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Wyświetlanie 1-6 z 6
Tytuł :
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
Autorzy :
Gazivoda T; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10000 Zagreb, Croatia.
Sokcević M
Kralj M
Suman L
Pavelić K
De Clercq E
Andrei G
Snoeck R
Balzarini J
Mintas M
Raić-Malić S
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2007 Aug 23; Vol. 50 (17), pp. 4105-12. Date of Electronic Publication: 2007 Aug 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antiviral Agents/*chemical synthesis
Ascorbic Acid/*analogs & derivatives
Ascorbic Acid/*chemical synthesis
Pyrimidines/*chemical synthesis
Pyrimidinones/*chemical synthesis
Animals ; Antineoplastic Agents/pharmacology ; Antiviral Agents/pharmacology ; Ascorbic Acid/pharmacology ; Cell Line ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Pyrimidines/pharmacology ; Pyrimidinones/pharmacology ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
Autorzy :
Prekupec S; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, P.O. Box 177, HR-10000 Zagreb, Croatia.
Makuc D
Plavec J
Suman L
Kralj M
Pavelić K
Balzarini J
Clercq ED
Mintas M
Raić-Malić S
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2007 Jun 28; Vol. 50 (13), pp. 3037-45. Date of Electronic Publication: 2007 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*chemical synthesis
Cytostatic Agents/*chemical synthesis
Pyrimidines/*chemical synthesis
Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cell Line ; Cell Line, Tumor ; Chlorocebus aethiops ; Cytostatic Agents/chemistry ; Cytostatic Agents/pharmacology ; Drug Screening Assays, Antitumor ; Humans ; Magnetic Resonance Spectroscopy ; Mice ; Models, Molecular ; Molecular Conformation ; Molecular Mimicry ; Positron-Emission Tomography ; Pyrimidine Nucleosides/chemistry ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.
Autorzy :
Opacić N; Department of Medicinal Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovacića. 1, HR-10 000 Zagreb, Croatia.
Barbarić M
Zorc B
Cetina M
Nagl A
Frković D
Kralj M
Pavelić K
Balzarini J
Andrei G
Snoeck R
De Clercq E
Raić-Malić S
Mintas M
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2005 Jan 27; Vol. 48 (2), pp. 475-82.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acids/*chemical synthesis
Antineoplastic Agents/*chemical synthesis
Antiviral Agents/*chemical synthesis
Hydantoins/*chemical synthesis
Hydroxyurea/*analogs & derivatives
Hydroxyurea/*chemical synthesis
Amino Acids/chemistry ; Amino Acids/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cell Line ; Cell Line, Tumor ; Crystallography, X-Ray ; Cytomegalovirus/drug effects ; Drug Screening Assays, Antitumor ; Herpesvirus 3, Human/drug effects ; Humans ; Hydantoins/chemistry ; Hydantoins/pharmacology ; Hydroxyurea/chemistry ; Hydroxyurea/pharmacology ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy)methyl purine nucleoside analogues.
Autorzy :
Prekupec S; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, Croatia.
Svedruzić D
Gazivoda T
Mrvos-Sermek D
Nagl A
Grdisa M
Pavelić K
Balzarini J
De Clercq E
Folkers G
Scapozza L
Mintas M
Raić-Malić S
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2003 Dec 18; Vol. 46 (26), pp. 5763-72.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorine*
Iodine*
Antineoplastic Agents/*chemical synthesis
Antiviral Agents/*chemical synthesis
Guanine/*chemical synthesis
Purine Nucleosides/*chemical synthesis
Thiones/*chemical synthesis
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cell Line ; Cell Line, Tumor ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Guanine/analogs & derivatives ; Guanine/chemistry ; Guanine/pharmacology ; Humans ; Magnetic Resonance Spectroscopy ; Mice ; Molecular Structure ; Purine Nucleosides/chemistry ; Purine Nucleosides/pharmacology ; Thiones/chemistry ; Thiones/pharmacology
Czasopismo naukowe
    Wyświetlanie 1-6 z 6

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