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Wyświetlanie 1-12 z 12
Tytuł :
Impact of mRNA chemistry and manufacturing process on innate immune activation.
Autorzy :
Nelson J; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Sorensen EW; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Mintri S; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Rabideau AE; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Zheng W; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Besin G; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Khatwani N; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Su SV; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Miracco EJ; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Issa WJ; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Hoge S; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Stanton MG; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
Joyal JL; Moderna Inc., 200 Technology Square, Cambridge, MA, USA.
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Źródło :
Science advances [Sci Adv] 2020 Jun 24; Vol. 6 (26), pp. eaaz6893. Date of Electronic Publication: 2020 Jun 24 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency.
Autorzy :
Cao J; Moderna, Inc., Cambridge, MA, USA.
An D; Moderna, Inc., Cambridge, MA, USA.
Galduroz M; Moderna, Inc., Cambridge, MA, USA.
Zhuo J; Moderna, Inc., Cambridge, MA, USA.
Liang S; Moderna, Inc., Cambridge, MA, USA.
Eybye M; Moderna, Inc., Cambridge, MA, USA.
Frassetto A; Moderna, Inc., Cambridge, MA, USA.
Kuroda E; Department of Molecular Oncology, Kagoshima University, Kagoshima, Japan.
Funahashi A; Department of Molecular Oncology, Kagoshima University, Kagoshima, Japan.
Santana J; Moderna, Inc., Cambridge, MA, USA.
Mihai C; Moderna, Inc., Cambridge, MA, USA.
Benenato KE; Moderna, Inc., Cambridge, MA, USA.
Kumarasinghe ES; Moderna, Inc., Cambridge, MA, USA.
Sabnis S; Moderna, Inc., Cambridge, MA, USA.
Salerno T; Moderna, Inc., Cambridge, MA, USA.
Coughlan K; Moderna, Inc., Cambridge, MA, USA.
Miracco EJ; Moderna, Inc., Cambridge, MA, USA.
Levy B; Moderna, Inc., Cambridge, MA, USA.
Besin G; Moderna, Inc., Cambridge, MA, USA.
Schultz J; Moderna, Inc., Cambridge, MA, USA.
Lukacs C; Moderna, Inc., Cambridge, MA, USA.
Guey L; Moderna, Inc., Cambridge, MA, USA.
Finn P; Moderna, Inc., Cambridge, MA, USA.
Furukawa T; Department of Molecular Oncology, Kagoshima University, Kagoshima, Japan.
Giangrande PH; Moderna, Inc., Cambridge, MA, USA.
Saheki T; Department of Molecular Oncology, Kagoshima University, Kagoshima, Japan.
Martini PGV; Moderna, Inc., Cambridge, MA, USA. Electronic address: .
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2019 Jul 03; Vol. 27 (7), pp. 1242-1251. Date of Electronic Publication: 2019 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Citrullinemia/*drug therapy
Citrullinemia/*metabolism
Drug Delivery Systems/*methods
Genetic Therapy/*methods
Mitochondrial Membrane Transport Proteins/*genetics
Mitochondrial Membrane Transport Proteins/*metabolism
RNA, Messenger/*therapeutic use
Animals ; Behavior, Animal/drug effects ; Disease Models, Animal ; Gene Knockout Techniques ; Glucosephosphate Dehydrogenase/genetics ; HeLa Cells ; Hep G2 Cells ; Humans ; Lipids/chemistry ; Loss of Function Mutation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; Nanoparticles/chemistry ; Open Reading Frames/genetics ; RNA, Messenger/chemical synthesis ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; Transfection ; Treatment Outcome
SCR Disease Name :
Adult-onset citrullinemia type 2
Czasopismo naukowe
Tytuł :
Oligonucleotide Sequence Mapping of Large Therapeutic mRNAs via Parallel Ribonuclease Digestions and LC-MS/MS.
Autorzy :
Jiang T; Moderna Inc. , 500 Technology Square , Cambridge , Massachusetts 02139 , United States.
Yu N; Department of Chemistry , University of Cincinnati , Cincinnati , Ohio 45221 , United States.
Kim J; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy , University of Georgia , Athens , Georgia 30602 , United States.
Murgo JR; Moderna Inc. , 500 Technology Square , Cambridge , Massachusetts 02139 , United States.
Kissai M; Moderna Inc. , 500 Technology Square , Cambridge , Massachusetts 02139 , United States.
Ravichandran K; Moderna Inc. , 500 Technology Square , Cambridge , Massachusetts 02139 , United States.
Miracco EJ; Moderna Inc. , 500 Technology Square , Cambridge , Massachusetts 02139 , United States.
Presnyak V; Moderna Inc. , 500 Technology Square , Cambridge , Massachusetts 02139 , United States.
Hua S; Moderna Inc. , 500 Technology Square , Cambridge , Massachusetts 02139 , United States.
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Źródło :
Analytical chemistry [Anal Chem] 2019 Jul 02; Vol. 91 (13), pp. 8500-8506. Date of Electronic Publication: 2019 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Chromatography, Liquid/*methods
Erythropoietin/*metabolism
Oligonucleotides/*analysis
RNA, Messenger/*metabolism
Tandem Mass Spectrometry/*methods
alpha Catenin/*metabolism
Colicins/metabolism ; DNA-Binding Proteins/metabolism ; Endoribonucleases/metabolism ; Erythropoietin/genetics ; Escherichia coli Proteins/metabolism ; High-Throughput Nucleotide Sequencing ; Humans ; RNA, Messenger/genetics ; Ribonuclease T1/metabolism ; Sequence Analysis, RNA ; Software ; alpha Catenin/genetics
Czasopismo naukowe
Tytuł :
Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.
Autorzy :
Jiang J; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Department of Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, CA 90095, USA. California Nanosystems Institute, UCLA, Los Angeles, CA 90095, USA.
Chan H; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Cash DD; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Miracco EJ; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Ogorzalek Loo RR; Department of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA.
Upton HE; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Cascio D; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. UCLA-U.S. Department of Energy (DOE) Institute of Genomics and Proteomics, UCLA, Los Angeles, CA 90095, USA.
O'Brien Johnson R; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Collins K; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Loo JA; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Department of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA. UCLA-U.S. Department of Energy (DOE) Institute of Genomics and Proteomics, UCLA, Los Angeles, CA 90095, USA.
Zhou ZH; Department of Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, CA 90095, USA. California Nanosystems Institute, UCLA, Los Angeles, CA 90095, USA.
Feigon J; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. California Nanosystems Institute, UCLA, Los Angeles, CA 90095, USA. UCLA-U.S. Department of Energy (DOE) Institute of Genomics and Proteomics, UCLA, Los Angeles, CA 90095, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2015 Oct 30; Vol. 350 (6260), pp. aab4070. Date of Electronic Publication: 2015 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
RNA/*chemistry
Telomerase/*chemistry
Tetrahymena/*enzymology
Catalytic Domain ; Cryoelectron Microscopy ; Crystallography, X-Ray ; DNA, Single-Stranded/chemistry ; Holoenzymes/chemistry ; Protein Binding ; Protein Conformation ; Protein Subunits/chemistry ; Replication Protein A/chemistry ; Telomere/chemistry ; Telomere Homeostasis ; Telomere-Binding Proteins
Czasopismo naukowe
Tytuł :
Progress in structural studies of telomerase.
Autorzy :
Miracco EJ; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jiang J; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA; California Nanosystems Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Cash DD; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.
Feigon J; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA; California Nanosystems Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: .
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Źródło :
Current opinion in structural biology [Curr Opin Struct Biol] 2014 Feb; Vol. 24, pp. 115-24. Date of Electronic Publication: 2014 Feb 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Telomerase/*chemistry
Animals ; Humans ; Models, Molecular ; Protein Multimerization ; Telomerase/metabolism ; Tetrahymena thermophila/chemistry ; Tetrahymena thermophila/enzymology
Czasopismo naukowe
Tytuł :
Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub.
Autorzy :
Hong K; Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Upton H
Miracco EJ
Jiang J
Zhou ZH
Feigon J
Collins K
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2013 Oct; Vol. 33 (19), pp. 3962-71. Date of Electronic Publication: 2013 Aug 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Holoenzymes/*metabolism
Protozoan Proteins/*metabolism
Tetrahymena/*enzymology
Catalytic Domain ; Electrophoresis, Polyacrylamide Gel ; Holoenzymes/chemistry ; Holoenzymes/ultrastructure ; Imaging, Three-Dimensional ; Microscopy, Electron ; Models, Molecular ; Protein Binding ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Protozoan Proteins/chemistry ; Protozoan Proteins/ultrastructure ; Ribonucleoproteins/chemistry ; Ribonucleoproteins/metabolism ; Ribonucleoproteins/ultrastructure
Czasopismo naukowe
Tytuł :
The architecture of Tetrahymena telomerase holoenzyme.
Autorzy :
Jiang J; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA.
Miracco EJ
Hong K
Eckert B
Chan H
Cash DD
Min B
Zhou ZH
Collins K
Feigon J
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Źródło :
Nature [Nature] 2013 Apr 11; Vol. 496 (7444), pp. 187-92. Date of Electronic Publication: 2013 Apr 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Telomerase/*chemistry
Telomerase/*ultrastructure
Tetrahymena thermophila/*enzymology
Catalytic Domain ; Holoenzymes/chemistry ; Holoenzymes/genetics ; Holoenzymes/ultrastructure ; Microscopy, Electron ; Models, Molecular ; Nucleic Acid Conformation ; Pliability ; Protein Structure, Tertiary ; Protein Subunits/analysis ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Protozoan Proteins/chemistry ; Protozoan Proteins/metabolism ; Protozoan Proteins/ultrastructure ; RNA/chemistry ; RNA/metabolism ; RNA/ultrastructure ; Ribonucleoproteins/chemistry ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Ribonucleoproteins/ultrastructure ; Telomerase/genetics ; Telomerase/metabolism ; Tetrahymena thermophila/chemistry ; Tetrahymena thermophila/genetics ; Tetrahymena thermophila/ultrastructure
Czasopismo naukowe
Tytuł :
Unexpected linear ion trap collision-induced dissociation and Fourier transform ion cyclotron resonance infrared multi-photon dissociation fragmentation of a hydrated C-glycoside of 5-fluorouridine formed by the action of the pseudouridine synthases RluA and TruB.
Autorzy :
Miracco EJ; University of Delaware, Department of Chemistry and Biochemistry, Newark, DE 19716, USA.
Bogdanov B
Mueller EG
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Źródło :
Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2011 Sep 30; Vol. 25 (18), pp. 2627-32.
Typ publikacji :
Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Hydro-Lyases/*metabolism
Intramolecular Transferases/*metabolism
Monosaccharides/*chemistry
Uridine/*analogs & derivatives
Glycosides ; Hydro-Lyases/genetics ; Intramolecular Transferases/genetics ; Molecular Structure ; Monosaccharides/metabolism ; Pseudouridine/chemistry ; Pseudouridine/metabolism ; RNA/chemistry ; RNA/metabolism ; Spectroscopy, Fourier Transform Infrared ; Uridine/chemistry ; Uridine/metabolism
Czasopismo naukowe
Tytuł :
The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another.
Autorzy :
Miracco EJ; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
Mueller EG
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2011 Aug 10; Vol. 133 (31), pp. 11826-9. Date of Electronic Publication: 2011 Jul 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Intramolecular Transferases/*metabolism
Uridine/*analogs & derivatives
Intramolecular Transferases/chemistry ; Molecular Structure ; Quantum Theory ; RNA/chemistry ; RNA/metabolism ; Stereoisomerism ; Uridine/biosynthesis ; Uridine/chemistry
Czasopismo naukowe
Tytuł :
The handling of the mechanistic probe 5-fluorouridine by the pseudouridine synthase TruA and its consistency with the handling of the same probe by the pseudouridine synthases TruB and RluA.
Autorzy :
McDonald MK; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Miracco EJ
Chen J
Xie Y
Mueller EG
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Źródło :
Biochemistry [Biochemistry] 2011 Jan 25; Vol. 50 (3), pp. 426-36. Date of Electronic Publication: 2010 Dec 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Intramolecular Transferases/*chemistry
Molecular Probes/*chemistry
Uridine/*analogs & derivatives
Aspartic Acid/chemistry ; Escherichia coli Proteins/chemistry ; Esters/chemistry ; Hydrolysis ; Nucleosides/chemistry ; RNA/chemistry ; Uridine/chemistry
Czasopismo naukowe
Tytuł :
Moulds, yeasts and aerobic plate counts in ginseng supplements.
Autorzy :
Tournas VH; Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA. />Katsoudas E
Miracco EJ
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Źródło :
International journal of food microbiology [Int J Food Microbiol] 2006 Apr 25; Vol. 108 (2), pp. 178-81. Date of Electronic Publication: 2006 Jan 23.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Bacteria, Aerobic/*isolation & purification
Food Contamination/*analysis
Fungi/*isolation & purification
Panax/*microbiology
Yeasts/*isolation & purification
Colony Count, Microbial ; Consumer Product Safety ; Dietary Supplements ; Food Microbiology ; Humans
Czasopismo naukowe
    Wyświetlanie 1-12 z 12

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