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Tytuł:
β-Adrenergic Receptor Antagonism of Cholinergic Stimulation of Airway Smooth Muscle Contraction: An Old Receptor Requires a Fresh Look.
Autorzy:
Leblanc N; Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
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Źródło:
Function (Oxford, England) [Function (Oxf)] 2023 Feb 03; Vol. 4 (2), pp. zqad006. Date of Electronic Publication: 2023 Feb 03 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms:
Adrenergic beta-Antagonists*
Receptor, Muscarinic M2*
Receptors, Muscarinic ; Receptors, Adrenergic, beta ; Cholinergic Agents
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases.
Autorzy:
Lenina OA; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, Kazan, Russia, 420088.
Petrov KA; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, Kazan, Russia, 420088. .; Kazan Federal University, 18 Kremlyovskaya str, Kazan, Russia, 420008. .
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 01; Vol. 12 (1), pp. 1688. Date of Electronic Publication: 2022 Feb 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antidotes/*administration & dosage
Atropine/*administration & dosage
Cholinesterase Inhibitors/*adverse effects
Diamines/*administration & dosage
Muscarinic Antagonists/*administration & dosage
Muscle Weakness/*chemically induced
Muscle Weakness/*prevention & control
Paraoxon/*adverse effects
Parasympatholytics/*administration & dosage
Protective Agents/*administration & dosage
Receptor, Muscarinic M1/*metabolism
Receptor, Muscarinic M2/*metabolism
Synaptic Transmission/*drug effects
Animals ; Cholinesterase Inhibitors/administration & dosage ; Cholinesterases/metabolism ; Diaphragm/drug effects ; Disease Models, Animal ; Mice ; Muscle Contraction/drug effects ; Muscle Weakness/metabolism ; Paraoxon/administration & dosage ; Pirenzepine/administration & dosage ; Receptor, Muscarinic M1/antagonists & inhibitors ; Receptor, Muscarinic M2/antagonists & inhibitors ; Signal Transduction/drug effects ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Long-Term-But Not Short-Term-Plasticity at the Mossy Fiber-CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice.
Autorzy:
Zheng F; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Wess J; Molecular Signaling Section, Laboratory of Biological Chemistry, NIDDK, NIH, Bethesda, MD 20892, USA.
Alzheimer C; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
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Źródło:
Cells [Cells] 2023 Jul 19; Vol. 12 (14). Date of Electronic Publication: 2023 Jul 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
MeSH Terms:
Acetylcholine*
Mossy Fibers, Hippocampal*/physiology
Mice ; Animals ; Receptor, Muscarinic M1 ; Mice, Knockout ; Hippocampus ; Pyramidal Cells/physiology ; Receptor, Muscarinic M2/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Allostery of atypical modulators at oligomeric G protein-coupled receptors.
Autorzy:
Shivnaraine RV; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada. .; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, B163 Beckman Center, 279 Campus Drive, Stanford, CA, 94305, USA. .
Kelly B; Departments of Computer Science, Molecular and Cellular Physiology, and Structural Biology, and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, 94305, USA.
Elmslie G; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.
Huang XP; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.; Department of Pharmacology, The National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Dong YJ; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada.
Seidenberg M; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.
Wells JW; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada. .
Ellis J; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA. .; Department of Psychiatry H073, Penn State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Apr 29; Vol. 11 (1), pp. 9265. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptor, Muscarinic M2/*metabolism
Tacrine/*pharmacology
Allosteric Regulation ; Allosteric Site ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Ligands ; Molecular Dynamics Simulation ; Receptor, Muscarinic M2/chemistry ; Receptor, Muscarinic M2/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The metronomic combination of paclitaxel with cholinergic agonists inhibits triple negative breast tumor progression. Participation of M2 receptor subtype.
Autorzy:
Español AJ; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.
Salem A; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.
Di Bari M; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.
Cristofaro I; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.
Sanchez Y; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.; Center of Neurobiology Daniel Bovet, Sapienza University of Rome, Rome, Italy.
Sales ME; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.
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Źródło:
PloS one [PLoS One] 2020 Sep 10; Vol. 15 (9), pp. e0226450. Date of Electronic Publication: 2020 Sep 10 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Cholinergic Agonists/*administration & dosage
Paclitaxel/*administration & dosage
Receptor, Muscarinic M2/*metabolism
Triple Negative Breast Neoplasms/*drug therapy
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Administration, Metronomic ; Animals ; Arecoline/administration & dosage ; Arecoline/analogs & derivatives ; Carbachol/administration & dosage ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Down-Regulation/drug effects ; ErbB Receptors/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mice ; Neoplasm Proteins/metabolism ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology ; RNA, Small Interfering/metabolism ; Receptor, Muscarinic M2/agonists ; Receptor, Muscarinic M2/genetics ; Triple Negative Breast Neoplasms/blood supply ; Triple Negative Breast Neoplasms/pathology ; Vascular Endothelial Growth Factor A/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells.
Autorzy:
Lucianò AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Perciballi E; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Fiore M; Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Del Bufalo D; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Research Centre of Neurobiology Daniel Bovet, 00185 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 10; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Arecoline/*analogs & derivatives
Neuroblastoma/*drug therapy
Receptor, Muscarinic M2/*agonists
ATP-Binding Cassette Transporters/genetics ; Arecoline/administration & dosage ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/administration & dosage ; Doxorubicin/administration & dosage ; Drug Resistance, Neoplasm ; Gene Expression/drug effects ; Humans ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Receptor, Muscarinic M2/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sodium ions allosterically modulate the M2 muscarinic receptor.
Autorzy:
Friedman S; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel.
Tauber M; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel.
Ben-Chaim Y; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 07; Vol. 10 (1), pp. 11177. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Allosteric Site*
Receptor, Muscarinic M2/*metabolism
Sodium/*metabolism
Acetylcholine/metabolism ; Allosteric Regulation ; Animals ; Receptor, Muscarinic M2/chemistry ; Xenopus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Associations of common genetic risk variants of the muscarinic acetylcholine receptor M2 with cardiac autonomic dysfunction in patients with schizophrenia.
Autorzy:
Refisch A; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Komatsuzaki S; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Ungelenk M; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Chung HY; Department of Neurology, Section Translational Neuroimmunology, Jena University Hospital, Jena, Germany.
Schumann A; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Schilling SS; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Jantzen W; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Schröder S; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Mühleisen TW; Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany.; Medical Faculty, Cécile and Oskar Vogt Institute of Brain Research, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Biomedicine, Human Genomics Research Group, University of Basel, Basel, Switzerland.
Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Hübner CA; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Bär KJ; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
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Źródło:
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2023 Jan; Vol. 24 (1), pp. 1-11. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Schizophrenia*/drug therapy
Schizophrenia*/genetics
Antipsychotic Agents*/adverse effects
Humans ; Genome-Wide Association Study ; Receptor, Muscarinic M2/genetics ; Polymorphism, Single Nucleotide ; Heart Rate/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors.
Autorzy:
Nascimento F; School of Psychology and Neuroscience, University of St. Andrews, St. Andrews, KY16 9JP, United Kingdom.
Spindler LRB; School of Psychology and Neuroscience, University of St. Andrews, St. Andrews, KY16 9JP, United Kingdom.
Miles GB; School of Psychology and Neuroscience, University of St. Andrews, St. Andrews, KY16 9JP, United Kingdom. .
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Źródło:
Scientific reports [Sci Rep] 2019 Oct 01; Vol. 9 (1), pp. 14051. Date of Electronic Publication: 2019 Oct 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylcholine/*metabolism
Locomotion/*physiology
Motor Neurons/*metabolism
Receptor, Muscarinic M2/*metabolism
Receptor, Muscarinic M3/*metabolism
Spinal Cord/*metabolism
Acetylcholine/physiology ; Action Potentials/drug effects ; Animals ; Animals, Newborn ; Diamines/pharmacology ; In Vitro Techniques ; Mice ; Mice, Inbred C57BL ; Motor Neurons/physiology ; Muscarine/pharmacology ; Piperidines/pharmacology ; Receptor, Muscarinic M2/antagonists & inhibitors ; Receptor, Muscarinic M2/physiology ; Receptor, Muscarinic M3/antagonists & inhibitors ; Receptor, Muscarinic M3/physiology ; Spinal Cord/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival.
Autorzy:
Cristofaro I; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Alessandrini F; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Spinello Z; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Guerriero C; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Fiore M; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Caffarelli E; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Laneve P; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Dini L; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Conti L; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.; Research center of Neurobiology, Sapienza, University of Rome, 00185 Rome, Italy.
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Źródło:
Cells [Cells] 2020 Mar 09; Vol. 9 (3). Date of Electronic Publication: 2020 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*/drug effects
Cell Cycle/*physiology
Cell Proliferation/*physiology
Glioblastoma/*pathology
Receptor, Muscarinic M2/*metabolism
Receptor, Notch1/*metabolism
Brain Neoplasms/genetics ; Cell Division/physiology ; Cell Line, Tumor ; ErbB Receptors/metabolism ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Humans ; Neoplastic Stem Cells/pathology ; Receptor, Muscarinic M2/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
M2 Receptor Activation Counteracts the Glioblastoma Cancer Stem Cell Response to Hypoxia Condition.
Autorzy:
Cristofaro I; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Limongi C; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Piscopo P; Depatment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.
Crestini A; Depatment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.
Guerriero C; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Fiore M; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Conti L; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy.
Confaloni A; Depatment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.; Research center of Neuroscience, Sapienza, University of Rome, 00185 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 02; Vol. 21 (5). Date of Electronic Publication: 2020 Mar 02.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms/*metabolism
Glioblastoma/*metabolism
Neoplastic Stem Cells/*metabolism
Oxygen/*metabolism
Receptor, Muscarinic M2/*metabolism
Brain Neoplasms/genetics ; Cell Hypoxia ; Glioblastoma/genetics ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Receptor, Muscarinic M2/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The coupling of the M2 muscarinic receptor to its G protein is voltage dependent.
Autorzy:
Ben-Chaim Y; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel.
Broide C; Department of Neurobiology, Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
Parnas H; Department of Neurobiology, Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
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Źródło:
PloS one [PLoS One] 2019 Oct 31; Vol. 14 (10), pp. e0224367. Date of Electronic Publication: 2019 Oct 31 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
G Protein-Coupled Inwardly-Rectifying Potassium Channels/*metabolism
Receptor, Muscarinic M2/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Acetylcholine/pharmacology ; Animals ; Binding Sites ; GTP-Binding Proteins/metabolism ; Ion Channel Gating/drug effects ; Membrane Potentials/drug effects ; Muscarinic Agonists/pharmacology ; Oocytes ; Patch-Clamp Techniques ; Receptor, Muscarinic M2/physiology ; Receptors, G-Protein-Coupled/physiology ; Signal Transduction/drug effects ; Xenopus Proteins ; Xenopus laevis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors.
Autorzy:
Alkawadri T; Smooth Muscle Research Centre, Dundalk Institute of Technology, Dublin Road, Dundalk, Co. Louth A91 K584, Ireland.
Wong PY; Smooth Muscle Research Centre, Dundalk Institute of Technology, Dublin Road, Dundalk, Co. Louth A91 K584, Ireland.
Fong Z; Smooth Muscle Research Centre, Dundalk Institute of Technology, Dublin Road, Dundalk, Co. Louth A91 K584, Ireland.
Lundy FT; The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland.
McGarvey LP; The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland.
Hollywood MA; Smooth Muscle Research Centre, Dundalk Institute of Technology, Dublin Road, Dundalk, Co. Louth A91 K584, Ireland.
Thornbury KD; Smooth Muscle Research Centre, Dundalk Institute of Technology, Dublin Road, Dundalk, Co. Louth A91 K584, Ireland.
Sergeant GP; Smooth Muscle Research Centre, Dundalk Institute of Technology, Dublin Road, Dundalk, Co. Louth A91 K584, Ireland.
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Źródło:
Function (Oxford, England) [Function (Oxf)] 2022 Sep 26; Vol. 3 (6), pp. zqac050. Date of Electronic Publication: 2022 Sep 26 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Muscle Contraction*
Receptors, Muscarinic*
Mice ; Animals ; Receptor, Muscarinic M2/genetics ; Muscarinic Antagonists/pharmacology ; Adrenergic beta-Agonists/pharmacology ; Muscle, Smooth ; Receptors, Adrenergic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Critical role of the finger loop in arrestin binding to the receptors.
Autorzy:
Zheng C; Department of Pharmacology, Vanderbilt University, Nashville, United States of America.
Tholen J; University of Applied Sciences Emden/Leer, Emden, Germany.
Gurevich VV; Department of Pharmacology, Vanderbilt University, Nashville, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Mar 15; Vol. 14 (3), pp. e0213792. Date of Electronic Publication: 2019 Mar 15 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Point Mutation*
Arrestins/*metabolism
Receptor, Muscarinic M2/*metabolism
Receptors, Adrenergic, beta-2/*metabolism
Receptors, Dopamine D1/*metabolism
Receptors, Dopamine D2/*metabolism
Amino Acid Sequence ; Arrestins/chemistry ; Arrestins/genetics ; HEK293 Cells ; Humans ; Protein Conformation ; Receptor, Muscarinic M2/chemistry ; Receptor, Muscarinic M2/genetics ; Receptors, Adrenergic, beta-2/chemistry ; Receptors, Adrenergic, beta-2/genetics ; Receptors, Dopamine D1/chemistry ; Receptors, Dopamine D1/genetics ; Receptors, Dopamine D2/chemistry ; Receptors, Dopamine D2/genetics ; Sequence Homology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Immunization with plasmids encoding M2 acetylcholine muscarinic receptor epitopes impairs cardiac function in mice and induces autophagy in the myocardium.
Autorzy:
Ribeiro KC; a Programa de Biologia Molecular e Estrutural, Instituto de Biofísica Carlos Chagas Filho , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.; b Instituto Nacional de Propriedade Industrial , Rio de Janeiro , Brazil.
Campelo RP; a Programa de Biologia Molecular e Estrutural, Instituto de Biofísica Carlos Chagas Filho , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.; c Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.
Rodrigues DDRF; a Programa de Biologia Molecular e Estrutural, Instituto de Biofísica Carlos Chagas Filho , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.; c Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.
Mattos EC; d Ecodata Exames Médicos Ltda , Rio de Janeiro , Brazil.
Brandão IT; e Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto , Universidade de São Paulo , Ribeirão Preto , Brazil.
da Silva CL; e Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto , Universidade de São Paulo , Ribeirão Preto , Brazil.
Bouskela E; f Lab. Pesq. Clínicas e Experimentais em Biologia Vascular - BioVasc Inst. De Biologia Roberto Alcântara Gomes e Fac. de Ciências Médicas , Universidade do Estado do Rio de Janeiro , Rio de Janeiro , Brazil.
Martinez CG; a Programa de Biologia Molecular e Estrutural, Instituto de Biofísica Carlos Chagas Filho , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.; g Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica , Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT , Rio de Janeiro , Brazil.
Kurtenbach E; a Programa de Biologia Molecular e Estrutural, Instituto de Biofísica Carlos Chagas Filho , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.; g Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica , Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT , Rio de Janeiro , Brazil.
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Źródło:
Autoimmunity [Autoimmunity] 2018 Aug; Vol. 51 (5), pp. 245-257. Date of Electronic Publication: 2018 Nov 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoantibodies*
Autophagy/*immunology
Cardiomyopathy, Dilated/*immunology
Myocardium/*immunology
Receptor, Muscarinic M2/*immunology
Animals ; Cardiomyopathy, Dilated/pathology ; Disease Models, Animal ; Epitopes/immunology ; Female ; Genetic Vectors/administration & dosage ; Genetic Vectors/genetics ; Humans ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron ; Myocardium/pathology ; Myocardium/ultrastructure ; Peptides/genetics ; Peptides/immunology ; Plasmids/genetics ; Receptor, Muscarinic M2/genetics
Czasopismo naukowe
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Tytuł:
Involvement of Allosteric Effect and K Ca Channels in Crosstalk between β₂-Adrenergic and Muscarinic M₂ Receptors in Airway Smooth Muscle.
Autorzy:
Kume H; Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan. .
Nishiyama O; Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan. .
Isoya T; Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan. .
Higashimoto Y; Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan. .
Tohda Y; Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan. .
Noda Y; Division of Clinical Sciences and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Jul 09; Vol. 19 (7). Date of Electronic Publication: 2018 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Muscle, Smooth/*metabolism
Receptor, Muscarinic M2/*metabolism
Receptors, Adrenergic, beta-2/*metabolism
Trachea/*metabolism
Adrenergic beta-2 Receptor Agonists/pharmacology ; Allosteric Regulation/drug effects ; Animals ; Guinea Pigs ; Male ; Muscarinic Antagonists/pharmacology ; Potassium Channels, Calcium-Activated/metabolism ; Receptor, Muscarinic M2/antagonists & inhibitors
Czasopismo naukowe
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Tytuł:
Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation.
Autorzy:
Di Bari M; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. .
Bevilacqua V; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. .
De Jaco A; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. .
Laneve P; Institute of Molecular Biology and Pathology, National Research Council of Italy, c/o Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. .
Piovesana R; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. .
Trobiani L; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. .
Talora C; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 291, 00161 Rome, Italy. .
Caffarelli E; Institute of Molecular Biology and Pathology, National Research Council of Italy, c/o Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. .
Tata AM; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. .; Research Center of Neurobiology 'Daniel Bovet', Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 May 31; Vol. 19 (6). Date of Electronic Publication: 2018 May 31.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*/drug effects
Signal Transduction*/drug effects
ErbB Receptors/*metabolism
Glioblastoma/*genetics
Glioblastoma/*metabolism
MicroRNAs/*genetics
Receptor, Muscarinic M2/*metabolism
Receptor, Notch1/*metabolism
Cell Line, Tumor ; Cell Proliferation ; Humans ; Models, Molecular ; Protein Binding ; RNA Interference ; Receptor, Muscarinic M2/agonists
Czasopismo naukowe
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Tytuł:
Differential voltage-dependent modulation of the ACh-gated K+ current by adenosine and acetylcholine.
Autorzy:
López-Serrano AL; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
Zamora-Cárdenas R; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
Aréchiga-Figueroa IA; CONACYT, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., Mexico.
Salazar-Fajardo PD; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
Ferrer T; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
Alamilla J; CONACYT, Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
Sánchez-Chapula JA; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
Navarro-Polanco RA; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
Moreno-Galindo EG; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., Mexico.
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Źródło:
PloS one [PLoS One] 2022 Jan 14; Vol. 17 (1), pp. e0261960. Date of Electronic Publication: 2022 Jan 14 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Acetylcholine/*pharmacology
Adenosine/*pharmacology
Adenosine A1 Receptor Agonists/*pharmacology
Ion Channel Gating/*drug effects
Myocytes, Cardiac/*metabolism
Potassium Channels/*metabolism
Receptor, Adenosine A1/*metabolism
Animals ; Female ; Guinea Pigs ; Male ; Receptor, Muscarinic M2/agonists ; Receptor, Muscarinic M2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Notch Signal Mediates the Cross-Interaction between M2 Muscarinic Acetylcholine Receptor and Neuregulin/ErbB Pathway: Effects on Schwann Cell Proliferation.
Autorzy:
Piovesana R; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Pisano A; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome and Policlinico Umberto I, 00185 Rome, Italy.
Loreti S; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Ricordy R; Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Talora C; Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Tata AM; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Research Centre of Neurobiology Daniel Bovet, 00185 Rome, Italy.
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Źródło:
Biomolecules [Biomolecules] 2022 Feb 01; Vol. 12 (2). Date of Electronic Publication: 2022 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Neuregulins*/metabolism
Receptor, ErbB-2*/metabolism
Receptors, Notch*/metabolism
Schwann Cells*/cytology
Schwann Cells*/metabolism
Signal Transduction*
Receptor, Muscarinic M2/*metabolism
Cell Proliferation ; Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Vibrational spectroscopy analysis of ligand efficacy in human M 2 muscarinic acetylcholine receptor (M 2 R).
Autorzy:
Katayama K; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. .; OptoBioTechnology Research Center, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. .; PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. .
Suzuki K; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan.
Suno R; Department of Medical Chemistry, Kansai Medical University, Hirakata, 573-1010, Japan.
Kise R; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.
Tsujimoto H; Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Iwata S; Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.
Kobayashi T; Department of Medical Chemistry, Kansai Medical University, Hirakata, 573-1010, Japan.; Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (AMED-CREST), Chiyoda-ku, Tokyo, 100-0004, Japan.
Kandori H; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. .; OptoBioTechnology Research Center, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. .
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Źródło:
Communications biology [Commun Biol] 2021 Nov 23; Vol. 4 (1), pp. 1321. Date of Electronic Publication: 2021 Nov 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptor, Muscarinic M2/*chemistry
Humans ; Ligands ; Spectrum Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 281

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