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Wyszukujesz frazę ""Muscarinic M2"" wg kryterium: Temat


Tytuł :
Dibenzodiazepinone-type muscarinic receptor antagonists conjugated to basic peptides: Impact of the linker moiety and unnatural amino acids on M 2 R selectivity.
Autorzy :
Weinhart CG; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Wifling D; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Schmidt MF; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich Alexander University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, D-91058, Erlangen, Germany; Department of Chemistry and Pharmacy, Computer-Chemistry-Center, Friedrich Alexander University Erlangen-Nürnberg, Nägelsbachstrasse 25, D-91052, Erlangen, Germany.
Neu E; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich Alexander University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, D-91058, Erlangen, Germany; Department of Chemistry and Pharmacy, Computer-Chemistry-Center, Friedrich Alexander University Erlangen-Nürnberg, Nägelsbachstrasse 25, D-91052, Erlangen, Germany.
Höring C; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Clark T; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich Alexander University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, D-91058, Erlangen, Germany; Department of Chemistry and Pharmacy, Computer-Chemistry-Center, Friedrich Alexander University Erlangen-Nürnberg, Nägelsbachstrasse 25, D-91052, Erlangen, Germany.
Gmeiner P; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich Alexander University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, D-91058, Erlangen, Germany.
Keller M; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 05; Vol. 213, pp. 113159. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acids/*antagonists & inhibitors
Benzodiazepinones/*pharmacology
Muscarinic Antagonists/*pharmacology
Peptides/*pharmacology
Receptor, Muscarinic M2/*antagonists & inhibitors
Amino Acids/metabolism ; Animals ; Benzodiazepinones/chemical synthesis ; Benzodiazepinones/chemistry ; Cells, Cultured ; Dose-Response Relationship, Drug ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Muscarinic Antagonists/chemical synthesis ; Muscarinic Antagonists/chemistry ; Peptides/chemistry ; Receptor, Muscarinic M2/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The optimization of a novel selective antagonist for human M 2 muscarinic acetylcholine receptor.
Autorzy :
Li M; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Huang C; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pu Jian Road, Shanghai 200127, China; College of Medical Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
Wu X; College of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
Ding F; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pu Jian Road, Shanghai 200127, China.
Hu Z; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pu Jian Road, Shanghai 200127, China.
Zhu Y; School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Zhao L; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Hou L; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Chen H; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Institute of Interdisciplinary Integrative Biomedical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Wang H; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Xu J; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: .
Tang D; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pu Jian Road, Shanghai 200127, China. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Dec 15; Vol. 30 (24), pp. 127632. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Muscarinic Antagonists/*chemistry
Muscarinic Antagonists/*pharmacology
Receptor, Muscarinic M2/*antagonists & inhibitors
Small Molecule Libraries/*chemistry
Small Molecule Libraries/*pharmacology
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Humans ; Molecular Docking Simulation ; Receptor, Muscarinic M2/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes.
Autorzy :
Pakharukova N; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Masoudi A; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Pani B; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Staus DP; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Lefkowitz RJ; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA; Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 04; Vol. 295 (49), pp. 16773-16784. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptor, Muscarinic M2/*metabolism
Receptors, Adrenergic, beta-2/*metabolism
Receptors, Vasopressin/*metabolism
beta-Arrestin 1/*metabolism
src-Family Kinases/*metabolism
Allosteric Regulation ; Enzyme Activation ; Humans ; Kinetics ; Mutagenesis, Site-Directed ; Nanostructures/chemistry ; Peptides/chemical synthesis ; Peptides/chemistry ; Phosphorylation ; Protein Binding ; Receptor, Muscarinic M2/chemistry ; Receptors, Adrenergic, beta-2/chemistry ; Receptors, Vasopressin/chemistry ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Substrate Specificity ; beta-Arrestin 1/chemistry ; beta-Arrestin 1/genetics ; src Homology Domains ; src-Family Kinases/chemistry
Czasopismo naukowe
Tytuł :
The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells.
Autorzy :
Lucianò AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Perciballi E; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Fiore M; Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Del Bufalo D; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Research Centre of Neurobiology Daniel Bovet, 00185 Rome, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 10; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Arecoline/*analogs & derivatives
Neuroblastoma/*drug therapy
Receptor, Muscarinic M2/*agonists
ATP-Binding Cassette Transporters/genetics ; Arecoline/administration & dosage ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/administration & dosage ; Doxorubicin/administration & dosage ; Drug Resistance, Neoplasm ; Gene Expression/drug effects ; Humans ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Receptor, Muscarinic M2/genetics
Czasopismo naukowe
Tytuł :
The metronomic combination of paclitaxel with cholinergic agonists inhibits triple negative breast tumor progression. Participation of M2 receptor subtype.
Autorzy :
Español AJ; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.
Salem A; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.
Di Bari M; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.
Cristofaro I; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.
Sanchez Y; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.; Center of Neurobiology Daniel Bovet, Sapienza University of Rome, Rome, Italy.
Sales ME; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.
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Źródło :
PloS one [PLoS One] 2020 Sep 10; Vol. 15 (9), pp. e0226450. Date of Electronic Publication: 2020 Sep 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Cholinergic Agonists/*administration & dosage
Paclitaxel/*administration & dosage
Receptor, Muscarinic M2/*metabolism
Triple Negative Breast Neoplasms/*drug therapy
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Administration, Metronomic ; Animals ; Arecoline/administration & dosage ; Arecoline/analogs & derivatives ; Carbachol/administration & dosage ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Down-Regulation/drug effects ; ErbB Receptors/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mice ; Neoplasm Proteins/metabolism ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology ; RNA, Small Interfering/metabolism ; Receptor, Muscarinic M2/agonists ; Receptor, Muscarinic M2/genetics ; Triple Negative Breast Neoplasms/blood supply ; Triple Negative Breast Neoplasms/pathology ; Vascular Endothelial Growth Factor A/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Voltage-induced structural modifications on M2 muscarinic receptor and their functional implications when interacting with the superagonist iperoxo.
Autorzy :
López-Serrano AL; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
De Jesús-Pérez JJ; Instituto de Física, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, Mexico; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
Zamora-Cárdenas R; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
Ferrer T; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
Rodríguez-Menchaca AA; Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, Mexico.
Tristani-Firouzi M; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA; Division of Pediatric Cardiology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Moreno-Galindo EG; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico. Electronic address: .
Navarro-Polanco RA; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Jul; Vol. 177, pp. 113961. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
Ion Channel Gating/*drug effects
Isoxazoles/*pharmacology
Quaternary Ammonium Compounds/*pharmacology
Receptor, Muscarinic M2/*physiology
Acetylcholine/pharmacology ; Animals ; Cats ; Cells, Cultured ; Electric Stimulation ; Female ; Ion Channel Gating/physiology ; Male ; Membrane Potentials/drug effects ; Models, Molecular ; Muscarinic Agonists/pharmacology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/physiology ; Oocytes/drug effects ; Oocytes/physiology ; Patch-Clamp Techniques ; Protein Conformation ; Receptor, Muscarinic M2/chemistry ; Receptor, Muscarinic M2/metabolism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Prevalence of Cardiac Arrhythmias and Distal Conduction Disorders in Patients With Chronic Chagas' Disease and Elevated Autoantibodies Against M2 Muscarinic Acetylcholine Receptors.
Autorzy :
Carbajales J; Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina. Electronic address: .
Krishnan D; Department of Medicine, Queen's University, Kingston Health Sciences Center, Kingston, Ontario, Canada.
Principato M; Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina.
Tomatti A; Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina.
Paolucci A; Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina.
Yoo HS; Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina.
von Wulffen A; Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina.
Ciampi N; Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina.
Tepper R; Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina.
Carradori J; Cardiovascular Genomic Section, Division of Cardiology, Acute General Hospital, Buenos Aires, Argentina.
Baranchuk A; Department of Medicine, Queen's University, Kingston Health Sciences Center, Kingston, Ontario, Canada. Electronic address: .
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Źródło :
Current problems in cardiology [Curr Probl Cardiol] 2021 Jun; Vol. 46 (6), pp. 100820. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Arrhythmias, Cardiac/*epidemiology
Autoantibodies/*immunology
Cardiac Conduction System Disease/*epidemiology
Chagas Disease/*epidemiology
Receptor, Muscarinic M2/*immunology
Aged ; Argentina/epidemiology ; Arrhythmias, Cardiac/blood ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/immunology ; Autoantibodies/blood ; Bolivia/epidemiology ; Cardiac Conduction System Disease/blood ; Cardiac Conduction System Disease/etiology ; Cardiac Conduction System Disease/immunology ; Chagas Disease/blood ; Chagas Disease/complications ; Chagas Disease/immunology ; Chronic Disease ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prevalence
Czasopismo naukowe
Tytuł :
Sodium ions allosterically modulate the M2 muscarinic receptor.
Autorzy :
Friedman S; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel.
Tauber M; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel.
Ben-Chaim Y; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 07; Vol. 10 (1), pp. 11177. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Allosteric Site*
Receptor, Muscarinic M2/*metabolism
Sodium/*metabolism
Acetylcholine/metabolism ; Allosteric Regulation ; Animals ; Receptor, Muscarinic M2/chemistry ; Xenopus
Czasopismo naukowe
Tytuł :
Novel analgesic agents obtained by molecular hybridization of orthosteric and allosteric ligands.
Autorzy :
Matera C; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133, Milano, Italy. Electronic address: .
Flammini L; Dipartimento di Farmacia, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
Riefolo F; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133, Milano, Italy.
Domenichini G; Dipartimento di Farmacia, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
De Amici M; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133, Milano, Italy.
Barocelli E; Dipartimento di Farmacia, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
Dallanoce C; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133, Milano, Italy.
Bertoni S; Dipartimento di Farmacia, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Jun 05; Vol. 876, pp. 173061. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics/*pharmacology
Drug Discovery/*methods
Heart Atria/*drug effects
Receptor, Muscarinic M2/*agonists
Allosteric Regulation ; Allosteric Site ; Analgesics/adverse effects ; Analgesics/chemistry ; Animals ; Atrial Function, Left ; Behavior, Animal/drug effects ; Dose-Response Relationship, Drug ; Guinea Pigs ; Heart Atria/metabolism ; In Vitro Techniques ; Ligands ; Male ; Mice ; Motor Activity/drug effects ; Pain/drug therapy ; Receptor, Muscarinic M2/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway.
Autorzy :
Luo L; School of Pharmacy, Nantong University, PR China.. Electronic address: .
Zhang G; School of Pharmacy, Nantong University, PR China.
Mao L; School of Pharmacy, Nantong University, PR China.
Wang P; Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China.
Xi C; School of Pharmacy, Nantong University, PR China.
Shi G; School of Pharmacy, Nantong University, PR China.
Leavenworth JW; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 May 15; Vol. 395, pp. 114978. Date of Electronic Publication: 2020 Mar 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidant Response Elements/*physiology
Liver Diseases/*physiopathology
NF-E2-Related Factor 2/*physiology
Receptor, Muscarinic M2/*physiology
Receptor, Muscarinic M4/*physiology
Receptors, Muscarinic/*physiology
Signal Transduction/*physiology
Animals ; Carbon Tetrachloride/pharmacology ; Cell Line ; Chemical and Drug Induced Liver Injury/physiopathology ; Gene Expression/drug effects ; Gene Knockdown Techniques ; Hepatocytes ; Liver Diseases/prevention & control ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NF-E2-Related Factor 2/deficiency ; NF-E2-Related Factor 2/genetics ; RNA, Small Interfering/pharmacology ; Receptor, Muscarinic M2/genetics ; Receptor, Muscarinic M4/genetics ; Receptors, Muscarinic/genetics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
The Firing of Theta State-Related Septal Cholinergic Neurons Disrupt Hippocampal Ripple Oscillations via Muscarinic Receptors.
Autorzy :
Ma X; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Life Science, East China Normal University, Shanghai, 200062, China.
Zhang Y; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Life Science, East China Normal University, Shanghai, 200062, China.
Wang L; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Life Science, East China Normal University, Shanghai, 200062, China.
Li N; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Life Science, East China Normal University, Shanghai, 200062, China.
Barkai E; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, 3498838 Israel.
Zhang X; State Key Laboratory of Cognitive Neuroscience & Learning, Beijing Normal University, Beijing, 100875, China.
Lin L; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Life Science, East China Normal University, Shanghai, 200062, China .; NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai, 200062, China.; Tongji University Brain and Spinal Cord Clinical Center, Shanghai, 200062, China.
Xu J; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Life Science, East China Normal University, Shanghai, 200062, China .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Apr 29; Vol. 40 (18), pp. 3591-3603. Date of Electronic Publication: 2020 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Action Potentials/*physiology
Cholinergic Neurons/*physiology
Hippocampus/*physiology
Receptor, Muscarinic M2/*physiology
Receptor, Muscarinic M4/*physiology
Theta Rhythm/*physiology
Action Potentials/drug effects ; Animals ; Cholinergic Agonists/pharmacology ; Cholinergic Neurons/chemistry ; Cholinergic Neurons/drug effects ; Hippocampus/chemistry ; Hippocampus/drug effects ; Male ; Mice ; Mice, Transgenic ; Muscarinic Antagonists/pharmacology ; Optogenetics/methods ; Organ Culture Techniques ; Receptor, Muscarinic M2/agonists ; Receptor, Muscarinic M2/antagonists & inhibitors ; Receptor, Muscarinic M4/agonists ; Receptor, Muscarinic M4/antagonists & inhibitors ; Receptors, Muscarinic/physiology ; Theta Rhythm/drug effects
Czasopismo naukowe
Tytuł :
Impairment of agonist-induced M 2 muscarinic receptor activation by autoantibodies from chagasic patients with cardiovascular dysautonomia.
Autorzy :
Beltrame SP; Laboratorio de Farmacología Molecular, Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET-UBA) and II Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 16, C1121ABG Buenos Aires, Argentina. Electronic address: .
Carrera Páez LC; Laboratorio de Farmacología Molecular, Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET-UBA) and II Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 16, C1121ABG Buenos Aires, Argentina. Electronic address: .
Auger SR; Hospital D.F. Santojanni, Pilar 950, PB, C1408INH Buenos Aires, Argentina. Electronic address: .
Sabra AH; Hospital D.F. Santojanni, Pilar 950, PB, C1408INH Buenos Aires, Argentina. Electronic address: .
Bilder CR; Laboratorio de Neurogastroenterología, Fundación Favaloro-Hospital Universitario, Av. Belgrano 1746, 1er Piso, C1093AAS Buenos Aires, Argentina. Electronic address: .
Waldner CI; Laboratorio de Inmunidad Celular y Molecular, Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET-UBA), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 16, C1121ABG Buenos Aires, Argentina. Electronic address: .
Goin JC; Laboratorio de Farmacología Molecular, Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET-UBA) and II Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 16, C1121ABG Buenos Aires, Argentina. Electronic address: .
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Mar; Vol. 212, pp. 108346. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoantibodies/*immunology
Autonomic Nervous System Diseases/*immunology
Chagas Disease/*immunology
Receptor, Muscarinic M2/*immunology
Adult ; Aged ; Allosteric Regulation ; Autoantibodies/metabolism ; Autoantibodies/pharmacology ; Autonomic Nervous System Diseases/etiology ; Autonomic Nervous System Diseases/metabolism ; Autonomic Nervous System Diseases/physiopathology ; Carbachol/pharmacology ; Chagas Disease/complications ; Chagas Disease/metabolism ; Chagas Disease/physiopathology ; Cholinergic Agonists/pharmacology ; Female ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; HEK293 Cells ; Heart Rate ; Humans ; Male ; Middle Aged ; Receptor, Muscarinic M2/drug effects ; Receptor, Muscarinic M2/metabolism ; beta-Arrestin 1/metabolism
Czasopismo naukowe
Tytuł :
Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival.
Autorzy :
Cristofaro I; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Alessandrini F; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Spinello Z; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Guerriero C; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Fiore M; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Caffarelli E; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Laneve P; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Dini L; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Conti L; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.; Research center of Neurobiology, Sapienza, University of Rome, 00185 Rome, Italy.
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Źródło :
Cells [Cells] 2020 Mar 09; Vol. 9 (3). Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*/drug effects
Cell Cycle/*physiology
Cell Proliferation/*physiology
Glioblastoma/*pathology
Receptor, Muscarinic M2/*metabolism
Receptor, Notch1/*metabolism
Brain Neoplasms/genetics ; Cell Division/physiology ; Cell Line, Tumor ; ErbB Receptors/metabolism ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Humans ; Neoplastic Stem Cells/pathology ; Receptor, Muscarinic M2/genetics
Czasopismo naukowe
Tytuł :
M2 Receptor Activation Counteracts the Glioblastoma Cancer Stem Cell Response to Hypoxia Condition.
Autorzy :
Cristofaro I; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Limongi C; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Piscopo P; Depatment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.
Crestini A; Depatment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.
Guerriero C; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Fiore M; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Conti L; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy.
Confaloni A; Depatment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.; Research center of Neuroscience, Sapienza, University of Rome, 00185 Rome, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 02; Vol. 21 (5). Date of Electronic Publication: 2020 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Neoplasms/*metabolism
Glioblastoma/*metabolism
Neoplastic Stem Cells/*metabolism
Oxygen/*metabolism
Receptor, Muscarinic M2/*metabolism
Brain Neoplasms/genetics ; Cell Hypoxia ; Glioblastoma/genetics ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Receptor, Muscarinic M2/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Further characterization of the synergistic activation mechanism of cationic channels by M 2 and M 3 muscarinic receptors in mouse intestinal smooth muscle cells.
Autorzy :
Tanahashi Y; Department of Animal Medical Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan.
Katsurada T; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Inasaki N; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Uchiyama M; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Sakamoto T; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Yamamoto M; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Matsuyama H; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Komori S; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Unno T; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Mar 01; Vol. 318 (3), pp. C514-C523. Date of Electronic Publication: 2019 Dec 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
GTP-Binding Protein alpha Subunits, Gi-Go/*metabolism
Intestinal Mucosa/*metabolism
Myocytes, Smooth Muscle/*metabolism
Receptor, Muscarinic M2/*metabolism
Receptor, Muscarinic M3/*metabolism
Animals ; Cholinergic Agonists/pharmacology ; Dose-Response Relationship, Drug ; Female ; GTP-Binding Protein alpha Subunits, Gi-Go/agonists ; Guinea Pigs ; Intestinal Mucosa/cytology ; Intestinal Mucosa/drug effects ; Male ; Mice ; Mice, 129 Strain ; Mice, Knockout ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/drug effects ; Peptides, Cyclic/pharmacology ; Receptor, Muscarinic M2/agonists ; Receptor, Muscarinic M3/agonists
Czasopismo naukowe
Tytuł :
Endocytic sorting and downregulation of the M2 acetylcholine receptor is regulated by ubiquitin and the ESCRT complex.
Autorzy :
Zenko D; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, AB25 2ZD, UK.
Thompson D; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, AB25 2ZD, UK.
Hislop JN; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, AB25 2ZD, UK. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Jan 01; Vol. 162, pp. 107828. Date of Electronic Publication: 2019 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endosomal Sorting Complexes Required for Transport/*metabolism
Lysosomes/*metabolism
Neurons/*metabolism
Receptor, Muscarinic M2/*metabolism
Ubiquitin/*metabolism
Animals ; Carbachol/pharmacology ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Chloroquine/pharmacology ; Cholinergic Agonists/pharmacology ; Down-Regulation ; Endosomal Sorting Complexes Required for Transport/drug effects ; Endosomes/drug effects ; Endosomes/metabolism ; Endosomes/ultrastructure ; Ganglia, Spinal/cytology ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Lysosomes/drug effects ; Lysosomes/ultrastructure ; Microscopy, Confocal ; Neurons/drug effects ; Neurons/ultrastructure ; Protein Transport/drug effects ; Proteolysis ; Rats ; Receptor, Muscarinic M2/drug effects ; Receptor, Muscarinic M2/genetics ; Transfection ; Ubiquitin/drug effects ; Ubiquitination
Czasopismo naukowe
Tytuł :
BRET- and fluorescence anisotropy-based assays for real-time monitoring of ligand binding to M 2 muscarinic acetylcholine receptors.
Autorzy :
Grätz L; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany. Electronic address: .
Laasfeld T; University of Tartu, Institute of Chemistry, Ravila 14a, 50411 Tartu, Estonia.
Allikalt A; University of Tartu, Institute of Chemistry, Ravila 14a, 50411 Tartu, Estonia.
Gruber CG; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.
Pegoli A; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.
Tahk MJ; University of Tartu, Institute of Chemistry, Ravila 14a, 50411 Tartu, Estonia.
Tsernant ML; University of Tartu, Institute of Chemistry, Ravila 14a, 50411 Tartu, Estonia.
Keller M; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.
Rinken A; University of Tartu, Institute of Chemistry, Ravila 14a, 50411 Tartu, Estonia. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Mar; Vol. 1868 (3), pp. 118930. Date of Electronic Publication: 2020 Dec 19.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescent Dyes/*chemistry
Receptor, Muscarinic M2/*metabolism
Rhodamines/*chemistry
Animals ; Bioluminescence Resonance Energy Transfer Techniques ; CHO Cells ; Cricetulus ; Fluorescence Polarization ; HEK293 Cells ; Humans ; Ligands ; Sf9 Cells
Czasopismo naukowe
Tytuł :
Muscarinic M1 and M2 receptor subtypes play opposite roles in LPS-induced septic shock.
Autorzy :
Wang Z; Department of Emergency Medicine, the 9th Clinical Medical College of Peking University, Beijing Shijitan Hospital, Capital Medical University, Beijng, China. Electronic address: .
Li M; Department of Emergency Medicine, the 9th Clinical Medical College of Peking University, Beijing Shijitan Hospital, Capital Medical University, Beijng, China.
Liu L; Department of Emergency Medicine, the 9th Clinical Medical College of Peking University, Beijing Shijitan Hospital, Capital Medical University, Beijng, China.
Geng B; Fuwai Hospital, Chinese Academy of Medical Science, Beijng, China.
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Źródło :
Pharmacological reports : PR [Pharmacol Rep] 2019 Dec; Vol. 71 (6), pp. 1108-1114. Date of Electronic Publication: 2019 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Atropine/*pharmacology
Pirenzepine/*analogs & derivatives
Pirenzepine/*pharmacology
Receptor, Muscarinic M1/*physiology
Receptor, Muscarinic M2/*physiology
Shock, Septic/*drug therapy
Shock, Septic/*physiopathology
Animals ; Cytokines/metabolism ; Lipopolysaccharides ; Liver/pathology ; Lung/pathology ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neutrophil Infiltration/drug effects ; Receptor, Muscarinic M1/antagonists & inhibitors ; Receptor, Muscarinic M2/antagonists & inhibitors ; Shock, Septic/chemically induced ; Shock, Septic/mortality ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors.
Autorzy :
Nascimento F; School of Psychology and Neuroscience, University of St. Andrews, St. Andrews, KY16 9JP, United Kingdom.
Spindler LRB; School of Psychology and Neuroscience, University of St. Andrews, St. Andrews, KY16 9JP, United Kingdom.
Miles GB; School of Psychology and Neuroscience, University of St. Andrews, St. Andrews, KY16 9JP, United Kingdom. .
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Źródło :
Scientific reports [Sci Rep] 2019 Oct 01; Vol. 9 (1), pp. 14051. Date of Electronic Publication: 2019 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcholine/*metabolism
Locomotion/*physiology
Motor Neurons/*metabolism
Receptor, Muscarinic M2/*metabolism
Receptor, Muscarinic M3/*metabolism
Spinal Cord/*metabolism
Acetylcholine/physiology ; Action Potentials/drug effects ; Animals ; Animals, Newborn ; Diamines/pharmacology ; In Vitro Techniques ; Mice ; Mice, Inbred C57BL ; Motor Neurons/physiology ; Muscarine/pharmacology ; Piperidines/pharmacology ; Receptor, Muscarinic M2/antagonists & inhibitors ; Receptor, Muscarinic M2/physiology ; Receptor, Muscarinic M3/antagonists & inhibitors ; Receptor, Muscarinic M3/physiology ; Spinal Cord/physiology
Czasopismo naukowe
Tytuł :
The coupling of the M2 muscarinic receptor to its G protein is voltage dependent.
Autorzy :
Ben-Chaim Y; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel.
Broide C; Department of Neurobiology, Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
Parnas H; Department of Neurobiology, Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
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Źródło :
PloS one [PLoS One] 2019 Oct 31; Vol. 14 (10), pp. e0224367. Date of Electronic Publication: 2019 Oct 31 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
G Protein-Coupled Inwardly-Rectifying Potassium Channels/*metabolism
Receptor, Muscarinic M2/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Acetylcholine/pharmacology ; Animals ; Binding Sites ; GTP-Binding Proteins/metabolism ; Ion Channel Gating/drug effects ; Membrane Potentials/drug effects ; Muscarinic Agonists/pharmacology ; Oocytes ; Patch-Clamp Techniques ; Receptor, Muscarinic M2/physiology ; Receptors, G-Protein-Coupled/physiology ; Signal Transduction/drug effects ; Xenopus Proteins ; Xenopus laevis
Czasopismo naukowe

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