Temat: "Models, Biological" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Use of kinetic data to model potential antioxidant activity: Radical scavenging capacity of Australian Eucalyptus honeys.
Autorzy :: Beiranvand S; GeneCology Research Centre, University of the Sunshine Coast, Qld, Australia; School of Health and Sport Sciences, University of the Sunshine Coast, Qld, Australia; CRC for Honey Bee Products Ltd., 128 Yanchep Beach Road, Yanchep, WA, Australia. Electronic address: .
Williams A; GeneCology Research Centre, University of the Sunshine Coast, Qld, Australia; School of Health and Sport Sciences, University of the Sunshine Coast, Qld, Australia.
Long S; GeneCology Research Centre, University of the Sunshine Coast, Qld, Australia; School of Health and Sport Sciences, University of the Sunshine Coast, Qld, Australia. Electronic address: .
Brooks PR; GeneCology Research Centre, University of the Sunshine Coast, Qld, Australia; School of Science and Engineering, University of the Sunshine Coast, Qld, Australia; CRC for Honey Bee Products Ltd., 128 Yanchep Beach Road, Yanchep, WA, Australia. Electronic address: .
Russell FD; GeneCology Research Centre, University of the Sunshine Coast, Qld, Australia; School of Health and Sport Sciences, University of the Sunshine Coast, Qld, Australia; CRC for Honey Bee Products Ltd., 128 Yanchep Beach Road, Yanchep, WA, Australia. Electronic address: .; Pokaż więcej
Źródło :: Food chemistry [Food Chem] 2021 Apr 16; Vol. 342, pp. 128332. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :: Journal Article
MeSH Terms :: Honey*/analysis
Models, Biological*
Eucalyptus/*chemistry
Free Radical Scavengers/*pharmacology
Australia ; Free Radical Scavengers/chemistry ; Kinetics ; Leptospermum/chemistry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Fat mass and vascular health in overweight/obese children.
Autorzy :: Licenziati MR; Obesity and Endocrine Disease Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital, Naples, Italy.
Iannuzzo G; Department of Clinical Medicine and Surgery Federico II University, Naples, Italy.
Morlino D; Department of Clinical Medicine and Surgery Federico II University, Naples, Italy.
Campana G; Obesity and Endocrine Disease Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital, Naples, Italy.
Renis M; Division of Internal Medicine, Cava dei Tirreni Hospital, Salerno, Italy.
Iannuzzi A; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, Naples, Italy. Electronic address: .
Valerio G; Department of Movement Sciences and Wellbeing, Parthenope University of Naples, Italy.; Pokaż więcej
Źródło :: Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Apr 09; Vol. 31 (4), pp. 1317-1323. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :: Journal Article
MeSH Terms :: Adiposity*
Carotid Intima-Media Thickness*
Models, Biological*
Carotid Artery Diseases/*diagnostic imaging
Pediatric Obesity/*diagnosis
Adolescent ; Age Factors ; Carotid Artery Diseases/etiology ; Child ; Child, Preschool ; Female ; Humans ; Italy ; Male ; Pediatric Obesity/complications ; Pediatric Obesity/physiopathology ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Risk Factors
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: A small molecule compound berberine as an orally active therapeutic candidate against COVID-19 and SARS: A computational and mechanistic study.
Autorzy :: Wang ZZ; Academy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou, China.; Department of Microbiology & Immunology, New York Medical College, Valhalla, NY, USA.
Li K; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
Maskey AR; Department of Microbiology & Immunology, New York Medical College, Valhalla, NY, USA.
Huang W; Department of Pathology, New York Medical College, Valhalla, NY, USA.
Toutov AA; Fuzionaire, Inc., The Woodlands, TX, USA.
Yang N; Department of Microbiology & Immunology, New York Medical College, Valhalla, NY, USA.; General Nutraceutical Technology, Elmsford, NY, USA.
Srivastava K; Department of Microbiology & Immunology, New York Medical College, Valhalla, NY, USA.; General Nutraceutical Technology, Elmsford, NY, USA.
Geliebter J; Department of Microbiology & Immunology, New York Medical College, Valhalla, NY, USA.; Department of Otolaryngology, School of Medicine, New York Medical College, Valhalla, NY, USA.
Tiwari R; Department of Microbiology & Immunology, New York Medical College, Valhalla, NY, USA.; Department of Otolaryngology, School of Medicine, New York Medical College, Valhalla, NY, USA.
Miao M; Academy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou, China.
Li XM; Department of Microbiology & Immunology, New York Medical College, Valhalla, NY, USA.; Department of Otolaryngology, School of Medicine, New York Medical College, Valhalla, NY, USA.; Pokaż więcej
Źródło :: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Apr; Vol. 35 (4), pp. e21360.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: COVID-19*/drug therapy
COVID-19*/metabolism
Models, Biological*
Severe Acute Respiratory Syndrome*/drug therapy
Severe Acute Respiratory Syndrome*/metabolism
Antiviral Agents/*pharmacology
Berberine/*pharmacology
Gene Expression Regulation/*drug effects
SARS Virus/*metabolism
SARS-CoV-2/*metabolism
Administration, Oral ; Cell Line ; Computer Simulation ; Humans ; Pandemics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: 3d tissue models as tools for radiotherapy screening for pancreatic cancer.
Autorzy :: Wishart G; Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford, UK.; Department of Physics, University of Surrey, Guildford, UK.
Gupta P; Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford, UK.
Schettino G; Department of Physics, University of Surrey, Guildford, UK.; National Physical Laboratory, Teddington, UK.
Nisbet A; Department of Physics, University of Surrey, Guildford, UK.; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
Velliou E; Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford, UK.; Centre for 3D models of Health and Disease, Division of Surgery and Interventional Science, University College London, London, United Kingdom.; Pokaż więcej
Źródło :: The British journal of radiology [Br J Radiol] 2021 Apr 01; Vol. 94 (1120), pp. 20201397. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Models, Biological*
Pancreatic Neoplasms/*radiotherapy
Radiotherapy Planning, Computer-Assisted/*methods
Humans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Rapid evolution promotes fluctuation-dependent species coexistence.
Autorzy :: Yamamichi M; School of Biological Sciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.; Department of International Health and Medical Anthropology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.
Letten AD; School of Biological Sciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.; Pokaż więcej
Źródło :: Ecology letters [Ecol Lett] 2021 Apr; Vol. 24 (4), pp. 812-818. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :: Letter
MeSH Terms :: Ecosystem*
Models, Biological*
Adaptation, Physiological ; Biological Evolution ; Plankton ; Population Dynamics
: Opinia redakcyjna

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: The model crisis, or how to have critical promiscuity in the time of Covid-19.
Autorzy :: Anderson W; University of Sydney, Sydney, NSW, Australia.; Pokaż więcej
Źródło :: Social studies of science [Soc Stud Sci] 2021 Apr; Vol. 51 (2), pp. 167-188. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :: Historical Article; Journal Article
MeSH Terms :: COVID-19*
Models, Biological*
Acquired Immunodeficiency Syndrome/history ; Biobehavioral Sciences ; History of Medicine ; History, 19th Century ; History, 20th Century ; Humans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: The unreliability of the reliability criteria in the estimation of QSAR for skin sensitivity: A pun or a reliable law?
Autorzy :: Toropov AA; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy.
Toropova AP; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy. Electronic address: .; Pokaż więcej
Źródło :: Toxicology letters [Toxicol Lett] 2021 Apr 01; Vol. 340, pp. 133-140. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :: Journal Article
MeSH Terms :: Computer Simulation*
Drug Hypersensitivity*
Drug-Related Side Effects and Adverse Reactions*
Models, Biological*
Humans ; Molecular Structure ; Quantitative Structure-Activity Relationship ; Reproducibility of Results
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Impact of updated BMD modeling methods on perchlorate and chlorate assessments of human health hazard.
Autorzy :: Haber LT; University of Cincinnati, Department of Environmental and Public Health Sciences, 160 Panzeca Way, Cincinnati, OH 45267, USA. Electronic address: .
Schoeny RS; Rita Schoeny LLC, 726 5th St NE, Washington DC, 20002, USA.
Allen BC; Independent Consultant, 101 Corbin Hill Circle, Chapel Hill, NC 27514, USA.; Pokaż więcej
Źródło :: Toxicology letters [Toxicol Lett] 2021 Apr 01; Vol. 340, pp. 89-100. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :: Journal Article
MeSH Terms :: Models, Biological*
Chlorates/*toxicity
Perchlorates/*toxicity
Chlorates/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Humans ; Iodine Radioisotopes/metabolism ; Male ; Middle Aged ; Perchlorates/administration & dosage
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients.
Autorzy :: Yao X; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.
Yan X; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, 999077, China.
Wang X; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Cai T; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Zhang S; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Cui C; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.
Wang X; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Hou Z; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Liu Q; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, China.
Li H; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, 100191, China.
Lin J; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Xiong Z; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Liu D; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China. .; Pokaż więcej
Źródło :: European journal of clinical pharmacology [Eur J Clin Pharmacol] 2021 Apr; Vol. 77 (4), pp. 583-593. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :: Journal Article; Meta-Analysis
MeSH Terms :: Drug Repositioning*
Models, Biological*
COVID-19/*drug therapy
Chloroquine/*analogs & derivatives
Administration, Oral ; Adult ; Aged ; COVID-19/virology ; Chloroquine/administration & dosage ; Chloroquine/adverse effects ; Chloroquine/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Gastrointestinal Absorption ; Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; SARS-CoV-2/drug effects
SCR Protocol :: COVID-19 drug treatment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Key event-informed risk models for benzene-induced acute myeloid leukaemia.
Autorzy :: North CM; ExxonMobil Biomedical Sciences, Inc., Annandale, NJ, USA. Electronic address: .
Schnatter AR; EpiSolutions LLC, Melbourne, FL, USA.
Rooseboom M; Shell International B.V. The Hague, the Netherlands.
Aygun Kocabas N; Total Refining and Chemicals, Feluy, Belgium.
Dalzell A; Penman Consulting Limited, Wantage, UK.
Williams SD; Penman Consulting Limited, Wantage, UK.; Pokaż więcej
Źródło :: Toxicology letters [Toxicol Lett] 2021 Apr 01; Vol. 340, pp. 141-152. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :: Journal Article
MeSH Terms :: Models, Biological*
Occupational Exposure*
Benzene/*toxicity
Leukemia, Myeloid, Acute/*chemically induced
Humans ; Risk Assessment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.
Autorzy :: Rajoli RKR; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Pertinez H; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Arshad U; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Box H; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Tatham L; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Curley P; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Neary M; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Sharp J; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Liptrott NJ; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Valentijn A; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
David C; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Rannard SP; Department of Chemistry, University of Liverpool, Liverpool, UK.
Aljayyoussi G; Centre for Drugs and Diagnostics, and Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Pennington SH; Centre for Drugs and Diagnostics, and Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Hill A; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Boffito M; Chelsea and Westminster NHS Foundation Trust and St Stephen's AIDS Trust 4th Floor, Chelsea and Westminster Hospital, London, UK.; Jefferiss Research Trust Laboratories, Department of Medicine, Imperial College, London, UK.
Ward SA; Centre for Drugs and Diagnostics, and Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Khoo SH; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.
Bray PG; Pat Bray Electrical, Orrell, Wigan, UK.
O'Neill PM; Department of Chemistry, University of Liverpool, Liverpool, UK.
Hong WD; Department of Chemistry, University of Liverpool, Liverpool, UK.
Biagini GA; Centre for Drugs and Diagnostics, and Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Owen A; Department of Molecular and Clinical Pharmacology, Materials Innovation Factory, University of Liverpool, Liverpool, UK.; Pokaż więcej
Źródło :: British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Apr; Vol. 87 (4), pp. 2078-2088. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :: Drug Repositioning*
Models, Biological*
Antiviral Agents/*administration & dosage
COVID-19/*drug therapy
COVID-19/*prevention & control
Nitro Compounds/*administration & dosage
Thiazoles/*administration & dosage
Adult ; Antiviral Agents/blood ; Antiviral Agents/pharmacokinetics ; COVID-19/blood ; Computer Simulation ; Drug Dosage Calculations ; Female ; Humans ; Lung/metabolism ; Male ; Middle Aged ; Nitro Compounds/blood ; Nitro Compounds/pharmacokinetics ; Reproducibility of Results ; Thiazoles/blood ; Thiazoles/pharmacokinetics ; Tissue Distribution ; Young Adult
SCR Protocol :: COVID-19 drug treatment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Food-dependent set-up of the DiDGI® dynamic in vitro system: Correlation with the porcine model for protein digestion of soya-based food.
Autorzy :: Reynaud Y; IMPROVE SAS, F-80480 Dury, France; STLO, INRAE, INSTITUT AGRO, F-35042 Rennes, France. Electronic address: .
Couvent A; IMPROVE SAS, F-80480 Dury, France. Electronic address: .
Manach A; Université Paris-Saclay, INRAE, AgroParisTech, SayFood, F-78850 Thiverval-Grignon, France. Electronic address: .
Forest D; Université Paris-Saclay, INRAE, AgroParisTech, SayFood, F-78850 Thiverval-Grignon, France. Electronic address: .
Lopez M; IMPROVE SAS, F-80480 Dury, France. Electronic address: .
Picque D; Université Paris-Saclay, INRAE, AgroParisTech, SayFood, F-78850 Thiverval-Grignon, France. Electronic address: .
Souchon I; Université Paris-Saclay, INRAE, AgroParisTech, SayFood, F-78850 Thiverval-Grignon, France. Electronic address: .
Rémond D; Université Clermont Auvergne, INRAE, UNH, Unité de Nutrition Humaine, F-63000 Clermont-Ferrand, France. Electronic address: .
Dupont D; STLO, INRAE, INSTITUT AGRO, F-35042 Rennes, France. Electronic address: .; Pokaż więcej
Źródło :: Food chemistry [Food Chem] 2021 Mar 30; Vol. 341 (Pt 2), pp. 128276. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :: Journal Article
MeSH Terms :: Models, Biological*
Plant Proteins, Dietary/*metabolism
Soybeans/*metabolism
Animals ; Digestion ; Duodenum/metabolism ; Gastric Emptying ; Ileum/metabolism ; In Vitro Techniques ; Jejunum/metabolism ; Milk Proteins/metabolism ; Nitrogen/metabolism ; Proteolysis ; Stomach ; Swine
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli.
Autorzy :: Hameri T; Laboratory of Computational Systems Biotechnology (LCSB), Swiss Federal Institute of Technology (EPFL), 1015, Lausanne, Switzerland.
Fengos G; Laboratory of Computational Systems Biotechnology (LCSB), Swiss Federal Institute of Technology (EPFL), 1015, Lausanne, Switzerland.
Hatzimanikatis V; Laboratory of Computational Systems Biotechnology (LCSB), Swiss Federal Institute of Technology (EPFL), 1015, Lausanne, Switzerland. .; Pokaż więcej
Źródło :: BMC bioinformatics [BMC Bioinformatics] 2021 Mar 20; Vol. 22 (1), pp. 134. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :: Journal Article
MeSH Terms :: Escherichia coli*/genetics
Metabolic Engineering*
Models, Biological*
Algorithms ; Kinetics ; Metabolic Networks and Pathways
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 14 14.

Tytuł :: Epidemiological analysis of asymptomatic SARS-CoV-2 transmission in the community: an individual-based model.
Autorzy :: Guo Z; Department of Disease Control, Center for Disease Control and Prevention in Northern Theater Command, Shenyang, China.
Xiao D; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, No. 119, South 4th Ring Road West, Fengtai District, Beijing, China. .; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2021 Mar 18; Vol. 11 (1), pp. 6251. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Models, Biological*
COVID-19/*transmission
Disease Outbreaks/*prevention & control
Asymptomatic Infections/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Computer Simulation ; Humans ; Incidence ; SARS-CoV-2
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 15 15.

Tytuł :: Accounting for confounding by time, early intervention adoption, and time-varying effect modification in the design and analysis of stepped-wedge designs: application to a proposed study design to reduce opioid-related mortality.
Autorzy :: Rennert L; Department of Public Health Sciences, Clemson University, Clemson, USA. .
Heo M; Department of Public Health Sciences, Clemson University, Clemson, USA.
Litwin AH; University of South Carolina School of Medicine, Greenville, SC, USA.; Prisma Health, Department of Medicine, Greenville, SC, USA.; Clemson University School of Health Research, Clemson, SC, USA.
Gruttola V; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, USA.; Pokaż więcej
Źródło :: BMC medical research methodology [BMC Med Res Methodol] 2021 Mar 16; Vol. 21 (1), pp. 53. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Cross-Over Studies*
Early Medical Intervention*
Models, Biological*
Randomized Controlled Trials as Topic*
Research Design*
Opioid-Related Disorders/*mortality
Computer Simulation ; Epidemics ; Humans ; Opioid-Related Disorders/epidemiology ; Outcome and Process Assessment, Health Care ; Random Allocation ; Time Factors
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 16 16.

Tytuł :: Vaccinating the oldest against COVID-19 saves both the most lives and most years of life.
Autorzy :: Goldstein JR; Department of Demography, University of California, Berkeley, CA 94720; .
Cassidy T; Department of Mathematics, Bucknell University, Lewisburg, PA 17837.
Wachter KW; Department of Demography, University of California, Berkeley, CA 94720.; Pokaż więcej
Źródło :: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 16; Vol. 118 (11).
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :: Life Expectancy*
Models, Biological*
SARS-CoV-2*
Vaccination*
COVID-19/*prevention & control
COVID-19 Vaccines/*administration & dosage
Age Factors ; Aged ; Aged, 80 and over ; COVID-19/mortality ; Female ; Humans ; Male ; Risk Factors
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Using digital twins in viral infection.
Autorzy :: Laubenbacher R; Department of Medicine, University of Florida, Gainesville, FL, USA. .
Sluka JP; Department of Intelligent Systems Engineering and Biocomplexity Institute, Indiana University, Bloomington, IN, USA. .
Glazier JA; Department of Intelligent Systems Engineering and Biocomplexity Institute, Indiana University, Bloomington, IN, USA. .; Pokaż więcej
Źródło :: Science (New York, N.Y.) [Science] 2021 Mar 12; Vol. 371 (6534), pp. 1105-1106.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :: Computer Simulation*
Models, Biological*
Patient-Specific Modeling*
Software*
Virus Diseases*/diagnosis
Virus Diseases*/therapy
Artificial Intelligence ; Humans ; Precision Medicine
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 18 18.

Tytuł :: MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2.
Autorzy :: Uemura K; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan.; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.; Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Sasaki M; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Sanaki T; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan.; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Toba S; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan.; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Takahashi Y; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
Orba Y; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.; International Collaboration Unit, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Hall WW; International Collaboration Unit, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.; National Virus Reference Laboratory, School of Medicine, University College of Dublin, Dublin, Ireland.; Global Virus Network, Baltimore, MD, USA.
Maenaka K; Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.; Center for Research and Education On Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.; Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo, Japan.
Sawa H; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.; International Collaboration Unit, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.; Global Virus Network, Baltimore, MD, USA.
Sato A; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan. .; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan. .; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2021 Mar 08; Vol. 11 (1), pp. 5376. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Cell Engineering*
Drug Discovery*
Models, Biological*
Angiotensin-Converting Enzyme 2/*metabolism
Antiviral Agents/*pharmacology
SARS-CoV-2/*physiology
Animals ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Cell Line ; Humans ; SARS-CoV-2/drug effects ; Viral Proteins/biosynthesis ; Virus Replication/drug effects
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 19 19.

Tytuł :: A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes' interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19.
Autorzy :: Ding J; Computational Biology Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.; The Meakins-Christie Laboratories at the Research Institute of the McGill University Heath Centre Research Institute, Montréal, Canada.
Hostallero DE; Department of Electrical and Computer Engineering, McGill University, Montréal, Canada.
El Khili MR; Department of Electrical and Computer Engineering, McGill University, Montréal, Canada.
Fonseca GJ; The Meakins-Christie Laboratories at the Research Institute of the McGill University Heath Centre Research Institute, Montréal, Canada.
Milette S; Goodman Cancer Research Centre, McGill University, Montréal, Canada.
Noorah N; The Meakins-Christie Laboratories at the Research Institute of the McGill University Heath Centre Research Institute, Montréal, Canada.
Guay-Belzile M; The Meakins-Christie Laboratories at the Research Institute of the McGill University Heath Centre Research Institute, Montréal, Canada.
Spicer J; Division of Thoracic and Upper Gastrointestinal Surgery, McGill University Health Centre Research Institute, Montréal, Canada.
Daneshtalab N; School of Pharmacy, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Sirois M; Montreal Heart Institute and Department of pharmacology and physiology, Faculty of medicine, Université de Montréal, Montréal, Canada.
Tremblay K; Pharmacology-physiology Department, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-Saint-Jean (Chicoutimi University Hospital) Research Center, Saguenay, Canada.
Emad A; Department of Electrical and Computer Engineering, McGill University, Montréal, Canada.
Rousseau S; The Meakins-Christie Laboratories at the Research Institute of the McGill University Heath Centre Research Institute, Montréal, Canada.; Pokaż więcej
Źródło :: PLoS computational biology [PLoS Comput Biol] 2021 Mar 08; Vol. 17 (3), pp. e1008810. Date of Electronic Publication: 2021 Mar 08 (Print Publication: 2021).
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Models, Biological*
COVID-19/*complications
COVID-19/*genetics
Extracellular Traps/*genetics
Lymphohistiocytosis, Hemophagocytic/*complications
Lymphohistiocytosis, Hemophagocytic/*genetics
SARS-CoV-2/*genetics
Thrombosis/*etiology
Thrombosis/*genetics
Algorithms ; Cell Degranulation/genetics ; Computational Biology ; Gene Expression Regulation ; Gene Regulatory Networks ; Genetic Predisposition to Disease ; Humans ; Pandemics ; Protein Interaction Maps ; Pulmonary Embolism/etiology ; Pulmonary Embolism/genetics ; Viral Proteins/genetics
: Czasopismo naukowe

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Skocz do pozycji: 20 20.

Tytuł :: Modelling and predicting the spatio-temporal spread of COVID-19, associated deaths and impact of key risk factors in England.
Autorzy :: Sartorius B; Department of Disease Control, Faculty of Tropical and Infectious Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, Bloomsbury, London, WC1E 7HT, UK. .; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. .; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA. .
Lawson AB; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA.
Pullan RL; Department of Disease Control, Faculty of Tropical and Infectious Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, Bloomsbury, London, WC1E 7HT, UK.; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2021 Mar 08; Vol. 11 (1), pp. 5378. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :: Journal Article
MeSH Terms :: Models, Biological*
Spatio-Temporal Analysis*
COVID-19/*epidemiology
COVID-19/*mortality
Bayes Theorem ; COVID-19/virology ; Disease Susceptibility ; England/epidemiology ; Geography ; Humans ; Multivariate Analysis ; Risk Factors ; SARS-CoV-2/physiology ; Time Factors
: Czasopismo naukowe

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