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Wyszukujesz frazę ""Models, Immunological"" wg kryterium: Temat


Tytuł :
Modeling of tumor response to macrophage and T lymphocyte interactions in the liver metastatic microenvironment.
Autorzy :
Curtis LT; Department of Bioengineering, University of Louisville, Lutz Hall 419, Louisville, KY, 40292, USA.
Sebens S; Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU), Kiel, Germany.; University Medical Center Schleswig-Holstein (UK-SH), Campus Kiel, Kiel, Germany.
Frieboes HB; Department of Bioengineering, University of Louisville, Lutz Hall 419, Louisville, KY, 40292, USA. .; Center for Predictive Medicine, University of Louisville, Louisville, KY, USA. .; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 May; Vol. 70 (5), pp. 1475-1488. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Immunological*
Immunotherapy/*methods
Liver Neoplasms/*immunology
Macrophages/*immunology
Th1 Cells/*immunology
Th2 Cells/*immunology
Cell Communication ; Cell Differentiation ; Cytokines/metabolism ; Cytotoxicity, Immunologic ; Humans ; Liver Neoplasms/therapy ; Lymphocyte Activation ; Neoplasm Metastasis ; Th1-Th2 Balance ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Time-dependent heterogeneity leads to transient suppression of the COVID-19 epidemic, not herd immunity.
Autorzy :
Tkachenko AV; Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973; .
Maslov S; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801; .; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Elbanna A; Department of Civil Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Wong GN; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Weiner ZJ; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Goldenfeld N; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Apr 27; Vol. 118 (17).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
COVID-19*/epidemiology
COVID-19*/immunology
COVID-19*/transmission
Epidemics*
Immunity, Herd*
Models, Immunological*
SARS-CoV-2/*immunology
Humans ; United States/epidemiology
Czasopismo naukowe
Tytuł :
Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
Autorzy :
Heuberger J; Department of Hepatology and Gastroenterology, Charité University Medicine, Berlin, Germany.; Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Trimpert J; Institute of Virology, Freie Universität Berlin, Berlin, Germany.
Vladimirova D; Institute of Virology, Freie Universität Berlin, Berlin, Germany.
Goosmann C; Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.
Lin M; Department of Hepatology and Gastroenterology, Charité University Medicine, Berlin, Germany.
Schmuck R; Department of Surgery, Charité University Medicine, Berlin, Germany.
Mollenkopf HJ; Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.
Brinkmann V; Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.
Tacke F; Department of Hepatology and Gastroenterology, Charité University Medicine, Berlin, Germany.
Osterrieder N; Institute of Virology, Freie Universität Berlin, Berlin, Germany.; Department of Infectious Disease and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong.
Sigal M; Department of Hepatology and Gastroenterology, Charité University Medicine, Berlin, Germany.; Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
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Źródło :
EMBO molecular medicine [EMBO Mol Med] 2021 Apr 09; Vol. 13 (4), pp. e13191. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Immunological*
SARS-CoV-2*/genetics
SARS-CoV-2*/immunology
SARS-CoV-2*/pathogenicity
COVID-19/*etiology
Interferon-gamma/*immunology
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; COVID-19/immunology ; COVID-19/pathology ; Cell Differentiation/immunology ; Colon/immunology ; Colon/pathology ; Colon/virology ; Disease Susceptibility ; Enterocytes/metabolism ; Enterocytes/pathology ; Enterocytes/virology ; Gene Expression ; Host Microbial Interactions/immunology ; Humans ; Interferon-gamma/administration & dosage ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Intestinal Mucosa/virology ; Mice ; Organoids/immunology ; Organoids/pathology ; Organoids/virology ; Virus Replication/immunology
Czasopismo naukowe
Tytuł :
[Substance P, proinflammatory cytokines, transient receptor potential vanilloid subtype 1 and COVID-19: A working hypothesis].
Autorzy :
Aguirre-Siancas EE; Universidad Nacional Mayor de San Marcos, Lima, Perú. Electronic address: .
Colona-Vallejos E; Universidad Nacional Mayor de San Marcos, Lima, Perú.
Ruiz-Ramirez E; Universidad Nacional Mayor de San Marcos, Lima, Perú.
Becerra-Bravo M; Universidad Nacional Mayor de San Marcos, Lima, Perú.
Alzamora-Gonzales L; Universidad Nacional Mayor de San Marcos, Lima, Perú.
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Transliterated Title :
Sustancia P, citocinas proinflamatorias, receptor de potencial transitorio vaniloide tipo 1 y COVID-19: una hipótesis de trabajo.
Źródło :
Neurologia (Barcelona, Spain) [Neurologia] 2021 Mar; Vol. 36 (2), pp. 184-185. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Letter
MeSH Terms :
Models, Immunological*
COVID-19/*immunology
Cytokines/*physiology
Neuroimmunomodulation/*physiology
SARS-CoV-2/*physiology
Substance P/*physiology
TRPV Cation Channels/*physiology
COVID-19/complications ; COVID-19/physiopathology ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/physiopathology ; Humans ; Neuropeptides/physiology
Opinia redakcyjna
Tytuł :
SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals.
Autorzy :
Kared H; ImmunoScape, Singapore, Singapore.
Redd AD; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.; Department of Medicine and.
Bloch EM; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Bonny TS; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sumatoh H; ImmunoScape, Singapore, Singapore.
Kairi F; ImmunoScape, Singapore, Singapore.
Carbajo D; ImmunoScape, Singapore, Singapore.
Abel B; ImmunoScape, Singapore, Singapore.
Newell EW; ImmunoScape, Singapore, Singapore.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Bettinotti MP; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Benner SE; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Patel EU; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Epidemiology and.
Littlefield K; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Laeyendecker O; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.; Department of Medicine and.
Shoham S; Department of Medicine and.
Sullivan D; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Casadevall A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Pekosz A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Nardin A; ImmunoScape, Singapore, Singapore.
Fehlings M; ImmunoScape, Singapore, Singapore.
Tobian AA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Quinn TC; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.; Department of Medicine and.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Mar 01; Vol. 131 (5).
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Convalescence*
Models, Immunological*
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Adult ; Aged ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; CD8-Positive T-Lymphocytes/pathology ; COVID-19/pathology ; Female ; HLA Antigens/immunology ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Atopic endotypes as a modulating factor for SARS-CoV-2 infection: mechanisms and implications.
Autorzy :
Huntley KS; Dr Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, Florida.
Fine L; Dr Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, Florida.
Bernstein JA; University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati, Ohio, USA.
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Źródło :
Current opinion in allergy and clinical immunology [Curr Opin Allergy Clin Immunol] 2021 Jun 01; Vol. 21 (3), pp. 252-260.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Models, Immunological*
Virus Internalization*
Asthma/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Angiotensin-Converting Enzyme 2/immunology ; Humans ; Risk Factors ; Serine Endopeptidases/immunology
Czasopismo naukowe
Tytuł :
How signalling games explain mimicry at many levels: from viral epidemiology to human sociology.
Autorzy :
Casey W; United States Naval Academy, Annapolis, MD 21402, USA.
Massey SE; Biology Department, University of Puerto Rico - Rio Piedras, San Juan, PR 00931, USA.
Mishra B; New York University Courant Institute of Mathematical Sciences, New York, NY 10012-1110, USA.
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Źródło :
Journal of the Royal Society, Interface [J R Soc Interface] 2021 Feb; Vol. 18 (175), pp. 20200689. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Models, Immunological*
Pandemics*
Molecular Mimicry/*immunology
SARS-CoV-2/*immunology
COVID-19/epidemiology ; COVID-19/immunology ; Humans
Czasopismo naukowe
Tytuł :
How IvIg Can Mitigate Covid-19 Disease: A Symmetrical Immune Network Model.
Autorzy :
Kohler H; Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky, USA.
Kaveri S; INSERM and CNRS, Paris, France.
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Źródło :
Monoclonal antibodies in immunodiagnosis and immunotherapy [Monoclon Antib Immunodiagn Immunother] 2021 Feb; Vol. 40 (1), pp. 17-20. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Immunological*
COVID-19/*drug therapy
COVID-19/*immunology
Immunoglobulins, Intravenous/*therapeutic use
Adaptive Immunity ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/prevention & control ; Humans ; Receptors, Antigen, B-Cell/immunology
Czasopismo naukowe
Tytuł :
Rogue antibodies could be driving severe COVID-19.
Autorzy :
Khamsi R
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Źródło :
Nature [Nature] 2021 Feb; Vol. 590 (7844), pp. 29-31.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Immunological*
Autoantibodies/*adverse effects
Autoantibodies/*immunology
Autoimmune Diseases/*etiology
Autoimmune Diseases/*immunology
COVID-19/*complications
COVID-19/*physiopathology
SARS-CoV-2/*pathogenicity
Aging/immunology ; Annexin A2/immunology ; Autoantibodies/isolation & purification ; Autoimmune Diseases/microbiology ; Autoimmune Diseases/virology ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Blood Coagulation/immunology ; Blood Vessels/immunology ; Blood Vessels/pathology ; Brain/immunology ; Brain/pathology ; COVID-19/etiology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Continental Population Groups ; Critical Illness ; Cytokine Release Syndrome/complications ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/pathology ; Cytokine Release Syndrome/physiopathology ; Female ; HLA-DRB1 Chains/immunology ; Helicobacter pylori/immunology ; Helicobacter pylori/pathogenicity ; Herpesvirus 4, Human/immunology ; Herpesvirus 4, Human/pathogenicity ; Humans ; Interferon Type I/antagonists & inhibitors ; Interferon Type I/immunology ; Male ; Myocardium/immunology ; Myocardium/pathology ; Phospholipids/immunology ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Sex Characteristics ; Streptococcus pyogenes/immunology ; Streptococcus pyogenes/pathogenicity ; Time Factors
SCR Disease Name :
post-acute COVID-19 syndrome
Czasopismo naukowe
Tytuł :
CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs.
Autorzy :
Johnson DK; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Magoffin W; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Myers SJ; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Finnell JG; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, United States.
Hancock JC; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Orton TS; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Persaud SP; Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, United States.
Christensen KA; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, United States.
Weber KS; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jan 19; Vol. 11, pp. 561889. Date of Electronic Publication: 2021 Jan 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocyte Activation*
Models, Immunological*
CD4 Antigens/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Receptors, Chimeric Antigen/*immunology
Signal Transduction/*immunology
T-Lymphocytes, Helper-Inducer/*immunology
Animals ; Antigens, Neoplasm/immunology ; Histocompatibility Antigens Class II/immunology ; Hybridomas ; Immunotherapy, Adoptive/methods ; Interleukin-2/metabolism ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Chimeric Antigen/genetics ; Transduction, Genetic ; Yeasts/immunology
Czasopismo naukowe
Tytuł :
Dendritic cell vaccine immunotherapy; the beginning of the end of cancer and COVID-19. A hypothesis.
Autorzy :
Saadeldin MK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy. Electronic address: .
Abdel-Aziz AK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Abdellatif A; Biology Department, School of Science and Engineering, American University in Cairo, New Cairo 11835, Egypt. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 Jan; Vol. 146, pp. 110365. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Models, Immunological*
COVID-19/*therapy
Dendritic Cells/*immunology
Immunotherapy/*methods
Neoplasms/*therapy
COVID-19/immunology ; COVID-19 Vaccines/therapeutic use ; Cancer Vaccines/therapeutic use ; Clinical Trials as Topic ; Combined Modality Therapy ; Drug Development ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Neoplasms/immunology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Persistence-Speed Coupling Enhances the Search Efficiency of Migrating Immune Cells.
Autorzy :
Shaebani MR; Department of Theoretical Physics, Saarland University, 66123 Saarbrücken, Germany.; Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.
Jose R; Department of Theoretical Physics, Saarland University, 66123 Saarbrücken, Germany.
Santen L; Department of Theoretical Physics, Saarland University, 66123 Saarbrücken, Germany.; Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.
Stankevicins L; INM-Leibniz Institute for New Materials, 66123 Saarbrücken, Germany.
Lautenschläger F; Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany.; INM-Leibniz Institute for New Materials, 66123 Saarbrücken, Germany.; Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany.
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Źródło :
Physical review letters [Phys Rev Lett] 2020 Dec 31; Vol. 125 (26), pp. 268102.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Immunological*
Cell Movement/*immunology
Dendritic Cells/*immunology
Animals ; Computer Simulation ; Dendritic Cells/cytology ; Mice ; Stochastic Processes
Czasopismo naukowe
Tytuł :
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness.
Autorzy :
Sego TJ; Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, United States of America.; Biocomplexity Institute, Indiana University, Bloomington, Indiana, United States of America.
Aponte-Serrano JO; Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, United States of America.; Biocomplexity Institute, Indiana University, Bloomington, Indiana, United States of America.
Ferrari Gianlupi J; Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, United States of America.; Biocomplexity Institute, Indiana University, Bloomington, Indiana, United States of America.
Heaps SR; Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, United States of America.
Breithaupt K; Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, United States of America.; Cognitive Science Program, Indiana University, Bloomington, Indiana, United States of America.
Brusch L; Center for Information Services and High Performance Computing (ZIH), Technische Universität, Dresden, Germany.
Crawshaw J; School of Mathematics and Statistics, University of Melbourne, Melbourne, Australia.
Osborne JM; School of Mathematics and Statistics, University of Melbourne, Melbourne, Australia.
Quardokus EM; Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, United States of America.
Plemper RK; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, United States of America.
Glazier JA; Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, United States of America.; Biocomplexity Institute, Indiana University, Bloomington, Indiana, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Dec 21; Vol. 16 (12), pp. e1008451. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Epithelium*/immunology
Epithelium*/virology
Models, Immunological*
Virus Diseases*/drug therapy
Virus Diseases*/immunology
Computational Biology/*methods
Antiviral Agents/therapeutic use ; COVID-19/immunology ; Computer Simulation ; Hepacivirus/immunology ; Hepatitis C/drug therapy ; Hepatitis C/immunology ; Humans ; SARS-CoV-2/immunology
Czasopismo naukowe
Tytuł :
Humoral Responses and Serological Assays in SARS-CoV-2 Infections.
Autorzy :
Galipeau Y; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Greig M; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Liu G; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Driedger M; The Ottawa Hospital, Ottawa, ON, Canada.
Langlois MA; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; uOttawa Center for Infection, Immunity and Inflammation (CI3), Ottawa, ON, Canada.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Dec 18; Vol. 11, pp. 610688. Date of Electronic Publication: 2020 Dec 18 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19*/diagnosis
COVID-19*/epidemiology
COVID-19*/immunology
COVID-19 Serological Testing*
Immunity, Humoral*
Models, Immunological*
Pandemics*
Antibodies, Viral/*immunology
SARS-CoV-2/*immunology
Humans
Czasopismo naukowe
Tytuł :
In silico trial to test COVID-19 candidate vaccines: a case study with UISS platform.
Autorzy :
Russo G; Department of Drug Sciences, University of Catania, 95125, Catania, Italy.
Pennisi M; Computer Science Institute, DiSIT, University of Eastern Piedmont, 15125, Alessandria, Italy.
Fichera E; Etna Biotech S.R.L., 95121, Catania, Italy.
Motta S; National Research Council of Italy, 00185, Rome, Italy.
Raciti G; Department of Drug Sciences, University of Catania, 95125, Catania, Italy. .
Viceconti M; Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna, 40136, Bologna, Italy.
Pappalardo F; Department of Drug Sciences, University of Catania, 95125, Catania, Italy. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2020 Dec 14; Vol. 21 (Suppl 17), pp. 527. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*/immunology
COVID-19*/prevention & control
COVID-19 Vaccines*
Models, Immunological*
Software*
SARS-CoV-2/*immunology
Computational Biology/methods ; Computer Simulation ; Humans
Czasopismo naukowe
Tytuł :
Within-host mechanisms of immune regulation explain the contrasting dynamics of two helminth species in both single and dual infections.
Autorzy :
Vanalli C; Center for Infectious Disease Dynamics and Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, USA.
Mari L; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy.
Righetto L; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy.
Casagrandi R; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy.
Gatto M; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy.
Cattadori IM; Center for Infectious Disease Dynamics and Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, USA.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Nov 23; Vol. 16 (11), pp. e1008438. Date of Electronic Publication: 2020 Nov 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Models, Immunological*
Host-Parasite Interactions/*immunology
Trichostrongyloidiasis/*immunology
Trichostrongylosis/*immunology
Animals ; Coinfection/immunology ; Coinfection/parasitology ; Computational Biology ; Computer Simulation ; Disease Models, Animal ; Linear Models ; Probability ; Rabbits ; Species Specificity ; Trichostrongyloidea/immunology ; Trichostrongyloidea/parasitology ; Trichostrongyloidiasis/complications ; Trichostrongyloidiasis/parasitology ; Trichostrongylosis/complications ; Trichostrongylosis/parasitology ; Trichostrongylus/immunology ; Trichostrongylus/parasitology
Czasopismo naukowe
Tytuł :
The Role of Age, Neutrophil Infiltration and Antibiotics Timing in the Severity of Streptococcus pneumoniae Pneumonia. Insights from a Multi-Level Mathematical Model Approach.
Autorzy :
Santos G; Laboratory of Systems Tumor Immunology, Department of Dermatology, Universitätsklinikum Erlangen and Faculty of Medicine, Friedrich-Alexander University Erlangen-Nürnberg, 91052 Erlangen, Germany.; Departamento de Bioquímica, Universidad de La Laguna, Microbiología, Biología Celular y Genética, 38200 San Cristóbal de La Laguna, Spain.
Vera J; Laboratory of Systems Tumor Immunology, Department of Dermatology, Universitätsklinikum Erlangen and Faculty of Medicine, Friedrich-Alexander University Erlangen-Nürnberg, 91052 Erlangen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 10; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Immunological*
Neutrophil Infiltration*
Anti-Bacterial Agents/*administration & dosage
Pneumonia, Pneumococcal/*drug therapy
Pneumonia, Pneumococcal/*immunology
Aged ; Aging/immunology ; Animals ; Bacterial Proteins/biosynthesis ; Computer Simulation ; Cytokines/immunology ; Drug Administration Schedule ; Humans ; Mathematical Concepts ; Mice ; Pneumonia, Pneumococcal/microbiology ; Pulmonary Alveoli/drug effects ; Pulmonary Alveoli/immunology ; Pulmonary Alveoli/microbiology ; Severity of Illness Index ; Streptococcus pneumoniae/immunology ; Streptococcus pneumoniae/pathogenicity ; Streptolysins/biosynthesis ; Systems Analysis
Czasopismo naukowe
Tytuł :
Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics.
Autorzy :
Yong KSM; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Her Z; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Tan SY; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Tan WWS; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Liu M; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Lai F; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Heng SM; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Fan Y; Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chang KTE; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore.; Department of Pathology, Duke-NUS Graduate Medical School, Singapore, Singapore.
Wang CI; Singapore Immunology Network, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Chan JKY; Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore.; Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Chen J; Interdisciplinary Research Group in Infectious Diseases, Singapore-Massachusetts Institute of Technology Alliance for Research and Technology, Singapore, Singapore.; The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, United States.
Chen Q; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Oct 15; Vol. 11, pp. 553362. Date of Electronic Publication: 2020 Oct 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Immunological*
Interleukin-2/*analogs & derivatives
Animals ; Drug Evaluation ; Fetus ; Humans ; Interleukin-2/adverse effects ; Interleukin-2/immunology ; Interleukin-2/pharmacology ; Mice ; Recombinant Proteins/adverse effects ; Recombinant Proteins/immunology ; Recombinant Proteins/pharmacology
Czasopismo naukowe
Tytuł :
POTN: A Human Leukocyte Antigen-A2 Immunogenic Peptides Screening Model and Its Applications in Tumor Antigens Prediction.
Autorzy :
Meng Q; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Wu Y; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Sui X; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Meng J; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Wang T; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Lin Y; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Wang Z; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Zhou X; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Qi Y; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Du J; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Gao Y; School of Life Sciences, Zhengzhou University, Zhengzhou, China.; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Oct 07; Vol. 11, pp. 02193. Date of Electronic Publication: 2020 Oct 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Immunological*
Antigens, Neoplasm/*immunology
HLA-A2 Antigen/*immunology
Peptides/*immunology
Testicular Neoplasms/*immunology
Antigens, Neoplasm/genetics ; HLA-A2 Antigen/genetics ; Humans ; Male ; Peptides/genetics ; Testicular Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease.
Autorzy :
Caruso A; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Vollmer J; LYO-X GmbH, Allschwil, Switzerland.
Machacek M; LYO-X GmbH, Allschwil, Switzerland.
Kortvely E; Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Oct 02; Vol. 16 (10), pp. e1008139. Date of Electronic Publication: 2020 Oct 02 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Models, Immunological*
Complement Pathway, Alternative/*physiology
Hemolysis/*physiology
Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Complement Activation/drug effects ; Complement Activation/physiology ; Complement Inactivating Agents/pharmacology ; Complement Inactivating Agents/therapeutic use ; Complement Pathway, Alternative/drug effects ; Computational Biology ; Hemoglobinuria, Paroxysmal/drug therapy ; Hemoglobinuria, Paroxysmal/physiopathology ; Hemolysis/drug effects ; Humans
Czasopismo naukowe

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