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Tytuł :
Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.
Autorzy :
Stipković Babić M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Makuc D; Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia; EN-FIST Centre of Excellence, Trg Osvobodilne fronte 13, SI-1000 Ljubljana, Slovenia.
Plavec J; Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia; EN-FIST Centre of Excellence, Trg Osvobodilne fronte 13, SI-1000 Ljubljana, Slovenia.
Martinović T; Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, HR-51000 Rijeka, Croatia.
Kraljević Pavelić S; Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, HR-51000 Rijeka, Croatia.
Pavelić K; Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, HR-51000 Rijeka, Croatia.
Snoeck R; Department of Microbiology and Immunology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Andrei G; Department of Microbiology and Immunology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Schols D; Department of Microbiology and Immunology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Wittine K; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Mintas M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia. Electronic address: mladen.mintas@fkit.hr.
Pokaż więcej
Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2015 Sep 18; Vol. 102, pp. 288-302. Date of Electronic Publication: 2015 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Antiviral Agents/*pharmacology
Ascorbic Acid/*chemistry
Ascorbic Acid/*pharmacology
Cytomegalovirus/*drug effects
Purines/*chemistry
Purines/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Ascorbic Acid/chemical synthesis ; Cell Line ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Fibroblasts/drug effects ; Humans ; Mice ; Microbial Sensitivity Tests ; Molecular Structure ; Purines/chemical synthesis ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The novel [4,5-e][1,3]diazepine-4,8-dione and acyclic carbamoyl imino-ureido derivatives of imidazole: synthesis, anti-viral and anti-tumor Activity evaluations.
Autorzy :
Wittine K; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, Zagreb HR-10000, Croatia. .
Poljak K
Kovač M
Makuc D
Plavec J
Balzarini J
Martinović T
Pavelić SK
Pavelić K
Mintas M
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2013 Oct 30; Vol. 18 (11), pp. 13385-97. Date of Electronic Publication: 2013 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Imidazoles/*chemistry
Imidazoles/*pharmacology
Antineoplastic Agents/adverse effects ; Antiviral Agents/adverse effects ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Viruses/drug effects ; HeLa Cells ; Humans ; Imidazoles/adverse effects ; RNA Viruses/drug effects ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Novel coumarin derivatives containing 1,2,4-triazole, 4,5-dicyanoimidazole and purine moieties: synthesis and evaluation of their cytostatic activity.
Autorzy :
Benci K; Department of Organic Chemistry, University of Zagreb, Zagreb, Croatia.
Mandić L
Suhina T
Sedić M
Klobučar M
Kraljević Pavelić S
Pavelić K
Wittine K
Mintas M
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2012 Sep 12; Vol. 17 (9), pp. 11010-25. Date of Electronic Publication: 2012 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Coumarins/*chemistry
Coumarins/*pharmacology
Imidazoles/*chemistry
Purines/*chemistry
Triazoles/*chemistry
Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; HeLa Cells ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Molecular Structure ; Neoplasms/drug therapy ; Nucleosides/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations.
Autorzy :
Wittine K; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Stipković Babić M
Makuc D
Plavec J
Kraljević Pavelić S
Sedić M
Pavelić K
Leyssen P
Neyts J
Balzarini J
Mintas M
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2012 Jun 01; Vol. 20 (11), pp. 3675-85. Date of Electronic Publication: 2012 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Antiviral Agents/*chemical synthesis
Antiviral Agents/*pharmacology
Ascorbic Acid/*analogs & derivatives
Hepacivirus/*drug effects
Imidazoles/*chemistry
Triazoles/*chemistry
Animals ; Antineoplastic Agents/chemistry ; Antiviral Agents/chemistry ; Ascorbic Acid/chemistry ; Cell Line, Tumor ; Dogs ; Drug Evaluation, Preclinical ; Drug Screening Assays, Antitumor ; Fibroblasts/drug effects ; Hepacivirus/physiology ; Humans ; IMP Dehydrogenase/antagonists & inhibitors ; Imidazoles/pharmacology ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
The unsaturated acyclic nucleoside analogues bearing a sterically constrained (Z)-4'-benzamido-2'-butenyl moiety: Synthesis, X-ray crystal structure study, cytostatic and antiviral activity evaluations.
Autorzy :
Benci K; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia.
Wittine K
Radan M
Cetina M
Sedić M
Kraljević Pavelić S
Pavelić K
Clercq ED
Mintas M
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2010 Sep 01; Vol. 18 (17), pp. 6249-57. Date of Electronic Publication: 2010 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenine/*analogs & derivatives
Antineoplastic Agents/*chemistry
Antiviral Agents/*chemistry
Nucleosides/*chemistry
Nucleosides/*pharmacology
Pyrimidines/*chemistry
Adenine/chemistry ; Adenine/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Epoxy Compounds ; Humans ; Isomerism ; Molecular Structure ; Nucleosides/chemical synthesis ; Pyrimidines/chemical synthesis ; Pyrimidines/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Novel lipophilic hydroxyurea derivatives: synthesis, cytostatic and antiviral activity evaluations.
Autorzy :
Perković I; Department of Medicinal Chemistry, Faculty of Pharmacy and Biochemistry, A. Kovacića 1, HR-10 000 Zagreb, Croatia.
Butula I
Zorc B
Hock K
Kraljević Pavelić S
Pavelić K
Clercq ED
Balzarini J
Mintas M
Pokaż więcej
Źródło :
Chemical biology & drug design [Chem Biol Drug Des] 2008 Jun; Vol. 71 (6), pp. 546-53. Date of Electronic Publication: 2008 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antiviral Agents/*chemistry
Hydroxyurea/*analogs & derivatives
Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Hydrophobic and Hydrophilic Interactions ; Hydroxyurea/chemical synthesis ; Hydroxyurea/pharmacology ; Inhibitory Concentration 50 ; Structure-Activity Relationship ; Viruses/drug effects
Czasopismo naukowe
Tytuł :
Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues.
Autorzy :
Gazivoda T; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10000 Zagreb, Croatia.
Raić-Malić S
Kristafor V
Makuc D
Plavec J
Bratulić S
Kraljević-Pavelić S
Pavelić K
Naesens L
Andrei G
Snoeck R
Balzarini J
Mintas M
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 May 15; Vol. 16 (10), pp. 5624-34. Date of Electronic Publication: 2008 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*chemical synthesis
Anti-HIV Agents/*pharmacology
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Leukemia L1210/*drug therapy
Pyrimidine Nucleosides/*chemical synthesis
Pyrimidine Nucleosides/*pharmacology
Animals ; Anti-HIV Agents/chemistry ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Fibroblasts/drug effects ; HIV-1/drug effects ; HIV-2/drug effects ; HeLa Cells ; Humans ; Leukemia L1210/pathology ; Mice ; Microbial Sensitivity Tests ; Molecular Structure ; Pyrimidine Nucleosides/chemistry ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
Autorzy :
Gazivoda T; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10000 Zagreb, Croatia.
Sokcević M
Kralj M
Suman L
Pavelić K
De Clercq E
Andrei G
Snoeck R
Balzarini J
Mintas M
Raić-Malić S
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2007 Aug 23; Vol. 50 (17), pp. 4105-12. Date of Electronic Publication: 2007 Aug 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antiviral Agents/*chemical synthesis
Ascorbic Acid/*analogs & derivatives
Ascorbic Acid/*chemical synthesis
Pyrimidines/*chemical synthesis
Pyrimidinones/*chemical synthesis
Animals ; Antineoplastic Agents/pharmacology ; Antiviral Agents/pharmacology ; Ascorbic Acid/pharmacology ; Cell Line ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Pyrimidines/pharmacology ; Pyrimidinones/pharmacology ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
Autorzy :
Gazivoda T; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10000 Zagreb, Croatia.
Raić-Malić S
Marjanović M
Kralj M
Pavelić K
Balzarini J
De Clercq E
Mintas M
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2007 Jan 15; Vol. 15 (2), pp. 749-58. Date of Electronic Publication: 2006 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Antiviral Agents/*chemical synthesis
Antiviral Agents/*pharmacology
Ascorbic Acid/*analogs & derivatives
Ascorbic Acid/*chemical synthesis
Uracil/*chemistry
Animals ; Ascorbic Acid/pharmacology ; Cell Line, Tumor ; Drug Evaluation, Preclinical ; Drug Screening Assays, Antitumor ; Fibroblasts/drug effects ; Humans ; Indicators and Reagents ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Mice ; Pyrimidines/chemistry ; Structure-Activity Relationship ; Viruses/drug effects
Czasopismo naukowe
Tytuł :
Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues.
Autorzy :
Kristafor V; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia.
Raić-Malić S
Cetina M
Kralj M
Suman L
Pavelić K
Balzarini J
De Clercq E
Mintas M
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2006 Dec 01; Vol. 14 (23), pp. 8126-38. Date of Electronic Publication: 2006 Aug 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antiviral Agents/*chemistry
Nucleosides/*chemical synthesis
Nucleosides/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; Cell Proliferation/drug effects ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Epoxy Compounds ; HIV-1/drug effects ; Humans ; Isomerism ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Hydantoin derivatives of L- and D-amino acids: synthesis and evaluation of their antiviral and antitumoral activity.
Autorzy :
Rajic Z; Department of Medicinal Chemistry, Faculty of Pharmacy and Biochemistry, A. Kovacića 1, HR-10000 Zagreb, Croatia. />Zorc B
Raic-Malic S
Ester K
Kralj M
Pavelic K
Balzarini J
De Clercq E
Mintas M
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2006 Nov 01; Vol. 11 (11), pp. 837-48. Date of Electronic Publication: 2006 Nov 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acids/*chemical synthesis
Amino Acids/*pharmacology
Antineoplastic Agents/*pharmacology
Antiviral Agents/*pharmacology
Hydantoins/*chemical synthesis
Hydantoins/*pharmacology
Amino Acids/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Fibroblasts/drug effects ; Humans ; Hydantoins/chemistry ; Magnetic Resonance Spectroscopy ; Viruses/drug effects
Czasopismo naukowe
Tytuł :
Synthesis, structural studies, and cytostatic evaluation of 5,6-di-O-modified L-ascorbic acid derivatives.
Autorzy :
Gazivoda T; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10000 Zagreb, Croatia.
Wittine K
Lovrić I
Makuc D
Plavec J
Cetina M
Mrvos-Sermek D
Suman L
Kralj M
Pavelić K
Mintas M
Raić-Malić S
Pokaż więcej
Źródło :
Carbohydrate research [Carbohydr Res] 2006 Mar 20; Vol. 341 (4), pp. 433-42. Date of Electronic Publication: 2006 Jan 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Ascorbic Acid/*chemical synthesis
Ascorbic Acid/*pharmacology
Antineoplastic Agents/chemistry ; Ascorbic Acid/analogs & derivatives ; Carbohydrate Conformation ; Cell Line, Tumor ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Humans ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Molecular Conformation ; Molecular Structure
Czasopismo naukowe
Tytuł :
The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.
Autorzy :
Opacić N; Department of Medicinal Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovacića. 1, HR-10 000 Zagreb, Croatia.
Barbarić M
Zorc B
Cetina M
Nagl A
Frković D
Kralj M
Pavelić K
Balzarini J
Andrei G
Snoeck R
De Clercq E
Raić-Malić S
Mintas M
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2005 Jan 27; Vol. 48 (2), pp. 475-82.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acids/*chemical synthesis
Antineoplastic Agents/*chemical synthesis
Antiviral Agents/*chemical synthesis
Hydantoins/*chemical synthesis
Hydroxyurea/*analogs & derivatives
Hydroxyurea/*chemical synthesis
Amino Acids/chemistry ; Amino Acids/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cell Line ; Cell Line, Tumor ; Crystallography, X-Ray ; Cytomegalovirus/drug effects ; Drug Screening Assays, Antitumor ; Herpesvirus 3, Human/drug effects ; Humans ; Hydantoins/chemistry ; Hydantoins/pharmacology ; Hydroxyurea/chemistry ; Hydroxyurea/pharmacology ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation.
Autorzy :
Gazivoda T; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10000 Zagreb, Croatia.
Plevnik M
Plavec J
Kraljević S
Kralj M
Pavelić K
Balzarini J
De Clercq E
Mintas M
Raić-Malić S
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2005 Jan 03; Vol. 13 (1), pp. 131-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Antiviral Agents/*chemical synthesis
Antiviral Agents/*pharmacology
Ascorbic Acid/*chemical synthesis
Ascorbic Acid/*pharmacology
Purines/*chemistry
Pyrimidines/*chemistry
Antineoplastic Agents/chemistry ; Antiviral Agents/chemistry ; Ascorbic Acid/chemistry ; Carbon Isotopes ; Cell Line, Tumor ; Drug Evaluation, Preclinical ; Humans ; Magnetic Resonance Spectroscopy ; Protons ; Spectrophotometry, Ultraviolet
Czasopismo naukowe
Tytuł :
Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives.
Autorzy :
Prekupec S; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Makuc D
Plavec J
Kraljević S
Kralj M
Pavelić K
Andrei G
Snoeck R
Balzarini J
De Clercq E
Raić-Malić S
Mintas M
Pokaż więcej
Źródło :
Antiviral chemistry & chemotherapy [Antivir Chem Chemother] 2005; Vol. 16 (5), pp. 327-38.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Antiviral Agents/*pharmacology
Thymine/*chemistry
Thymine/*pharmacology
Antineoplastic Agents/chemistry ; Antiviral Agents/chemistry ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Microbial Sensitivity Tests
Czasopismo naukowe
Tytuł :
Spirobipyridopyrans, spirobinaphthopyrans, indolinospiropyridopyrans, indolinospironaphthopyrans and indolinospironaphtho-1,4-oxazines: synthesis, study of X-ray crystal structure, antitumoral and antiviral evaluation.
Autorzy :
Raić-Malić S; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, PO Box 177, HR-10000 Zagreb, Croatia.
Tomasković L
Mrvos-Sermek D
Prugovecki B
Cetina M
Grdisa M
Pavelić K
Mannschreck A
Balzarini J
De Clercq E
Mintas M
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2004 Mar 01; Vol. 12 (5), pp. 1037-45.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antiviral Agents/*chemical synthesis
Oxazines/*chemical synthesis
Pyrans/*chemical synthesis
Spiro Compounds/*chemical synthesis
Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cell Division/drug effects ; Cell Line, Tumor ; Crystallography, X-Ray ; Fibroblasts/drug effects ; Humans ; Inhibitory Concentration 50 ; Molecular Structure ; Oxazines/pharmacology ; Pyrans/chemistry ; Pyrans/pharmacology ; Spiro Compounds/chemistry ; Spiro Compounds/pharmacology ; Viruses/drug effects
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy)methyl purine nucleoside analogues.
Autorzy :
Prekupec S; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, Croatia.
Svedruzić D
Gazivoda T
Mrvos-Sermek D
Nagl A
Grdisa M
Pavelić K
Balzarini J
De Clercq E
Folkers G
Scapozza L
Mintas M
Raić-Malić S
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2003 Dec 18; Vol. 46 (26), pp. 5763-72.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorine*
Iodine*
Antineoplastic Agents/*chemical synthesis
Antiviral Agents/*chemical synthesis
Guanine/*chemical synthesis
Purine Nucleosides/*chemical synthesis
Thiones/*chemical synthesis
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cell Line ; Cell Line, Tumor ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Guanine/analogs & derivatives ; Guanine/chemistry ; Guanine/pharmacology ; Humans ; Magnetic Resonance Spectroscopy ; Mice ; Molecular Structure ; Purine Nucleosides/chemistry ; Purine Nucleosides/pharmacology ; Thiones/chemistry ; Thiones/pharmacology
Czasopismo naukowe
Tytuł :
Synthesis, structural studies, and biological evaluation of some purine substituted 1-aminocyclopropane-1-carboxylic acids and 1-amino-1-hydroxymethylcyclopropanes.
Autorzy :
Dzolić Z; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Kristafor V
Cetina M
Nagl A
Hergold-Brundić A
Mrvos-Sermek D
Burgemeister T
Grdisa M
Slade N
Pavelić K
Balzarini J
De Clercq E
Mintas M
Pokaż więcej
Źródło :
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2003 Apr; Vol. 22 (4), pp. 373-89.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Antiviral Agents*/chemical synthesis
Antiviral Agents*/chemistry
Antiviral Agents*/pharmacology
Amino Acids, Cyclic/*chemistry
Cyclopropanes/*chemistry
Purines/*chemistry
Amino Acids/chemistry ; Animals ; Cell Line, Tumor ; Female ; Humans ; Mice
Czasopismo naukowe

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