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Wyszukujesz frazę ""Mitogen-Activated Protein Kinase 1"" wg kryterium: Temat


Tytuł :
Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis.
Autorzy :
Tang X; Shenzhen Key Laboratory of Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences, Shenzhen University, Shenzhen, China.; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, China.
Li G; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Shi L; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, China.
Su F; Shenzhen Key Laboratory of Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences, Shenzhen University, Shenzhen, China.
Qian M; Shenzhen Key Laboratory of Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences, Shenzhen University, Shenzhen, China.; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, China.
Liu Z; Shenzhen Key Laboratory of Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences, Shenzhen University, Shenzhen, China.; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, China.
Meng Y; Shenzhen Key Laboratory of Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences, Shenzhen University, Shenzhen, China.
Sun S; Shenzhen Key Laboratory of Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences, Shenzhen University, Shenzhen, China.
Li J; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Liu B; Shenzhen Key Laboratory of Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences, Shenzhen University, Shenzhen, China. .; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, China. .; Shenzhen Bay Laboratory, Shenzhen, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 25; Vol. 12 (1), pp. 5058. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fasting/*metabolism
Glycogen Synthase Kinase 3 beta/*metabolism
Mitogen-Activated Protein Kinase 1/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*administration & dosage
Sirtuins/*metabolism
Animals ; Combined Modality Therapy ; Doxorubicin/administration & dosage ; Female ; Glycogen Synthase Kinase 3 beta/genetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Phosphorylation ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Proteolysis ; Sirtuins/genetics
Czasopismo naukowe
Tytuł :
Loss of lymphocyte cytosolic protein 1 (LCP1) induces browning in 3T3-L1 adipocytes via β3-AR and the ERK-independent signaling pathway.
Autorzy :
Subramani M; Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, 38453, Republic of Korea.
Yun JW; Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, 38453, Republic of Korea. Electronic address: .
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Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2021 Sep; Vol. 138, pp. 106053. Date of Electronic Publication: 2021 Aug 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Stress, Physiological*
Adipocytes, White/*cytology
Adipose Tissue, Brown/*cytology
Microfilament Proteins/*deficiency
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Receptors, Adrenergic, beta-3/*metabolism
3T3-L1 Cells ; Adipocytes, White/metabolism ; Adipose Tissue, Brown/metabolism ; Animals ; Lipogenesis ; Lipolysis ; Mice ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Receptors, Adrenergic, beta-3/genetics ; Signal Transduction ; Thermogenesis
Czasopismo naukowe
Tytuł :
HOXB8 Counteracts MAPK/ERK Oncogenic Signaling in a Chicken Embryo Model of Neoplasia.
Autorzy :
Wilmerding A; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Bouteille L; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Rinaldi L; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.; Beth Israel Deaconess Medical Center, Department of Medicine and the Cancer Center, Division of Hematology, Harvard Initiative of RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
Caruso N; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Graba Y; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Delfini MC; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Carcinogenesis/*pathology
Homeodomain Proteins/*metabolism
MAP Kinase Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Neoplasms/*pathology
Animals ; Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Chick Embryo ; Chickens ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics ; Humans ; MAP Kinase Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Neoplasms/etiology ; Neoplasms/metabolism ; Prognosis ; Survival Rate ; Transcriptome
Czasopismo naukowe
Tytuł :
LINC01436 Inhibited miR-585-3p Expression and Upregulated MAPK1 Expression to Promote Gastric Cancer Progression.
Autorzy :
Xu Y; Department of Gastroenterology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, Shaanxi, China.
Dong M; Department of Surgical Oncology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, Shaanxi, China.
Wang J; Department of Gastroenterology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, Shaanxi, China.
Zhao W; Department of Gastroenterology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, Shaanxi, China.
Jiao M; Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, 710061, Shaanxi, China. .
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Źródło :
Digestive diseases and sciences [Dig Dis Sci] 2021 Jun; Vol. 66 (6), pp. 1885-1894. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Progression*
Gene Expression Regulation, Neoplastic*
MicroRNAs/*biosynthesis
Mitogen-Activated Protein Kinase 1/*biosynthesis
RNA, Long Noncoding/*biosynthesis
Stomach Neoplasms/*metabolism
Cell Line, Tumor ; HEK293 Cells ; Humans ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; Mitogen-Activated Protein Kinase 1/genetics ; RNA, Long Noncoding/genetics ; Stomach Neoplasms/genetics ; Up-Regulation/physiology
Czasopismo naukowe
Tytuł :
Wnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1/2 phosphorylation via a ROR1/DOCK2-dependent mechanism.
Autorzy :
Hasan MK; Center for Novel Therapeutics, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Ghia EM; Center for Novel Therapeutics, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Rassenti LZ; Center for Novel Therapeutics, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Widhopf GF 2nd; Center for Novel Therapeutics, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Kipps TJ; Center for Novel Therapeutics, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. .
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Źródło :
Leukemia [Leukemia] 2021 Jun; Vol. 35 (6), pp. 1621-1630. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Neoplastic*
GTPase-Activating Proteins/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Receptor Tyrosine Kinase-like Orphan Receptors/*metabolism
Wnt-5a Protein/*metabolism
Apoptosis ; Cell Proliferation ; GTPase-Activating Proteins/genetics ; Guanine Nucleotide Exchange Factors/genetics ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Receptor Tyrosine Kinase-like Orphan Receptors/genetics ; Tumor Cells, Cultured ; Wnt-5a Protein/genetics
Czasopismo naukowe
Tytuł :
MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation.
Autorzy :
Zhang B; Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xiao J; Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Cheng X; Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: .
Liu T; Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 21; Vol. 554, pp. 63-70. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Myelin and Lymphocyte-Associated Proteolipid Proteins/*metabolism
Pancreatic Neoplasms/*metabolism
ras GTPase-Activating Proteins/*metabolism
Cell Line, Tumor ; Cell Proliferation/physiology ; Computational Biology ; Databases, Genetic ; Humans ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Myelin and Lymphocyte-Associated Proteolipid Proteins/genetics ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Phosphorylation ; Prognosis ; Protein Interaction Domains and Motifs ; Survival Rate ; ras GTPase-Activating Proteins/genetics
Czasopismo naukowe
Tytuł :
Calculating Transfer Entropy from Variance-Covariance Matrices Provides Insight into Allosteric Communication in ERK2.
Autorzy :
Garcia Michel LR; Department of Chemistry, University of Mary, Bismarck, North Dakota 58504, United States.
Keirns CD; Department of Chemistry, University of Mary, Bismarck, North Dakota 58504, United States.
Ahlbrecht BC; Department of Chemistry, University of Mary, Bismarck, North Dakota 58504, United States.
Barr DA; Department of Chemistry, University of Mary, Bismarck, North Dakota 58504, United States.
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Źródło :
Journal of chemical theory and computation [J Chem Theory Comput] 2021 May 11; Vol. 17 (5), pp. 3168-3177. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Entropy*
Mitogen-Activated Protein Kinase 1/*metabolism
Allosteric Regulation ; Amino Acid Substitution ; Mitogen-Activated Protein Kinase 1/chemistry ; Molecular Dynamics Simulation ; Protein Conformation
Czasopismo naukowe
Tytuł :
The fibrillin-1 RGD motif posttranscriptionally regulates ERK1/2 signaling and fibroblast proliferation via miR-1208.
Autorzy :
Zhang RM; Faculty of Medicine and Health Sciences, Department of Anatomy and Cell Biology, McGill University, Montreal, Canada.
Zeyer KA; Faculty of Medicine and Health Sciences, Department of Anatomy and Cell Biology, McGill University, Montreal, Canada.
Odenthal N; Department of Natural Science, University of Lübeck, Lübeck, Germany.
Zhang Y; Faculty of Medicine and Health Sciences, Department of Anatomy and Cell Biology, McGill University, Montreal, Canada.
Reinhardt DP; Faculty of Medicine and Health Sciences, Department of Anatomy and Cell Biology, McGill University, Montreal, Canada.; Faculty of Dentistry, McGill University, Montreal, Canada.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 May; Vol. 35 (5), pp. e21598.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Processing, Post-Transcriptional*
Fibrillin-1/*metabolism
Fibroblasts/*cytology
MicroRNAs/*genetics
Mitogen-Activated Protein Kinase 1/*genetics
Mitogen-Activated Protein Kinase 3/*genetics
Oligopeptides/*metabolism
Cell Proliferation ; Cells, Cultured ; Fibrillin-1/genetics ; Fibroblasts/metabolism ; Humans ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Oligopeptides/genetics
Czasopismo naukowe
Tytuł :
Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis Infection.
Autorzy :
Xue Y; Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Chen W; Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Mai Z; Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Yu X; Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Wu Q; Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Wan C; Department of Microbiology, Southern Medical University, Guangzhou, China.
Su X; Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Wu Y; Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Rong Z; Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China; Research Center, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Zheng H; Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, China. Electronic address: .
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Źródło :
The Journal of investigative dermatology [J Invest Dermatol] 2021 Apr; Vol. 141 (4), pp. 852-862.e6. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chlamydia Infections/*drug therapy
Mitogen-Activated Protein Kinase 1/*antagonists & inhibitors
Mitogen-Activated Protein Kinase 3/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Ribosomal Protein S6 Kinases, 90-kDa/*genetics
Aminopyridines/pharmacology ; Aminopyridines/therapeutic use ; Animals ; Chlamydia Infections/immunology ; Chlamydia Infections/microbiology ; Chlamydia trachomatis/immunology ; Chlorocebus aethiops ; Disease Models, Animal ; Female ; Gene Knockdown Techniques ; HeLa Cells ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/immunology ; Humans ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; MAP Kinase Signaling System/immunology ; Mice ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Molecular Targeted Therapy/methods ; Protein Kinase Inhibitors/therapeutic use ; Pyrroles/pharmacology ; Pyrroles/therapeutic use ; Ribosomal Protein S6 Kinases, 90-kDa/metabolism ; Vero Cells
Czasopismo naukowe
Tytuł :
The C-terminal of the α1b-adreneroceptor is a key determinant for its structure integrity and biological functions.
Autorzy :
Liu Y; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.; Institute of Life Sciences, Jinzhou Medical University, Jinzhou, Liaoning, China.
Shao YT; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Ward R; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Ma L; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Gui HX; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Hao Q; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Mu X; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Yang Y; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
An S; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Guo XX; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Xu TR; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2021 Apr 24; Vol. 85 (5), pp. 1128-1139.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
Protein Processing, Post-Translational*
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Receptors, Adrenergic, alpha-1/*chemistry
beta-Arrestin 2/*genetics
Animals ; Fluorescence Resonance Energy Transfer ; Gene Expression ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Humans ; Mesocricetus ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Phenylephrine/pharmacology ; Phosphorylation/drug effects ; Plasmids/chemistry ; Plasmids/metabolism ; Protein Domains ; Protein Engineering/methods ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Receptors, Adrenergic, alpha-1/genetics ; Receptors, Adrenergic, alpha-1/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Serine/metabolism ; beta-Arrestin 2/antagonists & inhibitors ; beta-Arrestin 2/metabolism
Czasopismo naukowe
Tytuł :
OSCC cell-secreted exosomal CMTM6 induced M2-like macrophages polarization via ERK1/2 signaling pathway.
Autorzy :
Pang X; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, 610041, West China, China.
Wang SS; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, 610041, West China, China.
Zhang M; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, 610041, West China, China.
Jiang J; Department of Head and Neck Surgery, Sichuan Cancer Center, School of Medicine, Sichuan Cancer Hospital and Institute, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Fan HY; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, 610041, West China, China.
Wu JS; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, 610041, West China, China.
Wang HF; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, 610041, West China, China.
Liang XH; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, 610041, West China, China. .
Tang YL; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, 610041, West China, China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Apr; Vol. 70 (4), pp. 1015-1029. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Exosomes/*metabolism
MARVEL Domain-Containing Proteins/*metabolism
Macrophage Activation/*immunology
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Mouth Neoplasms/*pathology
Myelin Proteins/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Exosomes/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MARVEL Domain-Containing Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Mouth Neoplasms/immunology ; Mouth Neoplasms/metabolism ; Myelin Proteins/genetics ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/immunology ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Tumor Cells, Cultured ; Tumor Microenvironment ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Paracrine TGF-β1 from breast cancer contributes to chemoresistance in cancer associated fibroblasts via upregulation of the p44/42 MAPK signaling pathway.
Autorzy :
Chandra Jena B; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.
Kanta Das C; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.
Banerjee I; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.
Das S; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.
Bharadwaj D; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.
Majumder R; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.
Mandal M; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Apr; Vol. 186, pp. 114474. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*metabolism
Fibroblasts/*metabolism
Mitogen-Activated Protein Kinase 1/*biosynthesis
Mitogen-Activated Protein Kinase 3/*biosynthesis
Paracrine Communication/*physiology
Transforming Growth Factor beta1/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/physiology ; Female ; Fibroblasts/drug effects ; Humans ; MCF-7 Cells ; Mice ; Mice, Nude ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors ; Paracrine Communication/drug effects ; Transforming Growth Factor beta1/antagonists & inhibitors ; Up-Regulation/drug effects ; Up-Regulation/physiology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Zearalenone Induces Endothelial Cell Apoptosis through Activation of a Cytosolic Ca /ERK1/2/p53/Caspase 3 Signaling Pathway.
Autorzy :
Lee HJ; Graduate Program in System Health Science and Engineering, Department of Molecular Medicine, College of Medicine, Ewha Womans University, 25 Magokdong-ro-2-gil, Gangseo-gu, Seoul 07804, Korea.
Oh SY; Graduate Program in System Health Science and Engineering, Department of Molecular Medicine, College of Medicine, Ewha Womans University, 25 Magokdong-ro-2-gil, Gangseo-gu, Seoul 07804, Korea.
Jo I; Graduate Program in System Health Science and Engineering, Department of Molecular Medicine, College of Medicine, Ewha Womans University, 25 Magokdong-ro-2-gil, Gangseo-gu, Seoul 07804, Korea.
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Źródło :
Toxins [Toxins (Basel)] 2021 Mar 04; Vol. 13 (3). Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Calcium Signaling/*drug effects
Caspase 3/*metabolism
Endothelial Cells/*drug effects
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Tumor Suppressor Protein p53/*metabolism
Zearalenone/*toxicity
Animals ; Cattle ; Cells, Cultured ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Endothelial Cells/enzymology ; Endothelial Cells/pathology ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Phosphorylation ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
miR-199b-5p-DDR1-ERK signalling axis suppresses prostate cancer metastasis via inhibiting epithelial-mesenchymal transition.
Autorzy :
Zhao Z; Department of Urology & Andrology, The First Affiliated Hospital of Guangzhou Medical University; Guangdong Provincial Key Laboratory of Urology, 510230, Guangzhou, China. .
Zhao S; Department of Urology, Zhejiang Taizhou Central Hospital (Affiliated Hospital of Taizhou University), 318000, Taizhou, China.
Luo L; Department of Urology & Andrology, The First Affiliated Hospital of Guangzhou Medical University; Guangdong Provincial Key Laboratory of Urology, 510230, Guangzhou, China.
Xiang Q; Department of Urology & Andrology, The First Affiliated Hospital of Guangzhou Medical University; Guangdong Provincial Key Laboratory of Urology, 510230, Guangzhou, China.
Zhu Z; Department of Urology & Andrology, The First Affiliated Hospital of Guangzhou Medical University; Guangdong Provincial Key Laboratory of Urology, 510230, Guangzhou, China.
Wang J; Department of Urology & Andrology, The First Affiliated Hospital of Guangzhou Medical University; Guangdong Provincial Key Laboratory of Urology, 510230, Guangzhou, China.
Liu Y; Department of Urology & Andrology, The First Affiliated Hospital of Guangzhou Medical University; Guangdong Provincial Key Laboratory of Urology, 510230, Guangzhou, China.
Luo J; Department of Urology & Andrology, The First Affiliated Hospital of Guangzhou Medical University; Guangdong Provincial Key Laboratory of Urology, 510230, Guangzhou, China.
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Źródło :
British journal of cancer [Br J Cancer] 2021 Mar; Vol. 124 (5), pp. 982-994. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial-Mesenchymal Transition*
Gene Expression Regulation, Neoplastic*
Discoidin Domain Receptor 1/*metabolism
MicroRNAs/*genetics
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Prostatic Neoplasms/*pathology
Aged ; Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Movement ; Cell Proliferation ; Discoidin Domain Receptor 1/genetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Neoplasm Metastasis ; Prognosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer.
Autorzy :
Yamada K; Department of Biochemistry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Oikawa T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Kizawa R; Department of Biochemistry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Motohashi S; Department of Biochemistry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Yoshida S; Department of Biochemistry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Kumamoto T; Department of Biochemistry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Saeki C; Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Nakagawa C; Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Shimoyama Y; Department of Biochemistry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Aoki K; Department of Biochemistry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Tachibana T; Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Saruta M; Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Ono M; Department of Clinical Proteomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
Yoshida K; Department of Biochemistry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan. .
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Źródło :
Cancer research [Cancer Res] 2021 Jan 15; Vol. 81 (2), pp. 414-425. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Culture Media, Conditioned/*metabolism
Liver Neoplasms/*pathology
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Protein Kinase C-delta/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Case-Control Studies ; Cell Movement ; Cell Proliferation ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Male ; Mice ; Mice, Nude ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Phosphorylation ; Prognosis ; Signal Transduction ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Intermedin facilitates hepatocellular carcinoma cell survival and invasion via ERK1/2-EGR1/DDIT3 signaling cascade.
Autorzy :
Xiao F; Department of Intensive Care Unit of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China.
Li H; Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
Feng Z; Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No. 1, Ke Yuan 4th Road, Gao Peng Street, Chengdu, 610041, Sichuan, People's Republic of China.
Huang L; Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No. 1, Ke Yuan 4th Road, Gao Peng Street, Chengdu, 610041, Sichuan, People's Republic of China.
Kong L; Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No. 1, Ke Yuan 4th Road, Gao Peng Street, Chengdu, 610041, Sichuan, People's Republic of China.
Li M; Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No. 1, Ke Yuan 4th Road, Gao Peng Street, Chengdu, 610041, Sichuan, People's Republic of China.
Wang D; Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No. 1, Ke Yuan 4th Road, Gao Peng Street, Chengdu, 610041, Sichuan, People's Republic of China.
Liu F; Department of Liver Surgery, West China Hospital, Sichuan University, No. 1, Ke Yuan 4th Road, Gao Peng Street, Chengdu, 610041, Sichuan, People's Republic of China.
Zhu Z; Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China. .
Wei Y; Department of Liver Surgery, West China Hospital, Sichuan University, No. 1, Ke Yuan 4th Road, Gao Peng Street, Chengdu, 610041, Sichuan, People's Republic of China. .
Zhang W; Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No. 1, Ke Yuan 4th Road, Gao Peng Street, Chengdu, 610041, Sichuan, People's Republic of China. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jan 12; Vol. 11 (1), pp. 488. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carcinoma, Hepatocellular/*pathology
Early Growth Response Protein 1/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Peptide Hormones/*metabolism
Transcription Factor CHOP/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Movement ; Cell Proliferation ; Early Growth Response Protein 1/genetics ; Female ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Neoplasm Invasiveness ; Peptide Hormones/genetics ; Transcription Factor CHOP/genetics ; Tumor Cells, Cultured ; Wound Healing ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.
Autorzy :
Martinez R 3rd; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Huang W; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Samadani R; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Mackowiak B; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Centola G; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Chen L; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Conlon IL; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Hom K; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Kane MA; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Fletcher S; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland.
Shapiro P; Department of Pharmaceutical Sciences, University of Maryland, Baltimore- School of Pharmacy, Baltimore, Maryland .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Jan; Vol. 376 (1), pp. 84-97. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxidative Stress*
Antineoplastic Agents/*chemistry
MAP Kinase Signaling System/*drug effects
Melanoma/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Antineoplastic Agents/pharmacology ; Catalytic Domain ; Cell Proliferation/drug effects ; HeLa Cells ; Humans ; Jurkat Cells ; Mitogen-Activated Protein Kinase 1/chemistry ; Protein Binding ; Proto-Oncogene Proteins B-raf/genetics
Czasopismo naukowe
Tytuł :
DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division.
Autorzy :
Guo X; Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.
Ramirez I; Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.
Garcia YA; Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.
Velasquez EF; Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.
Gholkar AA; Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA.
Cohn W; Pasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Whitelegge JP; Pasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California, USA; Molecular Biology Institute, University of California, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.
Tofig B; California NanoSystems Institute, University of California, Los Angeles, California, USA.
Damoiseaux R; California NanoSystems Institute, University of California, Los Angeles, California, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.
Torres JZ; Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA; Molecular Biology Institute, University of California, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100676. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitosis*
Chromosomes, Human/*metabolism
Dual-Specificity Phosphatases/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Chromosomes, Human/genetics ; Dual-Specificity Phosphatases/genetics ; HCT116 Cells ; HeLa Cells ; Humans ; MAP Kinase Kinase Kinases/genetics ; MAP Kinase Kinase Kinases/metabolism ; Mitogen-Activated Protein Kinase 1/genetics ; Mutation ; Phosphorylation/genetics
Czasopismo naukowe
Tytuł :
Mechanical stress promotes angiogenesis through fibroblast exosomes.
Autorzy :
Xie F; China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China. Electronic address: .
Wen G; China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China. Electronic address: .
Sun W; China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China. Electronic address: .
Jiang K; China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China. Electronic address: .
Chen T; China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China. Electronic address: .
Chen S; China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China. Electronic address: .
Wen J; China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 10; Vol. 533 (3), pp. 346-353. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Exosomes/*genetics
Fibroblasts/*metabolism
Mechanotransduction, Cellular/*genetics
Mitogen-Activated Protein Kinase 1/*genetics
Mitogen-Activated Protein Kinase 3/*genetics
Neovascularization, Pathologic/*genetics
Cell Line ; Cell Movement ; Cell Proliferation ; Cell Survival ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Exosomes/metabolism ; Exosomes/pathology ; Fibroblasts/pathology ; Gene Expression Regulation ; Hallux Valgus/genetics ; Hallux Valgus/metabolism ; Hallux Valgus/pathology ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Stress, Mechanical
Czasopismo naukowe
Tytuł :
Brain-Derived Neurotrophic Factor Regulates Ishikawa Cell Proliferation through the TrkB-ERK1/2 Signaling Pathway.
Autorzy :
Cao M; College of Animal Sciences, Jilin University, Changchun 130062, China.
Niu Q; College of Animal Sciences, Jilin University, Changchun 130062, China.
Xiang X; College of Animal Sciences, Jilin University, Changchun 130062, China.
Yuan C; College of Animal Sciences, Jilin University, Changchun 130062, China.
Iqbal T; College of Animal Sciences, Jilin University, Changchun 130062, China.
Huang Y; College of Animal Sciences, Jilin University, Changchun 130062, China.
Tian M; College of Animal Sciences, Jilin University, Changchun 130062, China.
Zhao Z; College of Animal Sciences, Jilin University, Changchun 130062, China.
Li C; College of Animal Sciences, Jilin University, Changchun 130062, China.
Zhou X; College of Animal Sciences, Jilin University, Changchun 130062, China.
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Źródło :
Biomolecules [Biomolecules] 2020 Dec 08; Vol. 10 (12). Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain-Derived Neurotrophic Factor/*pharmacology
Endometrium/*drug effects
Membrane Glycoproteins/*genetics
Mitogen-Activated Protein Kinase 1/*genetics
Mitogen-Activated Protein Kinase 3/*genetics
Receptor, trkB/*genetics
Signal Transduction/*drug effects
Brain-Derived Neurotrophic Factor/antagonists & inhibitors ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Carbazoles/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Cyclins/genetics ; Cyclins/metabolism ; Endometrium/cytology ; Endometrium/metabolism ; Estradiol/pharmacology ; Female ; Flavonoids/pharmacology ; Gene Expression Regulation ; Humans ; Indole Alkaloids/pharmacology ; Membrane Glycoproteins/antagonists & inhibitors ; Membrane Glycoproteins/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Receptor, trkB/antagonists & inhibitors ; Receptor, trkB/metabolism ; Signal Transduction/genetics
Czasopismo naukowe

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