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Wyszukujesz frazę ""Mitogen-Activated Protein Kinase 14"" wg kryterium: Temat


Tytuł :
p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.
Autorzy :
Yokota T; Cardiovascular Research Laboratories, Department of Anesthesiology, Department of Physiology, and Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Li J; Cardiovascular Research Laboratories, Department of Anesthesiology, Department of Physiology, and Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Huang J; Cardiovascular Research Laboratories, Department of Anesthesiology, Department of Physiology, and Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Xiong Z; Cardiovascular Research Laboratories, Department of Anesthesiology, Department of Physiology, and Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.; Department of Cardiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhang Q; Integrative Biology and Physiology, David Geffen School of Medicine.
Chan T; Integrative Biology and Physiology, David Geffen School of Medicine.
Ding Y; Department of Bioengineering, School of Engineering and Applied Sciences.; Division of Cardiology and.
Rau C; Cardiovascular Research Laboratories, Department of Anesthesiology, Department of Physiology, and Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Sung K; Department of Bioengineering, School of Engineering and Applied Sciences.
Ren S; Cardiovascular Research Laboratories, Department of Anesthesiology, Department of Physiology, and Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Kulkarni R; Department of Bioengineering, School of Engineering and Applied Sciences.; Division of Dermatology, Department of Medicine, and.
Hsiai T; Department of Bioengineering, School of Engineering and Applied Sciences.; Division of Cardiology and.
Xiao X; Integrative Biology and Physiology, David Geffen School of Medicine.
Touma M; Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Minamisawa S; Department of Cell Physiology, Jikei University, Tokyo, Japan.
Wang Y; Cardiovascular Research Laboratories, Department of Anesthesiology, Department of Physiology, and Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.; Division of Cardiology and.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Oct 01; Vol. 130 (10), pp. 5287-5301.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Heart/*growth & development
Mitogen-Activated Protein Kinase 14/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Myocardium/*enzymology
Animals ; Animals, Newborn ; Apoptosis ; Cell Proliferation ; Cell Size ; Enzyme Activation ; Female ; Gene Expression Profiling ; Heart Ventricles/cytology ; Heart Ventricles/enzymology ; Heart Ventricles/growth & development ; Male ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinase 14/deficiency ; Mitogen-Activated Protein Kinase 14/genetics ; Mitogen-Activated Protein Kinases/deficiency ; Mitogen-Activated Protein Kinases/genetics ; Myocardium/cytology ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/enzymology ; Organ Specificity ; Vascular Remodeling/genetics ; Vascular Remodeling/physiology
Czasopismo naukowe
Tytuł :
Virus-induced p38 MAPK activation facilitates viral infection.
Autorzy :
Cheng Y; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.; Jiangsu Agri-animal Husbandry Vocational College, Jiangsu Key Laboratory for High-Tech Research and Development of Veterinary Biopharmaceuticals, Taizhou, 225300, China.
Sun F; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Wang L; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Gao M; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Xie Y; Zhongnan Hospital of Wuhan University, Wuhan 430071, Wuhan 430072, Hubei, China.
Sun Y; School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China.
Liu H; Zhongnan Hospital of Wuhan University, Wuhan 430071, Wuhan 430072, Hubei, China.
Yuan Y; Zhongnan Hospital of Wuhan University, Wuhan 430071, Wuhan 430072, Hubei, China.
Yi W; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China.
Huang Z; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Yan H; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Peng K; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, Hubei, China.
Wu Y; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Cao Z; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.; Hubei Province Engineering and Technology Research, Center for Fluorinated Pharmaceuticals, Wuhan University, Wuhan 430071, Hubei, China.
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Źródło :
Theranostics [Theranostics] 2020 Oct 30; Vol. 10 (26), pp. 12223-12240. Date of Electronic Publication: 2020 Oct 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*metabolism
Hepacivirus/*metabolism
Hepatitis C/*metabolism
Mitogen-Activated Protein Kinase 14/*metabolism
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
A549 Cells ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; COVID-19/virology ; Chlorocebus aethiops ; Enzyme Activation ; HEK293 Cells ; Hepatitis C/pathology ; Hepatitis C/virology ; Hepatocytes/metabolism ; Humans ; Imidazoles/pharmacology ; MAP Kinase Kinase Kinases/metabolism ; MAP Kinase Signaling System/drug effects ; Mitogen-Activated Protein Kinase 14/antagonists & inhibitors ; Phosphorylation ; Pyridines/pharmacology ; Vero Cells ; Viral Core Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Conformational selection vs. induced fit: insights into the binding mechanisms of p38α MAP Kinase inhibitors.
Autorzy :
Roser P; Department of Chemistry and Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany. .
Weisner J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany. .
Stehle J; Department of Chemistry and Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany. .
Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany. .
Drescher M; Department of Chemistry and Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany. .
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Aug 04; Vol. 56 (62), pp. 8818-8821.
Typ publikacji :
Journal Article
MeSH Terms :
Mitogen-Activated Protein Kinase 14/*antagonists & inhibitors
Mitogen-Activated Protein Kinase 14/*metabolism
Protein Kinase Inhibitors/*metabolism
Mitogen-Activated Protein Kinase 14/chemistry ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein Kinase Inhibitors/pharmacology ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Bioisosteric Replacement of Arylamide-Linked Spine Residues with N -Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.
Autorzy :
Pedreira JGB; Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Federal University of Rio de Janeiro (UFRJ), 21944-971 Rio de Janeiro, Brazil.; Graduate Program of Chemistry (PGQu), Chemistry Institute, UFRJ, 21941-909 Rio de Janeiro, Brazil.
Nahidino P; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
Kudolo M; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
Pantsar T; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; School of Pharmacy, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland.
Berger BT; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchman Institute for Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 15, D-60438 Frankfurt am Main, Germany.
Forster M; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
Knapp S; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchman Institute for Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 15, D-60438 Frankfurt am Main, Germany.
Laufer S; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076 Tübingen, Germany.
Barreiro EJ; Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Federal University of Rio de Janeiro (UFRJ), 21944-971 Rio de Janeiro, Brazil.; Graduate Program of Chemistry (PGQu), Chemistry Institute, UFRJ, 21941-909 Rio de Janeiro, Brazil.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jul 09; Vol. 63 (13), pp. 7347-7354. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Structure-Activity Relationship*
Dibenzocycloheptenes/*chemistry
Mitogen-Activated Protein Kinase 14/*antagonists & inhibitors
Protein Kinase Inhibitors/*chemistry
Protein Kinase Inhibitors/*pharmacology
Amides/chemistry ; Drug Design ; Drug Stability ; Humans ; Hydrazones/chemistry ; Microsomes, Liver/drug effects ; Mitogen-Activated Protein Kinase 14/chemistry ; Mitogen-Activated Protein Kinase 14/metabolism ; Organoselenium Compounds/chemistry ; Protein Kinase Inhibitors/pharmacokinetics ; Time Factors
Czasopismo naukowe
Tytuł :
Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α-TAB1 Complexes.
Autorzy :
Nichols C; British Heart Foundation Centre of Excellence, Department of Cardiology, The Rayne Institute, St Thomas' Hospital, King's College London, London SE1 7EH, U.K.; The Randall Centre for Cell & Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, U.K.
Ng J; The Randall Centre for Cell & Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, U.K.
Keshu A; The Randall Centre for Cell & Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, U.K.
Kelly G; NMR Facility, The Francis Crick Institute, London NW1 1AT, U.K.
Conte MR; The Randall Centre for Cell & Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, U.K.
Marber MS; British Heart Foundation Centre of Excellence, Department of Cardiology, The Rayne Institute, St Thomas' Hospital, King's College London, London SE1 7EH, U.K.
Fraternali F; The Randall Centre for Cell & Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, U.K.
De Nicola GF; British Heart Foundation Centre of Excellence, Department of Cardiology, The Rayne Institute, St Thomas' Hospital, King's College London, London SE1 7EH, U.K.; The Randall Centre for Cell & Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, U.K.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7559-7568. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Interleukin-1beta/*metabolism
Mitogen-Activated Protein Kinase 14/*metabolism
Protein Multimerization/*drug effects
Receptors, Interleukin-1/*metabolism
Adamantane/analogs & derivatives ; Adamantane/metabolism ; Adaptor Proteins, Signal Transducing/chemistry ; Animals ; Binding Sites ; Crystallography, X-Ray ; Databases, Protein ; Humans ; Interleukin-1beta/chemistry ; Mitogen-Activated Protein Kinase 14/chemistry ; Protein Binding/drug effects ; Receptors, Interleukin-1/chemistry ; Sulfonamides/chemistry ; Sulfonamides/metabolism ; Yeasts/chemistry
Czasopismo naukowe
Tytuł :
Altered expression of AKT1 and P38A in the colons of patients with Hirschsprung's disease.
Autorzy :
Wu L; Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China.
Xiao P; Department of Pathology, Capital Institute of Pediatrics Affiliated Children's Hospital, Beijing, 100020, China.
Li Q; Department of General Surgery, Capital Institute of Pediatrics Affiliated Children's Hospital, No. 2 Yabao Rd., Chaoyang District, Beijing, 100020, China.
Zhang Z; Department of General Surgery, Capital Institute of Pediatrics Affiliated Children's Hospital, No. 2 Yabao Rd., Chaoyang District, Beijing, 100020, China.
Wang H; Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China.
Jiang Q; Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China.
Li L; Department of General Surgery, Capital Institute of Pediatrics Affiliated Children's Hospital, No. 2 Yabao Rd., Chaoyang District, Beijing, 100020, China. .
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Źródło :
Pediatric surgery international [Pediatr Surg Int] 2020 Jun; Vol. 36 (6), pp. 719-725. Date of Electronic Publication: 2020 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Hirschsprung Disease/*genetics
Mitogen-Activated Protein Kinase 14/*genetics
Proto-Oncogene Proteins c-akt/*genetics
RNA/*genetics
Blotting, Western ; Down-Regulation ; Female ; Hirschsprung Disease/metabolism ; Humans ; Immunohistochemistry ; Infant ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Mitogen-Activated Protein Kinase 14/biosynthesis ; Proto-Oncogene Proteins c-akt/biosynthesis
Czasopismo naukowe
Tytuł :
In silico identification of MAPK14-related lncRNAs and assessment of their expression in breast cancer samples.
Autorzy :
Dashti S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Taherian-Esfahani Z; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Kholghi-Oskooei V; Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.; Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Noroozi R; Malopolska Centre of Biotechnology of the Jagiellonian University, Kraków, Poland.
Arsang-Jang S; Department of Biostatistics and Epidemiology, Cancer Gene Therapy Research Center, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Ghafouri-Fard S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .
Taheri M; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 20; Vol. 10 (1), pp. 8316. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*metabolism
Mitogen-Activated Protein Kinase 14/*metabolism
RNA, Long Noncoding/*metabolism
Adult ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Computer Simulation ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; MAP Kinase Signaling System ; Mammary Glands, Human/metabolism ; MicroRNAs/metabolism ; Middle Aged ; Mitogen-Activated Protein Kinase 14/genetics
Czasopismo naukowe
Tytuł :
Role of p38-mitogen-activated protein kinase in COPD: pathobiological implications and therapeutic perspectives.
Autorzy :
Pelaia C; Department of Health Sciences, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.
Vatrella A; Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
Sciacqua A; Department of Medical and Surgical Sciences, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.
Terracciano R; Department of Experimental and Clinical Medicine, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.
Pelaia G; Department of Health Sciences, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.
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Źródło :
Expert review of respiratory medicine [Expert Rev Respir Med] 2020 May; Vol. 14 (5), pp. 485-491. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mitogen-Activated Protein Kinase 14/*immunology
Pulmonary Disease, Chronic Obstructive/*enzymology
p38 Mitogen-Activated Protein Kinases/*immunology
Humans ; Inflammation ; Mitogen-Activated Protein Kinase 14/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
P38α-MAPK Signaling Inhibition Attenuates Soleus Atrophy during Early Stages of Muscle Unloading.
Autorzy :
Belova SP; Institute of Biomedical Problems, RAS, Moscow 123007, Russia.
Mochalova EP; Institute of Biomedical Problems, RAS, Moscow 123007, Russia.
Kostrominova TY; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine-Northwest, Gary, IN 46408, USA.
Shenkman BS; Institute of Biomedical Problems, RAS, Moscow 123007, Russia.
Nemirovskaya TL; Institute of Biomedical Problems, RAS, Moscow 123007, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 15; Vol. 21 (8). Date of Electronic Publication: 2020 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Mitogen-Activated Protein Kinase 14/*metabolism
Muscle, Skeletal/*drug effects
Muscular Atrophy/*metabolism
Protein Kinase Inhibitors/*administration & dosage
Pyridazines/*administration & dosage
Pyrimidines/*administration & dosage
Animals ; Calpain/genetics ; Calpain/metabolism ; Hindlimb Suspension ; Interleukin-6/metabolism ; Male ; Mitogen-Activated Protein Kinase 14/antagonists & inhibitors ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Atrophy/drug therapy ; Protein Biosynthesis/drug effects ; Protein Biosynthesis/genetics ; Proteolysis/drug effects ; Rats ; Rats, Wistar ; SKP Cullin F-Box Protein Ligases/genetics ; SKP Cullin F-Box Protein Ligases/metabolism ; Tripartite Motif Proteins/metabolism ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Requirement for epithelial p38α in KRAS-driven lung tumor progression.
Autorzy :
Vitos-Faleato J; Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Real SM; Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Gutierrez-Prat N; Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Villanueva A; Program Against Cancer Therapeutic Resistance, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, 08907 L'Hospitalet de Llobregat, Spain.
Llonch E; Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Drosten M; Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain.
Barbacid M; Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain.
Nebreda AR; Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; .; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 04; Vol. 117 (5), pp. 2588-2596. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma of Lung/*enzymology
Lung Neoplasms/*enzymology
Mitogen-Activated Protein Kinase 14/*metabolism
Proto-Oncogene Proteins p21(ras)/*metabolism
Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/mortality ; Adenocarcinoma of Lung/pathology ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Disease Models, Animal ; Disease Progression ; Humans ; Lung/enzymology ; Lung/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Mice ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinase 14/genetics ; Neoplastic Processes ; Proto-Oncogene Proteins p21(ras)/genetics
Czasopismo naukowe
Tytuł :
Promiscuity analysis of a kinase panel screen with designated p38 alpha inhibitors.
Autorzy :
González-Medina M; Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universität, Endenicher Allee 19c, D-53115, Bonn, Germany.
Miljković F; Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universität, Endenicher Allee 19c, D-53115, Bonn, Germany.
Haase GS; Department of Pharmacy and Biochemistry, Pharmaceutical/Medicinal Chemistry, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, D-72076, Tübingen, Germany.
Drueckes P; Novartis Pharma AG, CH-4002, Basel, Switzerland.
Trappe J; Novartis Pharma AG, CH-4002, Basel, Switzerland.
Laufer S; Department of Pharmacy and Biochemistry, Pharmaceutical/Medicinal Chemistry, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, D-72076, Tübingen, Germany. Electronic address: .
Bajorath J; Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universität, Endenicher Allee 19c, D-53115, Bonn, Germany. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Feb 01; Vol. 187, pp. 112004. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Journal Article
MeSH Terms :
Mitogen-Activated Protein Kinase 14/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Dose-Response Relationship, Drug ; Drug Design ; Drug Evaluation, Preclinical ; Humans ; Mitogen-Activated Protein Kinase 14/metabolism ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level.
Autorzy :
Alam JJ; EIP Pharma, Inc., Boston, Massachusetts, United States of America.
Krakovsky M; Pharmaseed Ltd., Ness-Ziona, Israel.
Germann U; EIP Pharma, Inc., Boston, Massachusetts, United States of America.
Levy A; Pharmaseed Ltd., Ness-Ziona, Israel.
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Źródło :
PloS one [PLoS One] 2020 Dec 04; Vol. 15 (12), pp. e0233073. Date of Electronic Publication: 2020 Dec 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Ischemia/*drug therapy
Pyridazines/*pharmacology
Pyrimidines/*pharmacology
Stroke/*drug therapy
Animals ; Brain/metabolism ; Brain Ischemia/complications ; Brain Ischemia/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Infarction, Middle Cerebral Artery/complications ; Ischemia/complications ; Male ; Mitogen-Activated Protein Kinase 14/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 14/metabolism ; Pyridazines/metabolism ; Pyrimidines/metabolism ; Rats ; Rats, Sprague-Dawley ; Recovery of Function/drug effects ; Recovery of Function/physiology ; Stroke/complications ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition.
Autorzy :
Wang J; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Wang G; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Cheng D; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Huang S; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Chang A; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Tan X; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.; Department of Respiratory Disease, South Campus, Renji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai, China.
Wang Q; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.
Zhao S; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.
Wu D; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Liu AT; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yang S; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.
Xiang R; Department of Immunology, School of Medicine, Nankai University, Tianjin, China. .
Sun P; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston Salem, NC, USA. .
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Źródło :
Oncogene [Oncogene] 2020 Oct; Vol. 39 (40), pp. 6313-6326. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*pathology
MAP Kinase Signaling System/*drug effects
Protein Phosphatase 2C/*antagonists & inhibitors
Receptor, ErbB-2/*metabolism
Aminopyridines/pharmacology ; Aminopyridines/therapeutic use ; Animals ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Dipeptides/pharmacology ; Dipeptides/therapeutic use ; Female ; Heat-Shock Proteins/metabolism ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Humans ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Mitogen-Activated Protein Kinase 14/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 14/metabolism ; Molecular Chaperones/metabolism ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/prevention & control ; Phosphorylation/drug effects ; Protein Phosphatase 2C/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
Autorzy :
Dumont AA; Département de Médecine, Service de Cardiologie, Centre de Recherche du CHUS, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
Dumont L; Département de Médecine, Service de Cardiologie, Centre de Recherche du CHUS, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
Berthiaume J; Département de Médecine, Service de Cardiologie, Centre de Recherche du CHUS, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
Auger-Messier M; Département de Médecine, Service de Cardiologie, Centre de Recherche du CHUS, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2019 Dec; Vol. 1866 (12), pp. 118557. Date of Electronic Publication: 2019 Sep 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing/*genetics
Mitogen-Activated Protein Kinase 14/*genetics
Myocytes, Cardiac/*metabolism
Animals ; Cells, Cultured ; Mitogen-Activated Protein Kinase 14/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.
Autorzy :
Astolfi A; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
Kudolo M; Department of Pharmaceutical & Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls University Tuebingen, Auf der Morgenstelle 8, 72076, Tuebingen, Germany.
Brea J; CIMUS Research Center, University of Santiago de Compostela, Avda de Barcelona s/n, Planta 3, Despacho1, 15782, Santiago de Compostela, Spain.
Manni G; Department of Experimental Medicine, University of Perugia, Piazzale Gambuli, 06100, Perugia, Italy.
Manfroni G; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
Palazzotti D; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
Sabatini S; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
Cecchetti F; Department of Experimental Medicine, University of Perugia, Piazzale Gambuli, 06100, Perugia, Italy.
Felicetti T; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
Cannalire R; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
Massari S; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
Tabarrini O; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
Loza MI; CIMUS Research Center, University of Santiago de Compostela, Avda de Barcelona s/n, Planta 3, Despacho1, 15782, Santiago de Compostela, Spain.
Fallarino F; Department of Experimental Medicine, University of Perugia, Piazzale Gambuli, 06100, Perugia, Italy.
Cecchetti V; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
Laufer SA; Department of Pharmaceutical & Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls University Tuebingen, Auf der Morgenstelle 8, 72076, Tuebingen, Germany.
Barreca ML; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, Via del Liceo 1, 06123, Perugia, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Nov 15; Vol. 182, pp. 111624. Date of Electronic Publication: 2019 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Mitogen-Activated Protein Kinase 14/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Healthy Volunteers ; Humans ; Mitogen-Activated Protein Kinase 14/metabolism ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Dibenzepinones, dibenzoxepines and benzosuberones based p38α MAP kinase inhibitors: Their pharmacophore modelling, 3D-QSAR and docking studies.
Autorzy :
Khan MF; Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Verma G; Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Alam P; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Akhter M; Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Bakht MA; Department of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, P.O. Box- 173, Al-Kharj, Saudi Arabia.
Hasan SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Integral University, Lucknow, 226026, India.
Shaquiquzzaman M; Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Alam MM; Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. Electronic address: .
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Źródło :
Computers in biology and medicine [Comput Biol Med] 2019 Jul; Vol. 110, pp. 175-185. Date of Electronic Publication: 2019 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Mitogen-Activated Protein Kinase 14*/antagonists & inhibitors
Mitogen-Activated Protein Kinase 14*/chemistry
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Protein Kinase Inhibitors/*chemistry
Humans ; Quantitative Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Nox2 Upregulation and p38α MAPK Activation in Right Ventricular Hypertrophy of Rats Exposed to Long-Term Chronic Intermittent Hypobaric Hypoxia.
Autorzy :
Pena E; Institute of Health Studies, Universidad Arturo Prat, Avenida Arturo Prat 2120, Iquique 1110939, Chile.; Institute DECIPHER, German-Chilean Institute for Research on Pulmonary Hypoxia and Its Health Sequelae, Hamburg (Germany) and Iquique (Chile), Avenida Arturo Prat 2120, Iquique 1110939, Chile.
Siques P; Institute of Health Studies, Universidad Arturo Prat, Avenida Arturo Prat 2120, Iquique 1110939, Chile.; Institute DECIPHER, German-Chilean Institute for Research on Pulmonary Hypoxia and Its Health Sequelae, Hamburg (Germany) and Iquique (Chile), Avenida Arturo Prat 2120, Iquique 1110939, Chile.
Brito J; Institute of Health Studies, Universidad Arturo Prat, Avenida Arturo Prat 2120, Iquique 1110939, Chile.; Institute DECIPHER, German-Chilean Institute for Research on Pulmonary Hypoxia and Its Health Sequelae, Hamburg (Germany) and Iquique (Chile), Avenida Arturo Prat 2120, Iquique 1110939, Chile.
Arribas SM; Department of Physiology, University Autónoma of Madrid, Calle Arzobispo Morcillo 4, 28029 Madrid, Spain.
Böger R; Institute DECIPHER, German-Chilean Institute for Research on Pulmonary Hypoxia and Its Health Sequelae, Hamburg (Germany) and Iquique (Chile), Avenida Arturo Prat 2120, Iquique 1110939, Chile.; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Hannemann J; Institute DECIPHER, German-Chilean Institute for Research on Pulmonary Hypoxia and Its Health Sequelae, Hamburg (Germany) and Iquique (Chile), Avenida Arturo Prat 2120, Iquique 1110939, Chile.; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
León-Velarde F; Department of Biological and Physiological Science, Facultad de Ciencias y Filosofía/IIA, Cayetano Heredia University, Avenida Honorio Delgado 430, Lima 15102, Peru.
González MC; Department of Physiology, University Autónoma of Madrid, Calle Arzobispo Morcillo 4, 28029 Madrid, Spain.
López MR; Department of Preventive Medicine and Public Health, University Autónoma of Madrid, Calle Arzobispo Morcillo 4, 28029 Madrid, Spain.
López de Pablo ÁL; Department of Physiology, University Autónoma of Madrid, Calle Arzobispo Morcillo 4, 28029 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 13; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Enzymologic*
MAP Kinase Signaling System*
Up-Regulation*
Hypertrophy, Right Ventricular/*enzymology
Hypoxia/*enzymology
Mitogen-Activated Protein Kinase 14/*metabolism
NADPH Oxidase 2/*biosynthesis
Animals ; Chronic Disease ; Disease Models, Animal ; Hypertrophy, Right Ventricular/etiology ; Hypertrophy, Right Ventricular/pathology ; Hypoxia/complications ; Hypoxia/pathology ; Male ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Mxi-2 Dependent Regulation of p53 in Prostate Cancer.
Autorzy :
KÖditz B; Department of Natural Sciences, University of Applied Sciences Bonn Rhein Sieg, Rheinbach, Germany.; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Fries JWU; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
GÖbel H; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Paffenholz P; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Richter K; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Heidenreich A; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
VON Brandenstein M; Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany .
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Źródło :
Anticancer research [Anticancer Res] 2020 Oct; Vol. 40 (10), pp. 5539-5544.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic/*drug effects
Mitogen-Activated Protein Kinase 14/*genetics
Prostatic Neoplasms/*genetics
Tumor Suppressor Protein p53/*genetics
p38 Mitogen-Activated Protein Kinases/*genetics
Argonaute Proteins/genetics ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Endothelin A Receptor Antagonists/pharmacology ; Endothelin B Receptor Antagonists/pharmacology ; Humans ; Male ; MicroRNAs/genetics ; Prostatic Neoplasms/pathology ; Receptor, Endothelin A/genetics ; Receptor, Endothelin B/genetics ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Opposing Oncogenic Functions of p38 Mitogen-activated Protein Kinase Alpha and Beta in Human Pancreatic Cancer Cells.
Autorzy :
Tian X; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.; Department of General Surgery, Peking University First Hospital, Beijing, P.R. China.
Traub B; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Xie X; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.; Department of General Surgery, Peking University First Hospital, Beijing, P.R. China.
Zhou S; Clinical Chemistry, University of Ulm, Ulm, Germany.
Henne-Bruns D; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Knippschild U; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Kornmann M; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany .
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Źródło :
Anticancer research [Anticancer Res] 2020 Oct; Vol. 40 (10), pp. 5545-5556.
Typ publikacji :
Journal Article
MeSH Terms :
Mitogen-Activated Protein Kinase 11/*genetics
Mitogen-Activated Protein Kinase 14/*genetics
Pancreatic Neoplasms/*genetics
p38 Mitogen-Activated Protein Kinases/*genetics
Carcinogenesis/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Pancreatic Neoplasms/pathology ; Phosphorylation ; Protein Isoforms/genetics ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.
Autorzy :
Myers SM; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Miller DC; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Molyneux L; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Arasta M; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Bawn RH; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Blackburn TJ; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Cook SJ; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Edwards N; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Endicott JA; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Golding BT; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Griffin RJ; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Hammonds T; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London, NW1 0NH, UK.
Hardcastle IR; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Harnor SJ; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Heptinstall AB; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Lochhead PA; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Martin MP; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Martin NC; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Newell DR; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Owen PJ; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London, NW1 0NH, UK.
Pang LC; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London, NW1 0NH, UK.
Reuillon T; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Rigoreau LJM; Cancer Research UK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Campus, Babraham, Cambridgeshire, CB22 3AT, UK.
Thomas HD; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Tucker JA; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Wang LZ; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Wong AC; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London, NW1 0NH, UK.
Noble MEM; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK. Electronic address: .
Wedge SR; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK. Electronic address: .
Cano C; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Sep 15; Vol. 178, pp. 530-543. Date of Electronic Publication: 2019 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Mitogen-Activated Protein Kinase 14/*antagonists & inhibitors
Mitogen-Activated Protein Kinase 7/*antagonists & inhibitors
Nuclear Proteins/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Transcription Factors/*antagonists & inhibitors
Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Biological Availability ; Cell Cycle Proteins ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Mice ; Mice, Nude ; Mitogen-Activated Protein Kinase 14/metabolism ; Mitogen-Activated Protein Kinase 7/metabolism ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Nuclear Proteins/metabolism ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship ; Transcription Factors/metabolism
Czasopismo naukowe

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