Temat: "Monoacylglycerol Lipases" - OpacWWW

Skocz do pozycji: 61.

Tytuł:: Pyrrolidin-2-one linked benzofused heterocycles as novel small molecule monoacylglycerol lipase inhibitors and antinociceptive agents.
Autorzy:: Altamimi ASA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj, Saudi Arabia.
Bawa S; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Athar F; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Hassan MQ; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Riadi Y; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj, Saudi Arabia.
Afzal O; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj, Saudi Arabia.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2020 Dec; Vol. 96 (6), pp. 1418-1432. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Analgesics/*pharmacology
Enzyme Inhibitors/*pharmacology
Heterocyclic Compounds/*pharmacology
Monoacylglycerol Lipases/*antagonists & inhibitors
Pyrrolidinones/*chemistry
Pyrrolidinones/*pharmacology
Analgesics/chemistry ; Enzyme Inhibitors/chemistry ; Heterocyclic Compounds/chemistry ; Humans ; Spectrum Analysis/methods ; Structure-Activity Relationship

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Skocz do pozycji: 62.

Tytuł:: Synthesis and characterization of a new fluorogenic substrate for monoacylglycerol lipase and application to inhibition studies.
Autorzy:: Lauria S; Dipartimento di Scienze Biomediche e Cliniche 'Luigi Sacco', Università degli Studi di Milano, via G. B. Grassi 74, 20157, Milan, Italy.
Casati S; Dipartimento di Scienze Biomediche e Cliniche 'Luigi Sacco', Università degli Studi di Milano, via G. B. Grassi 74, 20157, Milan, Italy.
Ciuffreda P; Dipartimento di Scienze Biomediche e Cliniche 'Luigi Sacco', Università degli Studi di Milano, via G. B. Grassi 74, 20157, Milan, Italy. .; Pokaż więcej
Źródło:: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2015 Oct; Vol. 407 (26), pp. 8163-7. Date of Electronic Publication: 2015 Sep 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arachidonic Acid/*metabolism
Enzyme Assays/*methods
Fluorescent Dyes/*metabolism
Monoacylglycerol Lipases/*metabolism
Oxazines/*metabolism
Arachidonic Acid/analysis ; Enzyme Inhibitors/pharmacology ; Fluorescent Dyes/analysis ; Humans ; Hydrolysis ; Monoacylglycerol Lipases/antagonists & inhibitors ; Oxazines/analysis ; Spectrometry, Fluorescence/methods

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Skocz do pozycji: 63.

Tytuł:: Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2.
Autorzy:: Kita Y; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; Life Sciences Core Facility, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Yoshida K; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Tokuoka SM; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Hamano F; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; Life Sciences Core Facility, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Yamazaki M; Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan.
Sakimura K; Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan.
Kano M; Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Shimizu T; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Jul 21; Vol. 10 (7), pp. e0133663. Date of Electronic Publication: 2015 Jul 21 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arachidonic Acids/*metabolism
Dinoprostone/*metabolism
Endocannabinoids/*metabolism
Fever/*metabolism
Glycerides/*metabolism
Monoacylglycerol Lipases/*metabolism
Animals ; Female ; Group IV Phospholipases A2/genetics ; Group IV Phospholipases A2/metabolism ; Hypothalamus/metabolism ; Lipoprotein Lipase/genetics ; Lipoprotein Lipase/metabolism ; Mice ; Mice, Inbred C57BL ; Monoacylglycerol Lipases/genetics ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB1/metabolism

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Skocz do pozycji: 64.

Tytuł:: Inhibition of monoacylglycerol lipase reduces nicotine withdrawal.
Autorzy:: Muldoon PP; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Chen J
Harenza JL
Abdullah RA
Sim-Selley LJ
Cravatt BF
Miles MF
Chen X
Lichtman AH
Damaj MI; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2015 Feb; Vol. 172 (3), pp. 869-82.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Benzodioxoles/*pharmacology
Enzyme Inhibitors/*pharmacology
Monoacylglycerol Lipases/*antagonists & inhibitors
Nicotine/*antagonists & inhibitors
Piperidines/*pharmacology
Substance Withdrawal Syndrome/*drug therapy
Animals ; Dose-Response Relationship, Drug ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Knockout ; Monoacylglycerol Lipases/deficiency ; Monoacylglycerol Lipases/metabolism ; Nicotine/administration & dosage ; RNA, Messenger/drug effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism

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Skocz do pozycji: 65.

Tytuł:: Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).
Autorzy:: Savinainen JR; School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Patel JZ; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Parkkari T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Navia-Paldanius D; School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Marjamaa JJ; School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Laitinen T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Nevalainen T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Laitinen JT; School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Oct 07; Vol. 9 (10), pp. e109869. Date of Electronic Publication: 2014 Oct 07 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Lymphocytes/*chemistry
Monoacylglycerol Lipases/*chemistry
Phospholipases/*chemistry
RNA, Messenger/*chemistry
Amino Acid Motifs ; Animals ; Camelids, New World ; Camelus ; Chiroptera ; Enzyme Inhibitors/chemistry ; Esters ; HEK293 Cells ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Kinetics ; Lactones/chemistry ; Lymphocytes/enzymology ; Mice ; Mole Rats ; Molecular Sequence Data ; Monoacylglycerol Lipases/antagonists & inhibitors ; Monoacylglycerol Lipases/genetics ; Monoglycerides/chemistry ; Phospholipases/antagonists & inhibitors ; Phospholipases/genetics ; Prostaglandin D2/analogs & derivatives ; Prostaglandin D2/chemistry ; RNA, Messenger/genetics ; Rats ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Sequence Alignment ; Sequence Homology, Amino Acid ; Species Specificity ; Structure-Activity Relationship ; Substrate Specificity ; Triglycerides/chemistry

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Skocz do pozycji: 66.

Tytuł:: A unique mono- and diacylglycerol lipase from Penicillium cyclopium: heterologous expression, biochemical characterization and molecular basis for its substrate selectivity.
Autorzy:: Tan ZB; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 2) Jiangsu Provincial Engineering Laboratory for Biomass Conversion and Process Integration, School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huai'an China.
Li JF; School of Food Science and Technology, Jiangnan University, Wuxi, China.
Li XT; Wuxi Medical School, Jiangnan University, Wuxi, China.
Gu Y; Wuxi Medical School, Jiangnan University, Wuxi, China.
Wu MC; Wuxi Medical School, Jiangnan University, Wuxi, China.
Wu J; Wuxi Medical School, Jiangnan University, Wuxi, China.
Wang JQ; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Jul 22; Vol. 9 (7), pp. e102040. Date of Electronic Publication: 2014 Jul 22 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Bacterial Proteins/*chemistry
Monoacylglycerol Lipases/*chemistry
Penicillium/*enzymology
Amino Acid Sequence ; Bacterial Proteins/biosynthesis ; Bacterial Proteins/genetics ; Catalytic Domain ; Chelating Agents/chemistry ; Diglycerides/chemistry ; Edetic Acid/chemistry ; Enzyme Stability ; Gene Expression ; Hydrogen-Ion Concentration ; Hydrolysis ; Iron/chemistry ; Mercury/chemistry ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Sequence Data ; Monoacylglycerol Lipases/biosynthesis ; Monoacylglycerol Lipases/genetics ; Monoglycerides/chemistry ; Pichia ; Protein Binding ; Substrate Specificity

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Skocz do pozycji: 67.

Tytuł:: The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells.
Autorzy:: Cipriano M
Gouveia-Figueira S
Persson E
Nording M
Fowler CJ; Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden. .; Pokaż więcej
Źródło:: BMC research notes [BMC Res Notes] 2014 Jul 10; Vol. 7, pp. 441. Date of Electronic Publication: 2014 Jul 10.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*
ErbB Receptors/*genetics
Monoacylglycerol Lipases/*genetics
Receptor, Cannabinoid, CB1/*genetics
Arachidonic Acids/metabolism ; Benzodioxoles/pharmacology ; Cannabinoids/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclohexanols/pharmacology ; Endocannabinoids/metabolism ; Enzyme Inhibitors/pharmacology ; ErbB Receptors/metabolism ; Ethanolamines/metabolism ; Glycerides/metabolism ; Humans ; Male ; Monoacylglycerol Lipases/antagonists & inhibitors ; Monoacylglycerol Lipases/metabolism ; Piperidines/pharmacology ; Polyunsaturated Alkamides/metabolism ; Prostate/drug effects ; Prostate/metabolism ; Prostate/pathology ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/metabolism ; Signal Transduction

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Skocz do pozycji: 68.

Tytuł:: Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression.
Autorzy:: Galli GG; Biotech Research and Innovation Centre, Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark.
Multhaupt HA; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Carrara M; Department of Clinical and Biological Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.
de Lichtenberg KH; Biotech Research and Innovation Centre, Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark.
Christensen IB; The Finsen Laboratory, Faculty of Health Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Linnemann D; Department of Pathology, Herlev Hospital, Herlev, Denmark.
Santoni-Rugiu E; Department of Pathology, Diagnostic Center, Righospitalet, Copenhagen, Denmark.
Calogero RA; Department of Clinical and Biological Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.
Lund AH; Biotech Research and Innovation Centre, Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark.; Pokaż więcej
Źródło:: Oncogene [Oncogene] 2014 Jun 19; Vol. 33 (25), pp. 3342-50. Date of Electronic Publication: 2013 Jul 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adenoma/*genetics
Adenomatous Polyposis Coli/*genetics
DNA-Binding Proteins/*genetics
Intestinal Neoplasms/*genetics
Monoacylglycerol Lipases/*biosynthesis
Transcription Factors/*genetics
Adenoma/enzymology ; Adenoma/metabolism ; Adenomatous Polyposis Coli/metabolism ; Animals ; Caco-2 Cells ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Line, Tumor ; DNA-Binding Proteins/metabolism ; Down-Regulation ; Humans ; Intestinal Neoplasms/enzymology ; Intestinal Neoplasms/metabolism ; Mice ; Monoacylglycerol Lipases/genetics ; Monoacylglycerol Lipases/metabolism ; Mutation ; Transcription Factors/metabolism ; Transcription Initiation Site ; Transcription, Genetic

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Skocz do pozycji: 69.

Tytuł:: Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12).
Autorzy:: Parkkari T; School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Haavikko R; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Laitinen T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Navia-Paldanius D; School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Rytilahti R; School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Vaara M; School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Lehtonen M; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Alakurtti S; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; VTT Technical Research Centre of Finland, Helsinki, Finland.
Yli-Kauhaluoma J; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Nevalainen T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Savinainen JR; School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Laitinen JT; School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 May 30; Vol. 9 (5), pp. e98286. Date of Electronic Publication: 2014 May 30 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Discovery*
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Monoacylglycerol Lipases/*antagonists & inhibitors
Triterpenes/*chemistry
Triterpenes/*pharmacology
Animals ; Enzyme Inhibitors/metabolism ; HEK293 Cells ; Humans ; Ligands ; Mice ; Molecular Docking Simulation ; Monoacylglycerol Lipases/chemistry ; Monoacylglycerol Lipases/metabolism ; Protein Conformation ; Structure-Activity Relationship ; Substrate Specificity ; Triterpenes/metabolism

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Skocz do pozycji: 70.

Tytuł:: Hippocampal 2-Arachidonoyl Glycerol Signaling Regulates Time-of-Day- and Stress-Dependent Effects on Rat Short-Term Memory.
Autorzy:: Santori A; Department of Physiology and Pharmacology, Sapienza University of Rome, 00185 Rome, Italy.; Neurobiology of Behavior Laboratory, Santa Lucia Foundation, 00143 Rome, Italy.
Morena M; Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.; Department of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, AB T2N 4N1, Canada .
Hill MN; Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.; Department of Cell Biology and Anatomy & Psychiatry, University of Calgary, Calgary, AB T2N 4N1, Canada .
Campolongo P; Department of Physiology and Pharmacology, Sapienza University of Rome, 00185 Rome, Italy.; Neurobiology of Behavior Laboratory, Santa Lucia Foundation, 00143 Rome, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Oct 03; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 03.
Typ publikacji:: Journal Article
MeSH Terms:: Arachidonic Acids/*metabolism
Endocannabinoids/*metabolism
Glycerides/*metabolism
Hippocampus/*metabolism
Memory, Short-Term/*physiology
Amidohydrolases/genetics ; Animals ; Arachidonic Acids/antagonists & inhibitors ; Arachidonic Acids/genetics ; Benzodioxoles/pharmacology ; Emotions/physiology ; Endocannabinoids/antagonists & inhibitors ; Endocannabinoids/genetics ; Glycerides/antagonists & inhibitors ; Glycerides/genetics ; Hippocampus/drug effects ; Hippocampus/physiology ; Humans ; Male ; Monoacylglycerol Lipases/genetics ; Piperidines/pharmacology ; Polyunsaturated Alkamides/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/genetics

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Skocz do pozycji: 71.

Tytuł:: CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition.
Autorzy:: Rojo-Bustamante E; Facultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, 31008 Pamplona, Spain.
Íñigo-Marco I; CIMA, Programa de Neurociencias, Universidad de Navarra, 31008 Pamplona, Spain.
Abellanas MA; Facultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, 31008 Pamplona, Spain.
Vinueza-Gavilanes R; CIMA, Programa de Neurociencias, Universidad de Navarra, 31008 Pamplona, Spain.
Baltanás A; CIMA, Programa de Neurociencias, Universidad de Navarra, 31008 Pamplona, Spain.
Luquin E; Facultad de Medicina, Departamento de Patología, Anatomía y Fisiología, Universidad de Navarra, 31008 Pamplona, Spain.
Arrasate M; CIMA, Programa de Neurociencias, Universidad de Navarra, 31008 Pamplona, Spain.; Facultad de Medicina, Departamento de Patología, Anatomía y Fisiología, Universidad de Navarra, 31008 Pamplona, Spain.; IdiSNA, Instituto de Investigación Sanitaria de Navarra, 31008 Pamplona, Spain.
Aymerich MS; Facultad de Ciencias, Departamento de Bioquímica y Genética, Universidad de Navarra, 31008 Pamplona, Spain.; CIMA, Programa de Neurociencias, Universidad de Navarra, 31008 Pamplona, Spain.; IdiSNA, Instituto de Investigación Sanitaria de Navarra, 31008 Pamplona, Spain.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2020 Aug 18; Vol. 10 (8). Date of Electronic Publication: 2020 Aug 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Benzodioxoles/*adverse effects
Neuroglia/*cytology
Neurons/*cytology
Piperidines/*adverse effects
Receptor, Cannabinoid, CB2/*metabolism
Animals ; Cell Communication ; Cell Survival/drug effects ; Cells, Cultured ; Coculture Techniques ; Monoacylglycerol Lipases/antagonists & inhibitors ; Neuroglia/drug effects ; Neuroglia/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Primary Cell Culture ; Rats

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Tytuł:: The herbicide quinclorac as potent lipase inhibitor: Discovery via virtual screening and in vitro/in vivo validation.
Autorzy:: Dahabiyeh LA; Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan.
Bustanji Y; Department of Clinical Pharmacy and Biopharmaceutics, School of Pharmacy, The University of Jordan, Amman, Jordan.
Taha MO; Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2019 May; Vol. 93 (5), pp. 787-797. Date of Electronic Publication: 2019 Jan 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Lipase/*antagonists & inhibitors
Quinolines/*chemistry
Animals ; Binding Sites ; Glycerol/blood ; Herbicides/chemistry ; Herbicides/metabolism ; Lipase/metabolism ; Male ; Molecular Docking Simulation ; Monoacylglycerol Lipases/antagonists & inhibitors ; Monoacylglycerol Lipases/metabolism ; Quinolines/administration & dosage ; Quinolines/metabolism ; Rats ; Rats, Wistar

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Skocz do pozycji: 73.

Tytuł:: Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats.
Autorzy:: Brosnihan KB; Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA. .
Pulgar VM
Gallagher PE
Neves LA
Yamaleyeva LM; Pokaż więcej
Źródło:: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2015 Jan 17; Vol. 13, pp. 5. Date of Electronic Publication: 2015 Jan 17.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Embryo Implantation*/drug effects
Embryo Implantation*/genetics
Amidohydrolases/*genetics
Angiotensin I/*administration & dosage
Endocannabinoids/*metabolism
Monoacylglycerol Lipases/*genetics
Peptide Fragments/*administration & dosage
Receptors, Cannabinoid/*genetics
Uterus/*drug effects
Amidohydrolases/metabolism ; Animals ; Arachidonic Acids/metabolism ; Decidua/drug effects ; Decidua/metabolism ; Female ; Gene Expression Regulation, Enzymologic/drug effects ; Glycerides/metabolism ; Infusion Pumps ; Monoacylglycerol Lipases/metabolism ; Pregnancy ; Pseudopregnancy ; Rats ; Rats, Sprague-Dawley ; Receptors, Cannabinoid/metabolism ; Up-Regulation/drug effects ; Up-Regulation/genetics ; Uterus/metabolism

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Skocz do pozycji: 74.

Tytuł:: Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
Autorzy:: Griebel G; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Pichat P; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Beeské S; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Leroy T; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Redon N; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Jacquet A; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Françon D; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Bert L; Exploratory Unit, Montpellier, France.
Even L; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Lopez-Grancha M; Therapeutic Strategic Unit Aging, Chilly-Mazarin, France.
Tolstykh T; Global Oncology Division, Cambridge, USA.
Sun F; Global Oncology Division, Cambridge, USA.
Yu Q; Global Oncology Division, Cambridge, USA.
Brittain S; Global Oncology Division, Cambridge, USA.
Arlt H; Global Oncology Division, Cambridge, USA.
He T; Global Oncology Division, Cambridge, USA.
Zhang B; Global Oncology Division, Cambridge, USA.
Wiederschain D; Global Oncology Division, Cambridge, USA.
Bertrand T; Lead Generation To Candidate Realization, Vitry-sur-Seine, France.
Houtmann J; Lead Generation To Candidate Realization, Vitry-sur-Seine, France.
Rak A; Lead Generation To Candidate Realization, Vitry-sur-Seine, France.
Vallée F; Lead Generation To Candidate Realization, Vitry-sur-Seine, France.
Michot N; Lead Generation To Candidate Realization, Vitry-sur-Seine, France.
Augé F; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Menet V; Therapeutic Strategic Unit Aging, Montpellier, France.
Bergis OE; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
George P; Therapeutic Strategic Unit Aging, Chilly-Mazarin, France.
Avenet P; Sanofi R&D, Exploratory Unit, Chilly-Mazarin, France.
Mikol V; Lead Generation To Candidate Realization, Vitry-sur-Seine, France.
Didier M; Exploratory Unit, Montpellier, France.
Escoubet J; Exploratory Unit, Montpellier, France.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2015 Jan 06; Vol. 5, pp. 7642. Date of Electronic Publication: 2015 Jan 06.
Typ publikacji:: Journal Article
MeSH Terms:: Analgesics/*pharmacology
Arachidonic Acids/*metabolism
Carbamates/*pharmacology
Endocannabinoids/*metabolism
Glycerides/*metabolism
Learning/*drug effects
Memory, Short-Term/*drug effects
Monoacylglycerol Lipases/*metabolism
Sulfonamides/*pharmacology
Acetylcholine/metabolism ; Administration, Oral ; Analgesics/chemistry ; Analgesics/therapeutic use ; Animals ; Arachidonic Acids/chemistry ; Binding Sites ; Brain/metabolism ; Cannabinoid Receptor Antagonists/pharmacology ; Carbamates/chemistry ; Carbamates/therapeutic use ; Chromatography, High Pressure Liquid ; Crystallography, X-Ray ; Disease Models, Animal ; Electric Stimulation ; Endocannabinoids/chemistry ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Glycerides/chemistry ; Hippocampus/drug effects ; Hippocampus/metabolism ; Humans ; Hydrolysis ; In Vitro Techniques ; Long-Term Potentiation/drug effects ; Mass Spectrometry ; Mice ; Mice, Inbred C57BL ; Mice, SCID ; Monoacylglycerol Lipases/antagonists & inhibitors ; Pain/drug therapy ; Pain/pathology ; Piperidines/pharmacology ; Protein Structure, Tertiary ; Pyrazoles/pharmacology ; Rimonabant ; Seizures/drug therapy ; Seizures/pathology ; Sulfonamides/chemistry ; Sulfonamides/therapeutic use

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Skocz do pozycji: 75.

Tytuł:: Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.
Autorzy:: Lau BK; Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, The University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia.
Drew GM
Mitchell VA
Vaughan CW; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2014 Dec; Vol. 171 (23), pp. 5225-36. Date of Electronic Publication: 2014 Sep 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Amidohydrolases/*physiology
Arachidonic Acids/*physiology
Endocannabinoids/*physiology
Glycerides/*physiology
Monoacylglycerol Lipases/*physiology
Periaqueductal Gray/*physiology
Amidohydrolases/antagonists & inhibitors ; Animals ; Benzamides/pharmacology ; Benzodioxoles/pharmacology ; Carbamates/pharmacology ; Female ; In Vitro Techniques ; Inhibitory Postsynaptic Potentials ; Male ; Monoacylglycerol Lipases/antagonists & inhibitors ; Neurons/drug effects ; Neurons/physiology ; Pain/drug therapy ; Pain/metabolism ; Pain/physiopathology ; Periaqueductal Gray/drug effects ; Piperidines/pharmacology ; Polyunsaturated Alkamides ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/physiology ; Synaptic Transmission/drug effects

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Tytuł:: Biochemical properties of a new cold-active mono- and diacylglycerol lipase from marine member Janibacter sp. strain HTCC2649.
Autorzy:: Yuan D; College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China. .
Lan D; College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China. .
Xin R; College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China. .
Yang B; School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China. .
Wang Y; College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2014 Jun 12; Vol. 15 (6), pp. 10554-66. Date of Electronic Publication: 2014 Jun 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Actinomycetales/*enzymology
Bacterial Proteins/*metabolism
Lipoprotein Lipase/*metabolism
Monoacylglycerol Lipases/*metabolism
Actinomycetales/classification ; Amino Acid Sequence ; Aspergillus/classification ; Aspergillus/enzymology ; Bacterial Proteins/chemistry ; Fungal Proteins/chemistry ; Fungal Proteins/metabolism ; Hydrogen-Ion Concentration ; Lipoprotein Lipase/chemistry ; Molecular Sequence Data ; Monoacylglycerol Lipases/chemistry ; Penicillium/classification ; Penicillium/enzymology ; Phylogeny ; Protein Stability ; Sequence Alignment ; Solvents/chemistry ; Substrate Specificity ; Temperature

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Skocz do pozycji: 77.

Tytuł:: Differential hepatoprotective role of the cannabinoid CB 1 and CB 2 receptors in paracetamol-induced liver injury.
Autorzy:: Rivera P; Department of Endocrinology, Fundación Investigación Biomédica del Hospital Infantil Universitario Niño Jesús, Instituto de Investigación Biomédica la Princesa, Madrid, Spain.; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.
Vargas A; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.
Pastor A; Farmacología Integrada y Neurociencia de Sistemas, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Boronat A; Farmacología Integrada y Neurociencia de Sistemas, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
López-Gambero AJ; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.
Sánchez-Marín L; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.
Medina-Vera D; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.
Serrano A; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.
Pavón FJ; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.; UGC Corazón, Hospital Universitario Virgen de la Victoria, IBIMA, Universidad de Málaga, Málaga, Spain.
de la Torre R; Farmacología Integrada y Neurociencia de Sistemas, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Agirregoitia E; Department of Physiology, Faculty of Medicine and Nursing, UPV/EHU, Leioa, Spain.
Lucena MI; Servicio de Farmacología Clínica, Hospital Universitario Virgen de la Victoria, IBIMA, Universidad de Málaga, Málaga, Spain.
Rodríguez de Fonseca F; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.
Decara J; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.
Suárez J; UGC Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2020 Jul; Vol. 177 (14), pp. 3309-3326. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cannabinoids*
Chemical and Drug Induced Liver Injury, Chronic*
Acetaminophen/toxicity ; Animals ; Disease Models, Animal ; Humans ; Mice ; Monoacylglycerol Lipases ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2

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Tytuł:: Genotype-phenotype correlation in a novel ABHD12 mutation underlying PHARC syndrome.
Autorzy:: Thimm A; Department of Neurology, University Hospital Essen, Essen, Germany.
Rahal A; Department of Ophthalmology, University Hospital Essen, Essen, Germany.
Schoen U; Medical Genetics Center, Munich, Germany.
Abicht A; Medical Genetics Center, Munich, Germany.
Klebe S; Department of Neurology, University Hospital Essen, Essen, Germany.
Kleinschnitz C; Department of Neurology, University Hospital Essen, Essen, Germany.
Hagenacker T; Department of Neurology, University Hospital Essen, Essen, Germany.
Stettner M; Department of Neurology, University Hospital Essen, Essen, Germany.; Pokaż więcej
Źródło:: Journal of the peripheral nervous system : JPNS [J Peripher Nerv Syst] 2020 Jun; Vol. 25 (2), pp. 112-116. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Ataxia/*genetics
Ataxia/*physiopathology
Cataract/*genetics
Cataract/*physiopathology
Monoacylglycerol Lipases/*genetics
Polyneuropathies/*genetics
Polyneuropathies/*physiopathology
Retinitis Pigmentosa/*genetics
Retinitis Pigmentosa/*physiopathology
Adult ; Ataxia/diagnosis ; Cataract/diagnosis ; Genetic Association Studies ; Humans ; Male ; Polyneuropathies/diagnosis ; Retinitis Pigmentosa/diagnosis ; Siblings ; Young Adult
SCR Disease Name:: Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract

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Tytuł:: Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB 2 receptors.
Autorzy:: Corcoran L; Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway, Galway, Ireland.; Galway Neuroscience Centre and Centre for Pain Research, National University of Ireland Galway, Galway, Ireland.
Mattimoe D; Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway, Galway, Ireland.; Galway Neuroscience Centre and Centre for Pain Research, National University of Ireland Galway, Galway, Ireland.
Roche M; Physiology, School of Medicine, National University of Ireland Galway, Galway, Ireland.; Galway Neuroscience Centre and Centre for Pain Research, National University of Ireland Galway, Galway, Ireland.
Finn DP; Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway, Galway, Ireland.; Galway Neuroscience Centre and Centre for Pain Research, National University of Ireland Galway, Galway, Ireland.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2020 May; Vol. 177 (10), pp. 2240-2255. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Analgesia*
Fear*
Gyrus Cinguli*
Receptor, Cannabinoid, CB2*
Monoacylglycerol Lipases/*antagonists & inhibitors
Animals ; Conditioning, Psychological ; Endocannabinoids ; Male ; Pain/drug therapy ; Rats

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Tytuł:: Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment.
Autorzy:: Gianessi CA; Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Interdepartmental Neuroscience Program, Yale University Graduate School of Arts and Sciences, New Haven, CT, USA.
Groman SM; Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Thompson SL; Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Jiang M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Taylor JR; Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Interdepartmental Neuroscience Program, Yale University Graduate School of Arts and Sciences, New Haven, CT, USA.; Department of Psychology, Yale University, New Haven, CT, USA.; Pokaż więcej
Źródło:: Addiction biology [Addict Biol] 2020 May; Vol. 25 (3), pp. e12768. Date of Electronic Publication: 2019 May 06.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Habits*
Motivation*
Alcohol Drinking/*metabolism
Arachidonic Acids/*metabolism
Endocannabinoids/*metabolism
Glycerides/*metabolism
Animals ; Arachidonic Acids/biosynthesis ; Arachidonic Acids/pharmacology ; Benzodioxoles/pharmacology ; Cannabinoid Receptor Antagonists/pharmacology ; Central Nervous System Depressants ; Drug-Seeking Behavior ; Endocannabinoids/biosynthesis ; Ethanol ; Glycerides/biosynthesis ; Lipoprotein Lipase/antagonists & inhibitors ; Lithium Chloride/pharmacology ; Mice ; Monoacylglycerol Lipases/antagonists & inhibitors ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/antagonists & inhibitors

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