protects neurons by regulating the activation of microglia in the model of optic nerve crush.
Autorzy:
Yang P; School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Wei L; School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Tian H; School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Yu F; School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Shi Y; School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Gao L; School of Life Sciences, Lanzhou University, Lanzhou, 730000, China. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Aug 27; Vol. 618, pp. 119-126. Date of Electronic Publication: 2022 May 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Microglia*/metabolism
Optic Nerve Injuries*/metabolism
Gadolinium ; Humans ; Nerve Crush ; Optic Nerve/metabolism ; Retinal Ganglion Cells/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors.
Autorzy:
Peng R; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: .
Dai W; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
Li D; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
Li Y; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: .
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Źródło:
Journal of psychiatric research [J Psychiatr Res] 2022 Aug; Vol. 152, pp. 128-138. Date of Electronic Publication: 2022 Jun 14.
Typ publikacji:
Journal Article
MeSH Terms:
Microglia*/metabolism
TNF Receptor-Associated Factor 6*/metabolism
TNF Receptor-Associated Factor 6*/pharmacology
Animals ; Depression/etiology ; Depression/metabolism ; Estradiol/metabolism ; Estradiol/pharmacology ; Gonadal Hormones/metabolism ; Gonadal Hormones/pharmacology ; Hippocampus ; Male ; Mice ; Receptors, Steroid ; Receptors, Thyroid Hormone ; Testosterone
Czasopismo naukowe
Szczegóły
Tytuł:
Derivatives of sarcodonin A isolated from Sarcodon scabrosus reversed LPS-induced M1 polarization in microglia through MAPK/NF-κB pathway.
Autorzy:
Cao CY; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China. Electronic address: .
Yang YX; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Xie Z; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Chen X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China. Electronic address: .
Shi XW; Xi'an Botanical Garden, Institute of Botany of Shaanxi Province, Xi'an 710061, Shanxi, China.
Yin X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Gao JM; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2022 Aug; Vol. 125, pp. 105854. Date of Electronic Publication: 2022 May 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Microglia*
NF-kappa B*/metabolism
Basidiomycota ; Lipopolysaccharides/metabolism ; Lipopolysaccharides/pharmacology ; Molecular Docking Simulation ; RNA, Messenger/metabolism ; Terpenes
SCR Organism:
Sarcodon scabrosus
Czasopismo naukowe
Szczegóły
Tytuł:
Bone marrow-derived inducible microglia-like cells ameliorate motor function and survival in a mouse model of amyotrophic lateral sclerosis.
Autorzy:
Kobashi S; Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science, Otsu, Japan; Department of Neurology, Shiga University of Medical Science, Otsu, Japan.
Terashima T; Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science, Otsu, Japan. Electronic address: .
Katagi M; Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science, Otsu, Japan.
Urushitani M; Department of Neurology, Shiga University of Medical Science, Otsu, Japan.
Kojima H; Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science, Otsu, Japan.
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Źródło:
Cytotherapy [Cytotherapy] 2022 Aug; Vol. 24 (8), pp. 789-801. Date of Electronic Publication: 2022 Apr 04.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/therapy
Microglia*/metabolism
Neurodegenerative Diseases*/therapy
Animals ; Bone Marrow/metabolism ; Disease Models, Animal ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Interleukin-4/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Spinal Cord/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Microglial integrin, chemokine receptors, and inflammatory response vary with development.
Autorzy:
Chen Y; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, 650500, China.
Zhang H; School of Food and Medicine, Yunnan Vocational and Technical College of Agriculture, Kunming, 650500, China.
Zhao Y; Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, 650500, China.
Zhang Y; The Department of Endocrinology, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, 650051, China.
Yin S; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, 650500, China.
Hu Y; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, 650500, China.
Ma G; Public Technology Service Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
Lu D; Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, 650500, China. Electronic address: .
Sun J; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, 650500, China. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Jul 30; Vol. 615, pp. 94-101. Date of Electronic Publication: 2022 May 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Microglia*/metabolism
Receptors, Chemokine*/metabolism
Adult ; CX3C Chemokine Receptor 1/metabolism ; Central Nervous System/metabolism ; Cytokines/metabolism ; Humans ; Infant, Newborn ; Integrins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Priming of microglia by type II interferon is lasting and resistant to modulation by interleukin-10 in situ.
Autorzy:
Hemmerich M; Institute of Physiology and Pathophysiology, University of Heidelberg, D-69120 Heidelberg, Germany.
Malorny N; Institute of Physiology and Pathophysiology, University of Heidelberg, D-69120 Heidelberg, Germany.
Lewen A; Institute of Physiology and Pathophysiology, University of Heidelberg, D-69120 Heidelberg, Germany.
Hollnagel JO; Institute of Physiology and Pathophysiology, University of Heidelberg, D-69120 Heidelberg, Germany.
Chausse B; Institute of Physiology and Pathophysiology, University of Heidelberg, D-69120 Heidelberg, Germany.
Kann O; Institute of Physiology and Pathophysiology, University of Heidelberg, D-69120 Heidelberg, Germany; Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, D-69120 Heidelberg, Germany. Electronic address: .
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Źródło:
Journal of neuroimmunology [J Neuroimmunol] 2022 Jul 15; Vol. 368, pp. 577881. Date of Electronic Publication: 2022 Apr 28.
Typ publikacji:
Journal Article
MeSH Terms:
Interferon-gamma*/metabolism
Interferon-gamma*/pharmacology
Microglia*/metabolism
Hippocampus/metabolism ; Interleukin-10 ; Lipopolysaccharides/pharmacology ; Neurons/metabolism ; Nitric Oxide ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Lipophilic Bioactive Compounds Transported in Triglyceride-Rich Lipoproteins Modulate Microglial Inflammatory Response.
Autorzy:
Espinosa JM; Department of Food and Health, Instituto de la Grasa-CSIC, Campus of the University Pablo de Olavide, Building 46, 41012 Seville, Spain.
Castellano JM; Department of Food and Health, Instituto de la Grasa-CSIC, Campus of the University Pablo de Olavide, Building 46, 41012 Seville, Spain.
Garcia-Rodriguez S; Department of Food and Health, Instituto de la Grasa-CSIC, Campus of the University Pablo de Olavide, Building 46, 41012 Seville, Spain.
Quintero-Flórez A; Department of Food and Health, Instituto de la Grasa-CSIC, Campus of the University Pablo de Olavide, Building 46, 41012 Seville, Spain.
Carrasquilla N; Department of Food and Health, Instituto de la Grasa-CSIC, Campus of the University Pablo de Olavide, Building 46, 41012 Seville, Spain.
Perona JS; Department of Food and Health, Instituto de la Grasa-CSIC, Campus of the University Pablo de Olavide, Building 46, 41012 Seville, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 12; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
Microglia*
Oleanolic Acid*/pharmacology
Cytokines ; Interleukin-6 ; Lipoproteins ; Triglycerides ; Tumor Necrosis Factor-alpha ; alpha-Tocopherol/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bacteria reduce flagellin synthesis to evade microglia-astrocyte-driven immunity in the brain.
Autorzy:
Sun H; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China; College of Life Sciences, Nankai University, Tianjin 300071, China.
Wan X; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China.
Fan Y; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China.
Liu P; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China.
Song Y; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China; College of Life Sciences, Nankai University, Tianjin 300071, China.
Zhu N; Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Duan Z; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China; College of Life Sciences, Nankai University, Tianjin 300071, China.
Wang Q; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China.
Chen F; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China.
Zhou C; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China.
Zheng Y; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China; College of Life Sciences, Nankai University, Tianjin 300071, China.
Ding P; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China.
Liu F; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China.
Feng L; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China; College of Life Sciences, Nankai University, Tianjin 300071, China.
Kim KS; Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Wang L; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China; Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin 300457, China; College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2022 Jul 05; Vol. 40 (1), pp. 111033.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Microglia*/metabolism
Bacteria/metabolism ; Brain/metabolism ; Flagellin/metabolism ; Flagellin/pharmacology ; Humans ; Infant, Newborn ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology.
Autorzy:
Karaahmet B; Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.
Le L; Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.
Mendes MS; Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.; Department of Biology, Stanford University, Stanford, CA, USA.
Majewska AK; Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA. ania_.
O'Banion MK; Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA. Kerry_.
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2022 Jul 04; Vol. 19 (1), pp. 173. Date of Electronic Publication: 2022 Jul 04.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Microglia*/metabolism
Chemokine CXCL13/*metabolism
tau Proteins/*metabolism
Amyloidogenic Proteins/metabolism ; Animals ; Humans ; Mice ; Mice, Transgenic ; Phosphorylation ; Plaque, Amyloid/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The transcription factor Hhex regulates inflammation-related genes in microglia.
Autorzy:
Sakate R; Division of Pharmacology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
Nishiyama M; Division of Pharmacology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan; Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-Cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
Fukuda Y; Nippon Zoki Pharmaceutical Co.Ltd., Minamiyama, Furukawa-Cho, Ono-shi, Hyogo 675-1363, Japan.
Kitaoka S; Division of Pharmacology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan; Department of Pharmacology, Hyogo Medical University Graduate School of Medicine, 1-1 Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan. Electronic address: .
Furuyashiki T; Division of Pharmacology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan; Japan Agency for Medical Research and Development (AMED), Tokyo, Japan. Electronic address: .
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Źródło:
Journal of pharmacological sciences [J Pharmacol Sci] 2022 Jul; Vol. 149 (3), pp. 166-171. Date of Electronic Publication: 2022 May 07.
Typ publikacji:
Journal Article
MeSH Terms:
Homeodomain Proteins*/metabolism
Microglia*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Animals ; Inflammation/genetics ; Inflammation/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor 4/agonists
Czasopismo naukowe
Szczegóły
Tytuł:
Isolation driven changes in Iba1-positive microglial morphology are associated with social recognition memory in adults and adolescents.
Autorzy:
Ferrara NC; Department of Foundational Sciences and Humanities, Discipline of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA; Center for Neurobiology of Stress Resilience and Psychiatric Disorders, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Electronic address: .
Trask S; Department of Psychological Sciences, Purdue University, West Lafayette, IN, USA.
Yan L; Department of Foundational Sciences and Humanities, Discipline of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA; Center for Neurobiology of Stress Resilience and Psychiatric Disorders, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Padival M; Department of Foundational Sciences and Humanities, Discipline of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA; Center for Neurobiology of Stress Resilience and Psychiatric Disorders, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Helmstetter FJ; Department of Department of Psychology, The University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Rosenkranz JA; Department of Foundational Sciences and Humanities, Discipline of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA; Center for Neurobiology of Stress Resilience and Psychiatric Disorders, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
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Źródło:
Neurobiology of learning and memory [Neurobiol Learn Mem] 2022 Jul; Vol. 192, pp. 107626. Date of Electronic Publication: 2022 May 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Microglia*/physiology
Neurons*
Amygdala ; Brain ; Social Isolation
Czasopismo naukowe
Szczegóły
Tytuł:
Engineered Nanoerythrocytes Alleviate Central Nervous System Inflammation by Regulating the Polarization of Inflammatory Microglia.
Autorzy:
Yin N; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.
Zhao Y; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.
Liu C; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.
Yang Y; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.
Wang ZH; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.
Yu W; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.
Zhang K; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.
Zhang Z; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou, 450001, P. R. China.
Liu J; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou, 450001, P. R. China.
Zhang Y; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou, 450001, P. R. China.
Shi J; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, P. R. China.; Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou, 450001, P. R. China.; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou, 450001, P. R. China.
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Źródło:
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2022 Jul; Vol. 34 (27), pp. e2201322. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
Inflammation*/metabolism
Microglia*
Anti-Inflammatory Agents/pharmacology ; Blood-Brain Barrier ; Humans ; Signal Transduction
Czasopismo naukowe
Szczegóły
Tytuł:
Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis.
Autorzy:
Duan N; Department of Anesthesiology and Center for Brain Science, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Zhang Y; Department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Tan S; Department of Anesthesiology and Center for Brain Science, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Sun J; Department of Anesthesiology and Center for Brain Science, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Ye M; Department of Anesthesiology and Center for Brain Science, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Gao H; Department of Anesthesiology and Center for Brain Science, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Pu K; Department of Anesthesiology and Center for Brain Science, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Wu M; Department of Anesthesiology and Center for Brain Science, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Wang Q; Department of Anesthesiology and Center for Brain Science, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. Electronic address: .
Zhai Q; Department of Anesthesiology and Center for Brain Science, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. Electronic address: .
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Źródło:
Neurobiology of disease [Neurobiol Dis] 2022 Jul; Vol. 169, pp. 105739. Date of Electronic Publication: 2022 Apr 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interferon Regulatory Factor-3*/metabolism
Interferon Regulatory Factor-3*/pharmacology
Microglia*/metabolism
Animals ; Cytokines/metabolism ; Depression/drug therapy ; Depression/etiology ; Membrane Proteins ; Mice ; Mice, Inbred C57BL ; Neuroinflammatory Diseases ; Phagocytosis ; Protein Serine-Threonine Kinases
Czasopismo naukowe
Szczegóły
Tytuł:
Compensatory engulfment and Müller glia reactivity in the absence of microglia.
Autorzy:
Thiel WA; Department of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Blume ZI; Department of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Mitchell DM; Department of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
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Źródło:
Glia [Glia] 2022 Jul; Vol. 70 (7), pp. 1402-1425. Date of Electronic Publication: 2022 Apr 21.
Typ publikacji:
Journal Article
MeSH Terms:
Microglia*/metabolism
Neurodegenerative Diseases*/metabolism
Animals ; Ependymoglial Cells/metabolism ; Neuroglia ; Retina ; Zebrafish
Czasopismo naukowe
Szczegóły
Tytuł:
DJ-1 activates the Atg5-Atg12-Atg16L1 complex via Sirt1 to influence microglial polarization and alleviate cerebral ischemia/reperfusion-induced inflammatory injury.
Autorzy:
Zhao N; Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China; Chengdu Second People's Hospital, 610000, Chengdu, PR China.
Li Y; Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China.
Wang C; Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China; Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, 400021, Chongqing, PR China.
Xue Y; Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China.
Peng L; Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China.
Wang T; Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China.
Zhao Y; Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China.
Xu G; Institute of Life Sciences, Chongqing Medical University, 400016, Chongqing, PR China.
Yu S; Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China. Electronic address: .
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Źródło:
Neurochemistry international [Neurochem Int] 2022 Jul; Vol. 157, pp. 105341. Date of Electronic Publication: 2022 Apr 14.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy-Related Proteins*/metabolism
Brain Ischemia*/drug therapy
Brain Ischemia*/metabolism
Microglia*/cytology
Microglia*/metabolism
Protein Deglycase DJ-1*/metabolism
Reperfusion Injury*/metabolism
Sirtuin 1*/metabolism
Anti-Inflammatory Agents/pharmacology ; Cell Polarity ; Humans ; Reperfusion
Czasopismo naukowe
Szczegóły
Tytuł:
Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization.
Autorzy:
Xue MT; Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Sheng WJ; Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Song X; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Shi YJ; Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Geng ZJ; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Shen L; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Wang R; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Lü HZ; Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.; Department of Immunology, Bengbu Medical College, Bengbu, P.R. China.
Hu JG; Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2022 Jul; Vol. 28 (7), pp. 1059-1071. Date of Electronic Publication: 2022 Apr 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Microglia*/pathology
Spinal Cord Injuries*/pathology
Animals ; Anti-Inflammatory Agents/pharmacology ; Lactones ; Macrophages/pathology ; Rats ; Sesquiterpenes ; Spinal Cord/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Retinal microglia: Functions and diseases.
Autorzy:
Fan W; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Ophthalmology, Chongqing, China.; Chongqing Eye Institute, Chongqing, China.; Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Huang W; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, China.
Chen J; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Li N; College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Mao L; Department of Immunology, School of Medicine, Nantong University, Nantong, China.
Hou S; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Ophthalmology, Chongqing, China.; Chongqing Eye Institute, Chongqing, China.; Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Pokaż więcej
Źródło:
Immunology [Immunology] 2022 Jul; Vol. 166 (3), pp. 268-286. Date of Electronic Publication: 2022 Apr 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Microglia*
Retinal Diseases*
Animals ; Macrophages ; Phagocytosis ; Retina/physiology
Czasopismo naukowe
Szczegóły
Tytuł:
Effects of astrocytes and microglia on neuroinflammation after spinal cord injury and related immunomodulatory strategies.
Autorzy:
Pang QM; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China; Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Chen SY; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Xu QJ; Department of Human Anatomy, Zunyi Medical University, Zunyi, Guizhou, China.
Zhang M; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Liang DF; Department of Human Anatomy, Zunyi Medical University, Zunyi, Guizhou, China.
Fu SP; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China; Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Yu J; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Liu ZL; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Zhang Q; Department of Human Anatomy, Zunyi Medical University, Zunyi, Guizhou, China. Electronic address: .
Zhang T; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China; Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China. Electronic address: .
Pokaż więcej
Źródło:
International immunopharmacology [Int Immunopharmacol] 2022 Jul; Vol. 108, pp. 108754. Date of Electronic Publication: 2022 Apr 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Microglia*
Spinal Cord Injuries*/complications
Animals ; Astrocytes/pathology ; Inflammation/pathology ; Neuroinflammatory Diseases ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/pathology
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 101072

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