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Wyszukujesz frazę ""Minocycline"" wg kryterium: Temat


Tytuł :
Microglia activation and adult neurogenesis in the hippocampus: New clues about the antidepressant effect of minocycline.
Autorzy :
Inta D; Department of Psychiatry (UPK), University of Basel, Switzerland; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Germany. Electronic address: .
Guzman R; Department of Biomedicine, University Hospital Basel, Switzerland; Department of Neurosurgery, University Hospital Basel, Switzerland.
Gass P; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Germany.
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 May; Vol. 94, pp. 27-28. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Microglia*
Minocycline*/pharmacology
Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Depression/drug therapy ; Hippocampus ; Neurogenesis/drug effects ; Phagocytosis
Czasopismo naukowe
Tytuł :
Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis.
Autorzy :
Bassett B; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Subramaniyam S; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Fan Y; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Varney S; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Pan H; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Carneiro AMD; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Chung CY; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; Division of Natural Science, Duke Kunshan University, Kunshan 215316, China. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Jan; Vol. 91, pp. 519-530. Date of Electronic Publication: 2020 Nov 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Microglia*
Minocycline*/pharmacology
Animals ; Depression/drug therapy ; Hippocampus ; Mice ; Neurogenesis ; Phagocytosis
Czasopismo naukowe
Tytuł :
Minocycline prevents the inflammatory response after retinal detachment, where microglia phenotypes being regulated through A20.
Autorzy :
Gao W; Department of Ophthalmology, Peking University First Hospital, Beijing, PR China.
Du J; Department of Ophthalmology, Peking University First Hospital, Beijing, PR China.
Chi Y; Department of Ophthalmology, Peking University First Hospital, Beijing, PR China.
Zhu R; Department of Ophthalmology, Peking University First Hospital, Beijing, PR China.
Gao X; Department of Ophthalmology, Peking University First Hospital, Beijing, PR China.
Yang L; Department of Ophthalmology, Peking University First Hospital, Beijing, PR China. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2021 Feb; Vol. 203, pp. 108403. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Inflammation/*prevention & control
Microglia/*drug effects
Minocycline/*pharmacology
Retinal Detachment/*complications
Tumor Necrosis Factor alpha-Induced Protein 3/*genetics
Animals ; Blotting, Western ; Coculture Techniques ; Disease Models, Animal ; Gene Expression Regulation/physiology ; In Situ Nick-End Labeling ; Inflammation/etiology ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Phenotype ; Photoreceptor Cells/drug effects ; Photoreceptor Cells/metabolism ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Transfection ; Tumor Necrosis Factor alpha-Induced Protein 3/metabolism
Czasopismo naukowe
Tytuł :
Microglia-Astrocyte Communication via C1q Contributes to Orofacial Neuropathic Pain Associated with Infraorbital Nerve Injury.
Autorzy :
Asano S; Department of Oral Diagnostic Science, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
Hayashi Y; Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
Iwata K; Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
Okada-Ogawa A; Department of Oral Diagnostic Science, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
Hitomi S; Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
Shibuta I; Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
Imamura Y; Department of Oral Diagnostic Science, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
Shinoda M; Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 17; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*metabolism
Complement C1q/*administration & dosage
Facial Pain/*metabolism
Microglia/*metabolism
Minocycline/*administration & dosage
Neuralgia/*metabolism
Trigeminal Nerve Injuries/*metabolism
Animals ; Astrocytes/drug effects ; Calcium-Binding Proteins/metabolism ; Citrates/administration & dosage ; Complement C1q/metabolism ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/metabolism ; Hyperalgesia/metabolism ; Male ; Microfilament Proteins/metabolism ; Microglia/drug effects ; Minocycline/pharmacology ; Nociceptors/metabolism ; Pain Measurement ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Diterpenoids and triterpenoids from Triadica rotundifolia and their effects on microglial nitric oxide production.
Autorzy :
Zhao HY; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Su BJ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Zhou WJ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Wang YQ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Liao HB; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Wang HS; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China. Electronic address: .
Liang D; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104332. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diterpenes/*chemistry
Euphorbiaceae/*chemistry
Microglia/*drug effects
Nitric Oxide/*metabolism
Plant Components, Aerial/*chemistry
Plant Extracts/*chemistry
Triterpenes/*chemistry
Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Diterpenes/pharmacology ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Humans ; Minocycline/pharmacology ; Minocycline/therapeutic use ; Models, Molecular ; Molecular Structure ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Plant Extracts/pharmacology ; Triterpenes/pharmacology
Czasopismo naukowe
Tytuł :
A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis.
Autorzy :
Zhou J; School of Ophthalmology & Optometry and Eye Hospital, Institute of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; State Key Laboratory of Optometry & Vision Science, Wenzhou 325027, Zhejiang, China.
Yang J; School of Ophthalmology & Optometry and Eye Hospital, Institute of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; State Key Laboratory of Optometry & Vision Science, Wenzhou 325027, Zhejiang, China.
Dai M; School of Ophthalmology & Optometry and Eye Hospital, Institute of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; State Key Laboratory of Optometry & Vision Science, Wenzhou 325027, Zhejiang, China.
Lin D; School of Ophthalmology & Optometry and Eye Hospital, Institute of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; State Key Laboratory of Optometry & Vision Science, Wenzhou 325027, Zhejiang, China.
Zhang R; School of Ophthalmology & Optometry and Eye Hospital, Institute of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; State Key Laboratory of Optometry & Vision Science, Wenzhou 325027, Zhejiang, China.
Liu H; School of Ophthalmology & Optometry and Eye Hospital, Institute of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; State Key Laboratory of Optometry & Vision Science, Wenzhou 325027, Zhejiang, China.
Yu A; School of Ophthalmology & Optometry and Eye Hospital, Institute of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; State Key Laboratory of Optometry & Vision Science, Wenzhou 325027, Zhejiang, China.
Vakal S; Structural Bioinformatics Laboratory, Biochemistry, Åbo Akademi University, Turku 20541, Finland.
Wang Y; School of Ophthalmology & Optometry and Eye Hospital, Institute of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; State Key Laboratory of Optometry & Vision Science, Wenzhou 325027, Zhejiang, China. Electronic address: .
Li X; School of Ophthalmology & Optometry and Eye Hospital, Institute of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China; State Key Laboratory of Optometry & Vision Science, Wenzhou 325027, Zhejiang, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114108. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoimmune Diseases/*drug therapy
Gastrointestinal Microbiome/*drug effects
Microglia/*drug effects
Minocycline/*therapeutic use
Retina/*drug effects
Uveitis/*drug therapy
Animals ; Autoimmune Diseases/immunology ; Cellular Microenvironment/drug effects ; Cellular Microenvironment/immunology ; Disease Models, Animal ; Gastrointestinal Microbiome/immunology ; Histocompatibility Antigens Class II/biosynthesis ; Male ; Microglia/immunology ; Rats ; Rats, Inbred Lew ; Retina/immunology ; Th17 Cells/drug effects ; Th17 Cells/immunology ; Th17 Cells/pathology ; Uveitis/immunology ; Uveitis/pathology
Czasopismo naukowe
Tytuł :
Injection of minocycline into the periaqueductal gray attenuates morphine withdrawal signs.
Autorzy :
Liu Q; Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, China.
Tang S; Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, China.
Du X; Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, China.
Sun Y; Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, China.
Lai J; Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, China.
Wang X; Department of Pathogenic Biology, Chengdu Medical College, Chengdu, China. Electronic address: .
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Źródło :
Neuroscience letters [Neurosci Lett] 2020 Sep 25; Vol. 736, pp. 135283. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microglia/*drug effects
Minocycline/*administration & dosage
Morphine/*adverse effects
Naloxone/*administration & dosage
Periaqueductal Gray/*drug effects
Substance Withdrawal Syndrome/*metabolism
Animals ; Calcium-Binding Proteins/metabolism ; Connexins/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Male ; Microfilament Proteins/metabolism ; Microglia/metabolism ; Microinjections ; Narcotic Antagonists/administration & dosage ; Narcotics/adverse effects ; Nerve Tissue Proteins/metabolism ; Periaqueductal Gray/metabolism ; Phosphorylation/drug effects ; Rats ; Rats, Wistar ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress.
Autorzy :
Cai Z; Department of Pharmacy, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu Province, China.
Ye T; Department of Pharmacy, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu Province, China.
Xu X; Department of Pharmacy, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu Province, China.
Gao M; Department of Pharmacology, Nantong Health College of Jiangsu Province, #288 Zhenxing East Road, Nantong 226010, Jiangsu Province, China.
Zhang Y; Department of Pharmacy, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu Province, China.
Wang D; Department of Pharmacy, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu Province, China.
Gu Y; Department of Pharmacy, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu Province, China.
Zhu H; Department of Pharmacy, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu Province, China.
Tong L; Department of Pharmacy, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu Province, China.
Lu J; Department of Pharmacy, The People's Hospital of Taizhou, The Fifth Affiliated Hospital of Nantong University, #210 Yingchun Road, Taizhou 225300, Jiangsu, China.
Chen Z; Invasive Technology Department, Nantong First People's Hospital, The Second Affiliated Hospital of Nantong University, #6 North Road Hai'er Xiang, Nantong 226001, Jiangsu Province, China.
Huang C; Department of Pharmacy, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu Province, China. Electronic address: .
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Źródło :
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2020 Jul 13; Vol. 101, pp. 109931. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Antidepressive Agents/*therapeutic use
Depression/*metabolism
Microglia/*metabolism
Stress, Psychological/*metabolism
Animals ; Antidepressive Agents/pharmacology ; Depression/drug therapy ; Depression/pathology ; Dose-Response Relationship, Drug ; Immobilization/methods ; Immobilization/psychology ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/pathology ; Minocycline/pharmacology ; Stress, Psychological/drug therapy ; Stress, Psychological/pathology
Czasopismo naukowe
Tytuł :
The effect of minocycline on amelioration of cognitive deficits and pro-inflammatory cytokines levels in patients with schizophrenia.
Autorzy :
Zhang L; Department of Psychiatry and Mental Health Institute of the Second Xiangya Hospital, Central South University; Chinese National Clinical Research Center on Mental Disorders, Chinese National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China; Department of Psychiatry, Guangzhou First People's Hospital, the Second Affiliated Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Zheng H; GuangzhouBaiyun Psychiatric Hospital, Guangzhou, Guangdong, China.
Wu R; Department of Psychiatry and Mental Health Institute of the Second Xiangya Hospital, Central South University; Chinese National Clinical Research Center on Mental Disorders, Chinese National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China.
Kosten TR; Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.
Zhang XY; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, TX, USA.
Zhao J; Department of Psychiatry and Mental Health Institute of the Second Xiangya Hospital, Central South University; Chinese National Clinical Research Center on Mental Disorders, Chinese National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China; The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, Guangdong, China. Electronic address: .
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Źródło :
Schizophrenia research [Schizophr Res] 2019 Oct; Vol. 212, pp. 92-98. Date of Electronic Publication: 2019 Aug 12.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Antipsychotic Agents/*administration & dosage
Cognitive Dysfunction/*drug therapy
Inflammation/*drug therapy
Interleukin-1beta/*drug effects
Interleukin-6/*blood
Microglia/*drug effects
Minocycline/*pharmacology
Schizophrenia/*drug therapy
Tumor Necrosis Factor-alpha/*drug effects
Adolescent ; Adult ; Anti-Inflammatory Agents/administration & dosage ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/physiopathology ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Inflammation/blood ; Interleukin-1beta/blood ; Male ; Middle Aged ; Minocycline/administration & dosage ; Risperidone/administration & dosage ; Schizophrenia/blood ; Schizophrenia/complications ; Schizophrenia/physiopathology ; Treatment Outcome ; Tumor Necrosis Factor-alpha/blood ; Young Adult
Czasopismo naukowe
Tytuł :
Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression.
Autorzy :
Wang Y; Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Wang Q; Affiliated First Clinical College of Xuzhou Medical University, Xuzhou 221004, China.; Department of Geriatric Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, China.
Yu R; Department of Genetics, Xuzhou Medical University, Xuzhou 221004, China.
Zhang Q; Experimental Animal Center, Xuzhou Medical University, Xuzhou 221004, China.
Zhang Z; Deprtment of Physiology, Xuzhou Medical University, Xuzhou 221004, China.
Li H; Department of Pathology, Xuzhou Medical University, Xuzhou 221004, China.
Ren C; Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China.
Yang R; Affiliated First Clinical College of Xuzhou Medical University, Xuzhou 221004, China.; Department of Geriatric Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, China.
Niu H; Department of Genetics, Xuzhou Medical University, Xuzhou 221004, China.; Public Experimental Research Center of Xuzhou Medical University, Xuzhou 221004, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Jul 24; Vol. 12 (14), pp. 14232-14243. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons/*pathology
Microglia/*drug effects
Minocycline/*pharmacology
Nerve Degeneration/*pathology
Substantia Nigra/*pathology
alpha-Synuclein/*biosynthesis
Animals ; Behavior, Animal ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Dopamine/metabolism ; Humans ; Lewy Bodies/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Motor Activity ; Mutation ; Parkinson Disease/genetics ; Parkinson Disease/psychology ; Receptors, Interleukin-1 Type I/biosynthesis ; Receptors, Interleukin-1 Type I/genetics ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner.
Autorzy :
Schmidtner AK; University of Regensburg, Department of Behavioural and Molecular Neurobiology, Regensburg Center of Neuroscience, Regensburg, Germany. .
Slattery DA; University of Regensburg, Department of Behavioural and Molecular Neurobiology, Regensburg Center of Neuroscience, Regensburg, Germany.; University Hospital Frankfurt, Goethe University, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.
Gläsner J; University Hospital Regensburg, Institute of Clinical Microbiology and Hygiene, Regensburg, Germany.
Hiergeist A; University Hospital Regensburg, Institute of Clinical Microbiology and Hygiene, Regensburg, Germany.
Gryksa K; University of Regensburg, Department of Behavioural and Molecular Neurobiology, Regensburg Center of Neuroscience, Regensburg, Germany.
Malik VA; University Regensburg, Department of Psychiatry and Psychotherapy, Regensburg Center of Neuroscience, Regensburg, Germany.
Hellmann-Regen J; Department of Psychiatry, Charité-Campus Benjamin Franklin, Section Neurobiology, University Medicine Berlin, Berlin, Germany.
Heuser I; Department of Psychiatry, Charité-Campus Benjamin Franklin, Section Neurobiology, University Medicine Berlin, Berlin, Germany.
Baghai TC; University Regensburg, Department of Psychiatry and Psychotherapy, Regensburg Center of Neuroscience, Regensburg, Germany.
Gessner A; University Hospital Regensburg, Institute of Clinical Microbiology and Hygiene, Regensburg, Germany.
Rupprecht R; University Regensburg, Department of Psychiatry and Psychotherapy, Regensburg Center of Neuroscience, Regensburg, Germany.
Di Benedetto B; University Regensburg, Department of Psychiatry and Psychotherapy, Regensburg Center of Neuroscience, Regensburg, Germany.
Neumann ID; University of Regensburg, Department of Behavioural and Molecular Neurobiology, Regensburg Center of Neuroscience, Regensburg, Germany.
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Źródło :
Translational psychiatry [Transl Psychiatry] 2019 Sep 13; Vol. 9 (1), pp. 223. Date of Electronic Publication: 2019 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anxiety/*drug therapy
Behavior, Animal/*drug effects
Gastrointestinal Microbiome/*drug effects
Microglia/*drug effects
Minocycline/*pharmacology
Prefrontal Cortex/*drug effects
Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anxiety/metabolism ; Anxiety/microbiology ; Cecum/drug effects ; Cecum/microbiology ; Disease Models, Animal ; Female ; Male ; Microglia/metabolism ; Minocycline/therapeutic use ; Prefrontal Cortex/metabolism ; Rats ; Rats, Wistar ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice.
Autorzy :
Hu P; Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong, Jiangsu, 226001, China.
Wang D; Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong, Jiangsu, 226001, China.
Zhang Y; Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong, Jiangsu, 226001, China.
Cai Z; Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong, Jiangsu, 226001, China.
Ye T; Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong, Jiangsu, 226001, China.
Tong L; Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong, Jiangsu, 226001, China.
Xu X; Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong, Jiangsu, 226001, China.
Lu J; Department of Pharmacology, The People's Hospital of Taizhou, The Fifth Affiliated Hospital of Nantong University, #210 Yingchun Road, Taizhou, Jiangsu, 226001, China.
Liu F; Department of Neurology, Danyang People's Hospital, #2 Xinmin Western Road, Danyang, 212300, Jiangsu, China.
Lu X; Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong, Jiangsu, 226001, China.
Huang C; Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong, Jiangsu, 226001, China. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Jun 15; Vol. 170, pp. 108054. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alcohol Drinking/*adverse effects
Apoptosis/*drug effects
Depression/*chemically induced
Ethanol/*toxicity
Hippocampus/*drug effects
Microglia/*drug effects
Age Factors ; Alcohol Drinking/pathology ; Alcohol Drinking/psychology ; Animals ; Apoptosis/physiology ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Depression/pathology ; Depression/psychology ; Ethanol/administration & dosage ; Hippocampus/pathology ; Male ; Mice ; Microglia/pathology ; Minocycline/pharmacology
Czasopismo naukowe
Tytuł :
Participation of CXCL1 in the glial cells during neuropathic pain.
Autorzy :
Moraes TR; Laboratory of Experimental Physiotherapy, Science of Motricity Institute, Federal University of Alfenas, Minas Gerais, Brazil.
Elisei LS; Laboratory of Experimental Physiotherapy, Science of Motricity Institute, Federal University of Alfenas, Minas Gerais, Brazil.
Malta IH; Laboratory of Experimental Physiotherapy, Science of Motricity Institute, Federal University of Alfenas, Minas Gerais, Brazil.
Galdino G; Laboratory of Experimental Physiotherapy, Science of Motricity Institute, Federal University of Alfenas, Minas Gerais, Brazil. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 May 15; Vol. 875, pp. 173039. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
Chemokine CXCL1/*metabolism
Microglia/*metabolism
Neuralgia/*pathology
Nociception/*physiology
Spinal Cord/*metabolism
Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Chemokine CXCL1/administration & dosage ; Citrates/administration & dosage ; Disease Models, Animal ; Humans ; Injections, Spinal ; Male ; Microglia/drug effects ; Minocycline/administration & dosage ; Neuralgia/chemically induced ; Nociception/drug effects ; Phenylurea Compounds/administration & dosage ; Rats ; Receptors, Interleukin-8B/antagonists & inhibitors ; Receptors, Interleukin-8B/metabolism ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/metabolism ; Spinal Cord/cytology ; Spinal Cord/drug effects ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal α7 nicotinic acetylcholine receptors.
Autorzy :
Wang ZY; King's Lab, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Han QQ; King's Lab, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Deng MY; King's Lab, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhao MJ; King's Lab, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Apryani E; King's Lab, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Shoaib RM; King's Lab, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Wei DQ; School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China; King's Lab, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Wang YX; King's Lab, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 May 14; Vol. 525 (4), pp. 1087-1094. Date of Electronic Publication: 2020 Mar 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acrylamides/*pharmacology
Analgesics/*pharmacology
Cancer Pain/*drug therapy
Hyperalgesia/*drug therapy
Microglia/*drug effects
Neuralgia/*drug therapy
alpha7 Nicotinic Acetylcholine Receptor/*agonists
Aconitine/analogs & derivatives ; Aconitine/pharmacology ; Acrylamides/administration & dosage ; Acrylamides/therapeutic use ; Analgesics/administration & dosage ; Analgesics/therapeutic use ; Animals ; Female ; Formaldehyde ; Hyperalgesia/genetics ; Hyperalgesia/metabolism ; Injections, Spinal ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Male ; Mice ; Microglia/metabolism ; Minocycline/administration & dosage ; Naloxone/administration & dosage ; Rats ; Rats, Wistar ; Spinal Cord/metabolism ; Zanthoxylum/chemistry ; Zanthoxylum/metabolism ; alpha7 Nicotinic Acetylcholine Receptor/genetics ; alpha7 Nicotinic Acetylcholine Receptor/metabolism ; beta-Endorphin/genetics ; beta-Endorphin/metabolism
Czasopismo naukowe
Tytuł :
Treatment with Minocycline Suppresses Microglia Activation and Reverses Neural Stem Cells Loss after Simulated Microgravity.
Autorzy :
Lin T; Department of Neurology, The 306th Hospital of PLA, Beijing 100101, China.
Du J; Department of Neurology, The 306th Hospital of PLA, Beijing 100101, China.
Liu L; Department of Neurology, The 306th Hospital of PLA, Beijing 100101, China.
Wu Z; Department of Neurology, The 306th Hospital of PLA, Beijing 100101, China.
Kong X; Department of Neurology, The 306th Hospital of PLA, Beijing 100101, China.
Liu Y; Department of Neurology, The 306th Hospital of PLA, Beijing 100101, China.
Cai Y; Department of Neurology, The 306th Hospital of PLA, Beijing 100101, China.
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Źródło :
BioMed research international [Biomed Res Int] 2020 Apr 25; Vol. 2020, pp. 7348745. Date of Electronic Publication: 2020 Apr 25 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Hippocampus/*metabolism
Microglia/*metabolism
Minocycline/*pharmacology
Neural Stem Cells/*metabolism
Weightlessness Simulation/*adverse effects
Animals ; Hippocampus/pathology ; Male ; Microglia/pathology ; Neural Stem Cells/pathology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Microglial-induced apoptosis is potentially responsible for hyperalgesia variations during CFA-induced inflammation.
Autorzy :
Baniasadi M; Physiology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Manaheji H; Physiology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maghsoudi N; Department of Biology, Queens College and Graduate Center,, City University of New York, Flushing, NY, USA.; Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Danyali S; Physiology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zakeri Z; Department of Biology, Queens College and Graduate Center,, City University of New York, Flushing, NY, USA.
Maghsoudi A; Queens Borough Community College, New York, USA.
Zaringhalam J; Physiology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .; Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .
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Źródło :
Inflammopharmacology [Inflammopharmacology] 2020 Apr; Vol. 28 (2), pp. 475-485. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
Hyperalgesia/*physiopathology
Inflammation/*pathology
Microglia/*metabolism
Animals ; Disease Models, Animal ; Freund's Adjuvant ; Hyperalgesia/etiology ; Male ; Minocycline/pharmacology ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Spinal Cord/cytology ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł :
Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment.
Autorzy :
Chini M; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Pöpplau JA; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Lindemann C; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Carol-Perdiguer L; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Hnida M; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Oberländer V; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Xu X; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Ahlbeck J; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Bitzenhofer SH; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Mulert C; Psychiatry Neuroimaging Branch (PNB), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Hanganu-Opatz IL; Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Jan 08; Vol. 105 (1), pp. 60-74.e7. Date of Electronic Publication: 2019 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cognitive Dysfunction/*physiopathology
Cognitive Dysfunction/*prevention & control
Microglia/*physiology
Minocycline/*pharmacology
Prefrontal Cortex/*physiology
Pyramidal Cells/*physiology
Animals ; Animals, Newborn ; Atrophy/pathology ; Behavior, Animal/physiology ; Beta Rhythm/physiology ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/pathology ; Dendrites/pathology ; Dendritic Spines/pathology ; Female ; Gamma Rhythm/physiology ; Male ; Mice ; Mutation ; Nerve Tissue Proteins/genetics ; Neural Pathways/physiopathology ; Optogenetics ; Poly I-C ; Prefrontal Cortex/pathology
Czasopismo naukowe
Tytuł :
Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance.
Autorzy :
Du ER; Department of Physiology, Basic Medical College of Nanchang University, Nanchang 330006, China.
Fan RP; Department of Fourth Clinical Medicine, School of Medicine, Nanchang University, Nanchang 330006, China.
Rong LL; Department of Fourth Clinical Medicine, School of Medicine, Nanchang University, Nanchang 330006, China.
Xie Z; Department of First Clinical Medicine, School of Medicine, Nanchang University, Nanchang 330006, China.
Xu CS; Department of Physiology, Basic Medical College of Nanchang University, Nanchang 330006, China.; Key Laboratory of Autonomic Nervous Function and Disease of Jiangxi Province, Nanchang 330006, China.
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Źródło :
Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B] 2020 Mar.; Vol. 21 (3), pp. 204-217.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Microglia/*physiology
Morphine/*pharmacology
Neuralgia/*etiology
Calcitonin Gene-Related Peptide/antagonists & inhibitors ; Drug Tolerance ; Humans ; Hypoglycemic Agents/pharmacology ; MicroRNAs/physiology ; Microglia/drug effects ; Minocycline/pharmacology ; Neuralgia/drug therapy ; Plant Extracts/pharmacology ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus.
Autorzy :
Dai J; From the Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ding Z; From the Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhang J; Department of Anesthesiology, The Maternal and Child Health Hospital of Hunan Province, Changsha, China.
Xu W; Department of Anesthesiology, The Maternal and Child Health Hospital of Hunan Province, Changsha, China.
Guo Q; From the Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zou W; From the Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiong Y; From the Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Weng Y; From the Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yang Y; From the Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen S; Department of Anesthesiology, University of Cincinnati, Pain Research Center, Cincinnati, Ohio.
Zhang JM; Department of Anesthesiology, University of Cincinnati, Pain Research Center, Cincinnati, Ohio.
Song Z; From the Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
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Źródło :
Anesthesia and analgesia [Anesth Analg] 2019 Dec; Vol. 129 (6), pp. 1733-1741.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*drug therapy
Cancer Pain/*drug therapy
Depression/*drug therapy
Hippocampus/*drug effects
Microglia/*drug effects
Minocycline/*administration & dosage
Animals ; Bone Neoplasms/metabolism ; Bone Neoplasms/psychology ; Cancer Pain/metabolism ; Cancer Pain/psychology ; Depression/metabolism ; Depression/psychology ; Female ; Hippocampus/metabolism ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Injections, Intraventricular ; Microglia/metabolism ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Minocycline attenuates ethanol-induced cell death and microglial activation in the developing spinal cord.
Autorzy :
Ren Z; Department of Anatomy, School of Basic Medicine, Anhui Medical University, Hefei, Anhui, 230032, China; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, United States.
Wang X; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, United States.
Xu M; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, United States.
Frank JA; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, United States.
Luo J; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, United States; Lexington Veterans Administration Health Care System, Research & Development, 1101 Veterans Drive, Lexington, KY 40502, United States. Electronic address: .
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Źródło :
Alcohol (Fayetteville, N.Y.) [Alcohol] 2019 Sep; Vol. 79, pp. 25-35. Date of Electronic Publication: 2018 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Apoptosis/*drug effects
Microglia/*drug effects
Minocycline/*pharmacology
Spinal Cord/*drug effects
Animals ; Caspase 3/metabolism ; Cytokines/metabolism ; Ethanol/adverse effects ; Female ; Glycogen Synthase Kinase 3 beta/metabolism ; MAP Kinase Signaling System ; Male ; Mice ; Neurogenic Inflammation/drug therapy ; Proto-Oncogene Proteins c-akt/metabolism ; Spinal Cord/growth & development ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe

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