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Tytuł :
Impact of Pregnancy and Glucocorticoid Treatment on NF-κB and MUC5AC in Mucosa of Rat Larynx.
Autorzy :
Ulkumen B; Manisa Celal Bayar University, Faculty of Medicine, Department of Otorhinolaryngology-Head Neck Surgery, Manisa, Turkey. Electronic address: .
Artunc Ulkumen B; Manisa Celal Bayar University, Faculty of Medicine, Department of Obstetrics and Gynecology, Manisa, Turkey.
Batir MB; Manisa Celal Bayar University, Faculty of Medicine, Department of Medical Genetics, Manisa, Turkey.
Pala HG; The University of Health Sciences Tepecik Training and Research Hospital, Department of Obstetrics and Gynecology, İzmir, Turkey.
Vatansever S; Manisa Celal Bayar University, Faculty of Medicine, Department of Histology-Embryology, Manisa, Turkey and Near East University, Experimental Research Center of Health (DESAM), Mersin, Turkey.
Cam S; Manisa Celal Bayar University, Faculty of Medicine, Department of Medical Genetics, Manisa, Turkey.
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Źródło :
Journal of voice : official journal of the Voice Foundation [J Voice] 2021 May; Vol. 35 (3), pp. 342-348. Date of Electronic Publication: 2019 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Larynx*
Mucin 5AC*/genetics
Mucin 5AC*/metabolism
Mucous Membrane*
NF-kappa B*/metabolism
Animals ; Female ; Glucocorticoids/pharmacology ; Glucocorticoids/therapeutic use ; Pregnancy ; Rats
Czasopismo naukowe
Tytuł :
ATF4-mediated GDF15 suppresses LPS-induced inflammation and MUC5AC in human nasal epithelial cells through the PI3K/Akt pathway.
Autorzy :
Li A; Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, PR China.
Zhao F; Department of Medical Imaging, Chang'an Hospital, Xi'an 710016, Shaanxi, PR China.
Zhao Y; Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, PR China.
Liu H; Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, PR China.
Wang Z; Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 15; Vol. 275, pp. 119356. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Activating Transcription Factor 4/*physiology
Growth Differentiation Factor 15/*physiology
Inflammation/*metabolism
Mucin 5AC/*metabolism
Nasal Mucosa/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Activating Transcription Factor 4/metabolism ; Cells, Cultured ; Chromatin Immunoprecipitation ; Cytokines/metabolism ; Cytokines/physiology ; Growth Differentiation Factor 15/metabolism ; Humans ; Inflammation/physiopathology ; Lipopolysaccharides/pharmacology ; Mucin 5AC/physiology ; Nasal Mucosa/physiopathology ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Molecular mechanism underlying miR‑130b‑Sp1 transcriptional regulation in LPS‑induced upregulation of MUC5AC in the bile duct epithelium.
Autorzy :
Wu X; Department of Secondary General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
Yao C; Department of Secondary General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
Kong J; Department of Secondary General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
Tian Y; Department of Secondary General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
Fan Y; Department of Secondary General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
Zhang Z; Department of Secondary General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
Han J; Department of Secondary General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
Wu S; Department of Secondary General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Feb; Vol. 23 (2). Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Bile Ducts/*metabolism
Lipopolysaccharides/*toxicity
MicroRNAs/*metabolism
Mucin 5AC/*biosynthesis
Sp1 Transcription Factor/*metabolism
Up-Regulation/*drug effects
Animals ; Bile Ducts/pathology ; Cell Line ; Epithelium/metabolism ; Epithelium/pathology ; Humans ; Male ; MicroRNAs/genetics ; Mucin 5AC/genetics ; Rats ; Rats, Sprague-Dawley ; Sp1 Transcription Factor/genetics ; Transcriptional Activation/drug effects
Czasopismo naukowe
Tytuł :
Caged Dexamethasone/Quercetin Nanoparticles, Formed of the Morphogenetic Active Inorganic Polyphosphate, are Strong Inducers of MUC5AC .
Autorzy :
Neufurth M; ERC Advanced Investigator Grant Research Group, Institute for Physiological Chemistry, University Medical Center, Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.
Wang X; ERC Advanced Investigator Grant Research Group, Institute for Physiological Chemistry, University Medical Center, Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.
Wang S; ERC Advanced Investigator Grant Research Group, Institute for Physiological Chemistry, University Medical Center, Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.
Schröder HC; ERC Advanced Investigator Grant Research Group, Institute for Physiological Chemistry, University Medical Center, Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.
Müller WEG; ERC Advanced Investigator Grant Research Group, Institute for Physiological Chemistry, University Medical Center, Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.
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Źródło :
Marine drugs [Mar Drugs] 2021 Jan 27; Vol. 19 (2). Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Dexamethasone/*pharmacology
Mucin 5AC/*biosynthesis
Mucin 5AC/*drug effects
Quercetin/*pharmacology
A549 Cells ; Anti-Inflammatory Agents/chemistry ; Antioxidants/chemistry ; COVID-19 ; Dexamethasone/chemistry ; Free Radical Scavengers/pharmacology ; Gene Expression Regulation/drug effects ; Humans ; Magnesium/chemistry ; Mucin 5AC/genetics ; Mucins/biosynthesis ; Mucins/chemistry ; Nanoparticles ; Particle Size ; Plants/chemistry ; Polyphosphates/chemistry ; Quercetin/chemistry ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Upregulation of miR-92a contributes to blocking goblet cell metaplasia by targeting MUC5AC in asthma.
Autorzy :
Dai J; Zhejiang Provincial Key Laboratory of Geriatrics & Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
Ma B; Department of Breast Surgery, Zhejiang Hospital, Hangzhou, China.
Wen X; Zhejiang Provincial Key Laboratory of Geriatrics & Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
Yang Z; Zhejiang Provincial Key Laboratory of Geriatrics & Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
Yue Y; Zhejiang Provincial Key Laboratory of Geriatrics & Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
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Źródło :
Journal of receptor and signal transduction research [J Recept Signal Transduct Res] 2020 Dec; Vol. 40 (6), pp. 613-619. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Asthma/*complications
Goblet Cells/*pathology
Metaplasia/*prevention & control
MicroRNAs/*genetics
Mucin 5AC/*metabolism
Animals ; Asthma/chemically induced ; Asthma/pathology ; Female ; Goblet Cells/metabolism ; Metaplasia/etiology ; Metaplasia/metabolism ; Metaplasia/pathology ; Mice ; Mice, Inbred C57BL ; Mucin 5AC/genetics ; Ovalbumin/toxicity
Czasopismo naukowe
Tytuł :
S-allylmercaptocysteine inhibits mucin overexpression and inflammation via MAPKs and PI3K-Akt signaling pathways in acute respiratory distress syndrome.
Autorzy :
An L; School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Zhao J; School of Basic Medical Sciences, Cheelloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
Sun X; School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Zhou Y; School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Zhao Z; School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China; Shandong Key University Laboratory of Pharmaceutics & Drug Delivery Systems, 44 West Wenhua Road, Jinan, Shandong 250012, PR China; Shandong Engineering & Technology Research Center for Jujube Food and Drug, 44 West Wenhua Road, Jinan, Shandong 250012, PR China. Electronic address: .
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Źródło :
Pharmacological research [Pharmacol Res] 2020 Sep; Vol. 159, pp. 105032. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Cysteine/*analogs & derivatives
Lung/*drug effects
Mitogen-Activated Protein Kinases/*metabolism
Mucin 5AC/*metabolism
Mucin-5B/*metabolism
Phosphatidylinositol 3-Kinase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Respiratory Distress Syndrome/*drug therapy
Animals ; Cell Line ; Cysteine/pharmacology ; Cytokines/metabolism ; Humans ; Inflammation Mediators/metabolism ; Lipopolysaccharides ; Lung/enzymology ; Lung/pathology ; Mice, Inbred BALB C ; Mucin 5AC/genetics ; Mucin-5B/genetics ; Phosphorylation ; Respiratory Distress Syndrome/chemically induced ; Respiratory Distress Syndrome/enzymology ; Respiratory Distress Syndrome/genetics ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease.
Autorzy :
Li J; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Ye Z; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Sep 27; Vol. 25 (19). Date of Electronic Publication: 2020 Sep 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Signal Transduction*
Bronchi/*metabolism
Mucin 5AC/*metabolism
Mucus/*metabolism
Pulmonary Disease, Chronic Obstructive/*metabolism
Bronchi/pathology ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Humans ; Interleukin-13/genetics ; Interleukin-13/metabolism ; Mucin 5AC/genetics ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-ets/genetics ; Proto-Oncogene Proteins c-ets/metabolism ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/pathology ; STAT6 Transcription Factor/genetics ; STAT6 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Effects of macromolecular crowding on the folding and aggregation of glycosylated MUC5AC.
Autorzy :
Jing W; Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
Qin Y; Department of Intensive Care Unit, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
Tong J; Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Sep 03; Vol. 529 (4), pp. 984-990. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Dextrans/*pharmacology
Ficoll/*pharmacology
Mucin 5AC/*metabolism
Polyethylene Glycols/*pharmacology
Serum Albumin, Bovine/*pharmacology
Amino Acid Sequence ; Animals ; Cattle ; Cloning, Molecular ; Dextrans/chemistry ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Ficoll/chemistry ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glycosylation/drug effects ; HEK293 Cells ; Humans ; Kinetics ; Mucin 5AC/chemistry ; Peptides/chemical synthesis ; Peptides/metabolism ; Polyethylene Glycols/chemistry ; Protein Aggregates/drug effects ; Protein Folding/drug effects ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Serum Albumin, Bovine/chemistry ; Uridine Diphosphate N-Acetylgalactosamine/analogs & derivatives ; Uridine Diphosphate N-Acetylgalactosamine/chemistry ; Uridine Diphosphate N-Acetylgalactosamine/metabolism
Czasopismo naukowe
Tytuł :
Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer.
Autorzy :
Battista S; Pathology Department, 'S. Maria della Misericordia Hospital', Friuli-Venezia Giulia, 33100 Udine, Italy.
Ambrosio MR; Pathology Department, 'Az. USL, Tuscany North-West', Tuscany, 56121 Pisa, Italy.
Limarzi F; Pathology Department, 'G.B. Morgagni-L. Pierantoni Hospital', Emilia-Romagna, 47121 Forlì, Italy.
Gallo G; Pathology Department, 'M. Bufalini Hospital', Emilia Romagna, 47521 Cesena, Italy.
Saragoni L; Pathology Department, 'G.B. Morgagni-L. Pierantoni Hospital', Emilia-Romagna, 47121 Forlì, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 22; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Stomach Neoplasms/*metabolism
Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Early Detection of Cancer ; GATA6 Transcription Factor/analysis ; GATA6 Transcription Factor/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Intestines ; Metaplasia/diagnosis ; Metaplasia/genetics ; Metaplasia/metabolism ; Mucin 5AC/analysis ; Mucin 5AC/genetics ; Mucin-2/analysis ; Mucin-2/genetics ; Mucin-6/analysis ; Mucin-6/genetics ; Mutation ; Prognosis ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/genetics ; Tumor Suppressor Protein p53/analysis ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
MUC5AC enhances tumor heterogeneity in lung adenocarcinoma with mucin production and is associated with poor prognosis.
Autorzy :
Dong Y; Department of Pathology, Key Laboratory of Head and Neck Molecular Diagnosis Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China, and.; Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Zhou L; Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Zhao D; Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Li K; Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Liu Z; Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Che N; Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Liu H; Department of Pathology, Key Laboratory of Head and Neck Molecular Diagnosis Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China, and.
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Źródło :
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2020 Jun 10; Vol. 50 (6), pp. 701-711.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
Mucin 5AC/*genetics
Thyroid Nuclear Factor 1/*genetics
Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/surgery ; Adenocarcinoma, Mucinous/genetics ; Adenocarcinoma, Mucinous/metabolism ; Adenocarcinoma, Mucinous/surgery ; Adult ; Aged ; Aged, 80 and over ; ErbB Receptors/genetics ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms/metabolism ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Mucin 5AC/analysis ; Mutation ; Prognosis ; Proto-Oncogene Proteins p21(ras)/genetics ; Thyroid Nuclear Factor 1/analysis
Czasopismo naukowe
Tytuł :
Mechanism of azithromycin in airway diseases.
Autorzy :
Yang J; Central Laboratory, Danyang People's Hospital of Jiangsu Province, Danyang, Jiangsu, China.
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Źródło :
The Journal of international medical research [J Int Med Res] 2020 Jun; Vol. 48 (6), pp. 300060520932104.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Azithromycin*/metabolism
Azithromycin*/pharmacology
Azithromycin*/therapeutic use
Mucin 5AC*/genetics
Mucin 5AC*/metabolism
Epithelial Cells/metabolism ; Gene Expression ; MAP Kinase Signaling System ; Respiratory Mucosa/metabolism
Czasopismo naukowe
Tytuł :
Mucin 5AC is significantly upregulated in exosomes from the nasal lavage fluid and may promote the expression of COX-2, VEGF and MMP-9: an implication in nasal polyp pathogenesis.
Autorzy :
Wang LF; Department of Otolaryngology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Otolaryngology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Lee CH; Department of Pharmacology, School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Liang SS; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan.
Hung CC; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wu YR; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chien CY; Department of Otolaryngology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Otolaryngology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Lee CH; National Yujing Senior Vocational School of Technology and Commerce, Tainan, Taiwan.
Chen JY; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
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Źródło :
Rhinology [Rhinology] 2021 Jun 01; Vol. 59 (3), pp. 328-336.
Typ publikacji :
Journal Article
MeSH Terms :
Exosomes*
Nasal Polyps*
Chromatography, Liquid ; Cyclooxygenase 2 ; Humans ; Matrix Metalloproteinase 9 ; Mucin 5AC ; Nasal Lavage Fluid ; Tandem Mass Spectrometry ; Vascular Endothelial Growth Factor A
Czasopismo naukowe
Tytuł :
Effect of Korean Red Ginseng and Rg3 on Asian Sand Dust-Induced MUC5AC, MUC5B, and MUC8 Expression in Bronchial Epithelial Cells.
Autorzy :
Shin SH; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea.
Ye MK; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea.
Lee DW; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea.
Kang BJ; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea.
Chae MH; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 01; Vol. 26 (7). Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Dust*
Gene Expression Regulation*
Sand*
Epithelial Cells/*drug effects
Epithelial Cells/*metabolism
Ginsenosides/*pharmacology
Mucins/*genetics
Panax/*chemistry
Cell Line ; Cell Survival/drug effects ; Cells, Cultured ; Ginsenosides/chemistry ; Humans ; Molecular Structure ; Mucin 5AC/biosynthesis ; Mucin 5AC/genetics ; Mucin-5B/biosynthesis ; Mucin-5B/genetics ; Mucins/biosynthesis ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/metabolism
Czasopismo naukowe
Tytuł :
Benzo(a)pyrene induces MUC5AC expression through the AhR/mitochondrial ROS/ERK pathway in airway epithelial cells.
Autorzy :
Sun Y; Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
Shi Z; Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
Lin Y; Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
Zhang M; Department of Laboratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
Liu J; Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
Zhu L; Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
Chen Q; Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
Bi J; Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
Li S; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
Ni Z; Central lab, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China. Electronic address: .
Wang X; Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Mar 01; Vol. 210, pp. 111857. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Air Pollutants/*toxicity
Benzo(a)pyrene/*toxicity
Epithelial Cells/*drug effects
Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Line ; Epithelial Cells/metabolism ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mucin 5AC/genetics ; Mucin 5AC/metabolism ; Reactive Oxygen Species/metabolism ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Respiratory System/cytology ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Wood Smoke Particles Stimulate MUC5AC Overproduction by Human Bronchial Epithelial Cells Through TRPA1 and EGFR Signaling.
Autorzy :
Memon TA; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah.
Nguyen ND; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah.
Burrell KL; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah.
Scott AF; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah.
Almestica-Roberts M; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah.
Rapp E; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah.
Deering-Rice CE; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah.
Reilly CA; Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah.
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Źródło :
Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2020 Apr 01; Vol. 174 (2), pp. 278-290.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bronchi/*drug effects
Epithelial Cells/*drug effects
Mucin 5AC/*metabolism
Smoke/*adverse effects
TRPA1 Cation Channel/*metabolism
Animals ; Bronchi/metabolism ; Cells, Cultured ; Epithelial Cells/metabolism ; ErbB Receptors/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Inhalation Exposure ; Mice, Inbred C57BL ; Mucin 5AC/genetics ; Signal Transduction ; Up-Regulation ; Wood ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
A case of gallbladder adenocarcinoma arising in association with intracystic papillary neoplasm (ICPN) with abundant mucin production.
Autorzy :
Oba T; Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan. .
Sato N; Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.
Tamura T; Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.
Komeda M; Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.
Adachi Y; Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.
Matsuyama A; Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hirata K; Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.
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Źródło :
Clinical journal of gastroenterology [Clin J Gastroenterol] 2021 Feb; Vol. 14 (1), pp. 319-324. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Adenocarcinoma*/complications
Adenocarcinoma*/diagnosis
Adenocarcinoma, Papillary*/complications
Adenocarcinoma, Papillary*/diagnosis
Adenocarcinoma, Papillary*/surgery
Ampulla of Vater*
Gallbladder Neoplasms*/complications
Gallbladder Neoplasms*/diagnosis
Aged ; Biomarkers, Tumor ; Female ; Humans ; Mucin 5AC ; Mucin-2 ; Mucin-6 ; Mucins
Czasopismo naukowe
Tytuł :
Effects of dexamethasone on VEGF-induced MUC5AC expression in human primary bronchial epithelial cells: Implications for asthma.
Autorzy :
Kim SH; Department of Respiration, Tianjin First Central Hospital, Tianjin, China. Electronic address: .
Pei QM; Department of Radiology, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Tianjin, China. Electronic address: .
Jiang P; Department of Respiration, Tianjin First Central Hospital, Tianjin, China. Electronic address: .
Liu J; Department of Respiration, Tianjin First Central Hospital, Tianjin, China. Electronic address: .
Sun RF; Department of Respiration, Tianjin First Central Hospital, Tianjin, China. Electronic address: .
Qian XJ; Department of Respiration, Tianjin First Central Hospital, Tianjin, China. Electronic address: .
Liu JB; Department of Respiration, Tianjin First Central Hospital, Tianjin, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Apr 15; Vol. 389 (2), pp. 111897. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Asthma/*pathology
Bronchi/*metabolism
Dexamethasone/*pharmacology
Epithelial Cells/*metabolism
Gene Expression Regulation/*drug effects
Mucin 5AC/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Asthma/metabolism ; Bronchi/cytology ; Bronchi/drug effects ; Caveolin 1/genetics ; Caveolin 1/metabolism ; Cells, Cultured ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Glucocorticoids/pharmacology ; Humans ; Mucin 5AC/genetics ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor Receptor-2/genetics ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Copy Number Variation in MUC5AC and Susceptibility to Allergic Rhinitis: A Low-Coverage Whole-Genome Sequencing and Validation Cohort Study.
Autorzy :
Wang Y; Department of Otolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Li L; Department of Otolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Yang Y; Department of Otolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Feng J; Department of Otolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Wang L; Department of Otolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Zhang H; Department of Otolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
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Źródło :
Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2020 Apr; Vol. 24 (4), pp. 173-180. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Mucin 5AC/*genetics
Rhinitis, Allergic/*genetics
Adult ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Child ; China ; Cohort Studies ; DNA Copy Number Variations/genetics ; Family ; Female ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Mucin 5AC/metabolism ; Pedigree ; Polymorphism, Single Nucleotide/genetics ; Whole Genome Sequencing/methods
Czasopismo naukowe
Tytuł :
Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance.
Autorzy :
Pothuraju R; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Rachagani S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Krishn SR; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Chaudhary S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Nimmakayala RK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Siddiqui JA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Ganguly K; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Lakshmanan I; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Cox JL; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Mallya K; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Kaur S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Batra SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. .; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA. .; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. .; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. .
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Źródło :
Molecular cancer [Mol Cancer] 2020 Feb 25; Vol. 19 (1), pp. 37. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Drug Resistance, Neoplasm*
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*pathology
Hyaluronan Receptors/*metabolism
Mucin 5AC/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Disease Progression ; Fluorouracil/administration & dosage ; Gene Expression Regulation, Neoplastic ; Humans ; Hyaluronan Receptors/genetics ; Mice ; Mice, Nude ; Mucin 5AC/genetics ; Oxaliplatin/administration & dosage ; Prognosis ; Survival Rate ; Tumor Cells, Cultured ; Wnt Signaling Pathway ; Xenograft Model Antitumor Assays ; beta Catenin/genetics ; beta Catenin/metabolism
Czasopismo naukowe

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