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Wyszukujesz frazę ""Molecular Probes"" wg kryterium: Temat


Tytuł :
9-Cyanopyronin probe palette for super-multiplexed vibrational imaging.
Autorzy :
Miao Y; Department of Chemistry, Columbia University, New York, NY, USA.
Qian N; Department of Chemistry, Columbia University, New York, NY, USA.
Shi L; Department of Chemistry, Columbia University, New York, NY, USA.
Hu F; Department of Chemistry, Columbia University, New York, NY, USA.
Min W; Department of Chemistry, Columbia University, New York, NY, USA. .; Kavli Institute for Brain Science, Columbia University, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 26; Vol. 12 (1), pp. 4518. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Coloring Agents/*chemistry
Molecular Probes/*chemistry
Nonlinear Optical Microscopy/*methods
Optical Imaging/*methods
Pyronine/*chemistry
Coloring Agents/chemical synthesis ; HeLa Cells ; Humans ; Models, Chemical ; Molecular Probes/chemical synthesis ; Molecular Structure ; Pyronine/analogs & derivatives ; Pyronine/chemical synthesis ; Spectrum Analysis, Raman/methods ; Vibration
Czasopismo naukowe
Tytuł :
The chromatographic behaviour of new double-labelled oligodeoxynucleotide probes containing azaphthalocyanine dye as a quencher with respect to evaluation of their purity.
Autorzy :
Kučera R; Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Charles University, Hradec Králové, Czech Republic.
Sčensná A; Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Charles University, Hradec Králové, Czech Republic.
Miletín M; Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Charles University, Hradec Králové, Czech Republic.
Zimčík P; Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Charles University, Hradec Králové, Czech Republic.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2021 Apr; Vol. 35 (4), pp. e5033. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article
MeSH Terms :
Aza Compounds*/analysis
Aza Compounds*/chemistry
Fluorescent Dyes*/analysis
Fluorescent Dyes*/chemistry
Molecular Probes*/analysis
Molecular Probes*/chemistry
Oligodeoxyribonucleotides*/analysis
Oligodeoxyribonucleotides*/chemistry
Chromatography, High Pressure Liquid/*methods
Acetonitriles/chemistry ; Hydrophobic and Hydrophilic Interactions ; Solvents
Czasopismo naukowe
Tytuł :
Computation-guided optimization of split protein systems.
Autorzy :
Dolberg TB; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Northwestern University, Evanston, IL, USA.
Meger AT; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Boucher JD; Center for Synthetic Biology, Northwestern University, Evanston, IL, USA.; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA.
Corcoran WK; Center for Synthetic Biology, Northwestern University, Evanston, IL, USA.; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA.
Schauer EE; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Northwestern University, Evanston, IL, USA.
Prybutok AN; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Northwestern University, Evanston, IL, USA.
Raman S; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. .; Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, USA. .; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. .; Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA. .
Leonard JN; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA. .; Center for Synthetic Biology, Northwestern University, Evanston, IL, USA. .; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA. .; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA. .; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 May; Vol. 17 (5), pp. 531-539. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Molecular Probes/*chemistry
Protein Engineering/*methods
Transcription Factors/*genetics
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Endopeptidases/chemistry ; Endopeptidases/metabolism ; Genes, Reporter ; HEK293 Cells ; Humans ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Molecular Probes/genetics ; Molecular Probes/metabolism ; Mutation ; Protein Multimerization ; Proteolysis ; Sirolimus/metabolism ; Sirolimus/pharmacology ; Tacrolimus Binding Proteins/genetics ; Tacrolimus Binding Proteins/metabolism ; Transcription Factors/metabolism ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Development of a 1,2-difluorofucoside activity-based probe for profiling GH29 fucosidases.
Autorzy :
Luijkx YMCA; Department Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands. .
Jongkees S
Strijbis K
Wennekes T
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Źródło :
Organic & biomolecular chemistry [Org Biomol Chem] 2021 Apr 07; Vol. 19 (13), pp. 2968-2977. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fucose/*chemistry
Molecular Probes/*chemistry
alpha-L-Fucosidase/*analysis
Bacteroides fragilis/enzymology ; Fucose/analogs & derivatives ; Fucose/pharmacology ; Gastrointestinal Microbiome ; Humans ; Molecular Probes/chemical synthesis ; Molecular Probes/pharmacology ; Molecular Structure ; alpha-L-Fucosidase/antagonists & inhibitors ; alpha-L-Fucosidase/metabolism
Czasopismo naukowe
Tytuł :
Specific enrichment and glycosylation discrepancy profiling of cellular exosomes using a dual-affinity probe.
Autorzy :
Zhang N; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China and Department of Chemistry, Fudan University, Shanghai, 200433, China. .
Hu X; Department of Chemistry, Fudan University, Shanghai, 200433, China. .
Chen H; Department of Chemistry, Fudan University, Shanghai, 200433, China. .
Deng C; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China and Department of Chemistry, Fudan University, Shanghai, 200433, China. .
Sun N; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Jun 24; Vol. 57 (51), pp. 6249-6252.
Typ publikacji :
Journal Article
MeSH Terms :
Exosomes/*metabolism
Glycoproteins/*analysis
Molecular Probes/*metabolism
Cell Line, Tumor ; Ferrosoferric Oxide/chemistry ; Glutathione/chemistry ; Glutathione/metabolism ; Glycoproteins/metabolism ; Glycosylation ; Humans ; Hydrophobic and Hydrophilic Interactions ; Magnetite Nanoparticles/chemistry ; Molecular Probes/chemistry ; Proteomics/methods ; Titanium/chemistry
Czasopismo naukowe
Tytuł :
Molecular rotors as intracellular probes of red blood cell stiffness.
Autorzy :
Briole A; Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS - Université de Paris, 75013 Paris, France. .
Podgorski T; Laboratoire Rhéologie et Procédés, UMR 5520 CNRS-UGA-G.INP - Domaine Universitaire, BP 53 38041 Grenoble Cedex 9, France. .
Abou B; Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS - Université de Paris, 75013 Paris, France. .
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Źródło :
Soft matter [Soft Matter] 2021 May 05; Vol. 17 (17), pp. 4525-4537.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorescent Dyes*
Molecular Probes*
Erythrocytes ; Rheology ; Viscosity
Czasopismo naukowe
Tytuł :
Clinically relevant dual probe difference specimen imaging (DDSI) protocol for freshly resected breast cancer specimen staining.
Autorzy :
House BJ; Biomedical Engineering Department, Oregon Health & Science University, 2730 S Moody Ave, Mail Code: CL3SG, Portland, OR, 97201, USA.
Kwon MJ; Biomedical Engineering Department, Oregon Health & Science University, 2730 S Moody Ave, Mail Code: CL3SG, Portland, OR, 97201, USA.
Schaefer JM; Biomedical Engineering Department, Oregon Health & Science University, 2730 S Moody Ave, Mail Code: CL3SG, Portland, OR, 97201, USA.
Barth CW; Biomedical Engineering Department, Oregon Health & Science University, 2730 S Moody Ave, Mail Code: CL3SG, Portland, OR, 97201, USA.
Solanki A; Biomedical Engineering Department, Oregon Health & Science University, 2730 S Moody Ave, Mail Code: CL3SG, Portland, OR, 97201, USA.
Davis SC; Thayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Gibbs SL; Biomedical Engineering Department, Oregon Health & Science University, 2730 S Moody Ave, Mail Code: CL3SG, Portland, OR, 97201, USA. .; Knight Cancer Institute, Oregon Health & Science University, 2730 S Moody Ave, Mail Code: CL3SG, Portland, OR, 97201, USA. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Apr 21; Vol. 21 (1), pp. 440. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Probes*
Breast Neoplasms/*diagnostic imaging
Breast Neoplasms/*pathology
Diagnostic Imaging/*methods
Animals ; Breast Neoplasms/surgery ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Humans ; Mice ; Neoplasm Staging ; Staining and Labeling/methods
Czasopismo naukowe
Tytuł :
The Function of Sialidase Revealed by Sialidase Activity Imaging Probe.
Autorzy :
Minami A; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Kurebayashi Y; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Takahashi T; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Otsubo T; Department of Organic Chemistry, School of Pharmaceutical Sciences, Hiroshima International University, Hiroshima 737-0112, Japan.
Ikeda K; Department of Organic Chemistry, School of Pharmaceutical Sciences, Hiroshima International University, Hiroshima 737-0112, Japan.
Suzuki T; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 20; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Imaging*/methods
Molecular Probes*/chemistry
Molecular Probes*/metabolism
Neuraminidase/*metabolism
Animals ; Contrast Media ; Enzyme Activation ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Glutamic Acid/biosynthesis ; Humans ; Neurons/metabolism ; Optical Imaging/methods ; Organ Specificity ; Virus Diseases/diagnostic imaging ; Virus Diseases/metabolism ; Virus Diseases/virology
Czasopismo naukowe
Tytuł :
Identifying Poly(ADP-ribose)-Binding Proteins with Photoaffinity-Based Proteomics.
Autorzy :
Dasovich M; Department of Chemistry, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland 21218, United States.; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Beckett MQ; Department of Biophysics and Biophysical Chemistry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Bailey S; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.; Department of Biophysics and Biophysical Chemistry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Ong SE; Department of Pharmacology, University of Washington, Seattle, Washington 98195, United States.
Greenberg MM; Department of Chemistry, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Leung AKL; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.; Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, United States.; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2021 Mar 03; Vol. 143 (8), pp. 3037-3042. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Light*
Molecular Probes/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
Proteomics/*methods
Molecular Probes/chemical synthesis ; Molecular Probes/chemistry ; Signal Transduction
Czasopismo naukowe
Tytuł :
Novel luminescent affiprobes for molecular detection of Staphylococcus aureus using flow cytometry.
Autorzy :
Shakeran Z; Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Javadi-Zarnaghi F; Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Emamzadeh R; Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.; NanoBioPhotonics Lab, Department of Biological Engineering, Utah State University, Utah, United States.
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Źródło :
Journal of applied microbiology [J Appl Microbiol] 2021 Feb; Vol. 130 (2), pp. 493-503. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
Bacteriological Techniques/*methods
Flow Cytometry/*methods
Molecular Probes/*metabolism
Staphylococcus aureus/*isolation & purification
Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/isolation & purification ; Green Fluorescent Proteins/metabolism ; Humans ; Luminescence ; Molecular Probes/genetics ; Molecular Probes/isolation & purification ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/isolation & purification ; Recombinant Fusion Proteins/metabolism ; Species Specificity ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/cytology ; Staphylococcus aureus/metabolism
Czasopismo naukowe
Tytuł :
NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins.
Autorzy :
Scheu AHA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
Lim SYT; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
Metzner FJ; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377, Munich, Germany.
Mohammed S; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
Howarth M; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 29; Vol. 12 (1), pp. 717. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*genetics
Membrane Proteins/*genetics
Molecular Probes/*metabolism
Protein Engineering/*methods
Recombinant Fusion Proteins/*metabolism
Staining and Labeling/*methods
Anhydrides/metabolism ; Animals ; Molecular Imaging/methods ; Molecular Probes/chemistry ; Molecular Probes/genetics ; Proteolysis ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics
Czasopismo naukowe
Tytuł :
Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study.
Autorzy :
Atkinson EL; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Iegre J; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Brear PD; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
Zhabina EA; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
Hyvönen M; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
Spring DR; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 31; Vol. 26 (7). Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Casein Kinase II/*metabolism
Molecular Probes/*chemistry
Protein Kinase Inhibitors/*chemistry
Protein Kinases/*chemistry
Protein Kinases/*metabolism
Adenosine Triphosphate/metabolism ; Binding Sites ; COVID-19 ; Casein Kinase II/chemistry ; Dichlororibofuranosylbenzimidazole/chemistry ; Dichlororibofuranosylbenzimidazole/pharmacology ; Humans ; Molecular Probes/metabolism ; Naphthyridines/chemistry ; Naphthyridines/pharmacology ; Phenazines/chemistry ; Phenazines/pharmacology ; Polyphenols/chemistry ; Polyphenols/pharmacology ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Investigating eosin Y as a photocatalyst for the radical-dependent activity-based probing of deubiquitinating enzymes.
Autorzy :
Taylor NC; School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St., Dublin 2, Ireland. .
McGouran JF; School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St., Dublin 2, Ireland. .
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Źródło :
Organic & biomolecular chemistry [Org Biomol Chem] 2021 Mar 18; Vol. 19 (10), pp. 2177-2181.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine Endopeptidases/*chemistry
Deubiquitinating Enzymes/*chemistry
Eosine Yellowish-(YS)/*chemistry
Molecular Probes/*chemistry
Alkenes/chemistry ; Catalysis/radiation effects ; Cysteine/chemistry ; Eosine Yellowish-(YS)/radiation effects ; HEK293 Cells ; Humans ; Light ; Molecular Probes/radiation effects
Czasopismo naukowe
Tytuł :
F-Labelled pyrrolopyrimidines reveal brain leucine-rich repeat kinase 2 expression implicated in Parkinson's disease.
Autorzy :
Chen X; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Zhang Q; Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, China; Fujian Key Laboratory of Molecular Neurology, Key Laboratory of Brain Aging and Neurodegenerative Disease, Fujian Medical University, Fuzhou, Fujian, 350001, China.
Zhang Y; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Fang J; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Jiang D; PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Mou Z; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Liu H; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Su R; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
Wang C; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
He F; School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Chen X; Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, China; Fujian Key Laboratory of Molecular Neurology, Key Laboratory of Brain Aging and Neurodegenerative Disease, Fujian Medical University, Fuzhou, Fujian, 350001, China. Electronic address: .
Xie F; PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address: .
Pan X; Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, China; Fujian Key Laboratory of Molecular Neurology, Key Laboratory of Brain Aging and Neurodegenerative Disease, Fujian Medical University, Fuzhou, Fujian, 350001, China. Electronic address: .
Li Z; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 15; Vol. 214, pp. 113245. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*metabolism
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*genetics
Molecular Probes/*chemistry
Parkinson Disease/*metabolism
Pyrimidines/*chemistry
Pyrroles/*chemistry
Animals ; Brain/pathology ; Dose-Response Relationship, Drug ; Fluorine Radioisotopes ; HEK293 Cells ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Molecular Docking Simulation ; Molecular Probes/chemical synthesis ; Molecular Structure ; Parkinson Disease/pathology ; Positron-Emission Tomography ; Pyrimidines/chemical synthesis ; Pyrroles/chemical synthesis ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling.
Autorzy :
Iwashita H; Department of Chemistry, University of California, Berkeley, CA 94720.
Castillo E; Department of Neurology, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94143.
Messina MS; Department of Chemistry, University of California, Berkeley, CA 94720.
Swanson RA; Department of Neurology, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94143.; Neurology Service, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121.
Chang CJ; Department of Chemistry, University of California, Berkeley, CA 94720; .; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.; Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 02; Vol. 118 (9).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Fluorescent Dyes/*metabolism
Hydrogen Peroxide/*metabolism
Microglia/*metabolism
Molecular Probes/*metabolism
Neurons/*metabolism
Signal Transduction/*physiology
Animals ; Boronic Acids/chemistry ; Cell Communication ; Cerebral Cortex/cytology ; Cerebral Cortex/metabolism ; Coculture Techniques ; Embryo, Mammalian ; Fluorescent Dyes/chemical synthesis ; HeLa Cells ; Humans ; Mice ; Microglia/cytology ; Microglia/drug effects ; Molecular Probes/chemical synthesis ; Neurons/cytology ; Neurons/drug effects ; Oxidation-Reduction ; Paraquat/pharmacology ; RAW 264.7 Cells ; Staining and Labeling/methods
Czasopismo naukowe
Tytuł :
Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay.
Autorzy :
Sundström Y; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Shang MM; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Panda SK; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Grönwall C; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Wermeling F; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Gunnarsson I; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Lundberg IE; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Sundström M; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Jakobsson PJ; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Berg L; Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. Electronic address: .
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Źródło :
Translational research : the journal of laboratory and clinical medicine [Transl Res] 2021 Mar; Vol. 229, pp. 69-82. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoimmune Diseases/*pathology
B-Lymphocytes/*drug effects
B-Lymphocytes/*pathology
Molecular Probes/*pharmacology
Adult ; Aged ; B-Lymphocytes/immunology ; Case-Control Studies ; Cells, Cultured ; Cytokines/metabolism ; Epigenesis, Genetic ; Female ; Humans ; Immunoglobulin Isotypes/metabolism ; Leukocytes, Mononuclear ; Lupus Erythematosus, Systemic/pathology ; Male ; Middle Aged ; Molecular Probes/chemistry ; Myositis, Inclusion Body/pathology ; Piperidines/pharmacology ; Polymyositis/pathology ; Pyrimidines/pharmacology
Czasopismo naukowe
Tytuł :
Application of molecular probes in nuclear imaging of neuroendocrine tumors.
Autorzy :
Yan J; Department of PET,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China.
Zhang T; Department of PET,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China.
Zhao K; Department of PET,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China.
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Źródło :
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2021 Feb 25; Vol. 50 (1), pp. 131-137.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Probes*
Neuroendocrine Tumors*/diagnostic imaging
Diagnostic Imaging ; Humans ; Neoplasm Recurrence, Local ; Radionuclide Imaging
Czasopismo naukowe
Tytuł :
Toolkit for Quickly Generating and Characterizing Molecular Probes Specific for SARS-CoV-2 Nucleocapsid as a Primer for Future Coronavirus Pandemic Preparedness.
Autorzy :
Sherwood LJ; Disease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, Texas 78227, United States.
Hayhurst A; Disease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, Texas 78227, United States.
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Źródło :
ACS synthetic biology [ACS Synth Biol] 2021 Feb 19; Vol. 10 (2), pp. 379-390. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Pandemics*/prevention & control
COVID-19/*epidemiology
COVID-19/*virology
Coronavirus Nucleocapsid Proteins/*genetics
Molecular Probes/*genetics
SARS-CoV-2/*genetics
SARS-CoV-2/*immunology
Antibodies, Viral/genetics ; Antibody Specificity/genetics ; COVID-19/immunology ; Communicable Diseases, Emerging/virology ; Coronavirus Nucleocapsid Proteins/immunology ; Escherichia coli/genetics ; Fluorescent Antibody Technique ; Genes, Synthetic ; Genes, Viral ; HEK293 Cells ; Humans ; Molecular Probes/immunology ; Peptide Library ; Phosphoproteins/genetics ; Phosphoproteins/immunology ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; SARS-CoV-2/pathogenicity ; Single-Domain Antibodies/genetics ; Synthetic Biology
Czasopismo naukowe
Tytuł :
Ratiometric Fluorescence Assay for Nitroreductase Activity: Locked-Flavylium Fluorophore as a NTR-Sensitive Molecular Probe.
Autorzy :
Kim SJ; Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea.
Yoon JW; Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea.
Yoon SA; Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea.
Lee MH; Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 19; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Assays/*methods
Fluorescent Dyes/*chemistry
Molecular Probes/*chemistry
Nitroreductases/*metabolism
A549 Cells ; Animals ; Cell Death ; Chromatography, High Pressure Liquid ; Endocytosis ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Mice ; Molecular Probes/chemical synthesis ; NIH 3T3 Cells ; Spectrometry, Fluorescence
Czasopismo naukowe

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