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    Wyświetlanie 1-13 z 13
    Tytuł:
    Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy Japanese and non-Asian male subjects
    Autorzy:
    Hall J
    Gillen M
    Liu S
    Miner JN
    Valdez S
    Shen Z
    Lee C
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    Temat:
    Pharmacokinetics
    pharmacodynamics
    selective uric acid reabsorption inhibitor
    serum urate
    urinary uric acid
    Therapeutics. Pharmacology
    RM1-950
    Źródło:
    Drug Design, Development and Therapy, Vol Volume 12, Pp 1799-1807 (2018)
    Opis pliku:
    electronic resource
    Relacje:
    https://www.dovepress.com/ppharmacokinetics-pharmacodynamics-and-tolerability-of-verinurad--peer-reviewed-article-DDDT; https://doaj.org/toc/1177-8881
    Dostęp URL:
    https://doaj.org/article/55ca08c1e27144f8af76c39e0986638d  Link otwiera się w nowym oknie
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjects
    Autorzy:
    Shen Z
    Gillen M
    Miner JN
    Bucci G
    Wilson DM
    Hall JW
    Pokaż więcej
    Temat:
    Pharmacokinetics
    pharmacodynamics
    selective uric acid reabsorption inhibitor
    serum urate
    urinary uric acid
    Therapeutics. Pharmacology
    RM1-950
    Źródło:
    Drug Design, Development and Therapy, Vol Volume 11, Pp 2077-2086 (2017)
    Opis pliku:
    electronic resource
    Relacje:
    https://www.dovepress.com/pharmacokinetics-pharmacodynamics-and-tolerability-of-verinurad-a-sele-peer-reviewed-article-DDDT; https://doaj.org/toc/1177-8881
    Dostęp URL:
    https://doaj.org/article/1e3e8ebc8c2c416ba280648bce2920eb  Link otwiera się w nowym oknie
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    Multimodal NASH prognosis using 3D imaging flow cytometry and artificial intelligence to characterize liver cells.
    Autorzy:
    Subramanian R; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
    Tang R; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
    Zhang Z; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
    Joshi V; Viscient Biosciences Inc, San Diego, CA, 92121, USA.
    Miner JN; Viscient Biosciences Inc, San Diego, CA, 92121, USA.
    Lo YH; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA. .
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    Źródło:
    Scientific reports [Sci Rep] 2022 Jul 01; Vol. 12 (1), pp. 11180. Date of Electronic Publication: 2022 Jul 01.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Non-alcoholic Fatty Liver Disease*/diagnostic imaging
    Artificial Intelligence ; Flow Cytometry ; Humans ; Imaging, Three-Dimensional ; Prognosis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties.
    Autorzy:
    Nyborg AC; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Ward C; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Zacco A; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Chacko B; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Grinberg L; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Geoghegan JC; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Bean R; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Wendeler M; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Bartnik F; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    O'Connor E; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Gruia F; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Iyer V; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Feng H; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Roy V; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Berge M; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Miner JN; Ardea Biosciences, San Diego, California, United States of America.
    Wilson DM; Ardea Biosciences, San Diego, California, United States of America.
    Zhou D; Ardea Biosciences, San Diego, California, United States of America.
    Nicholson S; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Wilker C; Ardea Biosciences, San Diego, California, United States of America.
    Wu CY; MedImmune LLC, Mountain View, California, United States of America.
    Wilson S; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Jermutus L; MedImmune LTD, Cambridge, United Kingdom.
    Wu H; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Owen DA; MedImmune LTD, Cambridge, United Kingdom.
    Osbourn J; MedImmune LTD, Cambridge, United Kingdom.
    Coats S; MedImmune LLC, Gaithersburg, Maryland, United States of America.
    Baca M; MedImmune LLC, Gaithersburg, Maryland, United States of America.
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    Źródło:
    PloS one [PLoS One] 2016 Dec 21; Vol. 11 (12), pp. e0167935. Date of Electronic Publication: 2016 Dec 21 (Print Publication: 2016).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Gout/*drug therapy
    Urate Oxidase/*therapeutic use
    Animals ; Calorimetry, Differential Scanning ; Dogs ; Escherichia coli/metabolism ; Half-Life ; Humans ; Hydrogen-Ion Concentration ; Kinetics ; Papio ; Polyethylene Glycols/chemistry ; Rats ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/immunology ; Recombinant Proteins/pharmacokinetics ; Recombinant Proteins/therapeutic use ; Substrate Specificity ; Swine ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Urate Oxidase/adverse effects ; Urate Oxidase/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Mechanism of high affinity inhibition of the human urate transporter URAT1.
    Autorzy:
    Tan PK; Department of Biology, Ardea Biosciences (A member of the AstraZeneca Group), 9390 Towne Centre Drive, San Diego, CA, 92121 USA.
    Ostertag TM; Department of Biology, Ardea Biosciences (A member of the AstraZeneca Group), 9390 Towne Centre Drive, San Diego, CA, 92121 USA.
    Miner JN; Department of Biology, Ardea Biosciences (A member of the AstraZeneca Group), 9390 Towne Centre Drive, San Diego, CA, 92121 USA.
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    Źródło:
    Scientific reports [Sci Rep] 2016 Oct 07; Vol. 6, pp. 34995. Date of Electronic Publication: 2016 Oct 07.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Organic Anion Transporters/*antagonists & inhibitors
    Organic Cation Transport Proteins/*antagonists & inhibitors
    Amino Acid Substitution ; Animals ; Anion Transport Proteins/antagonists & inhibitors ; Anion Transport Proteins/chemistry ; Anion Transport Proteins/genetics ; Binding Sites/genetics ; HEK293 Cells ; Humans ; Kinetics ; Models, Molecular ; Mutagenesis, Site-Directed ; Organic Anion Transport Protein 1/chemistry ; Organic Anion Transporters/chemistry ; Organic Anion Transporters/genetics ; Organic Cation Transport Proteins/chemistry ; Organic Cation Transport Proteins/genetics ; Protein Interaction Domains and Motifs ; Rats ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Uric Acid/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-13 z 13

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