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Tytuł:
Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays.
Autorzy:
Pelkonen A; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Pistono C; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Klecki P; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Gómez-Budia M; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Dougalis A; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Konttinen H; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Stanová I; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Fagerlund I; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Leinonen V; Department of Neurosurgery, Kuopio University Hospital, 70029 Kuopio, Finland.; Neurosurgery, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, 70029 Kuopio, Finland.
Korhonen P; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Malm T; A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
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Źródło:
Cells [Cells] 2021 Dec 29; Vol. 11 (1). Date of Electronic Publication: 2021 Dec 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Models, Biological*
Brain/*physiology
Pluripotent Stem Cells/*metabolism
Humans ; Microelectrodes ; Neurons/physiology ; Organoids/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transcriptomic Mapping of Neural Diversity, Differentiation and Functional Trajectory in iPSC-Derived 3D Brain Organoid Models.
Autorzy:
Kiaee K; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Jodat YA; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Bassous NJ; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Matharu N; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94143, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.; Innovative Genomics Institute, University of California San Francisco, San Francisco, CA 94720, USA.
Shin SR; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
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Źródło:
Cells [Cells] 2021 Dec 05; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Brain/*metabolism
Cell Differentiation/*genetics
Induced Pluripotent Stem Cells/*metabolism
Organoids/*metabolism
Transcriptome/*genetics
Brain/embryology ; Databases, Genetic ; Gene Expression Regulation, Developmental ; Humans ; Neurons/cytology ; Neurons/metabolism ; Reproduction ; Sequence Analysis, RNA ; Signal Transduction/genetics ; Single-Cell Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Experimental Epileptogenesis in a Cell Culture Model of Primary Neurons from Rat Brain: A Temporal Multi-Scale Study.
Autorzy:
Jablonski J; Department of Neuropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Hoffmann L; Department of Neuropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Blümcke I; Department of Neuropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Fejtová A; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Uebe S; NGS Core Unit, Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Ekici AB; NGS Core Unit, Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Gnatkovsky V; Department of Epileptology, University Hospital Bonn, 53127 Bonn, Germany.
Kobow K; Department of Neuropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
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Źródło:
Cells [Cells] 2021 Nov 03; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Brain/*pathology
Epilepsy/*pathology
Neurons/*pathology
Animals ; Calbindins/metabolism ; Calcium/metabolism ; Cells, Cultured ; DNA Methylation/genetics ; Epigenesis, Genetic ; Epilepsy/genetics ; GABAergic Neurons/pathology ; Gene Regulatory Networks ; Neurons/metabolism ; Principal Component Analysis ; Rats ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prediction Models for Brain Distribution of Drugs Based on Biomimetic Chromatographic Data.
Autorzy:
Vallianatou T; Medical Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, 751 24 Uppsala, Sweden.
Tsopelas F; Laboratory of Inorganic and Analytical Chemistry, School of Chemical Engineering, National Technical University of Athens, 157 80 Athens, Greece.
Tsantili-Kakoulidou A; Faculty of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 07; Vol. 27 (12). Date of Electronic Publication: 2022 Jun 07.
Typ publikacji:
Journal Article
MeSH Terms:
Biomimetics*
Brain*/metabolism
Biological Transport ; Blood-Brain Barrier/metabolism ; Chromatography ; Humans ; Models, Biological
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimization of cerebral organoids: a more qualified model for Alzheimer's disease research.
Autorzy:
Bi FC; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China.; Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China.
Yang XH; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Cheng XY; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital, Soochow University, Suzhou, 215004, China.
Deng WB; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510275, China.
Guo XL; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Yang H; Research Center of Medical Science and Technology, Ningxia Medical University, Yinchuan, 750004, China.
Wang Y; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China. .
Li J; Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China. .; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China. .
Yao Y; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2021 Aug 09; Vol. 10 (1), pp. 27. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Models, Biological*
Alzheimer Disease/*pathology
Biomedical Research/*trends
Brain/*pathology
Organoids/*pathology
Alzheimer Disease/metabolism ; Animals ; Biomedical Research/methods ; Brain/metabolism ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Organoids/metabolism ; Protein Folding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unveiling a key role of oxaloacetate-glutamate interaction in regulation of respiration and ROS generation in nonsynaptic brain mitochondria using a kinetic model.
Autorzy:
Selivanov VA; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.; CIBER of Hepatic and Digestive Diseases (CIBEREHD) and Metabolomics Node at Spanish National Bioinformatics Institute (INB-ISCIII-ES- ELIXIR), Institute of Health Carlos III (ISCIII), Madrid, Spain.
Zagubnaya OA; Department of Mathematical Modeling and Statistical Analysis, Institute of Cytochemistry and Molecular Pharmacology, Moscow, Russia.
Nartsissov YR; Department of Mathematical Modeling and Statistical Analysis, Institute of Cytochemistry and Molecular Pharmacology, Moscow, Russia.
Cascante M; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.; CIBER of Hepatic and Digestive Diseases (CIBEREHD) and Metabolomics Node at Spanish National Bioinformatics Institute (INB-ISCIII-ES- ELIXIR), Institute of Health Carlos III (ISCIII), Madrid, Spain.
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Źródło:
PloS one [PLoS One] 2021 Aug 03; Vol. 16 (8), pp. e0255164. Date of Electronic Publication: 2021 Aug 03 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Brain/*metabolism
Glutamic Acid/*metabolism
Mitochondria/*metabolism
Oxaloacetic Acid/*metabolism
Reactive Oxygen Species/*metabolism
Synapses/*metabolism
Adenosine Triphosphate/metabolism ; Antimycin A/analogs & derivatives ; Antimycin A/pharmacology ; Biological Transport/drug effects ; Calcium/metabolism ; Cell Respiration/drug effects ; Electron Transport Complex II/metabolism ; Energy Metabolism/drug effects ; Hydrogen Peroxide/metabolism ; Kinetics ; Methacrylates/pharmacology ; Mitochondria/drug effects ; Phantoms, Imaging ; Synapses/drug effects ; Thiazoles/pharmacology ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Shotgun lipidomics of liver and brain tissue of Alzheimer's disease model mice treated with acitretin.
Autorzy:
Lauer AA; Experimental Neurology, Saarland University, Homburg, Saar, Germany.
Janitschke D; Experimental Neurology, Saarland University, Homburg, Saar, Germany.
Dos Santos Guilherme M; Department of Psychiatry and Psychotherapy, University Medical Center Johannes Gutenberg-University, Mainz, Germany.
Nguyen VTT; Department of Psychiatry and Psychotherapy, University Medical Center Johannes Gutenberg-University, Mainz, Germany.
Bachmann CM; Experimental Neurology, Saarland University, Homburg, Saar, Germany.
Qiao S; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.
Schrul B; Medical Biochemistry and Molecular Biology, Center for Molecular Signaling (PZMS), Faculty of Medicine, Saarland University, Homburg, Saar, Germany.
Boehm U; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.
Grimm HS; Experimental Neurology, Saarland University, Homburg, Saar, Germany.
Hartmann T; Experimental Neurology, Saarland University, Homburg, Saar, Germany.; Deutsches Institut Für Demenzprävention (DIDP), Neurodegeneration and Neurobiology, Saarland University, Homburg, Saar, Germany.
Endres K; Department of Psychiatry and Psychotherapy, University Medical Center Johannes Gutenberg-University, Mainz, Germany. .
Grimm MOW; Experimental Neurology, Saarland University, Homburg, Saar, Germany. .; Deutsches Institut Für Demenzprävention (DIDP), Neurodegeneration and Neurobiology, Saarland University, Homburg, Saar, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 27; Vol. 11 (1), pp. 15301. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
Lipidomics*
Models, Biological*
Acitretin/*pharmacology
Alzheimer Disease/*drug therapy
Brain/*metabolism
Liver/*metabolism
Alzheimer Disease/metabolism ; Animals ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity.
Autorzy:
Chesnut M; Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Hartung T; Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.; Center for Alternatives to Animal Testing (CAAT-Europe), University of Konstanz, 78464 Konstanz, Germany.
Hogberg H; Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Pamies D; Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.; Department of Physiology, University of Lausanne, 1005 Lausanne, Switzerland.; Swiss Centre for Applied Human Toxicology (SCAHT), 4055 Basel, Switzerland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 25; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Models, Biological*
Myelin Sheath*
Oligodendroglia*
Brain/*physiopathology
Neurodevelopmental Disorders/*etiology
Neurotoxicity Syndromes/*etiology
Animals ; Humans ; Neurodevelopmental Disorders/chemically induced ; Neurodevelopmental Disorders/physiopathology ; Neurotoxicity Syndromes/physiopathology ; Organoids ; Toxicity Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
On the influence of prior information evaluated by fully Bayesian criteria in a personalized whole-brain model of epilepsy spread.
Autorzy:
Hashemi M; Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Vattikonda AN; Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Sip V; Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Diaz-Pier S; SimLab Neuroscience, Jülich Supercomputing Centre (JSC), Institute for Advanced Simulation, JARA, Forschungszentrum Jülich GmbH, Jülich, Germany.
Peyser A; SimLab Neuroscience, Jülich Supercomputing Centre (JSC), Institute for Advanced Simulation, JARA, Forschungszentrum Jülich GmbH, Jülich, Germany.; Google, München, Germany.
Wang H; Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Guye M; Aix Marseille Univ, CNRS, CRMBM, Marseille, France.
Bartolomei F; Epileptology Department, and Clinical Neurophysiology Department, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
Woodman MM; Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Jirsa VK; Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Jul 14; Vol. 17 (7), pp. e1009129. Date of Electronic Publication: 2021 Jul 14 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bayes Theorem*
Models, Biological*
Brain/*physiopathology
Epilepsy/*physiopathology
Adult ; Algorithms ; Brain/diagnostic imaging ; Brain/pathology ; Brain/surgery ; Computational Biology ; Epilepsy/diagnostic imaging ; Epilepsy/pathology ; Epilepsy/surgery ; Humans ; Magnetic Resonance Imaging ; Male
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.
Autorzy:
Steg LC; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Shireby GL; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Imm J; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Davies JP; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Franklin A; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Flynn R; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Namboori SC; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Bhinge A; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Jeffries AR; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Burrage J; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Neilson GWA; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Walker EM; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Perfect LW; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Price J; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
McAlonan G; Department of Forensic and Neurodevelopmental Sciences, King's College London, London, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.; Behavioural and Developmental Psychiatry, South London and Maudsley NHS Foundation Trust, London, UK.
Srivastava DP; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.
Bray NJ; Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
Cope EL; School of Biosciences, Cardiff University, Cardiff, UK.
Jones KM; School of Biosciences, Cardiff University, Cardiff, UK.
Allen ND; School of Biosciences, Cardiff University, Cardiff, UK.
Pishva E; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands.
Dempster EL; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Lunnon K; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Mill J; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.
Hannon E; College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK. .
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Źródło:
Molecular brain [Mol Brain] 2021 Jun 26; Vol. 14 (1), pp. 98. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*/genetics
Epigenesis, Genetic*
Models, Biological*
Biological Clocks/*genetics
Brain/*embryology
Fetus/*cytology
Induced Pluripotent Stem Cells/*cytology
Neurons/*cytology
DNA Methylation/genetics ; Databases, Genetic ; Female ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Neurons/metabolism ; Pregnancy ; Reproducibility of Results
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses.
Autorzy:
Farajzadeh Khosroshahi S; Dyson School of Design Engineering, Imperial College London, London, UK. .
Yin X; Shanghai Institute of Materia Medica, Shanghai, China.
K Donat C; Department of Brain Sciences, Imperial College London, London, UK.; Centre for Blast Injury Studies, Imperial College London, London, UK.
McGarry A; Department of Brain Sciences, Imperial College London, London, UK.
Yanez Lopez M; Department of Brain Sciences, Imperial College London, London, UK.
Baxan N; Biological Imaging Centre, Imperial College London, London, UK.
J Sharp D; Department of Brain Sciences, Imperial College London, London, UK.
Sastre M; Department of Brain Sciences, Imperial College London, London, UK.
Ghajari M; Dyson School of Design Engineering, Imperial College London, London, UK.
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 21; Vol. 11 (1), pp. 12927. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
Models, Biological*
Stress, Mechanical*
Brain/*blood supply
Brain/*pathology
Brain Injuries, Traumatic/*etiology
Animals ; Biomarkers ; Brain/diagnostic imaging ; Cerebral Angiography ; Disease Susceptibility ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies.
Autorzy:
Bloomingdale P; Quantitative Pharmacology and Pharmacometrics, Merck & Co. Inc, Kenilworth, New Jersey, USA.
Karelina T; InSysBio, Moscow, Russia.
Cirit M; Javelin Biotech, Inc, Woburn, Massachusetts, USA.
Muldoon SF; Mathematics Department, CDSE Program, Neuroscience Program, University at Buffalo, SUNY, Buffalo, New York, USA.
Baker J; Harvard Medical School, Boston, Massachusetts, USA.
McCarty WJ; Skyhawk Therapeutics, Waltham, Massachusetts, USA.
Geerts H; Certara, QSP, Berwyn, Pennsylvania, USA.
Macha S; Quantitative Pharmacology, Sanofi, Bridgewater, New Jersey, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 May; Vol. 10 (5), pp. 412-419. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Drug Discovery*
Models, Biological*
Network Pharmacology*
Brain/*metabolism
Neurodegenerative Diseases/*drug therapy
Congresses as Topic ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children.
Autorzy:
Verscheijden LFM; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Litjens CHC; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Koenderink JB; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Mathijssen RHJ; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Verbeek MM; Departments of Neurology and Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
de Wildt SN; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.; Intensive Care and Department of Paediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Russel FGM; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Mar 04; Vol. 17 (3), pp. e1008786. Date of Electronic Publication: 2021 Mar 04 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Analgesics, Opioid*/administration & dosage
Analgesics, Opioid*/blood
Analgesics, Opioid*/pharmacokinetics
Models, Biological*
Morphine*/administration & dosage
Morphine*/blood
Morphine*/pharmacokinetics
Morphine Derivatives*/administration & dosage
Morphine Derivatives*/blood
Morphine Derivatives*/pharmacokinetics
Brain/*metabolism
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Adult ; Age Factors ; Analgesia ; Blood-Brain Barrier/metabolism ; Child ; Child, Preschool ; Computational Biology ; Female ; Humans ; Infant, Newborn ; Male
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anti-Inflammatory Effects of Rhamnetin on Bradykinin-Induced Matrix Metalloproteinase-9 Expression and Cell Migration in Rat Brain Astrocytes.
Autorzy:
Yang CC; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Kwei-San, Tao-Yuan 33302, Taiwan.; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan 33302, Taiwan.
Hsiao LD; Department of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Shih YF; Department of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Yu ZY; Department of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Yang CM; Department of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.; Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, Taichung 40402, Taiwan.; Department of Post-Baccalaureate Veterinary Medicine, College of Medical and Health Science, Asia University, Wufeng, Taichung 41354, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 06; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Movement*/drug effects
Anti-Inflammatory Agents/*pharmacology
Astrocytes/*enzymology
Astrocytes/*pathology
Bradykinin/*pharmacology
Brain/*pathology
Matrix Metalloproteinase 9/*metabolism
Quercetin/*analogs & derivatives
Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Cell Line ; MAP Kinase Signaling System/drug effects ; Models, Biological ; NADPH Oxidases/metabolism ; NF-kappa B/metabolism ; Promoter Regions, Genetic/genetics ; Protein Kinase C-delta/metabolism ; Quercetin/pharmacology ; Rats ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression.
Autorzy:
Won E; Department of Psychiatry, Chaum, Seoul 06062, Korea.; Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.
Na KS; Department of Psychiatry, Gachon University Gil Medical Center, Incheon 21565, Korea.
Kim YK; Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 28; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Brain/*pathology
Depression/*pathology
Melatonin/*metabolism
Neuroinflammatory Diseases/*pathology
Animals ; Depression/immunology ; Humans ; Immune System/pathology ; Models, Biological ; Neuroinflammatory Diseases/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Consolidation and maintenance of long-term memory involve dual functions of the developmental regulator Apterous in clock neurons and mushroom bodies in the Drosophila brain.
Autorzy:
Inami S; Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Sato T; Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Kurata Y; Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Suzuki Y; Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Kitamoto T; Department of Anesthesia and Neuroscience & Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.; Interdisciplinary Programs in Genetics and Neuroscience, University of Iowa, Iowa City, Iowa, United States of America.
Sakai T; Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.
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Źródło:
PLoS biology [PLoS Biol] 2021 Dec 03; Vol. 19 (12), pp. e3001459. Date of Electronic Publication: 2021 Dec 03 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biological Clocks/*physiology
Brain/*physiology
Drosophila Proteins/*metabolism
Drosophila melanogaster/*physiology
LIM-Homeodomain Proteins/*metabolism
Memory Consolidation/*physiology
Memory, Long-Term/*physiology
Mushroom Bodies/*physiology
Neurons/*physiology
Transcription Factors/*metabolism
Animals ; Drosophila Proteins/genetics ; Heterozygote ; LIM-Homeodomain Proteins/genetics ; Models, Biological ; Mutation/genetics ; Phenotype ; Synaptic Transmission/physiology ; Transcription Factors/genetics ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin.
Autorzy:
Liu X; Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.; State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Zhou Q; Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Zhang JH; Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Wang KY; Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Saito T; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama 351-0198, Japan.; Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
Saido TC; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama 351-0198, Japan.
Wang X; State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Gao X; State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Azuma K; Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
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Źródło:
Cells [Cells] 2021 Nov 22; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sex Characteristics*
Alzheimer Disease/*drug therapy
Alzheimer Disease/*pathology
Brain/*pathology
Diosgenin/*analogs & derivatives
Microglia/*pathology
Amyloid beta-Protein Precursor/metabolism ; Animals ; Body Weight/drug effects ; Brain/drug effects ; Brain/ultrastructure ; Cytokines/metabolism ; Diosgenin/pharmacology ; Diosgenin/therapeutic use ; Disease Models, Animal ; Female ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Biological ; NF-kappa B/metabolism ; Signal Transduction ; Synapses/drug effects ; Synapses/pathology ; Synapses/ultrastructure ; beta Catenin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Porphyromonas gingivalis Induces Proinflammatory Cytokine Expression Leading to Apoptotic Death through the Oxidative Stress/NF-κB Pathway in Brain Endothelial Cells.
Autorzy:
Charoensaensuk V; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chen YC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Lin YH; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Ou KL; 3D Global Biotech Inc., New Taipei City 22175, Taiwan.
Yang LY; Department of Physiology, School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan.; Laboratory for Neural Repair, China Medical University Hospital, Taichung 40447, Taiwan.
Lu DY; Department of Pharmacology, School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan.; Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan.
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Źródło:
Cells [Cells] 2021 Nov 05; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Oxidative Stress*
Signal Transduction*
Brain/*pathology
Cytokines/*metabolism
Endothelial Cells/*pathology
NF-kappa B/*metabolism
Porphyromonas gingivalis/*physiology
Animals ; Bacterial Adhesion ; Cell Shape ; Cell Survival ; Endothelial Cells/metabolism ; Endothelial Cells/microbiology ; Inflammation Mediators/metabolism ; Male ; Mice, Inbred C57BL ; Models, Biological ; Reactive Oxygen Species/metabolism ; Up-Regulation ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The importance of modeling the human cerebral vasculature in blunt trauma.
Autorzy:
Subramaniam DR; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Development Command, FCMR-TT, 504 Scott Street, Fort Detrick, MD, 21702-5012, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Drive, Bethesda, MD, 20817, USA.
Unnikrishnan G; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Development Command, FCMR-TT, 504 Scott Street, Fort Detrick, MD, 21702-5012, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Drive, Bethesda, MD, 20817, USA.
Sundaramurthy A; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Development Command, FCMR-TT, 504 Scott Street, Fort Detrick, MD, 21702-5012, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Drive, Bethesda, MD, 20817, USA.
Rubio JE; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Development Command, FCMR-TT, 504 Scott Street, Fort Detrick, MD, 21702-5012, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Drive, Bethesda, MD, 20817, USA.
Kote VB; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Development Command, FCMR-TT, 504 Scott Street, Fort Detrick, MD, 21702-5012, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Drive, Bethesda, MD, 20817, USA.
Reifman J; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Development Command, FCMR-TT, 504 Scott Street, Fort Detrick, MD, 21702-5012, USA. .
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Źródło:
Biomedical engineering online [Biomed Eng Online] 2021 Jan 14; Vol. 20 (1), pp. 11. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Biological*
Brain/*blood supply
Wounds, Nonpenetrating/*physiopathology
Biomechanical Phenomena ; Finite Element Analysis ; Humans ; Intracranial Pressure ; Skull
Czasopismo naukowe
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