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Wyświetlanie 1-20 z 26
Tytuł:
The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin.
Autorzy:
Quagliariello V; Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy. .
De Laurentiis M; Breast Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.
Rea D; SSD Sperimentazione Animale, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.
Barbieri A; SSD Sperimentazione Animale, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.
Monti MG; Department of Translational Medical Sciences, University of Naples 'Federico II', Naples, Italy.
Carbone A; Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.
Paccone A; Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.
Altucci L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138, Naples, Italy.
Conte M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138, Naples, Italy.
Canale ML; Cardiology Division, Azienda USL Toscana Nord-Ovest, Versilia Hospital, Lido Di Camaiore, Italy.
Botti G; Scientific Direction, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.
Maurea N; Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy. .
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Źródło:
Cardiovascular diabetology [Cardiovasc Diabetol] 2021 Jul 23; Vol. 20 (1), pp. 150. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzhydryl Compounds/*pharmacology
Cytokines/*metabolism
Glucosides/*pharmacology
Heart Diseases/*drug therapy
Inflammation Mediators/*metabolism
Myocytes, Cardiac/*drug effects
Sodium-Glucose Transporter 2 Inhibitors/*pharmacology
Ventricular Function, Left/*drug effects
Animals ; Anti-Inflammatory Agents/pharmacology ; Antifibrotic Agents/pharmacology ; Apoptosis/drug effects ; Cardiotoxicity ; Cell Line ; Disease Models, Animal ; Doxorubicin ; Female ; Ferroptosis/drug effects ; Fibrosis ; Heart Diseases/chemically induced ; Heart Diseases/metabolism ; Heart Diseases/pathology ; Inflammasomes/metabolism ; Mice, Inbred C57BL ; Myeloid Differentiation Factor 88/metabolism ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Signal Transduction ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Doxorubicin impairs the insulin-like growth factor-1 system and causes insulin-like growth factor-1 resistance in cardiomyocytes.
Autorzy:
Fabbi P; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
Spallarossa P; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
Garibaldi S; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
Barisione C; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
Mura M; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
Altieri P; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
Rebesco B; Antiblastic Drug Unit, IRCCS AOU San Martino-IST, Genova, Italy.
Monti MG; Department of Medical Translational Sciences, University of Napoli Federico II, Napoli, Italy.
Canepa M; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
Ghigliotti G; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
Brunelli C; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
Ameri P; Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy.
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Źródło:
PloS one [PLoS One] 2015 May 08; Vol. 10 (5), pp. e0124643. Date of Electronic Publication: 2015 May 08 (Print Publication: 2015).
Typ publikacji:
Journal Article
MeSH Terms:
Doxorubicin/*pharmacology
Insulin-Like Growth Factor I/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Annexin A5/metabolism ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Line ; In Situ Nick-End Labeling ; Insulin-Like Growth Factor Binding Protein 3/metabolism ; Insulin-Like Growth Factor I/pharmacology ; Intracellular Space/metabolism ; Myocytes, Cardiac/drug effects ; Propidium/metabolism ; Rats ; Receptor, IGF Type 1/metabolism ; Signal Transduction/drug effects ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 26

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