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Wyszukujesz frazę ""Molecular Medicine"" wg kryterium: Temat


Tytuł :
Gene therapy matures to medicines.
Autorzy :
Davidson BL; The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, the Children's Hospital of Philadelphia.; The Department of Pathology and Laboratory Medicine Perelman School at the University of Pennsylvania.
Arruda VR; The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, the Children's Hospital of Philadelphia.; The Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA USA.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2019 Oct 01; Vol. 28 (R1), pp. R1-R2.
Typ publikacji :
Editorial
MeSH Terms :
Genetic Therapy*/methods
Genetic Therapy*/trends
Molecular Medicine*/methods
Molecular Medicine*/trends
Humans
Opinia redakcyjna
Tytuł :
Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury.
Autorzy :
Hara-Chikuma M; Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan. .
Tanaka M; Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.; Keio Global Research Institute, Center for Water Biology and Medicine, Tokyo, Japan.
Verkman AS; Departments of Medicine and Physiology, University of California San Francisco, San Francisco, CA, USA.
Yasui M; Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.; Keio Global Research Institute, Center for Water Biology and Medicine, Tokyo, Japan.
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Źródło :
Nature communications [Nat Commun] 2020 Nov 09; Vol. 11 (1), pp. 5666. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*pharmacology
Aquaporin 3/*antagonists & inhibitors
Aquaporin 3/*metabolism
Chemical and Drug Induced Liver Injury/*drug therapy
Macrophages/*drug effects
Macrophages/*metabolism
Animals ; Aquaporin 3/genetics ; CHO Cells ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/prevention & control ; Chemokine CCL4/adverse effects ; Cricetulus ; Disease Models, Animal ; Drug Discovery ; Glycerol/metabolism ; Hydrogen Peroxide/metabolism ; Liver/metabolism ; Liver/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Medicine ; NF-kappa B/metabolism ; Oxidative Stress ; Signal Transduction ; Transcriptome
Czasopismo naukowe
Tytuł :
Cryptogenic cirrhosis: Old and new perspectives in the era of molecular and genomic medicine.
Autorzy :
Nalbantoglu I; Yale School of Medicine, Department of Anatomic Pathology, 20 York Street EP2-608B, New Haven, CT, USA. Electronic address: .
Jain D; Yale School of Medicine, Department of Anatomic Pathology, 20 York Street EP2-608B, New Haven, CT, USA.
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Źródło :
Seminars in diagnostic pathology [Semin Diagn Pathol] 2019 Nov; Vol. 36 (6), pp. 389-394. Date of Electronic Publication: 2019 Jul 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genomics*
Molecular Medicine*
Liver Cirrhosis/*congenital
Genetic Testing ; High-Throughput Nucleotide Sequencing ; Humans ; Liver Cirrhosis/genetics ; Whole Exome Sequencing
SCR Disease Name :
Cirrhosis, Cryptogenic
Czasopismo naukowe
Tytuł :
Leveraging the power of new molecular technologies in the clinical setting requires unprecedented awareness of limitations and drawbacks: experience of one diagnostic laboratory.
Autorzy :
Nfonsam L; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Ordorica S; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Ghani M; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Potter R; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Schaffer A; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Daoud H; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Vasli N; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Chisholm C; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Sinclair-Bourque E; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
McGowan-Jordan J; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Smith AC; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Jarinova O; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Bronicki L; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.
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Źródło :
Journal of medical genetics [J Med Genet] 2019 Jun; Vol. 56 (6), pp. 408-412. Date of Electronic Publication: 2018 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Diagnostic Techniques*/methods
Molecular Diagnostic Techniques*/standards
Molecular Medicine*/methods
Molecular Medicine*/standards
Alleles ; Computational Biology/methods ; Disease Management ; Gene Duplication ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Molecular Sequence Annotation
Czasopismo naukowe
Tytuł :
Still a place for conventional histopathological analysis in the era of molecular medicine: predicting prognosis of resectable ductal pancreatic adenocarcinoma.
Autorzy :
Fernández Aceñero MJ; Department of Surgical Pathology, Hospital Clínico San Carlos, Avda. Prof. Martín Lagos s/n, 28040, Madrid, Spain. .
Martínez-Useros J; Department of Traslational Oncology, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.
Díez-Valladares L; Surgery (Pancreatobiliary Unit), Hospital Clínico San Carlos, Madrid, Spain.
García-Botella S; Surgery (Pancreatobiliary Unit), Hospital Clínico San Carlos, Madrid, Spain.
Ortega Medina L; Department of Surgical Pathology, Hospital Clínico San Carlos, Avda. Prof. Martín Lagos s/n, 28040, Madrid, Spain.
Pérez Aguirre E; Surgery (Pancreatobiliary Unit), Hospital Clínico San Carlos, Madrid, Spain.
de la Serna Esteban S; Surgery (Pancreatobiliary Unit), Hospital Clínico San Carlos, Madrid, Spain.
Latorre E; Department of Surgical Pathology, Hospital Clínico San Carlos, Avda. Prof. Martín Lagos s/n, 28040, Madrid, Spain.
Neelsen L; Department of Surgical Pathology, Hospital Clínico San Carlos, Avda. Prof. Martín Lagos s/n, 28040, Madrid, Spain.
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Źródło :
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2019 Jul; Vol. 21 (7), pp. 954-959. Date of Electronic Publication: 2018 Dec 18.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Medicine*
Adenocarcinoma/*pathology
Carcinoma, Pancreatic Ductal/*pathology
Neoplasm Recurrence, Local/*pathology
Pancreatic Neoplasms/*pathology
Pancreaticoduodenectomy/*methods
Adenocarcinoma/surgery ; Aged ; Carcinoma, Pancreatic Ductal/surgery ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Neoplasm Recurrence, Local/surgery ; Pancreatic Neoplasms/surgery ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Navigating the disease landscape: knowledge representations for contextualizing molecular signatures.
Autorzy :
Saqi M; Mansoor Saqi Data Science Institute, Imperial College London, UK.
Lysenko A; Artem Lysenko Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Guo YK; Yi-Ke Guo Data Science Institute, Imperial College London, UK.
Tsunoda T; Tatsuhiko Tsunoda Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan CREST, JST, Tokyo, Japan Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Auffray C; Charles Auffray European Institute for Systems Biology and Medicine, Lyon, France.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2019 Mar 25; Vol. 20 (2), pp. 609-623.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Computational Biology*
Molecular Medicine*
Humans ; Precision Medicine
Czasopismo naukowe
Tytuł :
Cellular census of human fibrosis defines functionally distinct stromal cell types and states.
Autorzy :
Layton TB; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Williams L; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
McCann F; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Zhang M; Department of Inflammation Research, Celgene Corporation, San Diego, CA, USA.
Fritzsche M; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Colin-York H; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, UK.
Cabrita M; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Ng MTH; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, UK.
Feldmann M; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Sansom SN; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Furniss D; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford, UK.
Xie W; Department of Inflammation Research, Celgene Corporation, San Diego, CA, USA.; Institute of Materia Medica, Shandong First Medical University & Shandong, Academy of Medical Sciences, Jinan, Shandong Province, P. R. China.
Nanchahal J; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 02; Vol. 11 (1), pp. 2768. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Dupuytren Contracture/*immunology
Dupuytren Contracture/*metabolism
Fibrosis/*immunology
Fibrosis/*metabolism
Stromal Cells/*metabolism
Actins/metabolism ; Biomarkers/metabolism ; Chemokines, CXC/metabolism ; Dupuytren Contracture/pathology ; Fibrosis/pathology ; Humans ; Intercellular Adhesion Molecule-1/metabolism ; Molecular Medicine ; Myofibroblasts/metabolism ; Tetraspanins/metabolism ; Tumor Microenvironment/physiology
Czasopismo naukowe
Tytuł :
CRISPR in Sub-Saharan Africa: Applications and Education.
Autorzy :
Ogaugwu CE; Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697-4500, USA; Department of Animal and Environmental Biology, Federal University Oye-Ekiti, 371010 Ekiti State, Nigeria; Laboratory website: http://sites.uci.edu/jameslab. Electronic address: .
Agbo SO; Department of Animal and Environmental Biology, Federal University Oye-Ekiti, 371010 Ekiti State, Nigeria.
Adekoya MA; Department of Plant Science and Biotechnology, Federal University Oye-Ekiti, 371010 Ekiti State, Nigeria.
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Źródło :
Trends in biotechnology [Trends Biotechnol] 2019 Mar; Vol. 37 (3), pp. 234-237. Date of Electronic Publication: 2018 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Agriculture/*methods
Biotechnology/*methods
Gene Editing/*methods
Molecular Medicine/*methods
Africa South of the Sahara ; Agriculture/education ; Biotechnology/education ; Molecular Medicine/education
Czasopismo naukowe
Tytuł :
Single-Molecule Sequencing: Towards Clinical Applications.
Autorzy :
Ameur A; Department of Immunology, Genetics and Pathology, Uppsala University, Science for Life Laboratory, Uppsala, 75108, Sweden; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; All authors contributed equally to this work; ORCID: 0000-0001-6085-6749 (A. Ameur) and 0000-0003-3357-4580 (W.P. Kloosterman). Electronic address: .
Kloosterman WP; Department of Genetics, Center for Molecular Medicine, UMC Utrecht, Utrecht, 3584 CG, The Netherlands; All authors contributed equally to this work; ORCID: 0000-0001-6085-6749 (A. Ameur) and 0000-0003-3357-4580 (W.P. Kloosterman). Electronic address: .
Hestand MS; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; All authors contributed equally to this work. Electronic address: .
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Źródło :
Trends in biotechnology [Trends Biotechnol] 2019 Jan; Vol. 37 (1), pp. 72-85. Date of Electronic Publication: 2018 Aug 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
High-Throughput Nucleotide Sequencing/*methods
Molecular Diagnostic Techniques/*methods
Molecular Medicine/*methods
Sequence Analysis, DNA/*methods
Humans ; Molecular Diagnostic Techniques/trends ; Molecular Medicine/trends
Czasopismo naukowe
Tytuł :
Healthy Pollinators: Evaluating Pesticides with Molecular Medicine Approaches.
Autorzy :
López-Osorio F; Department of Organismal Biology, School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK.
Wurm Y; Department of Organismal Biology, School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK; Alan Turing Institute, London NW1 2DB, UK. Electronic address: .
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Źródło :
Trends in ecology & evolution [Trends Ecol Evol] 2020 May; Vol. 35 (5), pp. 380-383. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pesticides*
Agriculture ; Molecular Medicine
Czasopismo naukowe
Tytuł :
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer.
Autorzy :
Acar A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Department of Biological Sciences, Middle East Technical University, Ankara, Turkey.
Nichol D; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Fernandez-Mateos J; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Cresswell GD; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Barozzi I; Department of Surgery and Cancer, Imperial College London, London, UK.
Hong SP; Department of Surgery and Cancer, Imperial College London, London, UK.
Trahearn N; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Spiteri I; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Stubbs M; CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.
Burke R; CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.
Stewart A; Clinical Pharmacology-Adaptive Therapy Group, Division of Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, London, UK.
Caravagna G; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Werner B; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Vlachogiannis G; Gastrointestinal Cancer Biology and Genomics Team, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Maley CC; Arizona Cancer Evolution Center, Biodesign Institute, Arizona State University, Tempe, USA.
Magnani L; Department of Surgery and Cancer, Imperial College London, London, UK.
Valeri N; Gastrointestinal Cancer Biology and Genomics Team, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK.
Banerji U; CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK. .; Clinical Pharmacology-Adaptive Therapy Group, Division of Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, London, UK. .; Drug Development Unit, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, London, UK. .
Sottoriva A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Apr 21; Vol. 11 (1), pp. 1923. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Resistance, Neoplasm*
Evolution, Molecular*
Antineoplastic Agents/*pharmacology
Lung Neoplasms/*drug therapy
Lung Neoplasms/*genetics
Clonal Evolution ; Computational Biology ; Computer Simulation ; Gefitinib/pharmacology ; Genotype ; Humans ; Lung Neoplasms/pathology ; Models, Theoretical ; Molecular Medicine ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; Stochastic Processes
Czasopismo naukowe
Tytuł :
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects.
Autorzy :
Tomasovic A; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 44139, Dortmund, Germany.
Brand T; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 44139, Dortmund, Germany.
Schanbacher C; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 44139, Dortmund, Germany.
Kramer S; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.
Hümmert MW; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.; Department of Neurology, Hannover Medical School, 30625, Hannover, Germany.
Godoy P; IfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, 44139, Dortmund, Germany.
Schmidt-Heck W; Leibniz Institute for Natural Product Research and Infection Biology -Hans Knoell Institute-, 07745, Jena, Germany.
Nordbeck P; Comprehensive Heart Failure Center, 97078, Würzburg, Germany.
Ludwig J; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Erlangen, Germany.
Homann S; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.
Wiegering A; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital of Würzburg, 97080, Würzburg, Germany.
Shaykhutdinov T; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 12489, Berlin, Germany.
Kratz C; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 12489, Berlin, Germany.
Knüchel R; Institute of Pathology, University Hospital Aachen, RWTH Aachen, 52074, Aachen, Germany.
Müller-Hermelink HK; Institute of Pathology, University of Würzburg, 97080, Würzburg, Germany.
Rosenwald A; Institute of Pathology, University of Würzburg, 97080, Würzburg, Germany.
Frey N; Department of Internal Medicine III, University of Kiel, 24105, Kiel, Germany.; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Kiel, Germany.
Eichler J; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Erlangen, Germany.
Dobrev D; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, 45147, Essen, Germany.
El-Armouche A; Department of Pharmacology and Toxicology, TU Dresden, 01307, Dresden, Germany.
Hengstler JG; IfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, 44139, Dortmund, Germany.
Müller OJ; Department of Internal Medicine III, University of Kiel, 24105, Kiel, Germany.; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Kiel, Germany.
Hinrichs K; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 12489, Berlin, Germany.
Cuello F; Institute of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Zernecke A; Institute of Experimental Biomedicine, University Hospital Würzburg, University of Würzburg, 97080, Würzburg, Germany.
Lorenz K; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany. .; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 44139, Dortmund, Germany. .; Comprehensive Heart Failure Center, 97078, Würzburg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Apr 07; Vol. 11 (1), pp. 1733. Date of Electronic Publication: 2020 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiotoxicity*
Dimerization*
MAP Kinase Signaling System*/drug effects
MAP Kinase Signaling System*/physiology
Cell-Penetrating Peptides/*pharmacology
Extracellular Signal-Regulated MAP Kinases/*metabolism
Animals ; Cell Culture Techniques ; Cell-Penetrating Peptides/chemical synthesis ; Cell-Penetrating Peptides/toxicity ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/metabolism ; Drug Delivery Systems ; Extracellular Signal-Regulated MAP Kinases/drug effects ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Medicine ; Rats ; Rats, Sprague-Dawley ; Signal Transduction
Czasopismo naukowe
Tytuł :
Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine.
Autorzy :
Radi R; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay; .; Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jun 05; Vol. 115 (23), pp. 5839-5848. Date of Electronic Publication: 2018 May 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Molecular Medicine*
Nitric Oxide*/metabolism
Nitric Oxide*/physiology
Oxidation-Reduction*
Peroxynitrous Acid*/metabolism
Peroxynitrous Acid*/physiology
Free Radicals/*metabolism
Animals ; Biomedical Research ; Humans ; Proteins/metabolism ; Superoxide Dismutase/metabolism ; Tyrosine/metabolism
Czasopismo naukowe
Tytuł :
Looking Good in Your Genes: Maximizing One's Personalized Molecular Fingerprint for Optimal Health.
Autorzy :
Bluth MH; Bluth Bio Industries, Southfield, MI 48034, USA; Wayne State University School of Medicine, Detroit, MI 48201, USA; Pathology Laboratories, Michigan Surgical Hospital, Warren, MI 48091, USA; Kids Kicking Cancer, Southfield, MI 48034, USA. Electronic address: .
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Źródło :
Clinics in laboratory medicine [Clin Lab Med] 2018 Jun; Vol. 38 (2), pp. xiii-xvi.
Typ publikacji :
Editorial
MeSH Terms :
Genomics*
Molecular Medicine*
Precision Medicine*
Genetic Predisposition to Disease ; Humans
Opinia redakcyjna
Tytuł :
Molecular testing practices and perceptions among dermatopathologists.
Autorzy :
Torre K; University of Connecticut School of Medicine, Farmington, Connecticut.
Jhorar P; Department of Dermatology, UConn Health, Farmington, Connecticut.
Wu R; The Biostatistics Center, Connecticut Institute for Clinical and Translational Science, Farmington, Connecticut.
Pfeifer J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
Elaba Z; Department of Pathology, Hartford Hospital, Hartford, Connecticut.
Murphy M; University of Connecticut School of Medicine, Farmington, Connecticut.; Department of Dermatology, UConn Health, Farmington, Connecticut.
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Źródło :
Journal of cutaneous pathology [J Cutan Pathol] 2018 Jun; Vol. 45 (6), pp. 387-394. Date of Electronic Publication: 2018 Mar 22.
Typ publikacji :
Journal Article
MeSH Terms :
Dermatologists*
Health Knowledge, Attitudes, Practice*
Molecular Medicine*
Pathologists*
Practice Patterns, Physicians'/*statistics & numerical data
Skin Neoplasms/*diagnosis
Adult ; Aged ; Dermatology ; Female ; Humans ; Male ; Middle Aged ; Pathology, Clinical ; Skin Neoplasms/genetics ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training.
Autorzy :
Berger A
Matloubian M
Shah NP
Wachter RM
DeRisi JL
Anderson M
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Źródło :
Journal of graduate medical education [J Grad Med Educ] 2020 Feb; Vol. 12 (1), pp. 92-97.
Typ publikacji :
Journal Article
MeSH Terms :
Attitude of Health Personnel*
Molecular Medicine/*education
Physicians/*psychology
Research/*education
Students, Medical/*psychology
Education, Medical, Undergraduate ; Humans ; Internship and Residency ; Laboratory Personnel ; Program Evaluation ; Research Personnel ; San Francisco
Czasopismo naukowe
Tytuł :
Biomarker-guided therapy for colorectal cancer: strength in complexity.
Autorzy :
Sveen A; Department of Molecular Oncology, Institute for Cancer Research & K.G. Jebsen Colorectal Cancer Research Centre, Division for Cancer Medicine, Oslo University Hospital, Oslo, Norway. .; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. .
Kopetz S; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lothe RA; Department of Molecular Oncology, Institute for Cancer Research & K.G. Jebsen Colorectal Cancer Research Centre, Division for Cancer Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
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Źródło :
Nature reviews. Clinical oncology [Nat Rev Clin Oncol] 2020 Jan; Vol. 17 (1), pp. 11-32. Date of Electronic Publication: 2019 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*therapy
Molecular Targeted Therapy/*methods
Precision Medicine/*methods
Clinical Trials as Topic ; Colorectal Neoplasms/genetics ; Humans ; Molecular Medicine/methods ; Prognosis
Czasopismo naukowe

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