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Wyszukujesz frazę ""Molecular cell [Mol Cell] NLMUID: 9802571"" wg kryterium: JN


Tytuł:
Deaminase deluge yields new opportunities for biotechnology and genome engineering.
Autorzy:
Harris RS; Department of Biochemistry and Structural Biology and Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address: .
Carpenter MA; Department of Biochemistry and Structural Biology and Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 816-818.
Typ publikacji:
Journal Article
MeSH Terms:
Biotechnology*
Cytosine Deaminase*
Czasopismo naukowe
Tytuł:
Discovery of cytosine deaminases enables base-resolution methylome mapping using a single enzyme.
Autorzy:
Vaisvila R; New England Biolabs Inc., 240 County Road, Ipswich, MA 01938, USA. Electronic address: .
Johnson SR; New England Biolabs Inc., 240 County Road, Ipswich, MA 01938, USA.
Yan B; New England Biolabs Inc., 240 County Road, Ipswich, MA 01938, USA.
Dai N; New England Biolabs Inc., 240 County Road, Ipswich, MA 01938, USA.
Bourkia BM; New England Biolabs Inc., 240 County Road, Ipswich, MA 01938, USA.
Chen M; New England Biolabs Inc., 240 County Road, Ipswich, MA 01938, USA.
Corrêa IR Jr; New England Biolabs Inc., 240 County Road, Ipswich, MA 01938, USA.
Yigit E; New England Biolabs Inc., 240 County Road, Ipswich, MA 01938, USA.
Sun Z; New England Biolabs Inc., 240 County Road, Ipswich, MA 01938, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 854-866.e7. Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cytosine Deaminase*
Epigenome*
DNA/genetics ; Cytosine ; DNA, Single-Stranded/genetics ; Cytidine Deaminase/genetics
Czasopismo naukowe
Tytuł:
Feeding two birds with one scone: The dual roles of SMARCAL1 in antitumor immunity.
Autorzy:
Toufektchan E; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Maciejowski J; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 819-821.
Typ publikacji:
Journal Article
MeSH Terms:
Neoplasms*/immunology
DNA
Czasopismo naukowe
Tytuł:
Plot twists and cutting corners with atypical SMCs.
Autorzy:
Haarhuis JHI; Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands. Electronic address: .
Rowland BD; Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 814-815.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Chromosomes*/metabolism
DNA ; DNA Repair ; DNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
Structure of the multi-subunit chloroplast RNA polymerase.
Autorzy:
do Prado PFV; University Medical Center Göttingen, Department of Cellular Biochemistry, Humboldtallee 23, 37073 Göttingen, Germany; Max Planck Institute for Multidisciplinary Sciences, Research Group Structure and Function of Molecular Machines, Am Fassberg 11, 37077 Göttingen, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37075 Göttingen, Germany.
Ahrens FM; Institute of Botany, Plant Physiology, Leibniz University Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany.
Liebers M; Institute of Botany, Plant Physiology, Leibniz University Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany.
Ditz N; Institute of Plant Genetics, Plant Molecular Biology and Plant Proteomics, Leibniz University Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany.
Braun HP; Institute of Plant Genetics, Plant Molecular Biology and Plant Proteomics, Leibniz University Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany.
Pfannschmidt T; Institute of Botany, Plant Physiology, Leibniz University Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany. Electronic address: .
Hillen HS; University Medical Center Göttingen, Department of Cellular Biochemistry, Humboldtallee 23, 37073 Göttingen, Germany; Max Planck Institute for Multidisciplinary Sciences, Research Group Structure and Function of Molecular Machines, Am Fassberg 11, 37077 Göttingen, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37075 Göttingen, Germany; Göttingen Center for Molecular Biosciences (GZMB), Research Group Structure and Function of Molecular Machines, University of Göttingen, 37077 Göttingen, Germany. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 910-925.e5. Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
RNA, Chloroplast*/metabolism
DNA-Directed RNA Polymerases*/genetics
DNA-Directed RNA Polymerases*/metabolism
Chloroplasts/genetics ; Chloroplasts/metabolism ; Plastids/genetics ; Plastids/metabolism ; Gene Expression Regulation, Plant ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
Single-molecule tracking reveals the functional allocation, in vivo interactions, and spatial organization of universal transcription factor NusG.
Autorzy:
El Sayyed H; Gene Machines Group, Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Kavli Institute of Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK. Electronic address: .
Pambos OJ; Gene Machines Group, Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Kavli Institute of Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.
Stracy M; Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford, UK.
Gottesman ME; Department of Microbiology & Immunology, Columbia University Medical Center, New York, NY, USA.
Kapanidis AN; Gene Machines Group, Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Kavli Institute of Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 926-937.e4. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Transcription Factors*/genetics
Transcription Factors*/chemistry
Escherichia coli Proteins*/genetics
Escherichia coli Proteins*/chemistry
Transcription, Genetic ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Peptide Elongation Factors/metabolism ; DNA-Directed RNA Polymerases/genetics ; DNA-Directed RNA Polymerases/metabolism ; Bacterial Proteins/genetics
Czasopismo naukowe
Tytuł:
Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils.
Autorzy:
Jeppsson K; Karolinska Institutet, Department of Cell and Molecular Biology, Biomedicum, Tomtebodavägen 16, 171 77 Stockholm, Sweden; Karolinska Institutet, Department of Biosciences and Nutrition, Neo, Hälsovägen 7c, 141 83 Huddinge, Sweden; Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: .
Pradhan B; Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Sutani T; Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Sakata T; Karolinska Institutet, Department of Cell and Molecular Biology, Biomedicum, Tomtebodavägen 16, 171 77 Stockholm, Sweden; Karolinska Institutet, Department of Biosciences and Nutrition, Neo, Hälsovägen 7c, 141 83 Huddinge, Sweden; Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Umeda Igarashi M; Karolinska Institutet, Department of Cell and Molecular Biology, Biomedicum, Tomtebodavägen 16, 171 77 Stockholm, Sweden; Karolinska Institutet, Department of Biosciences and Nutrition, Neo, Hälsovägen 7c, 141 83 Huddinge, Sweden.
Berta DG; Karolinska Institutet, Department of Cell and Molecular Biology, Biomedicum, Tomtebodavägen 16, 171 77 Stockholm, Sweden.
Kanno T; Karolinska Institutet, Department of Cell and Molecular Biology, Biomedicum, Tomtebodavägen 16, 171 77 Stockholm, Sweden; Karolinska Institutet, Department of Biosciences and Nutrition, Neo, Hälsovägen 7c, 141 83 Huddinge, Sweden.
Nakato R; Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Shirahige K; Karolinska Institutet, Department of Cell and Molecular Biology, Biomedicum, Tomtebodavägen 16, 171 77 Stockholm, Sweden; Karolinska Institutet, Department of Biosciences and Nutrition, Neo, Hälsovägen 7c, 141 83 Huddinge, Sweden; Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Kim E; Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany. Electronic address: .
Björkegren C; Karolinska Institutet, Department of Cell and Molecular Biology, Biomedicum, Tomtebodavägen 16, 171 77 Stockholm, Sweden; Karolinska Institutet, Department of Biosciences and Nutrition, Neo, Hälsovägen 7c, 141 83 Huddinge, Sweden. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 867-882.e5. Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Cycle Proteins*/metabolism
Saccharomyces cerevisiae Proteins*/metabolism
Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; DNA, Superhelical/genetics ; Cohesins ; DNA/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Chromosomes/metabolism
Czasopismo naukowe
Tytuł:
COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells.
Autorzy:
Pelosi L; Université Grenoble Alpes, CNRS UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France.
Morbiato L; Clinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128 Padova, Italy; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.
Burgardt A; Genetics of Prokaryotes, Faculty of Biology, and Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany.
Tonello F; CNR Institute of Neuroscience, 35121 Padova, Italy.
Bartlett AK; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Guerra RM; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ferizhendi KK; Université Grenoble Alpes, CNRS UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France.
Desbats MA; Clinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128 Padova, Italy; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.
Rascalou B; Université Grenoble Alpes, CNRS UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France.
Marchi M; Clinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128 Padova, Italy; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.
Vázquez-Fonseca L; Clinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128 Padova, Italy; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.
Agosto C; Pediatric Pain and Palliative Care Unit, Department of Women and Children's Health, University Hospital of Padova, 35128 Padova, Italy.
Zanotti G; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padua, Italy.
Roger-Margueritat M; Université Grenoble Alpes, CNRS UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France.
Alcázar-Fabra M; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
García-Corzo L; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
Sánchez-Cuesta A; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
Navas P; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
Brea-Calvo G; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
Trevisson E; Clinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128 Padova, Italy; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.
Wendisch VF; Genetics of Prokaryotes, Faculty of Biology, and Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany.
Pagliarini DJ; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Salviati L; Clinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128 Padova, Italy; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy; Study Center for Neurodegeneration (CESNE), University of Padua, Padua 35131, Italy. Electronic address: .
Pierrel F; Université Grenoble Alpes, CNRS UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 981-989.e7. Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquinone*
Eukaryotic Cells*/metabolism
Humans ; Decarboxylation ; Oxidation-Reduction ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Oxidative Stress ; Mitochondrial Proteins/metabolism
Czasopismo naukowe
Tytuł:
Persistence of backtracking by human RNA polymerase II.
Autorzy:
Yang KB; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Rasouly A; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, NYU Langone Health, New York, NY 10016, USA.
Epshtein V; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Martinez C; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Nguyen T; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Shamovsky I; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Nudler E; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, NYU Langone Health, New York, NY 10016, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 897-909.e4. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
RNA Polymerase II*/genetics
RNA Polymerase II*/metabolism
RNA*/genetics
Humans ; Transcription, Genetic ; DNA-Directed RNA Polymerases/genetics
Czasopismo naukowe
Tytuł:
Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91.
Autorzy:
Shenol A; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lückmann M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Trauelsen M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lambrughi M; Cancer Structural Biology, Danish Cancer Society Research Center, Copenhagen, Denmark.
Tiberti M; Cancer Structural Biology, Danish Cancer Society Research Center, Copenhagen, Denmark.
Papaleo E; Cancer Structural Biology, Danish Cancer Society Research Center, Copenhagen, Denmark; Cancer Systems Biology, Section for Bioinformatics, Department of Health and Technology, Technical University of Denmark, Lyngby, Denmark.
Frimurer TM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Schwartz TW; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 955-966.e4. Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Succinic Acid*/metabolism
Receptors, G-Protein-Coupled*/metabolism
Mice ; Rats ; Animals ; Humans ; Molecular Dynamics Simulation ; Succinates/metabolism ; Stress, Physiological
Czasopismo naukowe
Tytuł:
Structural basis for plasmid restriction by SMC JET nuclease.
Autorzy:
Roisné-Hamelin F; Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), 1015 Lausanne, Switzerland.
Liu HW; Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), 1015 Lausanne, Switzerland.
Taschner M; Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), 1015 Lausanne, Switzerland.
Li Y; Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), 1015 Lausanne, Switzerland.
Gruber S; Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), 1015 Lausanne, Switzerland. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 883-896.e7. Date of Electronic Publication: 2024 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
DNA*/metabolism
Endonucleases*
Plasmids/genetics ; Prokaryotic Cells ; Cell Cycle Proteins/metabolism
Czasopismo naukowe
Tytuł:
PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.
Autorzy:
Hou S; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 101408, China.
Zhang J; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215031, China.
Jiang X; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Yang Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 101408, China.
Shan B; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Zhang M; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Liu C; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; Shanghai Key Laboratory of Aging Studies, Shanghai 201210, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Yuan J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; Shanghai Key Laboratory of Aging Studies, Shanghai 201210, China.
Xu D; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; Shanghai Key Laboratory of Aging Studies, Shanghai 201210, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 938-954.e8. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Necroptosis*/genetics
Phase Separation*
Animals ; Mice ; Apoptosis/physiology ; Cell Death ; Fibroblasts/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł:
Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide.
Autorzy:
Russo M; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy. Electronic address: .
Gualdrini F; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy. Electronic address: .
Vallelonga V; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Prosperini E; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Noberini R; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Pedretti S; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano 20133, Italy.
Borriero C; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Di Chiaro P; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Polletti S; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Imperato G; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano 20133, Italy.
Marenda M; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Ghirardi C; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Bedin F; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Cuomo A; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Rodighiero S; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy.
Bonaldi T; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy; Department of Hematology and Hematology-Oncology (DIPO), Università degli Studi di Milano, Milano 20122, Italy.
Mitro N; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano 20133, Italy.
Ghisletti S; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy. Electronic address: .
Natoli G; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 967-980.e10. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Histones*/genetics
Histones*/metabolism
Nitric Oxide*/metabolism
Acetyl Coenzyme A/metabolism ; Acetylation ; Mediator Complex/metabolism ; Oxidoreductases/metabolism
Czasopismo naukowe
Tytuł:
Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Autorzy:
Hu Q; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Zhao D; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Cui G; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Bhandari J; The Hormel Institute, University of Minnesota, Austin, MN, USA.
Thompson JR; The Hormel Institute, University of Minnesota, Austin, MN, USA.
Botuyan MV; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA. Electronic address: .
Mer G; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cancer Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 839-853.e12. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Nucleosomes*/genetics
Ubiquitin-Protein Ligases*/metabolism
Cryoelectron Microscopy ; Ubiquitination ; Histones/metabolism ; Chromatin/genetics ; DNA Repair ; Ubiquitin/metabolism ; Tumor Suppressor p53-Binding Protein 1/genetics ; DNA Damage
Czasopismo naukowe
Tytuł:
Chromatin gene-gene loops support the cross-regulation of genes with related function.
Autorzy:
Pollex T; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Marco-Ferreres R; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Ciglar L; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Ghavi-Helm Y; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Rabinowitz A; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Viales RR; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Schaub C; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Jankowski A; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Girardot C; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Furlong EEM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 822-838.e8. Date of Electronic Publication: 2023 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatin*/genetics
Chromosomes*
Animals ; In Situ Hybridization, Fluorescence ; Drosophila/genetics
Czasopismo naukowe
Tytuł:
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
Autorzy:
Ma X; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
Yin J; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China; Chongqing Key Laboratory of Precision Optics, Chongqing Institute of East China Normal University, Chongqing 401120, China.
Qiao L; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
Wan H; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
Liu X; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
Zhou Y; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China; Wuhu Hospital, Health Science Center, East China Normal University, Wuhu City 241001, China.
Wu J; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
Niu L; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
Wu M; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
Wang X; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
Ye H; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 06. Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.
Autorzy:
Lando D; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Ma X; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Cao Y; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Jartseva A; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Stevens TJ; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Boucher W; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Reynolds N; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK.
Montibus B; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK.
Hall D; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK.
Lackner A; Max Perutz Laboratories Vienna, University of Vienna, Vienna Biocenter, Vienna, Austria.
Ragheb R; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK.
Leeb M; Max Perutz Laboratories Vienna, University of Vienna, Vienna Biocenter, Vienna, Austria.
Hendrich BD; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK. Electronic address: .
Laue ED; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Mar 05. Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction.
Autorzy:
Zhao J; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Lan J; Department of Bioinformatics, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
Wang M; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Liu C; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Fang Z; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Song A; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Zhang T; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Wang L; Beijing Advanced Innovation Center for Structure Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100101, China.
Zhu B; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Chen P; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. Electronic address: .
Yu J; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: .
Li G; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China; University of Chinese Academy of Sciences, Beijing 100049, China; New Cornerstone Science Laboratory, Frontier Science Center for Immunology and Metabolism, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, China. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Feb 29. Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Imprinted X chromosome inactivation at the gamete-to-embryo transition.
Autorzy:
Wei C; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Kesner B; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Yin H; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Lee JT; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Feb 29. Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
Czasopismo naukowe

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