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Wyszukujesz frazę ""Microtubules"" wg kryterium: Temat


Tytuł :
Radial alignment of microtubules through tubulin polymerization in an evaporating droplet.
Autorzy :
Keya JJ; Faculty of Science, Hokkaido University, Sapporo, Hokkaido, Japan.
Kudoh H; Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.
Kabir AMR; Faculty of Science, Hokkaido University, Sapporo, Hokkaido, Japan.
Inoue D; Department of Human Science Faculty of Design, Kyushu University, Fukuoka, Japan.
Miyamoto N; Department of Life, Environment and Materials Science, Fukuoka Institute of Technology, Fukuoka, Japan.
Tani T; Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA, United States of America.
Kakugo A; Faculty of Science, Hokkaido University, Sapporo, Hokkaido, Japan.; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Hokkaido, Japan.
Shikinaka K; Research Institute for Chemical Process Technology, National Institute of Advanced Industrial Science and Technology, Sendai, Miyagi, Japan.
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Źródło :
PloS one [PLoS One] 2020 Apr 10; Vol. 15 (4), pp. e0231352. Date of Electronic Publication: 2020 Apr 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS ONE Subsets: MEDLINE
MeSH Terms :
Microtubules/*chemistry
Tubulin/*chemistry
Animals ; Hot Temperature ; Microtubules/metabolism ; Polymerization ; Swine ; Tubulin/metabolism ; Volatilization ; Water/chemistry
Czasopismo naukowe
Tytuł :
Destructive Role of TMAO in T-Tubule and Excitation-Contraction Coupling in the Adult Cardiomyocytes.
Autorzy :
Jin B; Department of Pathology, the Affiliated Hospital of Qingdao University.; Department of Forensic Medicine, School of Basic Medicine, Qingdao University.
Ji F; The Medical Examination Center of Shandong Province Sanatorium.
Zuo A; Department of General Surgery, the Affiliated Hospital of Qingdao University.
Liu H; Department of Pathology, the Affiliated Hospital of Qingdao University.; Department of Forensic Medicine, School of Basic Medicine, Qingdao University.
Qi L; Department of Pathology, the Affiliated Hospital of Qingdao University.; Department of Forensic Medicine, School of Basic Medicine, Qingdao University.
He Y; Department of Pathology, the Affiliated Hospital of Qingdao University.; Department of Forensic Medicine, School of Basic Medicine, Qingdao University.
Wang Q; Department of Pathology, the Affiliated Hospital of Qingdao University.; Department of Forensic Medicine, School of Basic Medicine, Qingdao University.
Zhao P; Department of Pathology, the Affiliated Hospital of Qingdao University.; Department of Forensic Medicine, School of Basic Medicine, Qingdao University.
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Źródło :
International heart journal [Int Heart J] 2020 Mar 28; Vol. 61 (2), pp. 355-363. Date of Electronic Publication: 2020 Mar 14.
Typ publikacji :
Journal Article
Journal Info :
Publisher: International Heart Journal Association Country of Publication: Japan NLM ID: 101244240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-3299 (Electronic) Linking ISSN: 13492365 NLM ISO Abbreviation: Int Heart J Subsets: MEDLINE
MeSH Terms :
Heart Failure/*metabolism
Methylamines/*toxicity
Microtubules/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Calcium/metabolism ; Cells, Cultured ; Excitation Contraction Coupling ; Heart Failure/etiology ; Male ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Microtubules/drug effects ; Myocytes, Cardiac/drug effects ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Endosomal Wnt signaling proteins control microtubule nucleation in dendrites.
Autorzy :
Weiner AT; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Seebold DY; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Torres-Gutierrez P; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Folker C; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Swope RD; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Kothe GO; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Stoltz JG; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Zalenski MK; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Kozlowski C; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Barbera DJ; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Patel MA; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Thyagarajan P; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Shorey M; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Nye DMR; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Keegan M; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Behari K; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Song S; Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America.
Axelrod JD; Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America.
Rolls MM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
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Źródło :
PLoS biology [PLoS Biol] 2020 Mar 12; Vol. 18 (3), pp. e3000647. Date of Electronic Publication: 2020 Mar 12 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol. Subsets: MEDLINE
MeSH Terms :
Dendrites/*metabolism
Drosophila Proteins/*metabolism
Endosomes/*metabolism
Microtubules/*metabolism
Wnt Proteins/*metabolism
Animals ; Axin Signaling Complex/genetics ; Axin Signaling Complex/metabolism ; Axons/metabolism ; Cell Polarity ; Dendrites/genetics ; Drosophila ; Drosophila Proteins/genetics ; Endosomes/genetics ; Microtubules/genetics ; Mutation ; Receptors, Wnt/genetics ; Receptors, Wnt/metabolism ; Tubulin/genetics ; Tubulin/metabolism ; Wnt Proteins/genetics ; Wnt Signaling Pathway/genetics ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Microtubule-dependent processes precede pathological calcium influx in excitotoxin-induced axon degeneration.
Autorzy :
Tian N; Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia.
Hanson KA; Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia.
Canty AJ; Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia.
Vickers JC; Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia.
King AE; Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Mar; Vol. 152 (5), pp. 542-555. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J. Neurochem. Subsets: MEDLINE
MeSH Terms :
Axons/*metabolism
Calcium/*metabolism
Microtubules/*metabolism
Nerve Degeneration/*metabolism
Animals ; Axons/drug effects ; Axons/pathology ; Cells, Cultured ; Excitatory Amino Acid Agonists/toxicity ; Kainic Acid/toxicity ; Mice ; Mice, Inbred C57BL ; Microtubules/drug effects ; Nerve Degeneration/chemically induced ; Nerve Degeneration/pathology
Czasopismo naukowe
Tytuł :
Supported Solid Lipid Bilayers as a Platform for Single-Molecule Force Measurements.
Autorzy :
Sudhakar S; Eberheard Karls Universität Tübingen , ZMBP , Auf der Morgenstelle 32 , 72076 Tübingen , Germany.
Jachowski TJ; Eberheard Karls Universität Tübingen , ZMBP , Auf der Morgenstelle 32 , 72076 Tübingen , Germany.
Kittelberger M; Eberheard Karls Universität Tübingen , ZMBP , Auf der Morgenstelle 32 , 72076 Tübingen , Germany.
Maqbool A; Eberheard Karls Universität Tübingen , ZMBP , Auf der Morgenstelle 32 , 72076 Tübingen , Germany.
Hermsdorf GL; Eberheard Karls Universität Tübingen , ZMBP , Auf der Morgenstelle 32 , 72076 Tübingen , Germany.
Abdosamadi MK; Eberheard Karls Universität Tübingen , ZMBP , Auf der Morgenstelle 32 , 72076 Tübingen , Germany.
Schäffer E; Eberheard Karls Universität Tübingen , ZMBP , Auf der Morgenstelle 32 , 72076 Tübingen , Germany.
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Źródło :
Nano letters [Nano Lett] 2019 Dec 11; Vol. 19 (12), pp. 8877-8886. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett. Subsets: MEDLINE
MeSH Terms :
Microscopy, Atomic Force*
Microtubules*/chemistry
Microtubules*/ultrastructure
Models, Chemical*
DNA/*chemistry
Kinesin/*chemistry
Lipid Bilayers/*chemistry
Czasopismo naukowe
Tytuł :
C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules.
Autorzy :
Kumari A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
Srivastava S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
Manne RK; National Centre for Cell Science, University of Pune Campus, Pune, Maharashtra 411007, India.
Sisodiya S; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Punjab 160062, India.
Santra MK; National Centre for Cell Science, University of Pune Campus, Pune, Maharashtra 411007, India. Electronic address: .
Guchhait SK; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Punjab 160062, India. Electronic address: .
Panda D; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2019 Dec; Vol. 170, pp. 113663. Date of Electronic Publication: 2019 Oct 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem. Pharmacol. Subsets: MEDLINE
MeSH Terms :
Antineoplastic Agents, Phytogenic/*metabolism
Bibenzyls/*metabolism
Drug Delivery Systems/*methods
Melanoma, Experimental/*metabolism
Microtubules/*drug effects
Microtubules/*metabolism
A549 Cells ; Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Bibenzyls/administration & dosage ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; HeLa Cells ; Humans ; MCF-7 Cells ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Microtubules/pathology
Czasopismo naukowe
Tytuł :
Microtubules regulate cardiomyocyte transversal Young's modulus.
Autorzy :
Swiatlowska P; National Heart and Lung Institute, Imperial College London, W12 0NN London, United Kingdom.
Sanchez-Alonso JL; National Heart and Lung Institute, Imperial College London, W12 0NN London, United Kingdom.
Wright PT; National Heart and Lung Institute, Imperial College London, W12 0NN London, United Kingdom.
Novak P; School of Engineering and Materials Science, Queen Mary University of London, E1 4NS London, United Kingdom.
Gorelik J; National Heart and Lung Institute, Imperial College London, W12 0NN London, United Kingdom; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 11; Vol. 117 (6), pp. 2764-2766. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Subsets: MEDLINE
MeSH Terms :
Microtubules/*metabolism
Myocytes, Cardiac/*chemistry
Myocytes, Cardiac/*metabolism
Acetylation ; Animals ; Biomechanical Phenomena ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Cells, Cultured ; Elastic Modulus ; Male ; Microtubules/chemistry ; Protein Processing, Post-Translational ; Rats ; Rats, Inbred Lew ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule.
Autorzy :
Wang H; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zheng Z; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Han W; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yuan Y; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Li Y; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhou K; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wang Q; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xie L; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xu K; The Institute of Life Sciences, Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors, Biomedical Collaborative Innovation Center of Wenzhou, Wenzhou University, Wenzhou, Zhejiang, China 325035.
Zhang H; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xu H; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wu Y; The Institute of Life Sciences, Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors, Biomedical Collaborative Innovation Center of Wenzhou, Wenzhou University, Wenzhou, Zhejiang, China 325035.
Xiao J; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Jan 06; Vol. 2020, pp. 9741369. Date of Electronic Publication: 2020 Jan 06 (Print Publication: 2020).
Typ publikacji :
Journal Article
Journal Info :
Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
MeSH Terms :
Microtubules*/metabolism
Microtubules*/pathology
Spinal Cord Injuries*/drug therapy
Spinal Cord Injuries*/metabolism
Spinal Cord Injuries*/pathology
Axons/*physiology
Metformin/*pharmacology
Oxidative Stress/*drug effects
Regeneration/*drug effects
Animals ; Chromones/pharmacology ; Mitochondria/metabolism ; Mitochondria/pathology ; Morpholines/pharmacology ; NF-E2-Related Factor 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; Response Elements
Czasopismo naukowe
Tytuł :
Microtubule organelles in Giardia.
Autorzy :
Hagen KD; Department of Microbiology and Molecular Genetics, UC Davis, Davis, CA, United States.
McInally SG; Department of Microbiology and Molecular Genetics, UC Davis, Davis, CA, United States.
Hilton ND; Department of Microbiology and Molecular Genetics, UC Davis, Davis, CA, United States.
Dawson SC; Department of Microbiology and Molecular Genetics, UC Davis, Davis, CA, United States. Electronic address: .
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Źródło :
Advances in parasitology [Adv Parasitol] 2020; Vol. 107, pp. 25-96. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
Journal Info :
Publisher: Academic Press Country of Publication: England NLM ID: 0370435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-6079 (Electronic) Linking ISSN: 0065308X NLM ISO Abbreviation: Adv. Parasitol. Subsets: MEDLINE
MeSH Terms :
Giardia/*cytology
Giardia/*metabolism
Microtubules/*metabolism
Giardia/classification ; Giardia/ultrastructure ; Microtubules/chemistry ; Microtubules/ultrastructure ; Organelles/chemistry ; Organelles/metabolism ; Organelles/ultrastructure
Czasopismo naukowe
Tytuł :
AtKATANIN1 Modulates Microtubule Depolymerization and Reorganization in Response to Salt Stress in Arabidopsis .
Autorzy :
Yang J; Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops, Hainan University, Haikou 570228, China.
An B; Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops, Hainan University, Haikou 570228, China.
Luo H; Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops, Hainan University, Haikou 570228, China.
He C; Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops, Hainan University, Haikou 570228, China.
Wang Q; Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops, Hainan University, Haikou 570228, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 24; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
MeSH Terms :
Arabidopsis/*metabolism
Arabidopsis Proteins/*metabolism
Microtubules/*metabolism
Arabidopsis/drug effects ; Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Katanin/genetics ; Katanin/metabolism ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Microtubules/drug effects ; Microtubules/genetics ; Plants, Genetically Modified/drug effects ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; Salt Stress ; Salt Tolerance ; Sodium Chloride/pharmacology
Czasopismo naukowe
Tytuł :
Insights into the assembly and activation of the microtubule nucleator γ-TuRC.
Autorzy :
Liu P; Zentrum für Molekulare Biologie, Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Zupa E; Zentrum für Molekulare Biologie, Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Neuner A; Zentrum für Molekulare Biologie, Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Böhler A; Zentrum für Molekulare Biologie, Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Loerke J; Charite - Universitaetsmedizin Berlin, Institute for Medical Physics and Biophysics, Berlin, Germany.
Flemming D; Heidelberg University Biochemistry Center, Heidelberg, Germany.
Ruppert T; Zentrum für Molekulare Biologie, Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Rudack T; Department of Biophysics, Ruhr-University Bochum, Bochum, Germany.
Peter C; Institut für Genetik Universität Bonn, Bonn, Germany.
Spahn C; Charite - Universitaetsmedizin Berlin, Institute for Medical Physics and Biophysics, Berlin, Germany.
Gruss OJ; Institut für Genetik Universität Bonn, Bonn, Germany.
Pfeffer S; Zentrum für Molekulare Biologie, Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany. .
Schiebel E; Zentrum für Molekulare Biologie, Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany. .
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Źródło :
Nature [Nature] 2020 Feb; Vol. 578 (7795), pp. 467-471. Date of Electronic Publication: 2019 Dec 19.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
MeSH Terms :
Cryoelectron Microscopy*
Xenopus*
Microtubule-Associated Proteins/*chemistry
Microtubule-Associated Proteins/*ultrastructure
Microtubules/*metabolism
Multiprotein Complexes/*chemistry
Multiprotein Complexes/*ultrastructure
Actins/chemistry ; Actins/metabolism ; Actins/ultrastructure ; Animals ; Microtubule-Associated Proteins/metabolism ; Microtubules/chemistry ; Models, Molecular ; Tubulin/chemistry ; Tubulin/metabolism ; Tubulin/ultrastructure
Czasopismo naukowe
Tytuł :
Inhibition of polo-like kinase 1 suppresses microtubule dynamics in MCF-7 cells.
Autorzy :
Rashid A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076, India.
Naaz A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076, India.
Rai A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076, India.
Chatterji BP; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076, India.
Panda D; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076, India. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2020 Feb; Vol. 465 (1-2), pp. 27-36. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol. Cell. Biochem. Subsets: MEDLINE
MeSH Terms :
Cell Cycle Proteins/*metabolism
Microtubules/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Proto-Oncogene Proteins/*metabolism
Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Female ; Humans ; MCF-7 Cells ; Microtubules/genetics ; Protein Kinase Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/genetics ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/genetics ; Tubulin/genetics ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach.
Autorzy :
Du L; Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, OK, USA. .; Institute for Natural Products Applications and Research Technologies, The University of Oklahoma, Norman, OK, USA. .
Yee SS; Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX, USA.
Ramachandran K; Department of Medicine, Division of Nephrology, The University of Texas Health Science Center, San Antonio, TX, USA.
Risinger AL; Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX, USA. .; Mays Cancer Center, The University of Texas Health Science Center, San Antonio, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 31; Vol. 11 (1), pp. 654. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
MeSH Terms :
Microtubules/*chemistry
Steroids/*chemistry
Cell Line, Tumor ; Humans ; Kinetics ; Microtubules/metabolism ; Models, Molecular ; Steroids/metabolism ; Tubulin/chemistry ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Controlling the kinetics of interaction between microtubules and kinesins over a wide temperature range using the deep-sea osmolyte trimethylamine N-oxide.
Autorzy :
Munmun T; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan. .
Kabir AMR; Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
Katsumoto Y; Department of Chemistry, Faculty of Science, Fukuoka University, Nanakuma 8-19-1, Jonan-ku, Fukuoka 814-0180, Japan.
Sada K; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan. and Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
Kakugo A; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan. and Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jan 25; Vol. 56 (8), pp. 1187-1190. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem. Commun. (Camb.) Subsets: MEDLINE
MeSH Terms :
Temperature*
Kinesin/*metabolism
Methylamines/*pharmacology
Microtubules/*metabolism
Kinesin/chemistry ; Kinetics ; Methylamines/chemistry ; Microtubules/chemistry
Czasopismo naukowe
Tytuł :
Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies.
Autorzy :
Fujiwara H; Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan.
Watanabe S; Laboratory of Ion Channel Pathophysiology, Graduate School of Brain Science, Doshisha University, Kyoto, 610-0394, Japan.
Iwata M; Laboratory of Ion Channel Pathophysiology, Graduate School of Brain Science, Doshisha University, Kyoto, 610-0394, Japan.
Ueda S; Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan.
Nobuhara M; Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan.
Wada-Kakuda S; Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan.
Misonou H; Laboratory of Ion Channel Pathophysiology, Graduate School of Brain Science, Doshisha University, Kyoto, 610-0394, Japan; Center for Research in Neurodegenerative Diseases, Doshisha University, Kyoto, 610-0394, Japan.
Miyasaka T; Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan; Center for Research in Neurodegenerative Diseases, Doshisha University, Kyoto, 610-0394, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jan 15; Vol. 521 (3), pp. 779-785. Date of Electronic Publication: 2019 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem. Biophys. Res. Commun. Subsets: MEDLINE
MeSH Terms :
Microtubules/*metabolism
Neurofibrillary Tangles/*metabolism
Neurons/*metabolism
Tubulin/*metabolism
tau Proteins/*metabolism
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Cell Body/metabolism ; Cell Body/pathology ; Cells, Cultured ; Female ; HEK293 Cells ; Humans ; Mice ; Microtubules/pathology ; Neurofibrillary Tangles/pathology ; Neurons/pathology ; Phosphorylation
Czasopismo naukowe
Tytuł :
Isoquinoline-based biaryls as a robust scaffold for microtubule inhibitors.
Autorzy :
Kraus Y; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstrasse 5-13, Munich, 81377, Germany.
Glas C; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstrasse 5-13, Munich, 81377, Germany.
Melzer B; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstrasse 5-13, Munich, 81377, Germany.
Gao L; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstrasse 5-13, Munich, 81377, Germany.
Heise C; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstrasse 5-13, Munich, 81377, Germany.
Preuße M; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstrasse 5-13, Munich, 81377, Germany.
Ahlfeld J; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstrasse 5-13, Munich, 81377, Germany.
Bracher F; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstrasse 5-13, Munich, 81377, Germany.
Thorn-Seshold O; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University of Munich, Butenandtstrasse 5-13, Munich, 81377, Germany. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Jan 15; Vol. 186, pp. 111865. Date of Electronic Publication: 2019 Nov 09.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
MeSH Terms :
Antineoplastic Agents/*pharmacology
Isoquinolines/*pharmacology
Microtubules/*drug effects
Tubulin Modulators/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HL-60 Cells ; HeLa Cells ; Humans ; Isoquinolines/chemical synthesis ; Isoquinolines/chemistry ; Microscopy, Confocal ; Microtubules/metabolism ; Molecular Structure ; Polymerization/drug effects ; Structure-Activity Relationship ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/chemistry
Czasopismo naukowe
Tytuł :
Polo regulates Spindly to prevent premature stabilization of kinetochore-microtubule attachments.
Autorzy :
Barbosa J; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; i3S, Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal.
Martins T; Department of Genetics, University of Cambridge, Cambridge, UK.
Bange T; MPI für molekulare Physiologie, Dortmund, Germany.
Tao L; Department of Biology, University of Hawaii, Hilo, HI, USA.
Conde C; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; i3S, Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal.
Sunkel C; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.; i3S, Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal.; ICBAS-Instituto de Ciência Biomédica de Abel Salazar, Universidade do Porto, Porto, Portugal.
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Źródło :
The EMBO journal [EMBO J] 2020 Jan 15; Vol. 39 (2), pp. e100789. Date of Electronic Publication: 2019 Dec 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Wiley Blackwell Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J. Subsets: MEDLINE
MeSH Terms :
Mitosis*
Spindle Apparatus*
Drosophila Proteins/*metabolism
Drosophila melanogaster/*physiology
Kinetochores/*metabolism
Microtubules/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Animals ; Cell Cycle Proteins/metabolism ; Chromosome Segregation ; Dyneins/metabolism ; Female ; Kinetochores/chemistry ; Male ; Microtubules/chemistry ; Signal Transduction
Czasopismo naukowe
Tytuł :
Three Beads Are Better Than One.
Autorzy :
Howard J; Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut. Electronic address: .
Hancock WO; Biomedical Engineering Department, Pennsylvania State University, University Park, Pennsylvania. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2020 Jan 07; Vol. 118 (1), pp. 1-3. Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Journal Article; Comment
Journal Info :
Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys. J. Subsets: MEDLINE
MeSH Terms :
Kinesin*
Microtubules*
Microspheres ; Physical Phenomena ; Weight-Bearing
Czasopismo naukowe
Tytuł :
Electron cryotomography of intact motile cilia defines the basal body to axoneme transition.
Autorzy :
Greenan GA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA.; The Howard Hughes Medical Institute, Chevy Chase, MD.
Vale RD; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA.; The Howard Hughes Medical Institute, Chevy Chase, MD.
Agard DA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA.; The Howard Hughes Medical Institute, Chevy Chase, MD.
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Źródło :
The Journal of cell biology [J Cell Biol] 2020 Jan 06; Vol. 219 (1).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J. Cell Biol. Subsets: MEDLINE
MeSH Terms :
Axoneme/*ultrastructure
Basal Bodies/*ultrastructure
Cilia/*ultrastructure
Cryoelectron Microscopy/*methods
Electron Microscope Tomography/*methods
Microtubules/*ultrastructure
Trachea/*ultrastructure
Animals ; Axoneme/metabolism ; Basal Bodies/metabolism ; Cattle ; Cilia/metabolism ; Microtubule Proteins/metabolism ; Microtubules/metabolism ; Trachea/metabolism
Czasopismo naukowe
Tytuł :
Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy.
Autorzy :
Genualdi C; Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Feinstein SC; Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Wilson L; Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Jordan MA; Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Stagg NJ; Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Jan 05; Vol. 315, pp. 108906. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem. Biol. Interact. Subsets: MEDLINE
MeSH Terms :
Antineoplastic Agents/*adverse effects
Antineoplastic Agents/*therapeutic use
Microtubules/*drug effects
Neoplasms/*drug therapy
Peripheral Nervous System Diseases/*chemically induced
Tubulin Modulators/*adverse effects
Tubulin Modulators/*therapeutic use
Animals ; Humans ; Microtubules/metabolism ; Neoplasms/metabolism ; Peripheral Nervous System Diseases/metabolism ; Tubulin/metabolism
Czasopismo naukowe

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