- Tytuł :
-
Differential inhibition of human CYP2C8 and
molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. - Autorzy :
- Źródło :
- Chemico-biological interactions [Chem Biol Interact] 2021 Apr 01; Vol. 338, pp. 109401. Date of Electronic Publication: 2021 Feb 05.
- Typ publikacji :
- Journal Article
- MeSH Terms :
-
Metabolome*
Molecular Docking Simulation *
Cytochrome P-450 CYP2C8/*chemistry
Cytochrome P-450 CYP2C8/*metabolism
Cytochrome P-450 CYP2C8 Inhibitors/*pharmacology
Oxides/*pharmacology
Sorafenib/*metabolism
Sorafenib/*pharmacology
Adult ; Biotransformation/drug effects ; Catalytic Domain ; Humans ; Losartan/pharmacology ; Male ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; Middle Aged ; Oxidation-Reduction ; Substrate Specificity/drug effects -
Czasopismo naukowe