- Tytuł:
-
The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to
paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest. - Autorzy:
- Źródło:
- Clinical epigenetics [Clin Epigenetics] 2018 Feb 27; Vol. 10 (1), pp. 26. Date of Electronic Publication: 2018 Feb 27.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
DNA Methylation*
Carcinoma/*genetics
Carrier Proteins/*genetics
Fluorouracil/*pharmacology
Nasopharyngeal Neoplasms/*genetics
Neoplasm Proteins/*geneticsPaclitaxel /*pharmacology
Signal Transduction/*drug effects
Adaptor Proteins, Signal Transducing ; Carcinoma/drug therapy ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; CpG Islands ; Down-Regulation/drug effects ; G2 Phase Cell Cycle Checkpoints/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Nasopharyngeal Neoplasms/drug therapy ; Promoter Regions, Genetic ; beta Catenin/genetics ; beta Catenin/metabolism ; cdc25 Phosphatases/genetics ; cdc25 Phosphatases/metabolism
Czasopismo naukowe