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    Tytuł:
    A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA A Receptor.
    Autorzy:
    Li G; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, College of Science, Southern University of Science and Technology, Shenzhen 518055, China.
    Nieman AN; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
    Mian MY; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
    Zahn NM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
    Mikulsky BN; Pantherics Incorporated, La Jolla, CA 92037, USA.
    Poe MM; Department of Chemistry, Western Michigan University, Kalamazoo, MI 49008, USA.
    Methuku KR; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
    Liu Y; National Institute of Mental Health Psychoactive Drug Screening Program, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.
    Cook JM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
    Stafford DC; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.; Pantherics Incorporated, La Jolla, CA 92037, USA.
    Arnold LA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.; Pantherics Incorporated, La Jolla, CA 92037, USA.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2020 Aug 25; Vol. 25 (17). Date of Electronic Publication: 2020 Aug 25.
    Typ publikacji:
    Comparative Study; Journal Article
    MeSH Terms:
    Azepines*/chemistry
    Azepines*/pharmacology
    GABA-A Receptor Agonists*/chemistry
    GABA-A Receptor Agonists*/pharmacology
    Receptors, GABA-A*/chemistry
    Receptors, GABA-A*/genetics
    Receptors, GABA-A*/metabolism
    Receptors, Opioid, delta*/agonists
    Receptors, Opioid, delta*/chemistry
    Receptors, Opioid, delta*/genetics
    Receptors, Opioid, delta*/metabolism
    Receptors, Opioid, kappa*/agonists
    Receptors, Opioid, kappa*/chemistry
    Receptors, Opioid, kappa*/genetics
    Receptors, Opioid, kappa*/metabolism
    Receptors, Opioid, mu*/agonists
    Receptors, Opioid, mu*/chemistry
    Receptors, Opioid, mu*/genetics
    Receptors, Opioid, mu*/metabolism
    Animals ; HEK293 Cells ; Humans ; Protein Binding ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABA A receptors without causing systemic immune suppression.
    Autorzy:
    Zahn NM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Huber AT; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Mikulsky BN; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Stepanski ME; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Kehoe AS; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Li G; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Schussman M; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Rashid Roni MS; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Kodali R; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Cook JM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Stafford DC; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Steeber DA; Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Arnold LA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
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    Źródło:
    Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2019 Jul; Vol. 125 (1), pp. 75-84. Date of Electronic Publication: 2019 Feb 21.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anti-Inflammatory Agents/*administration & dosage
    Asthma/*drug therapy
    Azepines/*administration & dosage
    Drugs, Investigational/*administration & dosage
    GABA-A Receptor Agonists/*administration & dosage
    Heterocyclic Compounds, 3-Ring/*administration & dosage
    Imidazoles/*administration & dosage
    Immune Tolerance/*drug effects
    Adjuvants, Immunologic/administration & dosage ; Administration, Oral ; Animals ; Anti-Inflammatory Agents/adverse effects ; Asthma/blood ; Asthma/immunology ; Azepines/pharmacology ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Drugs, Investigational/adverse effects ; Female ; GABA-A Receptor Agonists/adverse effects ; Hemocyanins/administration & dosage ; Hemocyanins/immunology ; Heterocyclic Compounds, 3-Ring/adverse effects ; Humans ; Imidazoles/pharmacology ; Leukocyte Count ; Male ; Mice ; Prednisone/administration & dosage ; Prednisone/adverse effects ; Weight Loss
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-2 z 2

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