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Tytuł :
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration.
Autorzy :
Li Y; Department of Pharmacy, Ludwig-Maximilians-Universität München, München, Germany.
Schön C; Department of Pharmacy, Ludwig-Maximilians-Universität München, München, Germany.
Chen CC; Department of Pharmacy, Ludwig-Maximilians-Universität München, München, Germany.; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yang Z; Department of Pharmacy, Ludwig-Maximilians-Universität München, München, Germany.
Liegl R; Department of Ophthalmology, University Hospital, LMU Munich, München, Germany.
Murenu E; Department of Pharmacy, Ludwig-Maximilians-Universität München, München, Germany.
Schworm B; Department of Ophthalmology, University Hospital, LMU Munich, München, Germany.
Klugbauer N; Institute for Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, Albert-Ludwigs-University, Freiburg, Germany.
Grimm C; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, München, Germany.
Wahl-Schott C; Institute for Neurophysiology, Hannover Medical School, Hannover, Germany.
Michalakis S; Department of Pharmacy, Ludwig-Maximilians-Universität München, München, Germany .; Department of Ophthalmology, University Hospital, LMU Munich, München, Germany.
Biel M; Department of Pharmacy, Ludwig-Maximilians-Universität München, München, Germany .
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Źródło :
Life science alliance [Life Sci Alliance] 2021 Jun 28; Vol. 4 (8). Date of Electronic Publication: 2021 Jun 28 (Print Publication: 2021).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice.
Autorzy :
Murenu E; Department of Ophthalmology, Ludwig-Maximilians-Universität München, Mathildenstraße 8, 80336 Munich, Germany.; Department of Pharmacy, Ludwig-Maximilians Universität München, Butenandtstr. 7, 81377 Munich, Germany.
Kostidis S; Leiden University Medical Center, Center for Proteomics & Metabolomics, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Lahiri S; Biomedical Center Munich-Molecular Biology, Ludwig-Maximilians-Universität München, Großhaderner Strasse 9, 82152 Planegg-Martinsried, Germany.
Geserich AS; Department of Pharmacy, Ludwig-Maximilians Universität München, Butenandtstr. 7, 81377 Munich, Germany.
Imhof A; Biomedical Center Munich-Molecular Biology, Ludwig-Maximilians-Universität München, Großhaderner Strasse 9, 82152 Planegg-Martinsried, Germany.
Giera M; Leiden University Medical Center, Center for Proteomics & Metabolomics, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Michalakis S; Department of Ophthalmology, Ludwig-Maximilians-Universität München, Mathildenstraße 8, 80336 Munich, Germany.; Department of Pharmacy, Ludwig-Maximilians Universität München, Butenandtstr. 7, 81377 Munich, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 26; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolome*
Lens, Crystalline/*metabolism
Retina/*metabolism
Retinal Degeneration/*metabolism
Vitreous Body/*metabolism
Animals ; Cyclic Nucleotide Phosphodiesterases, Type 6/genetics ; Disease Models, Animal ; Lens, Crystalline/pathology ; Mice ; Mutation ; Retina/pathology ; Retinal Degeneration/genetics ; Retinal Degeneration/pathology ; Vitreous Body/pathology
Czasopismo naukowe
Tytuł :
A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting.
Autorzy :
Murenu E; Department of Ophthalmology, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.; Department of Pharmacy, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
Pavlou M; Department of Ophthalmology, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.; Department of Pharmacy, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
Richter L; Core Facility Flow Cytometry, Biomedical Center, Ludwig-Maximilians-University Munich, 82152 Planegg-Martinsried, Germany.
Rapti K; Department of Infectious Diseases/Virology, Medical Faculty, University of Heidelberg, 69120 Heidelberg, Germany.; BioQuant Center, University of Heidelberg, 69120 Heidelberg, Germany.
Just S; Laboratory for Infection Biology and Gene Transfer, Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany.
Cehajic-Kapetanovic J; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, Oxford University and Oxford University Hospitals, Oxford OX3 9DU, UK.
Tafrishi N; Core Facility Flow Cytometry, Gene Center, BioSysM, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
Hayes A; Center for Biological Timing & School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Scholey R; Center for Biological Timing & School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Lucas R; Center for Biological Timing & School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Büning H; Laboratory for Infection Biology and Gene Transfer, Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany.; German Center for Infection Research (DZIF), partner site, Hannover, Germany.
Grimm D; Department of Infectious Diseases/Virology, Medical Faculty, University of Heidelberg, 69120 Heidelberg, Germany.; BioQuant Center, University of Heidelberg, 69120 Heidelberg, Germany.; German Center for Infection Research (DZIF) and German Center for Cardiovascular Research (DZHK), partner site, Heidelberg, Germany.
Michalakis S; Department of Ophthalmology, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.; Department of Pharmacy, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
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Źródło :
Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2021 Jan 26; Vol. 20, pp. 587-600. Date of Electronic Publication: 2021 Jan 26 (Print Publication: 2021).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3 -Deficient Mouse Model of Achromatopsia.
Autorzy :
Koch M; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.
Scheel C; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.
Ma H; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Yang F; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Stadlmeier M; Department of Chemistry, Ludwig-Maximilians-University, 81377 Munich, Germany.
Glück AF; Department of Chemistry, Ludwig-Maximilians-University, 81377 Munich, Germany.
Murenu E; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany.
Traube FR; Department of Chemistry, Ludwig-Maximilians-University, 81377 Munich, Germany.
Carell T; Department of Chemistry, Ludwig-Maximilians-University, 81377 Munich, Germany.
Biel M; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.
Ding XQ; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Michalakis S; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-University, 81377 Munich, Germany.; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 23; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
Color Vision Defects/*etiology
Color Vision Defects/*metabolism
Cyclic GMP-Dependent Protein Kinase Type II/*metabolism
Cyclic Nucleotide-Gated Cation Channels/*deficiency
Retinal Cone Photoreceptor Cells/*metabolism
Animals ; Biomarkers ; Color Vision Defects/pathology ; Cyclic GMP/metabolism ; Cyclic GMP-Dependent Protein Kinase Type II/genetics ; Disease Models, Animal ; Disease Susceptibility ; Endoplasmic Reticulum Stress ; Fluorescent Antibody Technique ; Gene Expression ; Mice ; Mice, Knockout ; Microscopy, Confocal ; Models, Biological ; Retinal Degeneration/etiology ; Retinal Degeneration/metabolism ; Retinal Degeneration/pathology ; Unfolded Protein Response
Czasopismo naukowe
Tytuł :
Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming.
Autorzy :
Gascón S; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany. Electronic address: .
Murenu E; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany.
Masserdotti G; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany.
Ortega F; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany; Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Complutense University, Avenue Puerta de Hierro, 28040 Madrid, Spain.
Russo GL; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany.
Petrik D; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany.
Deshpande A; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
Heinrich C; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
Karow M; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
Robertson SP; Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, 9016 Dunedin, New Zealand.
Schroeder T; Research Unit Stem Cell Dynamics, Helmholtz Center Munich, Neuherberg, 85764 Neuherberg, Germany.
Beckers J; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Center Munich GmbH, 85764 Neuherberg, Germany; Center of Life and Food Sciences Weihenstephan, Technical University Munich, 85354 Freising, Germany.
Irmler M; Institute of Experimental Genetics, Helmholtz Center Munich GmbH, 85764 Neuherberg, Germany.
Berndt C; Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Merowingerplatz 1a, 40225 Düsseldorf, Germany.
Angeli JP; Institute of Developmental Genetics, Helmholtz Center Munich, 85764 Neuherberg, Germany.
Conrad M; Institute of Developmental Genetics, Helmholtz Center Munich, 85764 Neuherberg, Germany.
Berninger B; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany; Focus Program Translational Neuroscience, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
Götz M; Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany; Excellence Cluster of Systems Neurology (SYNERGY), 80336 Munich, Germany. Electronic address: .
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Źródło :
Cell stem cell [Cell Stem Cell] 2016 Mar 03; Vol. 18 (3), pp. 396-409. Date of Electronic Publication: 2015 Dec 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming*
Cellular Reprogramming Techniques*
Transduction, Genetic*
Neuroglia/*metabolism
Neurons/*metabolism
Proto-Oncogene Proteins c-bcl-2/*biosynthesis
Animals ; Mice ; Neuroglia/cytology ; Neurons/cytology ; Oxidative Stress ; Proto-Oncogene Proteins c-bcl-2/genetics
Czasopismo naukowe
Tytuł :
MiR-124 and Small Molecules Synergistically Regulate the Generation of Neuronal Cells from Rat Cortical Reactive Astrocytes.
Autorzy :
Zheng Y; The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin, China.
Huang Z; China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130031, Jilin, China.
Xu J; The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin, China.
Hou K; The First Hospital of Jilin University, No. 1 Xinmin Avenue, Changchun, 130021, Jilin, China.
Yu Y; The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin, China.
Lv S; The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin, China.
Chen L; China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130031, Jilin, China.
Li Y; The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin, China. .
Quan C; The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin, China. .
Chi G; The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin, China. .
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2021 May; Vol. 58 (5), pp. 2447-2464. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: implications for autism spectrum disorders.
Autorzy :
Sgadò P; Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Italy.
Genovesi S
Kalinovsky A
Zunino G
Macchi F
Allegra M
Murenu E
Provenzano G
Tripathi PP
Casarosa S
Joyner AL
Bozzi Y
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Źródło :
Experimental neurology [Exp Neurol] 2013 Sep; Vol. 247, pp. 496-505. Date of Electronic Publication: 2013 Jan 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Autistic Disorder/*genetics
Autistic Disorder/*pathology
Cerebral Cortex/*cytology
GABAergic Neurons/*pathology
Hippocampus/*cytology
Nerve Tissue Proteins/*deficiency
Animals ; Disease Models, Animal ; Homeodomain Proteins ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neuropeptide Y/metabolism ; Parvalbumins/metabolism ; Somatostatin/metabolism
Czasopismo naukowe
Tytuł :
The positional identity of mouse ES cell-generated neurons is affected by BMP signaling.
Autorzy :
Bertacchi M; Scuola Normale Superiore di Pisa, Piazza dei Cavalieri 7, 56100, Pisa, Italy.
Pandolfini L
Murenu E
Viegi A
Capsoni S
Cellerino A
Messina A
Casarosa S
Cremisi F
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2013 Mar; Vol. 70 (6), pp. 1095-111. Date of Electronic Publication: 2012 Oct 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Morphogenetic Proteins/*metabolism
Cell Differentiation/*physiology
Embryonic Stem Cells/*cytology
Gene Expression Regulation, Developmental/*physiology
Neurons/*cytology
Signal Transduction/*physiology
Animals ; Brain/metabolism ; Carrier Proteins/metabolism ; Cells, Cultured ; Embryonic Stem Cells/metabolism ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Gene Expression Profiling ; Immunohistochemistry ; In Vitro Techniques ; Mice ; Microarray Analysis ; Neurons/metabolism ; Real-Time Polymerase Chain Reaction ; Tretinoin/metabolism
Czasopismo naukowe
Tytuł :
Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke.
Autorzy :
Jiang, Michael Qize
Yu, Shan Ping
Wei, Zheng Zachory
Zhong, Weiwei
Cao, Wenyuan
Gu, Xiaohuan
Wu, Anika
McCrary, Myles Randolph
Berglund, Ken
Wei, Ling
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Temat :
ISCHEMIC stroke
ASTROCYTES
NEURONS
GLUTAMATE transporters
GENETIC vectors
EVOKED potentials (Electrophysiology)
Źródło :
Frontiers in Aging Neuroscience; 3/26/2021, Vol. 13, pN.PAG-N.PAG, 20p
Czasopismo naukowe
Tytuł :
In vivo MRI evaluation of early postnatal development in normal and impaired rat eyes.
Autorzy :
Au JM; Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, USA.
Kancherla S; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Hamade M; Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, USA.
Mendoza M; Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, USA.; Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY, USA.
Chan KC; Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, USA. .; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA. .; Department of Radiology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, USA. .; Neuroscience Institute, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, USA. .; Center for Neural Science, College of Arts and Science, New York University, New York, NY, USA. .; Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY, USA. .; Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jul 30; Vol. 11 (1), pp. 15513. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Reprogramming Glial Cells into Functional Neurons for Neuro-regeneration: Challenges and Promise.
Autorzy :
Wang F; State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Cheng L; Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi-ASEAN Collaborative Innovation Center for Major Disease Prevention and Treatment, and Guangxi Key Laboratory of Regenerative Medicine, Center for Translational Medicine, Guangxi Medical University, Nanning, 530021, China. .; Department of Cell Biology and Genetics, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, China. .; Guangxi Health Commission Key Laboratory of Basic Research on Brain Function and Disease, Guangxi Medical University, Nanning, 530021, China. .
Zhang X; State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. .
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Źródło :
Neuroscience bulletin [Neurosci Bull] 2021 Jul 20. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe

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