Temat: "Models, Animal" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Smurf1 regulates ameloblast polarization by ubiquitination-mediated degradation of RhoA.
Autorzy:: Niu H; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Oral Pathology, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Bi F; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Zhao W; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Oral Pathology, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Xu Y; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Han Q; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Oral Pathology, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Guo W; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Chen Y; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Oral Pathology, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Pokaż więcej
Źródło:: Cell proliferation [Cell Prolif] 2023 Apr; Vol. 56 (4), pp. e13387. Date of Electronic Publication: 2022 Dec 29.
Typ publikacji:: Journal Article
MeSH Terms:: Ubiquitin-Protein Ligases*/metabolism
Signal Transduction*/physiology
Mice ; Rats ; Animals ; Ameloblasts/metabolism ; Actins/metabolism ; Ubiquitination ; Disease Models, Animal

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Skocz do pozycji: 2.

Tytuł:: Transfer of knowledge from model organisms to evolutionarily distant non-model organisms: The coral Pocillopora damicornis membrane signaling receptome.
Autorzy:: Kumar L; Department of Chemistry, Colorado School of Mines, Golden, CO, United States of America.
Brenner N; Department of Chemistry, Colorado School of Mines, Golden, CO, United States of America.
Sledzieski S; MIT Computer Science & Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
Olaosebikan M; Department of Computer Science, Tufts University, Medford, MA, United States of America.
Roger LM; Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, United States of America.
Lynn-Goin M; Department of Chemistry, Colorado School of Mines, Golden, CO, United States of America.
Klein-Seetharaman R; Yale University, New Haven, CT, United States of America.
Berger B; MIT Computer Science & Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
Putnam H; Department of Biological Sciences, University of Rhode Island, South Kingstown, RI, United States of America.
Yang J; Department of Department of Aeronautics & Astronautics, University of Washington, Seattle, WA, United States of America.
Lewinski NA; Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, United States of America.
Singh R; MIT Computer Science & Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
Daniels NM; Department of Computer Science and Statistics, University of Rhode Island, South Kingstown, RI, United States of America.
Cowen L; Department of Computer Science, Tufts University, Medford, MA, United States of America.
Klein-Seetharaman J; Department of Chemistry, Colorado School of Mines, Golden, CO, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Feb 03; Vol. 18 (2), pp. e0270965. Date of Electronic Publication: 2023 Feb 03 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Anthozoa*/genetics
Anthozoa*/physiology
Receptors, G-Protein-Coupled*/genetics
Receptors, G-Protein-Coupled*/metabolism
Signal Transduction*
Animals ; Humans ; Genome ; Models, Animal

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Skocz do pozycji: 3.

Tytuł:: S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma.
Autorzy:: Wang X; Department of Surgery, School of Medicine, University of Louisville, 511 S Floyd ST MDR Bldg Rm326A, Louisville, KY, 40202, USA.; Department of Hematology, Cancer Center, The First Hospital of Jilin University, No. 71. Xinmin Street, Changchun, 130021, Jilin, China.
Guo W; Department of Surgery, School of Medicine, University of Louisville, 511 S Floyd ST MDR Bldg Rm326A, Louisville, KY, 40202, USA.; Department of Hematology, Cancer Center, The First Hospital of Jilin University, No. 71. Xinmin Street, Changchun, 130021, Jilin, China.
Shi X; Department of Surgery, School of Medicine, University of Louisville, 511 S Floyd ST MDR Bldg Rm326A, Louisville, KY, 40202, USA.; Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Chen Y; Department of Surgery, School of Medicine, University of Louisville, 511 S Floyd ST MDR Bldg Rm326A, Louisville, KY, 40202, USA.; Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Yu Y; Department of Surgery, School of Medicine, University of Louisville, 511 S Floyd ST MDR Bldg Rm326A, Louisville, KY, 40202, USA.; Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Du B; Department of Cardiology, China-Japan Union hospital of Jilin University, Changchun, 130033, China.
Tan M; Department of Surgery, School of Medicine, University of Louisville, 511 S Floyd ST MDR Bldg Rm326A, Louisville, KY, 40202, USA.
Tong L; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Wang A; Department of Hematology, Cancer Center, The First Hospital of Jilin University, No. 71. Xinmin Street, Changchun, 130021, Jilin, China.
Yin X; Department of Hematology, Cancer Center, The First Hospital of Jilin University, No. 71. Xinmin Street, Changchun, 130021, Jilin, China.
Guo J; Department of Hematology, Cancer Center, The First Hospital of Jilin University, No. 71. Xinmin Street, Changchun, 130021, Jilin, China.
Martin RC; Department of Surgery, School of Medicine, University of Louisville, 511 S Floyd ST MDR Bldg Rm326A, Louisville, KY, 40202, USA.
Bai O; Department of Hematology, Cancer Center, The First Hospital of Jilin University, No. 71. Xinmin Street, Changchun, 130021, Jilin, China. .
Li Y; Department of Surgery, School of Medicine, University of Louisville, 511 S Floyd ST MDR Bldg Rm326A, Louisville, KY, 40202, USA. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Jan 05; Vol. 42 (1), pp. 3. Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*
Neoplasms*
Animals ; Mice ; Humans ; Sphingosine-1-Phosphate Receptors/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Disease Models, Animal ; Obesity/complications ; Obesity/genetics ; Tumor Microenvironment ; Arachidonate 15-Lipoxygenase ; Arachidonate 12-Lipoxygenase/metabolism

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Skocz do pozycji: 4.

Tytuł:: What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 4: Experimental Treatments in Pre-Clinical Studies (Cell Lines and Mouse Models).
Autorzy:: Palicelli A; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Croci S; Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Bisagni A; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Zanetti E; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
De Biase D; Department of Pharmacy and Biotechnology (FABIT), University of Bologna, 40126 Bologna, Italy.
Melli B; Fertility Center, Department of Obstetrics and Gynecology, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.; International Doctorate School in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Sanguedolce F; Pathology Unit, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.
Ragazzi M; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Zanelli M; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Chaux A; Department of Scientific Research, School of Postgraduate Studies, Norte University, Asunción 1614, Paraguay.
Cañete-Portillo S; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Bonasoni MP; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Soriano A; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.; Gastroenterology Division, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Ascani S; Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy.; Haematopathology Unit, CREO, Azienda Ospedaliera di Perugia, University of Perugia, 06129 Perugia, Italy.
Zizzo M; Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Castro Ruiz C; International Doctorate School in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy.; Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
De Leo A; Molecular Diagnostic Unit, Azienda USL Bologna, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Giordano G; Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Landriscina M; Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Carrieri G; Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy.
Cormio L; Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy.
Berney DM; Barts Cancer Institute, Queen Mary University of London, London EC1M 5PZ, UK.
Gandhi J; Department of Pathology and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
Santandrea G; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.; International Doctorate School in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Bonacini M; Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 14; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 14.
Typ publikacji:: Journal Article; Systematic Review
MeSH Terms:: Disease Models, Animal*
B7-H1 Antigen/*immunology
Immunotherapy/*methods
Prostatic Neoplasms/*therapy
Signal Transduction/*immunology
Animals ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Male ; Mice ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/immunology ; Signal Transduction/genetics

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Skocz do pozycji: 5.

Tytuł:: Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer's Disease.
Autorzy:: González de San Román E; Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Llorente-Ovejero A; Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Martínez-Gardeazabal J; Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Moreno-Rodríguez M; Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Giménez-Llort L; Department of Psychiatry and Forensic Medicine, Institute of Neuroscience, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Manuel I; Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.; Neurodegenerative Diseases, BioCruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
Rodríguez-Puertas R; Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.; Neurodegenerative Diseases, BioCruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 12; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:: Journal Article
MeSH Terms:: Disease Models, Animal*
Signal Transduction*
Alzheimer Disease/*metabolism
Lipids/*analysis
Lysophospholipids/*metabolism
Sphingosine/*analogs & derivatives
Alzheimer Disease/genetics ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Brain/metabolism ; Fatty Acids, Unsaturated/metabolism ; Hippocampus/metabolism ; Humans ; Male ; Mice, Transgenic ; Phospholipids/metabolism ; Presenilin-1/genetics ; Presenilin-1/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Sphingosine/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism

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Skocz do pozycji: 6.

Tytuł:: Dihydromyricetin Attenuates Depressive-like Behaviors in Mice by Inhibiting the AGE-RAGE Signaling Pathway.
Autorzy:: Huang J; School of Basic Medical Sciences, Shaoyang University, Shaoyang 422000, China.
Chen B; Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou 570100, China.
Wang H; School of Basic Medical Sciences, Shaoyang University, Shaoyang 422000, China.
Hu S; Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou 570100, China.; The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
Yu X; School of Basic Medical Sciences, Shaoyang University, Shaoyang 422000, China.
Reilly J; Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow G4 0BA, UK.
He Z; School of Basic Medical Sciences, Shaoyang University, Shaoyang 422000, China.
You Y; Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou 570100, China.; The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
Shu X; School of Basic Medical Sciences, Shaoyang University, Shaoyang 422000, China.; Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow G4 0BA, UK.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Nov 22; Vol. 11 (23). Date of Electronic Publication: 2022 Nov 22.
Typ publikacji:: Journal Article
MeSH Terms:: Glycation End Products, Advanced*/pharmacology
Signal Transduction*
Animals ; Mice ; Cytokines/metabolism ; Inflammation/drug therapy ; Disease Models, Animal

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Skocz do pozycji: 7.

Tytuł:: Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe Covid-19 pathology.
Autorzy:: Al-Ani B; Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
ShamsEldeen AM; Department of Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt.
Kamar SS; Department of Medical Histology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt.
Haidara MA; Department of Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt.
Al-Hashem F; Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Alshahrani MY; Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi Arabia.; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Al-Hakami AM; Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Kader DHA; Department of Medical Histology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt.
Maarouf A; Department of Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Pokaż więcej
Źródło:: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2022 Apr; Vol. 49 (4), pp. 483-491. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*
Acute Lung Injury/*etiology
Blood Coagulation Disorders/*etiology
COVID-19/*pathology
Cytokine Release Syndrome/*etiology
Hemorrhage/*etiology
Lipopolysaccharides/*adverse effects
Lung Diseases/*etiology
Receptor, Angiotensin, Type 1/*metabolism
STAT Transcription Factors/*metabolism
Acute Lung Injury/pathology ; Animals ; Blood Coagulation Disorders/pathology ; COVID-19/etiology ; Cytokine Release Syndrome/pathology ; Disease Models, Animal ; Hemorrhage/pathology ; Janus Kinases ; Lung Diseases/pathology ; Male ; Rats ; Rats, Wistar

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Skocz do pozycji: 8.

Tytuł:: Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model.
Autorzy:: Sakai D; Department of Biology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan. .
Sugawara T; Department of Medical Life Systems, Doshisha University, Kyotanabe, Kyoto, 610-0394, Japan.
Kurokawa T; Department of Medical Life Systems, Doshisha University, Kyotanabe, Kyoto, 610-0394, Japan.
Murakami Y; Department of Hygiene and Public Health, Kansai Medical University, Osaka, Hirakata, 573-1010, Japan.
Tomosugi M; Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.
Masuta H; Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.
Sakata-Haga H; Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.
Hatta T; Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.
Shoji H; Department of Biology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.; Pokaż więcej
Źródło:: Molecular brain [Mol Brain] 2022 Mar 31; Vol. 15 (1), pp. 28. Date of Electronic Publication: 2022 Mar 31.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Hypoxia*
Signal Transduction*
Animals ; Disease Models, Animal ; Mice ; Mice, Knockout ; Neurons

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Skocz do pozycji: 9.

Tytuł:: Dexmedetomidine alleviates airway hyperresponsiveness and allergic airway inflammation through the TLR4/NF‑κB signaling pathway in mice.
Autorzy:: Xiao S; Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China.
Wang Q; Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China.
Gao H; Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China.
Zhao X; Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China.
Zhi J; Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China.
Yang D; Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2022 Mar; Vol. 25 (3). Date of Electronic Publication: 2022 Jan 11.
Typ publikacji:: Journal Article
MeSH Terms:: Asthma/*metabolism
Dexmedetomidine/*pharmacology
NF-kappa B/*metabolism
Respiratory Hypersensitivity/*metabolism
Signal Transduction/*drug effects
Toll-Like Receptor 4/*metabolism
Animals ; Anti-Inflammatory Agents ; Asthma/drug therapy ; Asthma/etiology ; Asthma/pathology ; Biomarkers ; Bronchoalveolar Lavage Fluid ; Cytokines/metabolism ; Dexmedetomidine/therapeutic use ; Disease Models, Animal ; Disease Susceptibility ; Female ; Immunohistochemistry ; Mice ; Mucus/metabolism ; Respiratory Hypersensitivity/drug therapy ; Respiratory Hypersensitivity/etiology ; Respiratory Hypersensitivity/pathology

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Skocz do pozycji: 10.

Tytuł:: Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse.
Autorzy:: Kallenbach JG; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.
Freeberg MAT; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.
Abplanalp D; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.
Alenchery RG; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.
Ajalik RE; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.
Muscat S; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.
Myers JA; UR Genomics Research Center (GRC), University of Rochester Medical Center, Rochester, NY, USA.
Ashton JM; UR Genomics Research Center (GRC), University of Rochester Medical Center, Rochester, NY, USA.
Loiselle A; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY, 14642, USA.
Buckley MR; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.
van Wijnen AJ; Department of Biochemistry, University of Vermont, Burlington, VT, USA.
Awad HA; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA. hani_.; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA. hani_.; Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY, 14642, USA. hani_.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Feb 22; Vol. 12 (1), pp. 3026. Date of Electronic Publication: 2022 Feb 22.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Gene Expression Regulation, Developmental/*genetics
Gene Expression Regulation, Developmental/*physiology
Regeneration/*genetics
Regeneration/*physiology
Signal Transduction/*genetics
Signal Transduction/*physiology
Tendon Injuries/*physiopathology
Tendons/*physiology
Transforming Growth Factor beta1/*metabolism
Transforming Growth Factor beta1/*physiology
Wound Healing/*genetics
Wound Healing/*physiology
Animals ; Cell Adhesion/genetics ; Cell Adhesion/physiology ; Cell Cycle/genetics ; Cell Cycle/physiology ; Cell Proliferation/genetics ; Cell Proliferation/physiology ; Fibrosis/genetics ; Inflammation/genetics ; Mice, Inbred C57BL ; Mice, Inbred MRL lpr ; Models, Animal ; Tendons/cytology ; Mice

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Skocz do pozycji: 11.

Tytuł:: Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer.
Autorzy:: Buensuceso A; The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, ON, N6A 4L6, Canada.; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Fritz JL; The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, ON, N6A 4L6, Canada.; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Collins O; The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, ON, N6A 4L6, Canada.
Valdés YR; The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, ON, N6A 4L6, Canada.
Borrelli MJ; The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, ON, N6A 4L6, Canada.; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
DiMattia GE; The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, ON, N6A 4L6, Canada.; Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Shepherd TG; The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, ON, N6A 4L6, Canada. .; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. .; Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. .; Department of Obstetrics and Gynaecology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Feb 22; Vol. 12 (1), pp. 3011. Date of Electronic Publication: 2022 Feb 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Loss of Function Mutation*
Spheroids, Cellular*/metabolism
Spheroids, Cellular*/physiology
AMP-Activated Protein Kinase Kinases/*genetics
AMP-Activated Protein Kinase Kinases/*physiology
NF-kappa B/*metabolism
Ovarian Neoplasms/*genetics
Ovarian Neoplasms/*metabolism
Protein Kinases/*genetics
Protein Kinases/*physiology
Repressor Proteins/*genetics
Repressor Proteins/*physiology
Signal Transduction/*genetics
Signal Transduction/*physiology
Animals ; Cell Survival ; Disease Models, Animal ; Female ; Gene Expression Profiling ; Humans ; Mice ; Molecular Targeted Therapy ; Neoplasm Transplantation ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/therapy ; Reactive Oxygen Species/metabolism ; Transcriptome/genetics ; Tumor Cells, Cultured

Czasopismo naukowe

na półce

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Skocz do pozycji: 12.

Tytuł:: Selenium-Rich Yeast Peptide Fraction Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in Mice by Inhibiting Inflammation via MAPK and NF-κB Signaling Pathways.
Autorzy:: Guo H; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Li M; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Liu H; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.; Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Wuhan 430074, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Feb 14; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 14.
Typ publikacji:: Journal Article
MeSH Terms:: Dermatitis/*drug therapy
Inflammation/*drug therapy
Peptides/*pharmacology
Psoriasis/*drug therapy
Selenium/*pharmacology
Signal Transduction/*drug effects
Yeasts/*metabolism
Animals ; Cell Line ; Dermatitis/metabolism ; Disease Models, Animal ; Female ; Humans ; Hydrogen Peroxide/pharmacology ; Imiquimod/pharmacology ; Inflammation/metabolism ; Interleukin-17/metabolism ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Mice ; Mice, Inbred BALB C ; NF-kappa B/metabolism ; Psoriasis/chemically induced ; Psoriasis/metabolism ; RAW 264.7 Cells ; Skin/drug effects ; Skin/metabolism

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Skocz do pozycji: 13.

Tytuł:: Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway.
Autorzy:: Zhou W; Department of Anesthesiology, Zhuji People's Hospital of Zhejiang Province, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang 311800, China.; Department of Anesthesiology, Zhuji People's Hospital of Zhejiang Province, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang 311800, China.
Cai D; Department of Anesthesiology, Zhuji People's Hospital of Zhejiang Province, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang 311800, China.; Department of Anesthesiology, Zhuji People's Hospital of Zhejiang Province, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang 311800, China.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2022 Feb; Vol. 100 (2), pp. 117-124. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*drug effects
Apoptosis/*genetics
JNK Mitogen-Activated Protein Kinases/*metabolism
Midazolam/*pharmacology
Myocardial Reperfusion Injury/*drug therapy
Myocardial Reperfusion Injury/*genetics
Myocytes, Cardiac/*pathology
Signal Transduction/*genetics
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Cells, Cultured ; Disease Models, Animal ; Male ; Midazolam/therapeutic use ; Myocardial Infarction/drug therapy ; Myocardial Infarction/etiology ; Myocardial Reperfusion Injury/etiology ; Myocardial Reperfusion Injury/pathology ; Rats, Sprague-Dawley ; Signal Transduction/physiology ; Rats

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Skocz do pozycji: 14.

Tytuł:: Zebrafish: A Suitable Tool for the Study of Cell Signaling in Bone.
Autorzy:: Valenti MT; Department of Medicine, University of Verona, Ple Scuro 10, 37100 Verona, Italy.
Marchetto G; Department of Medicine, University of Verona, Ple Scuro 10, 37100 Verona, Italy.
Mottes M; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100 Verona, Italy.
Dalle Carbonare L; Department of Medicine, University of Verona, Ple Scuro 10, 37100 Verona, Italy.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Aug 17; Vol. 9 (8). Date of Electronic Publication: 2020 Aug 17.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Disease Models, Animal*
Bone Diseases/*metabolism
Osteogenesis/*genetics
Signal Transduction/*genetics
Zebrafish/*genetics
Zebrafish/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Animals, Genetically Modified ; Bone Diseases/genetics ; Cell Differentiation/genetics ; Gene Expression ; Humans ; Osteoblasts/metabolism ; Zebrafish Proteins/genetics

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Skocz do pozycji: 15.

Tytuł:: Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism.
Autorzy:: Khera R; Department of Pharmacology, Neuropharmacology Division, ISF College of Pharmacy, Moga 142001, Punjab, India.
Mehan S; Department of Pharmacology, Neuropharmacology Division, ISF College of Pharmacy, Moga 142001, Punjab, India.
Bhalla S; Department of Pharmacology, Neuropharmacology Division, ISF College of Pharmacy, Moga 142001, Punjab, India.
Kumar S; Department of Pharmacology, Neuropharmacology Division, ISF College of Pharmacy, Moga 142001, Punjab, India.
Alshammari A; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Alharbi M; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Sadhu SS; Chemistry Department, Northern Michigan University, 1401, Presque, Isle, Marquette, MI 49855, USA.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Jan 28; Vol. 27 (3). Date of Electronic Publication: 2022 Jan 28.
Typ publikacji:: Journal Article
MeSH Terms:: Autism Spectrum Disorder/*drug therapy
Neuroprotective Agents/*therapeutic use
Pregnenediones/*therapeutic use
Signal Transduction/*drug effects
Animals ; Autism Spectrum Disorder/chemically induced ; Autism Spectrum Disorder/metabolism ; Disease Models, Animal ; Female ; Janus Kinases/metabolism ; Male ; PPAR gamma/metabolism ; Propionates ; Rats, Wistar ; STAT Transcription Factors/metabolism ; Rats

Czasopismo naukowe

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Skocz do pozycji: 16.

Tytuł:: NLRP3 inflammasome in rosmarinic acid-afforded attenuation of acute kidney injury in mice.
Autorzy:: Akhter J; Molecular Toxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110062, India.
Khan J; Molecular Toxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110062, India.; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Baghel M; Metabolic Research Laboratory, National Institute of Immunology, New Delhi, 110067, India.
Beg MMA; Molecular Toxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110062, India.
Goswami P; Molecular Toxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110062, India.
Afjal MA; Molecular Toxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110062, India.
Ahmad S; Molecular Toxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110062, India.
Habib H; Molecular Toxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110062, India.
Najmi AK; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University), New Delhi, India.
Raisuddin S; Molecular Toxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110062, India. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Jan 25; Vol. 12 (1), pp. 1313. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Acute Kidney Injury/*drug therapy
Acute Kidney Injury/*metabolism
Anti-Inflammatory Agents/*administration & dosage
Antioxidants/*administration & dosage
Cinnamates/*administration & dosage
Depsides/*administration & dosage
Inflammasomes/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Signal Transduction/*drug effects
Acute Kidney Injury/chemically induced ; Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Cyclooxygenase 2/metabolism ; Disease Models, Animal ; Hepatitis A Virus Cellular Receptor 1/metabolism ; Kidney Tubules, Proximal/metabolism ; Male ; Mice ; NF-kappa B/metabolism ; Treatment Outcome ; Rosmarinic Acid

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Skocz do pozycji: 17.

Tytuł:: Wounding response in Porifera (sponges) activates ancestral signaling cascades involved in animal healing, regeneration, and cancer.
Autorzy:: Wu YC; Research Unit Marine Microbiology, Department Marine Ecology, GEOMAR Helmholtz Centre for Ocean Research, Kiel, Germany.; Christian-Albrechts University of Kiel, Kiel, Germany.
Franzenburg S; Institute of Clinical Molecular Biology (IKMB), Christian-Albrechts University of Kiel, Kiel, Germany.
Ribes M; Department Marine Biology and Oceanography, Institute of Marine Sciences (ICM-CSIC), Barcelona, Spain.
Pita L; Research Unit Marine Microbiology, Department Marine Ecology, GEOMAR Helmholtz Centre for Ocean Research, Kiel, Germany. .; Department Marine Biology and Oceanography, Institute of Marine Sciences (ICM-CSIC), Barcelona, Spain. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Jan 25; Vol. 12 (1), pp. 1307. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Neoplasms/*genetics
Porifera/*genetics
Signal Transduction/*genetics
Transcriptome/*genetics
Wound Healing/*genetics
Animals ; Down-Regulation/genetics ; Ecosystem ; Gene Regulatory Networks ; Humans ; Models, Animal ; Phylogeny ; Porifera/classification ; Protein Interaction Maps/genetics ; RNA-Seq/methods ; Up-Regulation/genetics

Czasopismo naukowe

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Skocz do pozycji: 18.

Tytuł:: circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis.
Autorzy:: Hu C; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China.; Guangdong cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China.
Xia R; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.; Department of Neonatal/General Surgery, Hunan Children's Hospital, Changsha, Hunan, 410007, People's Republic of China.
Zhang X; Department of Pancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China.
Li T; School of medicine, South China University of Technology, Guangzhou, Guangdong Province, 510006, People's Republic of China.
Ye Y; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.
Li G; Department of Hepatobiliary, Pancreatic and Splenic surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510655, People's Republic of China.
He R; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China.
Li Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China.; Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, People's Republic of China.
Lin Q; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China. .
Zheng S; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China. .
Chen R; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China. .; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China. .; School of medicine, South China University of Technology, Guangzhou, Guangdong Province, 510006, People's Republic of China. .; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2022 Jan 19; Vol. 21 (1), pp. 24. Date of Electronic Publication: 2022 Jan 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Resistance, Neoplasm*/genetics
RNA, Circular*
Signal Transduction*
Cancer-Associated Fibroblasts/*metabolism
Leukemia Inhibitory Factor/*metabolism
Rho Guanine Nucleotide Exchange Factors/*genetics
STAT3 Transcription Factor/*metabolism
Animals ; Caveolin 1/metabolism ; Cell Line, Tumor ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; MicroRNAs/genetics ; Models, Biological ; Pancreatic Neoplasms ; RNA Interference ; Xenograft Model Antitumor Assays ; Gemcitabine

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Skocz do pozycji: 19.

Tytuł:: Therapeutic CFTR Correction Normalizes Systemic and Lung-Specific S1P Level Alterations Associated with Heart Failure.
Autorzy:: Uhl FE; Department of Experimental Medical Sciences, Lund University, 221 84 Lund, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, 221 84 Lund, Sweden.
Vanherle L; Department of Experimental Medical Sciences, Lund University, 221 84 Lund, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, 221 84 Lund, Sweden.
Matthes F; Department of Experimental Medical Sciences, Lund University, 221 84 Lund, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, 221 84 Lund, Sweden.
Meissner A; Department of Experimental Medical Sciences, Lund University, 221 84 Lund, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, 221 84 Lund, Sweden.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 14; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 14.
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*
Cystic Fibrosis/*complications
Cystic Fibrosis/*genetics
Cystic Fibrosis Transmembrane Conductance Regulator/*genetics
Heart Failure/*etiology
Heart Failure/*metabolism
Lysophospholipids/*metabolism
Sphingosine/*analogs & derivatives
Animals ; Biomarkers ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Disease Models, Animal ; Disease Susceptibility ; Gene Expression ; Heart Failure/diagnosis ; Lung/metabolism ; Lysophospholipids/blood ; Mice ; Organ Specificity/genetics ; Pneumonia/etiology ; Pneumonia/metabolism ; Pneumonia/pathology ; Sphingosine/blood ; Sphingosine/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism

Czasopismo naukowe

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Skocz do pozycji: 20.

Tytuł:: eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling.
Autorzy:: Bermudez T; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Sammani S; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Song JH; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Hernon VR; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Kempf CL; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Garcia AN; Department of Radiation Oncology, University of Arizona Health Sciences, Tucson, AZ, USA.
Burt J; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Hufford M; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Camp SM; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Cress AE; Department of Cellular and Molecular Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Desai AA; Department of Medicine, Indiana University, Indianapolis, IN, USA.
Natarajan V; Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Jacobson JR; Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Dudek SM; Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Cancio LC; Institute of Surgical Research, San Antonio, TX, USA.
Alvarez J; Institute of Surgical Research, San Antonio, TX, USA.
Rafikov R; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Li Y; Institute of Surgical Research, San Antonio, TX, USA.
Zhang DD; College of Pharmacy, University of Arizona Health Sciences, Tucson, AZ, USA.
Casanova NG; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Bime C; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Garcia JGN; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Jan 13; Vol. 12 (1), pp. 696. Date of Electronic Publication: 2022 Jan 13.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Acute Chest Syndrome/*metabolism
Mechanistic Target of Rapamycin Complex 2/*metabolism
NF-kappa B/*metabolism
Nicotinamide Phosphoribosyltransferase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Signal Transduction/*physiology
Animals ; Antibodies, Neutralizing/metabolism ; Biomarkers/metabolism ; COVID-19/metabolism ; Disease Models, Animal ; Inflammation/metabolism ; Lipopolysaccharides/metabolism ; Lung/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; SARS-CoV-2/pathogenicity ; Swine

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