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Wyszukujesz frazę ""Monoacylglycerol Lipases"" wg kryterium: Temat


Tytuł :
Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase.
Autorzy :
Afzal O; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Altamimi ASA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Shahroz MM; Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore 466001, Madhya Pradesh, India.
Sharma HK; Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore 466001, Madhya Pradesh, India.
Riadi Y; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Hassan MQ; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 20; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*chemistry
Benzoxazoles/*chemistry
Monoacylglycerol Lipases/*antagonists & inhibitors
Pyrrolidinones/*pharmacology
Analgesics/chemistry ; Analgesics/pharmacology ; Antineoplastic Agents/pharmacology ; Benzoxazoles/pharmacology ; Cell Line, Tumor ; Enzyme Inhibitors/pharmacology ; Humans ; Molecular Docking Simulation ; Monoacylglycerol Lipases/chemistry ; Neoplasms/drug therapy ; Neoplasms/pathology ; Pyrrolidinones/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Human Interferon Inducible Transmembrane Protein 3 (IFITM3) Inhibits Influenza Virus A Replication and Inflammation by Interacting with ABHD16A.
Autorzy :
Chen L; Department of Infectious Diseases, Beijing Jishuitan Hospital, Beijing, China.
Zhu L; Department of Chronic and Infectious Diseases Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Chen J; Department of Pathology, Nanjing Drum Tower Hospital, Nanjing, China.
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Źródło :
BioMed research international [Biomed Res Int] 2021 Mar 03; Vol. 2021, pp. 6652147. Date of Electronic Publication: 2021 Mar 03 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Virus Replication*
Influenza A virus/*physiology
Membrane Proteins/*metabolism
Monoacylglycerol Lipases/*metabolism
RNA-Binding Proteins/*metabolism
HEK293 Cells ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/virology ; Membrane Proteins/genetics ; Monoacylglycerol Lipases/genetics ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Proteoform of Arabidopsis seed storage protein identified by functional proteomics approach exhibits acyl hydrolase activity during germination.
Autorzy :
Latha M; Lipid and Nutrition Laboratory, Department of Lipid Science, Council of Scientific and Industrial Research-Central Food Technological Research Institute, Mysore, Karnataka 570020, India; Academy of Scientific and Innovative Research, Ghaziabad 201002, Uttar Pradesh, India.
Dolui AK; Lipid and Nutrition Laboratory, Department of Lipid Science, Council of Scientific and Industrial Research-Central Food Technological Research Institute, Mysore, Karnataka 570020, India; Academy of Scientific and Innovative Research, Ghaziabad 201002, Uttar Pradesh, India.
Vijayaraj P; Lipid and Nutrition Laboratory, Department of Lipid Science, Council of Scientific and Industrial Research-Central Food Technological Research Institute, Mysore, Karnataka 570020, India; Academy of Scientific and Innovative Research, Ghaziabad 201002, Uttar Pradesh, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Mar 01; Vol. 172, pp. 452-463. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Plant*
Lipid Metabolism/*genetics
Monoacylglycerol Lipases/*metabolism
Monoglycerides/*metabolism
Seed Storage Proteins/*metabolism
Seeds/*enzymology
Amino Acid Sequence ; Arabidopsis ; Binding Sites ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Gene Expression Profiling ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Germination/physiology ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Kinetics ; Monoacylglycerol Lipases/genetics ; Protein Binding ; Proteomics/methods ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Seed Storage Proteins/genetics ; Seeds/genetics ; Seeds/growth & development ; Sequence Alignment ; Sequence Homology, Amino Acid ; Substrate Specificity ; Thermodynamics
Czasopismo naukowe
Tytuł :
Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
Autorzy :
Tardelli M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
Bruschi FV; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
Fuchs CD; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
Claudel T; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
Auer N; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
Kunczer V; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
Ronda OAHO; Center for Liver, Digestive and Metabolic Diseases, Departments of Pediatrics, University Medical Center Groningen, 9712 Groningen, The Netherlands.
Verkade HJ; Center for Liver, Digestive and Metabolic Diseases, Departments of Pediatrics, University Medical Center Groningen, 9712 Groningen, The Netherlands.
Stojakovic T; Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, 8036 Graz, Austria.
Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria.
Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 20; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Weight Gain*
Membrane Proteins/*deficiency
Monoacylglycerol Lipases/*deficiency
Non-alcoholic Fatty Liver Disease/*enzymology
Non-alcoholic Fatty Liver Disease/*pathology
Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Animals ; Cells, Cultured ; Fatty Acids/metabolism ; Humans ; Inflammation/pathology ; Lipid Metabolism ; Liver/pathology ; Macrophages/metabolism ; Male ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Monoacylglycerol Lipases/metabolism ; Oleic Acid ; Phenotype ; U937 Cells
Czasopismo naukowe
Tytuł :
An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present).
Autorzy :
Bononi G; Department of Pharmacy, University of Pisa , Pisa, Italy.
Poli G; Department of Pharmacy, University of Pisa , Pisa, Italy.
Rizzolio F; Pathology Unit, Centro Di Riferimento Oncologico Di Aviano (CRO) IRCCS , Aviano, Italy.; Department of Molecular Science and Nanosystems, Ca' Foscari University , Venezia, Italy.
Tuccinardi T; Department of Pharmacy, University of Pisa , Pisa, Italy.
Macchia M; Department of Pharmacy, University of Pisa , Pisa, Italy.
Minutolo F; Department of Pharmacy, University of Pisa , Pisa, Italy.
Granchi C; Department of Pharmacy, University of Pisa , Pisa, Italy.
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Źródło :
Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2021 Feb; Vol. 31 (2), pp. 153-168. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Development*
Enzyme Inhibitors/*pharmacology
Monoacylglycerol Lipases/*antagonists & inhibitors
Animals ; Endocannabinoids/metabolism ; Humans ; Inflammation/drug therapy ; Inflammation/enzymology ; Monoacylglycerol Lipases/metabolism ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/enzymology ; Patents as Topic
Czasopismo naukowe
Tytuł :
Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine.
Autorzy :
Della Pietra A; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Giniatullin R; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.
Savinainen JR; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 26; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Amidohydrolases/*metabolism
Endocannabinoids/*metabolism
Migraine Disorders/*etiology
Migraine Disorders/*metabolism
Monoacylglycerol Lipases/*metabolism
Amidohydrolases/antagonists & inhibitors ; Amidohydrolases/genetics ; Animals ; Central Nervous System/metabolism ; Central Nervous System/physiopathology ; Disease Models, Animal ; Enzyme Activation ; Enzyme Inhibitors/pharmacology ; Hydrolysis ; Male ; Monoacylglycerol Lipases/antagonists & inhibitors ; Monoacylglycerol Lipases/genetics ; Peripheral Nerves/metabolism ; Peripheral Nerves/physiopathology ; Rats
Czasopismo naukowe
Tytuł :
Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota.
Autorzy :
Dione N; Département de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in metabolic Health, Québec, QC G1V 4G5, Canada.; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, QC G1V 4G5, Canada.
Lacroix S; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in metabolic Health, Québec, QC G1V 4G5, Canada.; Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec, QC G1V 0A6, Canada.; Faculté des Sciences de L'agriculture et de L'alimentation, Université Laval, Québec, QC G1V 0A6, Canada.
Taschler U; Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.
Deschênes T; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in metabolic Health, Québec, QC G1V 4G5, Canada.; Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec, QC G1V 0A6, Canada.; Faculté des Sciences de L'agriculture et de L'alimentation, Université Laval, Québec, QC G1V 0A6, Canada.
Abolghasemi A; Département de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in metabolic Health, Québec, QC G1V 4G5, Canada.; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, QC G1V 4G5, Canada.
Leblanc N; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in metabolic Health, Québec, QC G1V 4G5, Canada.; Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec, QC G1V 0A6, Canada.; Faculté des Sciences de L'agriculture et de L'alimentation, Université Laval, Québec, QC G1V 0A6, Canada.
Di Marzo V; Département de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in metabolic Health, Québec, QC G1V 4G5, Canada.; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, QC G1V 4G5, Canada.; Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Québec, QC G1V 0A6, Canada.; Faculté des Sciences de L'agriculture et de L'alimentation, Université Laval, Québec, QC G1V 0A6, Canada.; Institute of Biomolecular Chemistry, National Research Council, 80078 Pozzuoli, NA, Italy.
Silvestri C; Département de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in metabolic Health, Québec, QC G1V 4G5, Canada.; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, QC G1V 4G5, Canada.
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Źródło :
Cells [Cells] 2020 Dec 17; Vol. 9 (12). Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diet, High-Fat*
Gastrointestinal Microbiome*
Monoacylglycerol Lipases/*genetics
Adipokines/blood ; Animals ; Feces/microbiology ; Glucose Tolerance Test ; Incretins/blood ; Insulin Resistance ; Lactobacillaceae/genetics ; Lactobacillaceae/isolation & purification ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Monoacylglycerol Lipases/deficiency ; Monoacylglycerol Lipases/metabolism ; Obesity/microbiology ; Obesity/pathology ; Principal Component Analysis ; Ruminococcus/genetics ; Ruminococcus/isolation & purification
Czasopismo naukowe
Tytuł :
Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice.
Autorzy :
Xu W; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Li H; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Wang L; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Zhang J; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Liu C; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Wan X; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Liu X; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Hu Y; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Fang Q; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Xiao Y; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Bu Q; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Wang H; Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, 264005, Yantai, People's Republic of China.
Tian J; Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, 264005, Yantai, People's Republic of China.
Zhao Y; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China.
Cen X; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, People's Republic of China. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 24; Vol. 11 (1), pp. 5962. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Monoacylglycerol Lipases*/genetics
Monoacylglycerol Lipases*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Arachidonic Acids/*metabolism
Endocannabinoids/*metabolism
Glycerides/*metabolism
Ketamine/*pharmacology
Signal Transduction/*drug effects
Animals ; Cannabinoid Receptor Agonists/metabolism ; Caudate Nucleus/metabolism ; Gene Expression ; Gene Expression Regulation ; Mice ; Neurons/metabolism ; Receptor, Cannabinoid, CB1/drug effects ; Receptor, Cannabinoid, CB1/metabolism ; Substance-Related Disorders/genetics ; Substance-Related Disorders/metabolism
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.
Autorzy :
Granchi C; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Bononi G; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Ferrisi R; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Gori E; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Mantini G; Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, DeBoelelaan 1117, 1081HV, Amsterdam, the Netherlands; Cancer Pharmacology Lab, Fondazione Pisana per La Scienza, Via Giovannini 13, 56017, San Giuliano Terme, Pisa, Italy.
Glasmacher S; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, CH-3012, Bern, Switzerland.
Poli G; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Palazzolo S; Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, Italy.
Caligiuri I; Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, Italy.
Rizzolio F; Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, Italy; Department of Molecular Sciences and Nanosystems, Ca' Foscari University, 30123, Venezia, Italy.
Canzonieri V; Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, Italy; Department of Medical, Surgical and Health Sciences, Università Degli Studi di Trieste, Strada di Fiume 447, Trieste, Italy.
Perin T; Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, Italy.
Gertsch J; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, CH-3012, Bern, Switzerland.
Sodi A; Department of Neurosciences, Psychology, Drug Research and Child Health Eye Clinic, University of Florence, AOU Careggi, 50139, Florence, Italy.
Giovannetti E; Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, DeBoelelaan 1117, 1081HV, Amsterdam, the Netherlands; Cancer Pharmacology Lab, Fondazione Pisana per La Scienza, Via Giovannini 13, 56017, San Giuliano Terme, Pisa, Italy.
Macchia M; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Minutolo F; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Tuccinardi T; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy. Electronic address: .
Chicca A; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, CH-3012, Bern, Switzerland.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 01; Vol. 209, pp. 112857. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Monoacylglycerol Lipases/*antagonists & inhibitors
Piperidines/*chemistry
Piperidines/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Humans ; Mice ; Molecular Dynamics Simulation ; Monoacylglycerol Lipases/metabolism ; Neoplasms/drug therapy ; Piperidines/chemical synthesis
Czasopismo naukowe
Tytuł :
Adipose ABHD6 regulates tolerance to cold and thermogenic programs.
Autorzy :
Poursharifi P; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Attané C; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France.
Mugabo Y; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Al-Mass A; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Department of Medicine, McGill University, Montréal, Québec, Canada.
Ghosh A; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Schmitt C; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Zhao S; Touchstone Diabetes Center, UT Southwestern Medical Center, Dallas, Texas, USA.
Guida J; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Lussier R; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Erb H; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Chenier I; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Peyot ML; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Joly E; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Noll C; Division of Endocrinology, Department of Medicine, Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Carpentier AC; Division of Endocrinology, Department of Medicine, Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Madiraju SRM; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Prentki M; Departments of Nutrition, Biochemistry, and Molecular Medicine, University of Montreal, and Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
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Źródło :
JCI insight [JCI Insight] 2020 Dec 17; Vol. 5 (24). Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Monoacylglycerol Lipases/*metabolism
Thermogenesis/*genetics
Thermotolerance/*genetics
Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Animals ; Cold Temperature ; Energy Metabolism ; Female ; Hydrolases/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Monoacylglycerol Lipases/genetics ; Monoglycerides/metabolism ; Obesity/metabolism ; PPAR alpha/metabolism ; Uncoupling Protein 1/metabolism
Czasopismo naukowe
Tytuł :
New Disulfiram Derivatives as MAGL-Selective Inhibitors.
Autorzy :
Omran Z; Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 30; Vol. 26 (11). Date of Electronic Publication: 2021 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Disulfiram/*pharmacology
Monoacylglycerol Lipases/*antagonists & inhibitors
Monoacylglycerol Lipases/*chemistry
Amidohydrolases/chemistry ; Arachidonic Acids/chemistry ; Carbamates/pharmacology ; Disulfiram/analogs & derivatives ; Endocannabinoids/chemistry ; Endocannabinoids/metabolism ; Enzyme Inhibitors/pharmacology ; Glycerides/chemistry ; Humans ; Hydrolysis ; Monoglycerides/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Therapeutic potential of targeting α/β-Hydrolase domain-containing 6 (ABHD6).
Autorzy :
Deng H; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Targeted Tracer Research and Development Laboratory, Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: .
Li W; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Targeted Tracer Research and Development Laboratory, Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Jul 15; Vol. 198, pp. 112353. Date of Electronic Publication: 2020 Apr 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Monoacylglycerol Lipases/*chemistry
Monoacylglycerol Lipases/*metabolism
Monoglycerides/*metabolism
Adipose Tissue, Brown/metabolism ; Animals ; Autoimmune Diseases/metabolism ; Eating/physiology ; Humans ; Hydrolysis ; Inflammation/metabolism ; Insulin Secretion/physiology ; Metabolic Diseases/metabolism ; Monoacylglycerol Lipases/genetics ; Nervous System Diseases/metabolism ; RNA, Messenger/metabolism ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Characterization of a monoacylglycerol lipase in the medicinal leech, Hirudo verbana.
Autorzy :
Kabeiseman E; Division of Basic Biomedical Sciences, Center for Brain and Behavior Research (CBBRe), Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, United States.
Paulsen R; Division of Basic Biomedical Sciences, Center for Brain and Behavior Research (CBBRe), Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, United States; USD Neuroscience, Nanotechnology, and Networks Program (USD-N3), Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069,United States.
Burrell BD; Division of Basic Biomedical Sciences, Center for Brain and Behavior Research (CBBRe), Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, United States; USD Neuroscience, Nanotechnology, and Networks Program (USD-N3), Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069,United States. Electronic address: .
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Źródło :
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology [Comp Biochem Physiol B Biochem Mol Biol] 2020 Jun; Vol. 243-244, pp. 110433. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji :
Journal Article
MeSH Terms :
Endocannabinoids/*metabolism
Leeches/*enzymology
Monoacylglycerol Lipases/*metabolism
Animals ; Benzodioxoles/pharmacology ; Carbamates/pharmacology ; Cell Membrane/metabolism ; Cloning, Molecular ; Enzyme Inhibitors/pharmacology ; HEK293 Cells ; Humans ; Leeches/chemistry ; Leeches/genetics ; Leeches/metabolism ; Monoacylglycerol Lipases/chemistry ; Monoacylglycerol Lipases/genetics ; Phylogeny ; Piperidines/pharmacology ; Succinimides/pharmacology
Czasopismo naukowe
Tytuł :
ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease.
Autorzy :
Ichu TA; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Reed A; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Ogasawara D; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Ulanovskaya O; Lundbeck, La Jolla, California 92121, United States.
Roberts A; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, United States.
Aguirre CA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, United States.
Bar-Peled L; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Gao J; Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California 90024, United States.
Germain J; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Barbas S; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Masuda K; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Conti B; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, United States.
Tontonoz P; Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California 90024, United States.
Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 May 19; Vol. 59 (19), pp. 1793-1799. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
1-Acylglycerophosphocholine O-Acyltransferase/*metabolism
Monoacylglycerol Lipases/*metabolism
Nervous System Diseases/*metabolism
Phosphatidylserines/*metabolism
1-Acylglycerophosphocholine O-Acyltransferase/deficiency ; 1-Acylglycerophosphocholine O-Acyltransferase/genetics ; Animals ; Mice ; Mice, Knockout ; Molecular Structure ; Monoacylglycerol Lipases/deficiency ; Monoacylglycerol Lipases/genetics
Czasopismo naukowe
Tytuł :
Endogenous opioid and cannabinoid systems modulate the muscle pain: A pharmacological study into the peripheral site.
Autorzy :
Gonçalves WA; Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Ferreira RCM; Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Rezende BM; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Mahecha GAB; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Gualdron M; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
de Macedo FHP; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Duarte IDG; Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Perez AC; Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Machado FS; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Cruz JS; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Romero TRL; Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Jun 15; Vol. 901, pp. 174089. Date of Electronic Publication: 2021 Apr 04.
Typ publikacji :
Journal Article
MeSH Terms :
Myalgia/*drug therapy
Receptors, Cannabinoid/*physiology
Receptors, Opioid/*physiology
Animals ; Arachidonic Acids/antagonists & inhibitors ; Carrageenan ; Cinnamates/pharmacology ; Endocannabinoids/antagonists & inhibitors ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/psychology ; Male ; Monoacylglycerol Lipases/antagonists & inhibitors ; Morphine Derivatives/pharmacology ; Myalgia/chemically induced ; Myalgia/psychology ; Naloxone/pharmacology ; Naltrexone/analogs & derivatives ; Naltrexone/pharmacology ; Pain Measurement/drug effects ; Polyunsaturated Alkamides/antagonists & inhibitors ; Rats ; Rats, Wistar ; Receptors, Cannabinoid/drug effects ; Receptors, Opioid/drug effects ; Receptors, Opioid, delta/drug effects ; Receptors, Opioid, kappa/drug effects ; Receptors, Opioid, mu/drug effects
Czasopismo naukowe
Tytuł :
Behavioral Battery for Testing Candidate Analgesics in Mice. II. Effects of Endocannabinoid Catabolic Enzyme Inhibitors and ∆9-Tetrahydrocannabinol.
Autorzy :
Diester CM; Department of Pharmacology and Toxicology (C.M.D., A.H.L., S.S.N.), School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia.
Lichtman AH; Department of Pharmacology and Toxicology (C.M.D., A.H.L., S.S.N.), School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia.
Negus SS; Department of Pharmacology and Toxicology (C.M.D., A.H.L., S.S.N.), School of Pharmacy (A.H.L.), Virginia Commonwealth University, Richmond, Virginia .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 May; Vol. 377 (2), pp. 242-253. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amidohydrolases/*antagonists & inhibitors
Analgesics/*pharmacology
Behavior, Animal/*drug effects
Dronabinol/*pharmacology
Enzyme Inhibitors/*pharmacology
Monoacylglycerol Lipases/*antagonists & inhibitors
Analgesics/adverse effects ; Animals ; Dronabinol/adverse effects ; Drug Evaluation, Preclinical/methods ; Drug Evaluation, Preclinical/standards ; Enzyme Inhibitors/adverse effects ; Female ; Male ; Mice ; Mice, Inbred ICR ; Nociception/drug effects
Czasopismo naukowe
Tytuł :
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors.
Autorzy :
Zhu B; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Connolly PJ; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Zhang YM; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
McDonnell ME; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Bian H; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Lin SC; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Liu L; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Zhang SP; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Chevalier KM; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Brandt MR; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Milligan CM; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Flores CM; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Macielag MJ; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Jul 15; Vol. 30 (14), pp. 127243. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Amides/*pharmacology
Azetidines/*pharmacology
Enzyme Inhibitors/*pharmacology
Monoacylglycerol Lipases/*antagonists & inhibitors
Piperazines/*pharmacology
Amides/chemistry ; Azetidines/chemistry ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Monoacylglycerol Lipases/metabolism ; Piperazines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease.
Autorzy :
Tardelli M; Division of Gastroenterology and Hepatology, Joan and Sanford I Weill Cornell Department of Medicine, Weill Cornell Medical College, New York, NY 10021, United States.
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Źródło :
World journal of gastroenterology [World J Gastroenterol] 2020 Jul 07; Vol. 26 (25), pp. 3577-3585.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Liver Diseases*/metabolism
Monoacylglycerol Lipases*/metabolism
Signal Transduction*
Humans ; Lipid Metabolism ; Lipogenesis ; Liver/metabolism ; Pain
Czasopismo naukowe
Tytuł :
Classics in Neuroimaging: Imaging the Endocannabinoid Pathway with PET.
Autorzy :
Varlow C; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario M5T-1R8, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario M5S-1A8, Canada.
Boileau I; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario M5T-1R8, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario M5S-1A8, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario M5T-1R8, Canada.
Wey HY; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Liang SH; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
Vasdev N; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario M5T-1R8, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario M5S-1A8, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario M5T-1R8, Canada.; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2020 Jul 01; Vol. 11 (13), pp. 1855-1862. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endocannabinoids*
Monoacylglycerol Lipases*/metabolism
Amidohydrolases/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Enzyme Inhibitors ; Positron-Emission Tomography ; Radiochemistry ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Tytuł :
Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC.
Autorzy :
Singh S; Department of Biology, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pashan, Pune, Maharashtra 411008, India.
Joshi A; Department of Biology, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pashan, Pune, Maharashtra 411008, India.
Kamat SS; Department of Biology, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pashan, Pune, Maharashtra 411008, India.
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Źródło :
Biochemistry [Biochemistry] 2020 Jun 23; Vol. 59 (24), pp. 2299-2311. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ataxia/*metabolism
Cataract/*metabolism
Cerebellum/*metabolism
Lysophospholipids/*metabolism
Monoacylglycerol Lipases/*metabolism
Polyneuropathies/*metabolism
Retinitis Pigmentosa/*metabolism
Animals ; Ataxia/genetics ; Ataxia/pathology ; Ataxia/physiopathology ; Cataract/genetics ; Cataract/pathology ; Cataract/physiopathology ; Cell Line ; Cerebellum/pathology ; Cerebellum/physiopathology ; Humans ; Lysophospholipids/genetics ; Mice ; Mice, Knockout ; Monoacylglycerol Lipases/genetics ; Polyneuropathies/genetics ; Polyneuropathies/pathology ; Polyneuropathies/physiopathology ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/pathology ; Retinitis Pigmentosa/physiopathology
SCR Disease Name :
Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract
Czasopismo naukowe

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