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Wyszukujesz frazę ""Monoamine Oxidase"" wg kryterium: Temat


Tytuł :
Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches.
Autorzy :
Duarte P; Instituto Teófilo Hernando y Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, Madrid, Spain.
Cuadrado A; Departmento de Bioquímica, Facultad de Medicina, Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Investigación Sanitaria La Paz (IdiPaz), Instituto de Investigaciones Biomédicas 'Alberto Sols' UAM-CSIC, Universidad Autónoma de Madrid, Madrid, Spain.
León R; Instituto Teófilo Hernando y Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain. .; Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, Madrid, Spain. .; Instituto de Química Médica, Consejo Superior de Investigaciones CientÚficas (IQM-CSIC), Madrid, Spain. .
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Źródło :
Handbook of experimental pharmacology [Handb Exp Pharmacol] 2021; Vol. 264, pp. 229-259.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Monoamine Oxidase Inhibitors*/pharmacology
Monoamine Oxidase Inhibitors*/therapeutic use
Parkinson Disease*/drug therapy
Antidepressive Agents ; Humans ; Hydrogen Peroxide ; Monoamine Oxidase
Czasopismo naukowe
Tytuł :
Selective Interactions of O -Methylated Flavonoid Natural Products with Human Monoamine Oxidase-A and -B.
Autorzy :
Chaurasiya ND; Department of Infectious Diseases, Division of Drug Discovery, Southern Research, Birmingham, AL 35205, USA.; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.
Midiwo J; Department of Chemistry, University of Nairobi, Nairobi P.O. Box 30197-00100, Kenya.
Pandey P; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.; Department of BioMolecular Sciences, Division of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.
Bwire RN; Department of pure and applied Chemistry, Masinde Muliro University of Science and Technology, Kakamega P.O. Box 190-50100, Kenya.
Doerksen RJ; Department of BioMolecular Sciences, Division of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.
Muhammad I; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.
Tekwani BL; Department of Infectious Diseases, Division of Drug Discovery, Southern Research, Birmingham, AL 35205, USA.; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Nov 17; Vol. 25 (22). Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Products/*metabolism
Flavonoids/*metabolism
Monoamine Oxidase/*metabolism
Biological Products/chemistry ; Biological Products/isolation & purification ; Enzyme Inhibitors/pharmacology ; Flavonoids/chemistry ; Flavonoids/isolation & purification ; Humans ; Kinetics ; Methylation ; Monoamine Oxidase/chemistry ; Monoamine Oxidase Inhibitors/chemistry ; Monoamine Oxidase Inhibitors/pharmacology ; Recombinant Proteins/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of 3-arylbenzofuranone derivatives as potential anti-Alzheimer's disease agents.
Autorzy :
Yang J; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong, Jinan, China.; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, Jinan, China.; Key Laboratory for Biotech-Drugs Ministry of Health, Shandong, Jinan, China.; Key Laboratory for Rare and Uncommon Diseases of Shandong Province, Shandong, Jinan, China.
Yun Y; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong, Jinan, China.; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, Jinan, China.; Key Laboratory for Biotech-Drugs Ministry of Health, Shandong, Jinan, China.; Key Laboratory for Rare and Uncommon Diseases of Shandong Province, Shandong, Jinan, China.
Miao Y; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong, Jinan, China.; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, Jinan, China.; Key Laboratory for Biotech-Drugs Ministry of Health, Shandong, Jinan, China.; Key Laboratory for Rare and Uncommon Diseases of Shandong Province, Shandong, Jinan, China.
Sun J; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, Jinan, China.; Key Laboratory for Biotech-Drugs Ministry of Health, Shandong, Jinan, China.; Key Laboratory for Rare and Uncommon Diseases of Shandong Province, Shandong, Jinan, China.
Wang X; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, Jinan, China.; Key Laboratory for Biotech-Drugs Ministry of Health, Shandong, Jinan, China.; Key Laboratory for Rare and Uncommon Diseases of Shandong Province, Shandong, Jinan, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 805-814.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Anti-Anxiety Agents/*pharmacology
Antioxidants/*pharmacology
Benzofurans/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Monoamine Oxidase Inhibitors/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Animals ; Anti-Anxiety Agents/chemical synthesis ; Anti-Anxiety Agents/chemistry ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Benzofurans/chemical synthesis ; Benzofurans/chemistry ; Biphenyl Compounds/antagonists & inhibitors ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Structure ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Picrates/antagonists & inhibitors ; Rats ; Rats, Wistar ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Design of enamides as new selective monoamine oxidase-B inhibitors.
Autorzy :
Kavully FS; Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna, India.
Oh JM; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, Korea.
Dev S; Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna, India.
Kaipakasseri S; Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna, India.
Palakkathondi A; Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna, India.
Vengamthodi A; Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna, India.
Abdul Azeez RF; Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna, India.
Tondo AR; Instituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
Nicolotti O; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Bari, Italy.
Kim H; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, Korea.
Bijo Mathew; Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, India.
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Źródło :
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2020 Jul; Vol. 72 (7), pp. 916-926. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Journal Article
MeSH Terms :
Amines*/chemistry
Amines*/pharmacology
Cinnamates*/chemistry
Cinnamates*/pharmacology
Drug Design*
Monoamine Oxidase Inhibitors*/chemistry
Monoamine Oxidase Inhibitors*/pharmacology
Alzheimer Disease/*drug therapy
Parkinson Disease/*drug therapy
Binding, Competitive ; Drug Discovery ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation/methods ; Molecular Structure ; Monoamine Oxidase/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door.
Autorzy :
Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi-682 041, India.
Carradori S; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Chieti 66100, Italy.
Guglielmi P; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Uddin MS; Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Kim H; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
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Źródło :
Current medicinal chemistry [Curr Med Chem] 2021; Vol. 28 (2), pp. 266-283.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Monoamine Oxidase/*metabolism
Chromones ; Halogens ; Humans ; Monoamine Oxidase Inhibitors/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Performance of Force-Field- and Machine Learning-Based Scoring Functions in Ranking MAO-B Protein-Inhibitor Complexes in Relevance to Developing Parkinson's Therapeutics.
Autorzy :
Murugan NA; Department of Theoretical Chemistry and Biology, School of Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 10691 Stockholm, Sweden.
Muvva C; BiomAILS India Pvt Ltd., Hyderabad 500 090, India.
Jeyarajpandian C; Department of Biotechnology, Dr. Umayal Ramanathan College for Women, Karaikudi 630 004, India.
Jeyakanthan J; Department of Bioinformatics, Alagappa University, Karaikudi 630 004, India.
Subramanian V; Centre for High Computing, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 16; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Comparative Study; Evaluation Study; Journal Article
MeSH Terms :
Machine Learning*
Antiparkinson Agents/*pharmacology
Molecular Docking Simulation/*methods
Monoamine Oxidase Inhibitors/*pharmacology
Antiparkinson Agents/chemistry ; Antiparkinson Agents/classification ; Drug Development ; Humans ; Molecular Docking Simulation/standards ; Monoamine Oxidase/chemistry ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/chemistry ; Monoamine Oxidase Inhibitors/classification ; Protein Binding
Czasopismo naukowe
Tytuł :
Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis .
Autorzy :
Jeong GS; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
Kang MG; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Korea.
Lee JY; National Institute for Korean Medicine Development, Gyeongsan 38540, Korea.
Lee SR; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
Park D; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Korea.
Cho M; National Institute for Korean Medicine Development, Gyeongsan 38540, Korea.
Kim H; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Aug 26; Vol. 25 (17). Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Cholinesterase Inhibitors*/chemistry
Cholinesterase Inhibitors*/isolation & purification
Coumarins*/chemistry
Coumarins*/isolation & purification
Flavanones*/chemistry
Flavanones*/isolation & purification
Monoamine Oxidase Inhibitors*/chemistry
Monoamine Oxidase Inhibitors*/isolation & purification
Butyrylcholinesterase/*chemistry
Glycyrrhiza uralensis/*chemistry
Monoamine Oxidase/*chemistry
Animals ; Electrophorus ; Humans
Czasopismo naukowe
Tytuł :
Luteolin, a Potent Human Monoamine Oxidase-A Inhibitor and Dopamine D 4 and Vasopressin V 1A Receptor Antagonist.
Autorzy :
Park SE; Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.
Paudel P; Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.; National Center for Natural Products Research, The University of Mississippi, Oxford, Mississippi 38677, United States.
Wagle A; Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.
Seong SH; Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.
Kim HR; Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.
Fauzi FM; Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor Branch, Puncak Alam Campus, 42 300 Bandar Puncak Alam, Selangor, Malaysia.
Jung HA; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Republic of Korea.
Choi JS; Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Sep 30; Vol. 68 (39), pp. 10719-10729. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antidiuretic Hormone Receptor Antagonists/*chemistry
Luteolin/*chemistry
Monoamine Oxidase Inhibitors/*chemistry
Plant Extracts/*chemistry
Receptors, Dopamine D4/*antagonists & inhibitors
Cirsium/chemistry ; Humans ; Kinetics ; Molecular Docking Simulation ; Monoamine Oxidase/chemistry ; Receptors, Vasopressin/chemistry
Czasopismo naukowe
Tytuł :
[The role of inhibitors of COMT and MAO-B in the therapy of Parkinson's disease].
Autorzy :
Woitalla D
Krüger R
Lorenzl S
Müller T
Oelwein G
Storch A
Wolz M
Wüllner U
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Transliterated Title :
Grundlagen und Stellenwert der COMT- und MAO-B-Inhibitoren in der Therapie des idiopathischen Parkinson-Syndroms.
Źródło :
Fortschritte der Neurologie-Psychiatrie [Fortschr Neurol Psychiatr] 2020 Sep; Vol. 88 (9), pp. 620-633. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiparkinson Agents/*therapeutic use
Catechol O-Methyltransferase Inhibitors/*therapeutic use
Monoamine Oxidase Inhibitors/*therapeutic use
Parkinson Disease/*drug therapy
Catechol O-Methyltransferase/metabolism ; Humans ; Levodopa/therapeutic use ; Monoamine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors.
Autorzy :
Özdemir Z; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Inonu University, 44280, Malatya, Turkey. .
Alagöz MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Inonu University, 44280, Malatya, Turkey.
Uslu H; Department of Anesthesiology, Vocational School of Health Services, Fırat University, 23119, Elazığ, Turkey.
Karakurt A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Inonu University, 44280, Malatya, Turkey.
Erikci A; Department of Biochemistry, Faculty of Pharmacy, Lokman Hekim University, 06510, Ankara, Turkey.
Ucar G; Department of Biochemistry, Faculty of Pharmacy, Lokman Hekim University, 06510, Ankara, Turkey.
Uysal M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06100, Ankara, Turkey.
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Źródło :
Pharmacological reports : PR [Pharmacol Rep] 2020 Jun; Vol. 72 (3), pp. 692-704. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Monoamine Oxidase Inhibitors/*chemical synthesis
Monoamine Oxidase Inhibitors/*pharmacology
Pyridazines/*chemical synthesis
Pyridazines/*pharmacology
Computer Simulation ; Drug Liberation ; Hep G2 Cells ; Humans ; Kinetics ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Monoamine Oxidase ; Monoamine Oxidase Inhibitors/chemistry ; Pyridazines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
[Synthesis and monoamine oxidase B inhibitory activities of isoquiritigenin derivatives].
Autorzy :
Kong Z; Department of Bioengineering,Zhuhai Campus,Zunyi Medical University Zhuhai 519041,China.
Sun DM; Department of Bioengineering,Zhuhai Campus,Zunyi Medical University Zhuhai 519041,China.
Chen AQ; Department of Bioengineering,Zhuhai Campus,Zunyi Medical University Zhuhai 519041,China.
Hu Y; Department of Bioengineering,Zhuhai Campus,Zunyi Medical University Zhuhai 519041,China.
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Źródło :
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2019 Nov; Vol. 44 (21), pp. 4653-4660.
Typ publikacji :
Journal Article
MeSH Terms :
Drugs, Chinese Herbal*
Monoamine Oxidase Inhibitors*
Animals ; Humans ; Monoamine Oxidase ; Plant Extracts ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors.
Autorzy :
Oh JM; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
Rangarajan TM; Department of Chemistry, Sri Venketeswara College, University of Delhi, New Delhi-110021, India.
Chaudhary R; Centre for Fire, Explosive and Environment Saftey, DRDO, Delhi-110054, India.; Department of Chemistry, University of Dehli, Dehli-110007, India.
Singh RP; Department of Chemistry, Sri Venketeswara College, University of Delhi, New Delhi-110021, India.
Singh M; Department of Chemistry, Shivaji College, University of Delhi, New Delhi-110027, India.
Singh RP; Centre for Fire, Explosive and Environment Saftey, DRDO, Delhi-110054, India.
Tondo AR; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', via E. Orabona, 4, I-70125 Bari, Italy.
Gambacorta N; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', via E. Orabona, 4, I-70125 Bari, Italy.
Nicolotti O; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', via E. Orabona, 4, I-70125 Bari, Italy.
Mathew B; Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad-678557, Kerala, India.
Kim H; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 May 18; Vol. 25 (10). Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Chalcone/*chemistry
Cholinesterase Inhibitors/*chemistry
Monoamine Oxidase Inhibitors/*chemistry
Oximes/*chemistry
Acetylcholinesterase/chemistry ; Acetylcholinesterase/drug effects ; Chalcone/pharmacology ; Cholinesterase Inhibitors/isolation & purification ; Cholinesterase Inhibitors/pharmacology ; Ethers/chemistry ; Ethers/pharmacology ; Humans ; Kinetics ; Monoamine Oxidase/chemistry ; Monoamine Oxidase/drug effects ; Monoamine Oxidase Inhibitors/isolation & purification ; Monoamine Oxidase Inhibitors/pharmacology ; Oximes/pharmacology
Czasopismo naukowe
Tytuł :
Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ 1-42 aggregation.
Autorzy :
Plazas E; Universidad Nacional de Colombia, Sede Bogotá, Facultad de Ciencias, Departamento de Química, Grupo de Investigación en Productos Naturales Vegetales Bioactivos, Cr 30 N°45-03, 111321 Bogotá, Colombia. Electronic address: .
Hagenow S; Heinrich Heine University Düsseldorf, Institute of Pharmaceutical and Medicinal Chemistry, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
Avila Murillo M; Universidad Nacional de Colombia, Sede Bogotá, Facultad de Ciencias, Departamento de Química, Grupo de Investigación en Productos Naturales Vegetales Bioactivos, Cr 30 N°45-03, 111321 Bogotá, Colombia.
Stark H; Heinrich Heine University Düsseldorf, Institute of Pharmaceutical and Medicinal Chemistry, Universitaetsstr. 1, 40225 Duesseldorf, Germany. Electronic address: .
Cuca LE; Universidad Nacional de Colombia, Sede Bogotá, Facultad de Ciencias, Departamento de Química, Grupo de Investigación en Productos Naturales Vegetales Bioactivos, Cr 30 N°45-03, 111321 Bogotá, Colombia.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 May; Vol. 98, pp. 103722. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkaloids/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Isoquinolines/*pharmacology
Monoamine Oxidase Inhibitors/*pharmacology
Plant Roots/*chemistry
Zanthoxylum/*chemistry
Acetylcholinesterase/metabolism ; Alkaloids/chemistry ; Alkaloids/isolation & purification ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/isolation & purification ; Dose-Response Relationship, Drug ; Electrophorus ; Horses ; Humans ; Isoquinolines/chemistry ; Isoquinolines/isolation & purification ; Kinetics ; Molecular Structure ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/chemistry ; Monoamine Oxidase Inhibitors/isolation & purification ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Evaluation of the inhibition of monoamine oxidase A by bioactive coffee compounds protecting serotonin degradation.
Autorzy :
Grzelczyk J; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-924 Lodz, Poland. Electronic address: .
Budryn G; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-924 Lodz, Poland. Electronic address: .
Peña-García J; Structural Bioinformatics and High-Performance Computing Research Group (BIO-HPC), Computer Science Department, Catholic University of Murcia (UCAM), Guadalupe, Murcia, Spain. Electronic address: .
Szwajgier D; Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Lublin, Poland. Electronic address: .
Gałązka-Czarnecka I; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-924 Lodz, Poland. Electronic address: .
Oracz J; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-924 Lodz, Poland. Electronic address: .
Pérez-Sánchez H; Structural Bioinformatics and High-Performance Computing Research Group (BIO-HPC), Computer Science Department, Catholic University of Murcia (UCAM), Guadalupe, Murcia, Spain. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Jun 30; Vol. 348, pp. 129108. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Coffee/*chemistry
Monoamine Oxidase/*metabolism
Monoamine Oxidase Inhibitors/*pharmacology
Serotonin/*metabolism
Caffeine/analysis ; Chlorogenic Acid/analysis ; Diabetes Mellitus, Type 2/metabolism ; Monoamine Oxidase Inhibitors/chemistry ; Seeds/chemistry
Czasopismo naukowe
Tytuł :
Discovery of N -(1-(3-fluorobenzoyl)-1 H -indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.
Autorzy :
Elkamhawy A; College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Paik S; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Kim HJ; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Department of Biotechnology, Yonsei University, Seoul, Republic of Korea.
Park JH; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Londhe AM; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Lee K; College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea.
Pae AN; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Park KD; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
Roh EJ; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1568-1580.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Indoles/*pharmacology
Monoamine Oxidase/*metabolism
Monoamine Oxidase Inhibitors/*pharmacology
Dose-Response Relationship, Drug ; Humans ; Indoles/chemistry ; Kinetics ; Models, Molecular ; Molecular Structure ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B.
Autorzy :
Kong Z; Department of Bioengineering, Zunyi Medical University, Zhuhai, China.
Sun D; Department of Bioengineering, Zunyi Medical University, Zhuhai, China.
Jiang Y; Department of Bioengineering, Zunyi Medical University, Zhuhai, China.
Hu Y; Department of Bioengineering, Zunyi Medical University, Zhuhai, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1513-1523.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Chalcones/*pharmacology
Dioxanes/*pharmacology
Monoamine Oxidase/*metabolism
Monoamine Oxidase Inhibitors/*pharmacology
Chalcones/chemical synthesis ; Chalcones/chemistry ; Dioxanes/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Monoamine oxidases in age-associated diseases: New perspectives for old enzymes.
Autorzy :
Santin Y; Institute of Metabolic and Cardiovascular Diseases (I2MC), INSERM, Université de Toulouse, Toulouse, France.
Resta J; Institute of Metabolic and Cardiovascular Diseases (I2MC), INSERM, Université de Toulouse, Toulouse, France.
Parini A; Institute of Metabolic and Cardiovascular Diseases (I2MC), INSERM, Université de Toulouse, Toulouse, France.
Mialet-Perez J; Institute of Metabolic and Cardiovascular Diseases (I2MC), INSERM, Université de Toulouse, Toulouse, France. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Mar; Vol. 66, pp. 101256. Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Monoamine Oxidase*/metabolism
Oxidative Stress*
Cellular Senescence ; Mitochondria/metabolism
Czasopismo naukowe
Tytuł :
Renalase is localized to the small intestine crypt and expressed upon the activation of NF-κB p65 in mice model of fasting-induced oxidative stress.
Autorzy :
Aoki K; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 1-1-1 Tennodai, 305-8577, Japan.
Yanazawa K; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 1-1-1 Tennodai, 305-8577, Japan.
Tokinoya K; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 1-1-1 Tennodai, 305-8577, Japan.
Sugasawa T; Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki 305-8577, Japan.
Suzuki T; Department of Food Science and Nutrition, Doshisha Women's College of Liberal Arts, Tera-machi Nishiiru, Imadegawa-dori, Kamigyo-ku, Kyoto 602-0893, Japan.
Yoshida Y; Department of Clinical Laboratory, Faculty of Health Sciences, Tsukuba International University, 6-20-1 Manabe, Tsuchiura, Ibaraki 300-0051, Japan.
Nakano T; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 1-1-1 Tennodai, 305-8577, Japan.
Omi N; Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8577, Japan.
Kawakami Y; Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki 305-8577, Japan.
Takekoshi K; Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki 305-8577, Japan. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 15; Vol. 267, pp. 118904. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article
MeSH Terms :
Intestine, Small/*drug effects
Monoamine Oxidase/*pharmacology
Oxidative Stress/*drug effects
Animals ; Caco-2 Cells ; Disease Models, Animal ; Epithelial Cells/metabolism ; Fasting ; Humans ; Ileum/metabolism ; Intestine, Small/metabolism ; Intestines/physiology ; Jejunum/metabolism ; Kidney/metabolism ; Male ; Mice ; Mice, Inbred ICR ; Monoamine Oxidase/metabolism ; NF-kappa B/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro.
Autorzy :
Faingold II; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia. .; Medicinal Chemistry Research and Education Center, Moscow Region State University, Mytischchi, Moscow oblast, Russia. .
Kotelnikova RA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
Smolina AV; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
Poletaeva DA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
Soldatova YV; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.; Medicinal Chemistry Research and Education Center, Moscow Region State University, Mytischchi, Moscow oblast, Russia.
Pokidova OV; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
Sadkov AP; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
Sanina NA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.; Medicinal Chemistry Research and Education Center, Moscow Region State University, Mytischchi, Moscow oblast, Russia.; Moscow State University, Moscow, Russia.
Aldoshin SM; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.; Moscow State University, Moscow, Russia.
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Źródło :
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2019 Sep; Vol. 488 (1), pp. 342-345. Date of Electronic Publication: 2019 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Electron Transport Complex IV*/antagonists & inhibitors
Electron Transport Complex IV*/metabolism
Iron*/chemistry
Iron*/pharmacology
Mitochondrial Proteins*/antagonists & inhibitors
Mitochondrial Proteins*/metabolism
Monoamine Oxidase Inhibitors*/chemical synthesis
Monoamine Oxidase Inhibitors*/chemistry
Monoamine Oxidase Inhibitors*/pharmacology
Nitrogen Oxides*/chemical synthesis
Nitrogen Oxides*/chemistry
Nitrogen Oxides*/pharmacology
Thiosulfates*/chemical synthesis
Thiosulfates*/chemistry
Thiosulfates*/pharmacology
Brain/*enzymology
Mitochondria/*enzymology
Animals ; Mice ; Monoamine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer.
Autorzy :
Wang K; Department of Urology, The 4th Affiliated Hospital of Harbin Medical University, NHC Key Lab of Molecular Probes and Targeted Diagnosis and Therapy, Harbin, 150001, China.; George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Luo J; George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Yeh S; George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 14642, USA.
You B; Department of Urology, The 4th Affiliated Hospital of Harbin Medical University, NHC Key Lab of Molecular Probes and Targeted Diagnosis and Therapy, Harbin, 150001, China.; George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Meng J; George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Chang P; Department of Neurology, Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA, 95051, USA.
Niu Y; Tianjin Institute of Urology, Tianjin Medical University, Tianjin, 300211, China.
Li G; Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Lu C; Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center, and James Buchanan Brady Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Zhu Y; Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center, and James Buchanan Brady Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Antonarakis ES; Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center, and James Buchanan Brady Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Luo J; Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center, and James Buchanan Brady Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Huang CP; Sex Hormone Research Center, Department of Urology, China Medical University and Hospital, Taichung, 404, Taiwan.
Xu W; Department of Urology, The 4th Affiliated Hospital of Harbin Medical University, NHC Key Lab of Molecular Probes and Targeted Diagnosis and Therapy, Harbin, 150001, China. .
Chang C; George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 14642, USA. .; Sex Hormone Research Center, Department of Urology, China Medical University and Hospital, Taichung, 404, Taiwan. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 01; Vol. 11 (1), pp. 2689. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Clorgyline/*pharmacology
Monoamine Oxidase Inhibitors/*pharmacology
Phenelzine/*pharmacology
Phenylthiohydantoin/*analogs & derivatives
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Alternative Splicing ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Enzyme Stability ; Gene Expression Regulation, Enzymologic/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice ; Mice, Nude ; Mice, SCID ; Monoamine Oxidase/chemistry ; Monoamine Oxidase/genetics ; Monoamine Oxidase/metabolism ; Neoplastic Cells, Circulating/metabolism ; Phenylthiohydantoin/pharmacology ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Signal Transduction/drug effects ; Up-Regulation/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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