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Tytuł:
M2 Muscarinic Receptor Stimulation Induces Autophagy in Human Glioblastoma Cancer Stem Cells via mTOR Complex-1 Inhibition.
Autorzy:
Guerriero C; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Manfredelli M; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Matera C; Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.
Iuzzolino A; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Institute of Molecular Biology and Pathology, National Research Council, 00185 Rome, Italy.
Conti L; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy.
Dallanoce C; Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.
De Amici M; Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.
Trisciuoglio D; Institute of Molecular Biology and Pathology, National Research Council, 00185 Rome, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Research Centre of Neurobiology Daniel Bovet, Sapienza University of Rome, 00185 Rome, Italy.; Consortium Interuniversity Biotechnologies (CIB), University of Ferrara, 44121 Ferrara, Italy.
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Źródło:
Cancers [Cancers (Basel)] 2023 Dec 20; Vol. 16 (1). Date of Electronic Publication: 2023 Dec 20.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of Muscarinic Acetylcholine Receptors in Intestinal Epithelial Homeostasis: Insights for the Treatment of Inflammatory Bowel Disease.
Autorzy:
Uwada J; Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada 920-0293, Japan.
Nakazawa H; Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada 920-0293, Japan.
Muramatsu I; Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada 920-0293, Japan.; Division of Genomic Science and Microbiology, School of Medicine, University of Fukui, Eiheiji 910-1193, Japan.; Kimura Hospital, Awara, Fukui 919-0634, Japan.
Masuoka T; Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada 920-0293, Japan.
Yazawa T; Department of Biochemistry, Asahikawa Medical University, Asahikawa 078-8510, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 30; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Intestinal Mucosa*
Inflammatory Bowel Diseases*/drug therapy
Inflammatory Bowel Diseases*/etiology
Humans ; Acetylcholine ; Receptors, Muscarinic ; Inflammation ; Homeostasis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cold stress-induced bladder overactivity in type 2 diabetic mellitus rats is mitigated by the combination of a M 3 -muscarinic antagonist and a β 3 -adrenergic agonist.
Autorzy:
Hara H; Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
Imamura T; Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
Suzuki A; Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
Ueno M; Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
Minagawa T; Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
Ogawa T; Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
Ishizuka O; Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
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Źródło:
Lower urinary tract symptoms [Low Urin Tract Symptoms] 2023 Mar; Vol. 15 (2), pp. 68-75. Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Urinary Bladder, Overactive*/drug therapy
Diabetes Mellitus, Type 2*
Rats ; Female ; Animals ; Urinary Bladder ; Muscarinic Antagonists/pharmacology ; Solifenacin Succinate/therapeutic use ; Cold-Shock Response ; Adrenergic Agonists/pharmacology ; Adrenergic Agonists/therapeutic use ; Quality of Life ; Receptors, Muscarinic/therapeutic use ; RNA, Messenger/pharmacology ; RNA, Messenger/therapeutic use ; Receptors, Adrenergic/therapeutic use ; Adrenergic beta-3 Receptor Agonists/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Carbachol increases locus coeruleus activation by targeting noradrenergic neurons, inhibitory interneurons and inhibitory synaptic transmission.
Autorzy:
Kuo CC; Department of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan.
Chan H; Department of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan.
Hung WC; Department of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan.
Chen RF; Department of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan.; Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan.
Yang HW; Department of Biomedical Sciences, Chung-Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung-Shan Medical University Hospital, Taichung, Taiwan.
Min MY; Department of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan.; Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2023 Jan; Vol. 57 (1), pp. 32-53. Date of Electronic Publication: 2022 Dec 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adrenergic Neurons*/metabolism
Carbachol/pharmacology ; Locus Coeruleus/metabolism ; Receptors, Glycine ; Synaptic Transmission/physiology ; Receptors, Muscarinic/metabolism ; Muscarinic Agonists/pharmacology ; Interneurons/metabolism ; gamma-Aminobutyric Acid/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Blocking Muscarinic Receptor 3 Attenuates Tumor Growth and Decreases Immunosuppressive and Cholinergic Markers in an Orthotopic Mouse Model of Colorectal Cancer.
Autorzy:
Kuol N; Institute for Health and Sport, Victoria University, Melbourne 3011, Australia.; Department of Physiology and Cell Biology, University of Nevada, Reno, NV 89557, USA.
Davidson M; Institute for Health and Sport, Victoria University, Melbourne 3011, Australia.
Karakkat J; Institute for Health and Sport, Victoria University, Melbourne 3011, Australia.
Filippone RT; Institute for Health and Sport, Victoria University, Melbourne 3011, Australia.
Veale M; La Trobe Institute of Molecule Science, La Trobe University, Melbourne 3086, Australia.
Luwor R; Royal Melbourne Hospital, University of Melbourne, Melbourne 3010, Australia.
Fraser S; Institute for Health and Sport, Victoria University, Melbourne 3011, Australia.
Apostolopoulos V; Institute for Health and Sport, Victoria University, Melbourne 3011, Australia.; Immunology Program, Australian Institute of Musculoskeletal Sciences, Melbourne 3021, Australia.
Nurgali K; Institute for Health and Sport, Victoria University, Melbourne 3011, Australia.; Department of Medicine Western Health, University of Melbourne, Melbourne 3010, Australia.; Regenerative Medicine and Stem Cells Program, Australian Institute of Musculoskeletal Sciences, Melbourne 3021, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 29; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 29.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Neoplasms*/metabolism
Colorectal Neoplasms*/drug therapy
Animals ; Mice ; B7-H1 Antigen ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Muscarinic M3/metabolism ; Cholinergic Agents/therapeutic use ; Receptors, Muscarinic ; Atropine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice.
Autorzy:
Fujita M; Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-Ku, Tokyo, 156-8506, Japan.
Ochiai Y; Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-Ku, Tokyo, 156-8506, Japan.; Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
Hagino Y; Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-Ku, Tokyo, 156-8506, Japan.
Kobayashi K; Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, Japan.
Pavey G; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
Dean B; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
Ikeda K; Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-Ku, Tokyo, 156-8506, Japan. .
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Źródło:
Molecular brain [Mol Brain] 2022 Nov 29; Vol. 15 (1), pp. 96. Date of Electronic Publication: 2022 Nov 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dopamine*
Psychomotor Agitation*
Mice ; Animals ; Acetylcholine/pharmacology ; Esters ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cardiovascular responses induced by the activation of muscarinic receptors of the pedunculopontine tegmental nucleus in anesthetized rats.
Autorzy:
Alikhani V; Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Nikyar T; Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohebbati R; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Shafei MN; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Ghorbani A; Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
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Źródło:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2022 May 19; Vol. 44 (4), pp. 297-305. Date of Electronic Publication: 2022 Mar 10.
Typ publikacji:
Journal Article
MeSH Terms:
Pedunculopontine Tegmental Nucleus*
Rats ; Animals ; Atropine/pharmacology ; Acetylcholine/pharmacology ; Receptors, Muscarinic/physiology ; Cholinergic Agents
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
M 1 muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior.
Autorzy:
Walker LC; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Campbell EJ; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Huckstep KL; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Chen NA; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Langmead CJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Lawrence AJ; Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2022 Feb; Vol. 10 (1), pp. e00907.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alcohol Drinking/*metabolism
Consummatory Behavior/*drug effects
Picolinic Acids/*pharmacology
Receptor, Muscarinic M1/*metabolism
Thiazoles/*pharmacology
Alcoholism/physiopathology ; Alcoholism/therapy ; Animals ; Male ; Rats ; Receptor, Muscarinic M1/agonists ; Reward ; Self Administration ; Sucrose/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Notch Signal Mediates the Cross-Interaction between M2 Muscarinic Acetylcholine Receptor and Neuregulin/ErbB Pathway: Effects on Schwann Cell Proliferation.
Autorzy:
Piovesana R; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Pisano A; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome and Policlinico Umberto I, 00185 Rome, Italy.
Loreti S; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Ricordy R; Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Talora C; Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Tata AM; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Research Centre of Neurobiology Daniel Bovet, 00185 Rome, Italy.
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Źródło:
Biomolecules [Biomolecules] 2022 Feb 01; Vol. 12 (2). Date of Electronic Publication: 2022 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Neuregulins*/metabolism
Receptor, ErbB-2*/metabolism
Receptors, Notch*/metabolism
Schwann Cells*/cytology
Schwann Cells*/metabolism
Signal Transduction*
Receptor, Muscarinic M2/*metabolism
Cell Proliferation ; Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Analysis of Signal Transduction Pathways Downstream M2 Receptor Activation: Effects on Schwann Cell Migration and Morphology.
Autorzy:
Botticelli E; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Roma, Italy.
Salazar Intriago MS; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Roma, Italy.
Piovesana R; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Roma, Italy.; Department of Neurosciences, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Roma, Italy.; Research Centre of Neurobiology Daniel Bovet, 00185 Rome, Italy.
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Źródło:
Life (Basel, Switzerland) [Life (Basel)] 2022 Jan 29; Vol. 12 (2). Date of Electronic Publication: 2022 Jan 29.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Muscarinic receptor binding activity in rat tissues by vibegron and prediction of its receptor occupancy levels in the human bladder.
Autorzy:
Yamada S; Center for Pharma-Food Research, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Chimoto J; Center for Pharma-Food Research, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Shiho M; Faculty of Pharma-Science, Teikyo University, Tokyo, Japan.
Okura T; Faculty of Pharma-Science, Teikyo University, Tokyo, Japan.
Morikawa K; Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
Kagota S; Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
Shinozuka K; Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
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Źródło:
International journal of urology : official journal of the Japanese Urological Association [Int J Urol] 2021 Dec; Vol. 28 (12), pp. 1298-1303. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji:
Journal Article
MeSH Terms:
Urinary Bladder*
Urinary Bladder, Overactive*/drug therapy
Animals ; Humans ; Pyrimidinones ; Pyrrolidines ; Rats ; Receptors, Muscarinic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Muscarinic M 4 and M 5 receptors in the ventral subiculum differentially modulate alcohol seeking versus consumption in male alcohol-preferring rats.
Autorzy:
Walker LC; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Huckstep KL; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Chen NA; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Hand LJ; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Lindsley CW; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA.
Langmead CJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Lawrence AJ; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2021 Sep; Vol. 178 (18), pp. 3730-3746. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cholinergic Agents*
Ethanol*
Animals ; Hippocampus ; Male ; Nucleus Accumbens ; Rats ; Ventral Tegmental Area
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Combined Treatment with Chemotherapeutic Agents and the Dualsteric Muscarinic Agonist Iper-8-Naphthalimide Affects Drug Resistance in Glioblastoma Stem Cells.
Autorzy:
Guerriero C; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Matera C; Department of Pharmaceutical Sciences, Medicinal Chemistry Section 'Pietro Pratesi', University of Milan, 20133 Milan, Italy.
Del Bufalo D; Preclinical Models and New Therapeutic Agents Unit, Regina Elena National Cancer Institute, 00187 Rome, Italy.
De Amici M; Department of Pharmaceutical Sciences, Medicinal Chemistry Section 'Pietro Pratesi', University of Milan, 20133 Milan, Italy.
Conti L; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy.
Dallanoce C; Department of Pharmaceutical Sciences, Medicinal Chemistry Section 'Pietro Pratesi', University of Milan, 20133 Milan, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Research Centre of Neurobiology Daniel Bovet, 00185 Rome, Italy.
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Źródło:
Cells [Cells] 2021 Jul 24; Vol. 10 (8). Date of Electronic Publication: 2021 Jul 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Neoplasm*
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
Muscarinic Agonists/*pharmacology
Naphthalimides/*pharmacology
Neoplastic Stem Cells/*drug effects
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; Doxorubicin/pharmacology ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Receptor, Muscarinic M2/agonists ; Receptor, Muscarinic M2/genetics ; Receptor, Muscarinic M2/metabolism ; Signal Transduction ; Temozolomide/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines.
Autorzy:
Di Bari M; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Tombolillo V; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Alessandrini F; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Guerriero C; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Fiore M; Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Asteriti IA; Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Castigli E; Department of Experimental Medicine, Section of Physiology and Biochemistry, University of Perugia, 06100 Perugia, Italy.
Sciaccaluga M; Department of Medicine and Surgery, University of Perugia, 06100 Perugia, Italy.
Guarguaglini G; Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Degrassi F; Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Research Centre of Neurobiology Daniel Bovet, 00185 Rome, Italy.
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Źródło:
Cells [Cells] 2021 Jul 08; Vol. 10 (7). Date of Electronic Publication: 2021 Jul 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mitosis*
Glioblastoma/*metabolism
Glioblastoma/*pathology
Receptor, Muscarinic M2/*metabolism
Spindle Apparatus/*metabolism
Acetylation/drug effects ; Arecoline/analogs & derivatives ; Arecoline/pharmacology ; Cell Line, Tumor ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Humans ; Metaphase/drug effects ; Sirtuin 2/metabolism ; Time-Lapse Imaging ; Tubulin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Aged Mice Devoid of the M 3 Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease.
Autorzy:
Musayeva A; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.; Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Jiang S; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Ruan Y; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Zadeh JK; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Chronopoulos P; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Pfeiffer N; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Müller WEG; ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center, Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany.
Ackermann M; Institute of Functional and Clinical Anatomy, University Medical Center, Johannes Gutenberg University Mainz, Johann-Joachim-Becher-Weg 13, 55128 Mainz, Germany.
Xia N; Department of Pharmacology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Li H; Department of Pharmacology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Gericke A; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 07; Vol. 22 (11). Date of Electronic Publication: 2021 Jun 07.
Typ publikacji:
Journal Article
MeSH Terms:
Conjunctiva/*pathology
Dry Eye Syndromes/*pathology
Epithelium, Corneal/*pathology
Goblet Cells/*pathology
Receptor, Muscarinic M3/*physiology
Animals ; Conjunctiva/metabolism ; Disease Models, Animal ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/metabolism ; Epithelium, Corneal/metabolism ; Goblet Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Reactive Oxygen Species/metabolism ; Tears/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Signaling and function of cardiac autonomic nervous system receptors: Insights from the GPCR signalling universe.
Autorzy:
Lymperopoulos A; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
Cora N; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
Maning J; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
Brill AR; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
Sizova A; Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
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Źródło:
The FEBS journal [FEBS J] 2021 Apr; Vol. 288 (8), pp. 2645-2659. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Autonomic Nervous System/*metabolism
Heart Failure/*genetics
Receptors, G-Protein-Coupled/*genetics
Synaptic Transmission/*genetics
Acetylcholine/metabolism ; Autonomic Nervous System/physiology ; Endothelial Cells/metabolism ; Heart Failure/metabolism ; Humans ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Functions of Muscarinic Receptor Subtypes in Gastrointestinal Smooth Muscle: A Review of Studies with Receptor-Knockout Mice.
Autorzy:
Tanahashi Y; Department of Advanced Life Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan.
Komori S; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Matsuyama H; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Kitazawa T; Department of Veterinary Science, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
Unno T; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 18; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Gastrointestinal Tract/*metabolism
Muscle, Smooth/*metabolism
Receptor, Muscarinic M2/*genetics
Receptor, Muscarinic M3/*genetics
Animals ; GTP-Binding Proteins/genetics ; Gastrointestinal Tract/growth & development ; Gastrointestinal Tract/pathology ; Mice, Knockout/genetics ; Muscle Contraction/genetics ; Muscle, Smooth/growth & development ; Signal Transduction/genetics ; Mice
Czasopismo naukowe
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Tytuł:
Are We missing out the role of oxytocin in overactive bladder syndrome?
Autorzy:
Canguven O; Hamad General Hospital, Doha, Qatar.; Weill Cornell Medicine, Urology, USA.
Talib R; Department of Urology & Andrology, Hamad General Hospital, Doha, Qatar.
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Źródło:
The aging male : the official journal of the International Society for the Study of the Aging Male [Aging Male] 2020 Dec; Vol. 23 (5), pp. 700-704. Date of Electronic Publication: 2019 Mar 23.
Typ publikacji:
Journal Article
MeSH Terms:
Urinary Bladder, Overactive*/drug therapy
Urinary Incontinence*
Humans ; Muscle Contraction ; Oxytocin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Activation of multiple receptors stimulates extracellular vesicle release from trophoblast cells.
Autorzy:
Conrad KP; Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, USA.; Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL, USA.; D. H. Barron Reproductive and Perinatal Biology Research Program, University of Florida, Gainesville, FL, USA.
Tuna KM; Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, USA.
Mestre CT; Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, USA.
Banwatt ES; Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, USA.
Alli AA; Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, USA.; Department of Medicine, Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL, USA.
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Źródło:
Physiological reports [Physiol Rep] 2020 Oct; Vol. 8 (20), pp. e14592.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Extracellular Vesicles/*metabolism
Receptors, Cholecystokinin/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Trophoblasts/*metabolism
Calcium/metabolism ; Cell Line, Tumor ; Cholecystokinin/pharmacology ; Diphenhydramine/pharmacology ; Extracellular Vesicles/drug effects ; Flufenamic Acid/pharmacology ; Humans ; Receptors, Cholecystokinin/agonists ; Receptors, G-Protein-Coupled/agonists ; Trophoblasts/cytology
Czasopismo naukowe
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Tytuł:
Navafenterol (AZD8871) in patients with mild asthma: a randomised placebo-controlled phase I study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator.
Autorzy:
Jimenez E; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, 08020, Barcelona, Spain. .
Astbury C; Research and Early Development, Respiratory, Inflammation and Autoimmune, BioPharmaceuticals R&D, AstraZeneca, Barcelona, Spain.
Albayaty M; Early Phase Clinical Unit, PAREXEL International GmbH, Harrow, UK.
Wählby-Hamrén U; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
Seoane B; Biometrics and Information Sciences, Late-Stage Development, BioPharmaceuticals R&D, AstraZeneca, Barcelona, Spain.
Villarroel C; Late-Stage Development, BioPharmaceuticals R&D, AstraZeneca, Barcelona, Spain.
Pujol H; Research and Early Development, Respiratory, Inflammation and Autoimmune, BioPharmaceuticals R&D, AstraZeneca, Barcelona, Spain.
Bermejo MJ; Patient Safety, Chief Medical Office, R&D, AstraZeneca, Barcelona, Spain.
Aggarwal A; Research and Early Development, Respiratory, Inflammation and Autoimmune, BioPharmaceuticals R&D, AstraZeneca, Barcelona, Spain.
Psallidas I; Research and Early Development, Respiratory, Inflammation and Autoimmune, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
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Źródło:
Respiratory research [Respir Res] 2020 Sep 09; Vol. 21 (Suppl 1), pp. 211. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
MeSH Terms:
Adrenergic beta-2 Receptor Agonists/*administration & dosage
Asthma/*drug therapy
Bronchoconstriction/*drug effects
Bronchodilator Agents/*administration & dosage
Lung/*drug effects
Muscarinic Antagonists/*administration & dosage
Quinolines/*administration & dosage
Triazoles/*administration & dosage
Administration, Inhalation ; Adrenergic beta-2 Receptor Agonists/adverse effects ; Adrenergic beta-2 Receptor Agonists/pharmacokinetics ; Adult ; Asthma/diagnosis ; Asthma/physiopathology ; Bronchodilator Agents/adverse effects ; Bronchodilator Agents/pharmacokinetics ; England ; Female ; Forced Expiratory Volume ; Humans ; Lung/physiopathology ; Male ; Middle Aged ; Muscarinic Antagonists/adverse effects ; Muscarinic Antagonists/pharmacokinetics ; Quinolines/adverse effects ; Quinolines/pharmacokinetics ; Recovery of Function ; Severity of Illness Index ; Single-Blind Method ; Treatment Outcome ; Triazoles/adverse effects ; Triazoles/pharmacokinetics
Czasopismo naukowe
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