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Wyszukujesz frazę ""Models, Animal"" wg kryterium: Temat


Tytuł :
Experimental replications in animal trials.
Autorzy :
Frommlet F; Center for Medical Statistics, Informatics and Intelligent Systems, Section for Medical Statistics, Medical University Vienna, Austria.
Heinze G; Center for Medical Statistics, Informatics and Intelligent Systems, Section for Clinical Biometrics, Medical University Vienna, Austria.
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Źródło :
Laboratory animals [Lab Anim] 2021 Feb; Vol. 55 (1), pp. 65-75. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Animal*
Reproducibility of Results*
Research Design/*standards
Animals ; Disease Models, Animal
Czasopismo naukowe
Tytuł :
Inosine induces acute hyperuricaemia in rhesus monkey ( Macaca mulatta ) as a potential disease animal model.
Autorzy :
Tang DH; Medical Primate Research Center of China, Institute of Medical Biology, Chinese Academy of Medical Sciences/Peking Union Medical College, Kunming, China.
Wang CY; Medical Primate Research Center of China, Institute of Medical Biology, Chinese Academy of Medical Sciences/Peking Union Medical College, Kunming, China.
Huang X; KPC Pharmaceuticals Inc., Kunming, China.
Yi HK; Medical Primate Research Center of China, Institute of Medical Biology, Chinese Academy of Medical Sciences/Peking Union Medical College, Kunming, China.
Li ZL; Medical Primate Research Center of China, Institute of Medical Biology, Chinese Academy of Medical Sciences/Peking Union Medical College, Kunming, China.
Ma KL; Medical Primate Research Center of China, Institute of Medical Biology, Chinese Academy of Medical Sciences/Peking Union Medical College, Kunming, China.
Ye YS; Medical Primate Research Center of China, Institute of Medical Biology, Chinese Academy of Medical Sciences/Peking Union Medical College, Kunming, China.
Zhang JW; KPC Pharmaceuticals Inc., Kunming, China.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2021 Dec; Vol. 59 (1), pp. 175-182.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Hyperuricemia/*chemically induced
Inosine/*pharmacology
Uric Acid/*blood
Acute Disease ; Allopurinol/pharmacology ; Animals ; Dose-Response Relationship, Drug ; Febuxostat/pharmacology ; Hyperuricemia/drug therapy ; Hyperuricemia/physiopathology ; Imino Furanoses/pharmacology ; Inosine/administration & dosage ; Macaca mulatta ; Male ; Pyrimidinones/pharmacology ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Preclinical models of medication-related osteonecrosis of the jaw (MRONJ).
Autorzy :
Aguirre JI; Department of Physiological Sciences, University of Florida (UF), Gainesville, FL, United States of America. Electronic address: .
Castillo EJ; Department of Physiological Sciences, University of Florida (UF), Gainesville, FL, United States of America. Electronic address: .
Kimmel DB; Department of Physiological Sciences, University of Florida (UF), Gainesville, FL, United States of America.
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Źródło :
Bone [Bone] 2021 Dec; Vol. 153, pp. 116184. Date of Electronic Publication: 2021 Sep 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Bisphosphonate-Associated Osteonecrosis of the Jaw*
Bone Density Conservation Agents*
Bone Neoplasms*
Disease Models, Animal*
Animals ; Denosumab ; Diphosphonates/adverse effects ; Dogs ; Humans ; Mice ; Rabbits ; Rats ; Sheep ; Swine
Czasopismo naukowe
Tytuł :
Roborovski hamster (Phodopus roborovskii) strain SH101 as a systemic infection model of SARS-CoV-2.
Autorzy :
Zhai C; Department of Biomedical Sciences and Institute for Medical Science, Jeonbuk National University Medical School, Jeonju, South Korea.
Wang M; Gwangju Center, Korea Basic Science Institute, Gwangju, South Korea.
Chung HJ
Hassan M; Department of Biomedical Sciences and Institute for Medical Science, Jeonbuk National University Medical School, Jeonju, South Korea.; JINIS BDRD Institute, JINIS Inc, Bongdong, South Korea.
Lee S; Department of Anatomic Pathology, School of Medicine, Kangwon National University, Kangwon National University Hospital, Chuncheon, South Korea.
Kim HJ; JINIS BDRD Institute, JINIS Inc, Bongdong, South Korea.
Hong ST; Department of Biomedical Sciences and Institute for Medical Science, Jeonbuk National University Medical School, Jeonju, South Korea.
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Źródło :
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 2430-2442.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/pathology
COVID-19*/physiopathology
Disease Models, Animal*
SARS-CoV-2*
Cricetinae/*classification
Animals ; Body Temperature ; Brain/pathology ; Female ; Liver/pathology ; Lung/pathology ; Male ; Mesocricetus ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models.
Autorzy :
Dettori I; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Fusco I; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Bulli I; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Gaviano L; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Coppi E; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Cherchi F; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Venturini M; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Di Cesare Mannelli L; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Ghelardini C; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Nocentini A; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical Sciences, University of Florence, Florence, Italy.
Supuran CT; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical Sciences, University of Florence, Florence, Italy.
Pugliese AM; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Pedata F; Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Division of Pharmacology and Toxicology, University of Florence, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 964-976.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Brain Ischemia/*drug therapy
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Neuroprotective Agents/*pharmacology
Animals ; Brain Ischemia/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Male ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Rats ; Rats, Wistar ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.
Autorzy :
Hwang YJ; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Hyeon SJ; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Kim Y; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Lim S; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST, Seoul, Republic of Korea.
Lee MY; Institute for Systems Biology, Seattle, WA, USA.
Kim J; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Londhe AM; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST, Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Gotina L; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST, Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Kim Y; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Pae AN; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST, Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Cho YS; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Seong J; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST, Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Seo H; Department of Molecular & Life Sciences, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, Republic of Korea.
Kim YK; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST, Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Choo H; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Ryu H; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Department of Neurology and Boston University Alzheimer's Disease Center, Boston University School of Medicine, Boston, MA, USA.
Min SJ; Department of Chemical & Molecular Engineering/Applied Chemistry, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, Republic of Korea.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 856-868.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Enzyme Inhibitors/*pharmacology
Heterochromatin/*drug effects
Histone-Lysine N-Methyltransferase/*antagonists & inhibitors
Huntington Disease/*drug therapy
Neurons/*drug effects
Animals ; Behavior, Animal/drug effects ; Biosensing Techniques ; Cell Survival/drug effects ; Cells, Cultured ; Enzyme Inhibitors/chemistry ; Fluorescence Resonance Energy Transfer ; Heterochromatin/metabolism ; Histone-Lysine N-Methyltransferase/metabolism ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Mice ; Mice, Transgenic ; Molecular Structure ; Neurons/metabolism ; Neurons/pathology
Czasopismo naukowe
Tytuł :
Advances in the creation of animal models of paroxysmal nocturnal hemoglobinuria.
Autorzy :
Chen Y; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Rong F; Department of Hematology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
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Źródło :
Hematology (Amsterdam, Netherlands) [Hematology] 2021 Dec; Vol. 26 (1), pp. 491-496.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Hemoglobinuria, Paroxysmal/*pathology
Animals ; Gene Knockout Techniques ; Hemoglobinuria, Paroxysmal/genetics ; Hemolysis ; Humans ; Macaca mulatta ; Membrane Proteins/genetics ; Mice ; Mutation
Czasopismo naukowe
Tytuł :
SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications.
Autorzy :
Yuan L; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, People's Republic of China.
Tang Q; Department of Microbiology, Howard University College of Medicine, Washington, DC, USA.
Zhu H; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People's Republic of China.; Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, People's Republic of China.
Guan Y; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People's Republic of China.; Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, People's Republic of China.
Cheng T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, People's Republic of China.
Xia N; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, People's Republic of China.; Research Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen, People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 1881-1889.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Models, Animal*
COVID-19/*virology
Primates/*virology
SARS-CoV-2/*physiology
Animals ; Antiviral Agents/administration & dosage ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/pathology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Humans ; Primates/immunology ; SARS-CoV-2/genetics
Czasopismo naukowe
Tytuł :
Human-like Response of Pig T Cells to Superagonistic Anti-CD28 Monoclonal Antibodies.
Autorzy :
Uehlein S; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Ding X; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Flößer J; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Schmidt S; Department of Pathobiology, Institute of Immunology, University of Veterinary Medicine Vienna, Vienna, Austria.
Steitz J; Faculty of Medicine, Institute for Laboratory Animal Science, RWTH Aachen University, Aachen, Germany.
Bille M; Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany; and.
Schnitter F; Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany; and.; Department of Medicine I, University Hospital Würzburg, Würzburg, Germany.
Baltes S; Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany; and.
Saalmüller A; Department of Pathobiology, Institute of Immunology, University of Veterinary Medicine Vienna, Vienna, Austria.
Gerner W; Department of Pathobiology, Institute of Immunology, University of Veterinary Medicine Vienna, Vienna, Austria.
Herrmann T; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Frey A; Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany; and.; Department of Medicine I, University Hospital Würzburg, Würzburg, Germany.
Kerkau T; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Hofmann U; Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany; and.; Department of Medicine I, University Hospital Würzburg, Würzburg, Germany.
Beyersdorf N; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany; .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Nov 15; Vol. 207 (10), pp. 2473-2488. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Animal*
Antibodies, Monoclonal/*immunology
CD28 Antigens/*immunology
Swine/*immunology
T-Lymphocytes/*immunology
Animals ; Antibodies, Monoclonal/pharmacology ; Humans ; Lymphocyte Activation/immunology
Czasopismo naukowe
Tytuł :
The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2.
Autorzy :
Ryu DK; Biotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Kang B; Biotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Noh H; Biotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Woo SJ; Science Unit, International Vaccine Institute, Seoul, South Korea.
Lee MH; New Drug Development Center, Osong Medical Innovation Foundation, Cheongju, South Korea.
Nuijten PM; Viroclinics Biosciences, Rotterdam, the Netherlands.
Kim JI; Biotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Seo JM; Biotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Kim C; Biotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Kim M; Biotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Yang E; Science Unit, International Vaccine Institute, Seoul, South Korea.
Lim G; Science Unit, International Vaccine Institute, Seoul, South Korea.
Kim SG; Science Unit, International Vaccine Institute, Seoul, South Korea.
Eo SK; Science Unit, International Vaccine Institute, Seoul, South Korea.
Choi JA; Science Unit, International Vaccine Institute, Seoul, South Korea.
Song M; Science Unit, International Vaccine Institute, Seoul, South Korea.
Oh SS; New Drug Development Center, Osong Medical Innovation Foundation, Cheongju, South Korea.
Chung HY; New Drug Development Center, Osong Medical Innovation Foundation, Cheongju, South Korea.
Tijsma AS; Viroclinics Biosciences, Rotterdam, the Netherlands.
van Baalen CA; Viroclinics Biosciences, Rotterdam, the Netherlands.
Kwon KS; Biotechnology Research Institute, Celltrion Inc., Incheon, South Korea.
Lee SY; Biotechnology Research Institute, Celltrion Inc., Incheon, South Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Nov 12; Vol. 578, pp. 91-96. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Antibodies, Monoclonal, Humanized/*pharmacology
Antibodies, Neutralizing/*pharmacology
COVID-19/*drug therapy
Immunoglobulin G/*pharmacology
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/pharmacology ; Body Weight/drug effects ; COVID-19/virology ; Female ; Humans ; Mice, Transgenic ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Survival Analysis
Czasopismo naukowe
Tytuł :
Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology.
Autorzy :
Vitner EB; Departments of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel .
Avraham R; Departments of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Politi B; Departments of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Melamed S; Departments of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Israely T; Departments of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel .
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Źródło :
Life science alliance [Life Sci Alliance] 2021 Nov 11; Vol. 5 (1). Date of Electronic Publication: 2021 Nov 11 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
COVID-19/*metabolism
Sphingolipids/*metabolism
Virus Replication/*physiology
Animals ; COVID-19/prevention & control ; COVID-19/virology ; Chlorocebus aethiops ; Chromatography, Liquid/methods ; Dioxanes/pharmacology ; Gangliosides/blood ; Gangliosides/metabolism ; Glucosyltransferases/antagonists & inhibitors ; Glucosyltransferases/metabolism ; Humans ; Mass Spectrometry/methods ; Mice, Transgenic ; Pyrrolidines/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Sphingolipids/blood ; Sphingosine/analogs & derivatives ; Sphingosine/blood ; Sphingosine/metabolism ; Vero Cells ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Arbutin protects brain against middle cerebral artery occlusion-reperfusion (MCAo/R) injury.
Autorzy :
Kumar M; Chitkara College of Pharmacy, Chitkara University, Punjab, India; Department of Pharmacology, Swift School of Pharmacy, Rajpura, Patiala, Punjab, India. Electronic address: .
Singh G; Department of Pharmacology, Swift School of Pharmacy, Rajpura, Patiala, Punjab, India.
Kushwah AS; Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Ropar, Punjab, India.
Surampalli G; Bharat Institute of Technology (BIT), Ibrahimpatnam, Hyderabad, India.
Singh TG; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Gupta S; Department of Pharmacology, Swift School of Pharmacy, Rajpura, Patiala, Punjab, India.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Nov 05; Vol. 577, pp. 52-57. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Arbutin/*pharmacology
Brain/*drug effects
Infarction, Middle Cerebral Artery/*prevention & control
Reperfusion Injury/*prevention & control
Animals ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/physiology ; Brain/physiopathology ; Chromatography, High Pressure Liquid ; Glutamic Acid/metabolism ; Humans ; Infarction, Middle Cerebral Artery/physiopathology ; Male ; Maze Learning/drug effects ; Maze Learning/physiology ; Memory, Short-Term/drug effects ; Memory, Short-Term/physiology ; Mice ; Neuroprotective Agents/pharmacology ; Neurotransmitter Agents/metabolism ; Permeability/drug effects ; Reperfusion Injury/physiopathology ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Tytuł :
Deficiency of cGAS signaling protects against sepsis-associated encephalopathy.
Autorzy :
Tan C; Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, PR China.
Xu F; Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, 410000, PR China.
Xie Q; Department of Cardiology, People's Hospital of Hunan Province, Changsha, 410000, PR China.
Li F; Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, PR China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Nov 05; Vol. 577, pp. 38-44. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Nucleotidyltransferases/*genetics
Sepsis-Associated Encephalopathy/*genetics
Signal Transduction/*genetics
Animals ; Animals, Newborn ; Astrocytes/metabolism ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/physiopathology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Humans ; Interferon Type I/metabolism ; Male ; Maze Learning/physiology ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/metabolism ; Neurons/metabolism ; Nucleotidyltransferases/deficiency ; Protective Agents/metabolism ; Sepsis/genetics ; Sepsis/metabolism ; Sepsis/physiopathology ; Sepsis-Associated Encephalopathy/metabolism
Czasopismo naukowe
Tytuł :
Tracking of human embryonic stem cell-derived mesenchymal stem cells in premature ovarian failure model mice.
Autorzy :
Bahrehbar K; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address: .
Khanjarpoor Malakhond M; Department of Medical Education Management, Yasuj University of Medical Sciences, Yasuj, Iran. Electronic address: .
Gholami S; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Nov 05; Vol. 577, pp. 6-11. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Human Embryonic Stem Cells/*metabolism
Mesenchymal Stem Cell Transplantation/*methods
Mesenchymal Stem Cells/*metabolism
Primary Ovarian Insufficiency/*therapy
Animals ; Cell Differentiation ; Cell Movement ; Cell Tracking/methods ; Cells, Cultured ; Cyclophosphamide ; Female ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Human Embryonic Stem Cells/cytology ; Humans ; Lung/cytology ; Lung/metabolism ; Mesenchymal Stem Cells/cytology ; Mice, Inbred C57BL ; Microscopy, Fluorescence/methods ; Myocardium/cytology ; Myocardium/metabolism ; Ovary/cytology ; Ovary/metabolism ; Primary Ovarian Insufficiency/chemically induced ; Primary Ovarian Insufficiency/metabolism
Czasopismo naukowe
Tytuł :
Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model.
Autorzy :
Kaczmarek JV; Division of Ocular Oncology and Pathology, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Bogan CM; Division of Ocular Oncology and Pathology, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Pierce JM; Division of Ocular Oncology and Pathology, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Tao YK; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States.
Chen SC; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Liu Q; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Liu X; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Boyd KL; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Calcutt MW; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, United States.
Bridges TM; Warren Center for Neuroscience Drug Discovery at Vanderbilt, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States.
Lindsley CW; Warren Center for Neuroscience Drug Discovery at Vanderbilt, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States.
Friedman DL; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Richmond A; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, Tennessee, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States.; Program in Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States.
Daniels AB; Division of Ocular Oncology and Pathology, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Program in Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States.; Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2021 Nov 01; Vol. 62 (14), pp. 8.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Disease Models, Animal*
Neoplasm Seeding*
Histone Deacetylase Inhibitors/*therapeutic use
Hydroxamic Acids/*therapeutic use
Retina/*drug effects
Retinal Neoplasms/*drug therapy
Retinoblastoma/*drug therapy
Sulfonamides/*therapeutic use
Animals ; Annexin A5 ; Antineoplastic Agents, Alkylating/therapeutic use ; Electroretinography ; Fluorescein Angiography ; Histone Deacetylase Inhibitors/pharmacokinetics ; Histone Deacetylase Inhibitors/toxicity ; Hydroxamic Acids/pharmacokinetics ; Hydroxamic Acids/toxicity ; Intravitreal Injections ; Maximum Tolerated Dose ; Melphalan/therapeutic use ; Rabbits ; Retina/physiology ; Retinal Neoplasms/diagnosis ; Retinal Neoplasms/physiopathology ; Retinoblastoma/diagnosis ; Retinoblastoma/physiopathology ; Retrospective Studies ; Sulfonamides/pharmacokinetics ; Sulfonamides/toxicity ; Tomography, Optical Coherence ; Vitreous Body/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Systematic review on the reporting accuracy of experimental details in publications using mouse femoral fracture models.
Autorzy :
Wolter A; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany; German Rheumatism Research Centre (DRFZ) Berlin, A Leibniz Institute, Pitzer Laboratory of Osteoarthritis Research, Berlin, Germany. Electronic address: .
Rapp AE; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany; German Rheumatism Research Centre (DRFZ) Berlin, A Leibniz Institute, Pitzer Laboratory of Osteoarthritis Research, Berlin, Germany. Electronic address: .
Durst MS; Division of Surgical Research, University Hospital Zurich, University Zurich, Switzerland. Electronic address: .
Hildebrand L; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Center for Regenerative Therapies, Berlin, Germany. Electronic address: .
Löhning M; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany; German Rheumatism Research Centre (DRFZ) Berlin, A Leibniz Institute, Pitzer Laboratory of Osteoarthritis Research, Berlin, Germany. Electronic address: .
Buttgereit F; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany; German Rheumatism Research Centre (DRFZ) Berlin, A Leibniz Institute, Pitzer Laboratory of Osteoarthritis Research, Berlin, Germany. Electronic address: .
Schmidt-Bleek K; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Center for Regenerative Therapies, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Julius Wolff Institute, Berlin, Germany. Electronic address: .
Jirkof P; Division of Surgical Research, University Hospital Zurich, University Zurich, Switzerland; Office for Animal Welfare and 3Rs, University of Zurich, Switzerland. Electronic address: .
Lang A; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany; German Rheumatism Research Centre (DRFZ) Berlin, A Leibniz Institute, Pitzer Laboratory of Osteoarthritis Research, Berlin, Germany. Electronic address: .
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Źródło :
Bone [Bone] 2021 Nov; Vol. 152, pp. 116088. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Femoral Fractures*/diagnostic imaging
Animals ; Bone Regeneration ; Humans ; Mice ; Pain ; Pain Management ; Periodicals as Topic/standards
Czasopismo naukowe
Tytuł :
Endothelial Nitric Oxide Synthase-Deficient Mice: A Model of Spontaneous Cerebral Small-Vessel Disease.
Autorzy :
Liao FF; Department of Pharmacology, Addiction Science, Toxicology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee. Electronic address: .
Lin G; Department of Pharmacology, Addiction Science, Toxicology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee; Department of Histology and Embryology, Basic Medical University, China Medical University, Shenyang, China.
Chen X; Department of Pharmacology, Addiction Science, Toxicology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee; Department of Neurology, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, China.
Chen L; Department of Pharmacology, Addiction Science, Toxicology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee; Department of Cell Biology and Genetics, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Zheng W; Department of Pharmacology, Addiction Science, Toxicology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee; Department of Histology and Embryology, Basic Medical University, China Medical University, Shenyang, China.
Raghow R; Department of Pharmacology, Addiction Science, Toxicology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee.
Zhou FM; Department of Pharmacology, Addiction Science, Toxicology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee.
Shih AY; Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, Washington.
Tan XL; Department of Pharmacology, Addiction Science, Toxicology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee; Department of Neurology, Nanhai Hospital of Southern Medical University, Foshan, China.
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Źródło :
The American journal of pathology [Am J Pathol] 2021 Nov; Vol. 191 (11), pp. 1932-1945. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Disease Models, Animal*
Bone Morphogenetic Protein 4/*metabolism
Cerebral Small Vessel Diseases/*metabolism
Cerebral Small Vessel Diseases/*physiopathology
Nitric Oxide Synthase Type III/*deficiency
Animals ; Cerebral Small Vessel Diseases/pathology ; Mice
Czasopismo naukowe
Tytuł :
Role of high-density lipoproteins in cardioprotection and in reverse remodeling: Therapeutic implications.
Autorzy :
De Geest B; Centre for Molecular and Vascular Biology, Catholic University of Leuven, Leuven, Belgium. Electronic address: .
Mishra M; Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2021 Nov; Vol. 1866 (11), pp. 159022. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Models, Animal*
Fibrosis/*metabolism
Lipoproteins, HDL/*metabolism
Myocardial Ischemia/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Cardiotonic Agents/therapeutic use ; Fibrosis/drug therapy ; Humans ; Myocardial Ischemia/drug therapy ; Myocytes, Cardiac/drug effects
Czasopismo naukowe
Tytuł :
Of mice and men - and guinea pigs?
Autorzy :
Maxeiner S; Institute for Anatomy and Cell Biology, Saarland University, Homburg, Germany. Electronic address: .
Gebhardt S; Institute for Anatomy and Cell Biology, Saarland University, Homburg, Germany.
Schweizer F; Institute for Anatomy and Cell Biology, Saarland University, Homburg, Germany.
Venghaus AE; Institute for Anatomy and Cell Biology, Saarland University, Homburg, Germany.
Krasteva-Christ G; Institute for Anatomy and Cell Biology, Saarland University, Homburg, Germany.
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Źródło :
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft [Ann Anat] 2021 Nov; Vol. 238, pp. 151765. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Guinea Pigs*
Models, Animal*
Animals ; Mammals ; Rats
Czasopismo naukowe
Tytuł :
Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis.
Autorzy :
Rai P; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, USA.
Chuong C; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, USA.
LeRoith T; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, USA.
Smyth JW; Center for Heart and Reparative Medicine, Fralin Biomedical Research Institute, Roanoke, VA, USA; Department of Biological Sciences, College of Science, Virginia Polytechnic State Institute and State University, Blacksburg, VA, USA; Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
Panov J; Tauber Bioinformatics Research Center, Haifa 3498838, Israel; Sagol Department of Neurobiology, University of Haifa, Haifa 3498838, Israel.
Levi M; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA.
Kehn-Hall K; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, USA.
Duggal NK; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, USA.
Lucarelli JW; Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, USA. Electronic address: .
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Źródło :
Virology [Virology] 2021 Nov; Vol. 563, pp. 98-106. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
COVID-19/*epidemiology
Obesity/*epidemiology
Animals ; Chlorocebus aethiops ; Comorbidity ; Female ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Morbidity ; Vero Cells
Czasopismo naukowe

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